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Headache in Pregnancy

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121. Predictors of Headache Before, During, and After Pregnancy: A Cohort Study. Full Text available with Trip Pro

to those without a history of headache, a history of headache prior to pregnancy was the strongest predictor of headache during pregnancy (9.8% vs 23.5%; risk ratio 2.4; 95% confidence interval [CI]: 1.4 to 4.0). Experiencing headache during pregnancy (adjusted hazard ratio HR 3.8; 95% CI: 2.4 to 6.2) and receiving needle-based regional anesthesia for pain treatment (adjusted hazard ratio 2.2; 95% CI: 1.1 to 4.5) were independently associated with headache within 72 hours after delivery with event (...) is a strong predictor of headache during and after pregnancy, the latter independent of but compounded by spinal injection. Physicians should attend to prior headache history when making decisions about pain management during and after childbirth. As the lack of formal International Classification of Headache Disorders, 2nd Edition (ICHD-II), headache diagnoses is a limitation of this study, future longitudinal studies should replicate the present design while including headache subtyping consistent

2012 Headache

122. Cervical ripening before first trimester surgical evacuation for non-viable pregnancy. (Abstract)

are required to determine whether the benefits of this treatment outweigh the risks. Further research should be powered to assess the rate of cervical and uterine injury between interventions. Future research should also guide clinicians in deciding whether the benefits of reduced manual cervical dilatation outweigh the risks of adverse effects associated with these agents (nausea, vomiting, headache, fever, diarrhoea and pain). Women's satisfaction and outcomes of future pregnancies should also (...) ; one trial, 120 women), and surgical time was reduced when misoprostol was used (mean difference (MD) -3.15, 95% CI -3.59 to -2.70; one trial, 120 women). However, compared to placebo, misoprostol, was associated with more abdominal pain (RR 29.00, 95% CI 1.77 to 475.35; one trial, 120 women), although no clear differences in the risk of other adverse effects (nausea, vomiting, headache or fever) were observed between groups.There was no clear differences between chemical dilation and mechanical

2015 Cochrane

123. Pharmacological interventions for promoting smoking cessation during pregnancy. Full Text available with Trip Pro

Pharmacological interventions for promoting smoking cessation during pregnancy. Smoking in pregnancy is a public health problem. When used by non-pregnant smokers, pharmacotherapies (nicotine replacement therapy (NRT), bupropion and varenicline) are effective for smoking cessation, however, their efficacy and safety in pregnancy remains unknown. Electronic Nicotine Delivery Systems (ENDS), or e-cigarettes, are becoming widely used but their efficacy and safety when used for smoking cessation (...) in pregnancy are also unknown.To determine the efficacy and safety of smoking cessation pharmacotherapies (including NRT, varenicline and bupropion), other medications, or ENDS when used for smoking cessation in pregnancy.We searched the Pregnancy and Childbirth Group's Trials Register (11 July 2015), checked references of retrieved studies, and contacted authors.Randomised controlled trials (RCTs) conducted in pregnant women with designs that permit the independent effects of any type of pharmacotherapy

2015 Cochrane

124. Self-reported Physical Health of Women Who Did and Did Not Terminate Pregnancy After Seeking Abortion Services: A Cohort Study. (Abstract)

facilities from 2008 to 2010.Of 1132 women seeking abortion who consented to participate, 874 were included in this analysis (328 who had first-trimester abortion, 383 who had second-trimester abortion, and 163 who gave birth).Self-reported overall health; chronic abdominal, pelvic, back, and joint pain; chronic headaches or migraines; obesity; asthma; gestational and nongestational hypertension and diabetes; and hyperlipidemia were assessed semiannually for 5 years. Mortality was assessed by using (...) verbal autopsy and public records.No significant differences were observed in self-rated health or chronic pain after first-trimester versus second-trimester abortion. At 5 years, 27% (95% CI, 21% to 34%) of women who gave birth reported fair or poor health compared with 20% (CI, 16% to 24%) of women who had first-trimester abortion and 21% (CI, 18% to 25%) who had second-trimester abortion. Women who gave birth also reported more chronic headaches or migraines and joint pain, but experienced similar

2019 Annals of Internal Medicine

125. Perimenopause and Menopause Are Associated With High Frequency Headache in Women With Migraine: Results of the American Migraine Prevalence and Prevention Study. (Abstract)

on the frequency of headache attacks in women with migraine has not been explored.This was a cross-sectional observational study. Using data from the 2006 American Migraine, Prevalence and Prevention study survey, women meeting modified ICHD-3 beta criteria for migraine between the ages of 35-65 years were included in analyses. Women who had never menstruated or were pregnant, breastfeeding, or using exogenous sex hormones were excluded. The 2006 survey was selected because it included detailed questions (...) Perimenopause and Menopause Are Associated With High Frequency Headache in Women With Migraine: Results of the American Migraine Prevalence and Prevention Study. To examine the relationship of headache frequency to the stages of the menopausal transition in mid-life women with migraine.Past studies suggest that the perimenopause is associated with an increased prevalence of migraine, particularly in those with a history of premenstrual syndrome. The effect of the menopausal transition

2016 Headache

126. Thunderclap Headache Secondary to Pneumocephalus Following Epidural Anesthesia Full Text available with Trip Pro

pneumocephalus pregnancy thunderclap headache 2016 7 2 6 0 2016 7 2 6 0 2016 7 2 6 1 ppublish 27366299 10.1177/1941874416632047 10.1177_1941874416632047 PMC4906556 Anaesthesist. 2003 Sep;52(9):798-800 14504806 JAMA. 2003 Mar 19;289(11):1430-3 12636467 Acta Anaesthesiol Scand. 2014 Aug;58(7):858-66 24961586 Continuum (Minneap Minn). 2014 Feb;20(1 Neurology of Pregnancy):128-47 24492815 Obstet Gynecol. 2006 Sep;108(3 Pt 2):795-8 17018506 (...) Thunderclap Headache Secondary to Pneumocephalus Following Epidural Anesthesia 27366299 2016 07 01 2018 11 13 1941-8744 6 3 2016 Jul The Neurohospitalist Neurohospitalist Thunderclap Headache Secondary to Pneumocephalus Following Epidural Anesthesia. 132-3 10.1177/1941874416632047 Avila J David JD Washington University School of Medicine, Department of Neurology, St Louis, MO, USA. eng Journal Article 2016 02 16 United States Neurohospitalist 101558199 1941-8744 epidural anesthesia

2016 The Neurohospitalist

127. Idiopathic intracranial hypertension presenting as postpartum headache Full Text available with Trip Pro

Idiopathic intracranial hypertension presenting as postpartum headache Postpartum headache is described as headache and neck or shoulder pain during the first 6 weeks after delivery. Common causes of headache in the puerperium are migraine headache and tension headache; other causes include pre-eclampsia/eclampsia, post-dural puncture headache, cortical vein thrombosis, subarachnoid hemorrhage, posterior reversible leukoencephalopathy syndrome, brain tumor, cerebral ischemia, meningitis, and so (...) forth. Idiopathic intracranial hypertension (IIH) is a rare cause of postpartum headache. It is usually associated with papilledema, headache, and elevated intracranial pressure without any focal neurologic abnormality in an otherwise healthy person. It is more commonly seen in obese women of reproductive age group, but rare during pregnancy and postpartum. We present a case of IIH who presented to us 18 days after cesarean section with severe headache and was successfully managed.

2016 Neurosciences

128. Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache

, 2017 Sponsor: The Cooper Health System Information provided by (Responsible Party): Christopher Jones, The Cooper Health System Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether patients in the emergency department with migraine headache who are administered an intravenous fluid bolus will report greater improvement in pain scores than control patients. Condition or disease Intervention/treatment Phase Migraine Headache Other: Normal saline (1000 (...) mL) Other: Control Phase 2 Phase 3 Detailed Description: The investigators intend to perform a small-scale pilot study assessing the effectiveness of IV fluid therapy for patients presenting to the ED with migraine headache. Patients will be randomly allocated to receive a bolus of 1000 ml normal saline or no fluid bolus. Patients and outcome assessors will be blinded to the assigned study group. Research assistants will assess pain scores, nausea, and functional disability at time 0 (just prior

2016 Clinical Trials

129. A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH)

for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Headache Cluster Headache Pain Neurologic Manifestations Signs and Symptoms Trigeminal Autonomic Cephalalgias Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Antibodies, Monoclonal Immunologic Factors Physiological Effects of Drugs (...) A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

130. Prazosin for Post-Concussive Headaches

and worsen to become a debilitating chronic pain syndrome. The purpose of this study is to evaluate the centrally acting alpha-1 adrenoreceptor (AR) antagonist drug prazosin as a prophylactic treatment for chronic posttraumatic headaches (PTHAs). The impetus for this study comes from a large open-label case series in Iraq and Afghanistan Veterans with mTBI and PTHAs and data from a placebo-controlled trial evaluating use of prazosin for posttraumatic stress disorder (PTSD) in active-duty Servicemembers (...) amnesia (up to 1 day post-injury). If available, the Glasgow Coma Scale score must be 13-15, and head imaging findings (if imaging was performed) must be negative. Frequent headaches (HAs) that started within 3 months after a head injury or marked worsening (a two-fold or greater increase in frequency and/or severity) of pre-existing headaches within 3 months of head injury. HAs either 1) must last 4 or more hours a day and reach a moderate to severe intensity at any point during the headache, or 2

2016 Clinical Trials

131. The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age 18 to 65 years Temperature < 100.4° F Diastolic Blood Pressure <104 mm Hg Normal neurological exam and mormal mental status Exclusion Criteria: Pregnant or breastfeeding. Meningeal signs are present Acute angle closure glaucoma is suspected. Head trauma (...) Additional relevant MeSH terms: Layout table for MeSH terms Headache Pain Neurologic Manifestations Signs and Symptoms Ketamine Diphenhydramine Ondansetron Prochlorperazine Promethazine Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics, Dissociative Anesthetics, Intravenous Anesthetics, General Anesthetics Central Nervous System Depressants Excitatory Amino Acid Antagonists Excitatory Amino Acid Agents Neurotransmitter Agents Molecular Mechanisms

2016 Clinical Trials

132. Specific Neck Rehabilitation for Unilateral Neck Related Headache and Structural Changes in the Brain

[ Time Frame: 6 months after baseline ] Two independent group comparison with a numeric variable (scale 0-7) Differences in grey matter volume of the brain and brain stem in patients with unilateral headache and neck pain vs. healthy controls [ Time Frame: Baseline ] Surface based volumetric analyses of cerebral grey matter Secondary Outcome Measures : Difference in pain intensity after specific neck rehabilitation vs. standard primary health care [ Time Frame: 6 months after baseline ] Two (...) independent group comparison with a numeric variable (scale 0-10) Improved neck function after specific neck rehabilitation vs. standard primary health care [ Time Frame: 6 months after baseline ] Two independent group comparison with a numeric variable (scale 0-100) Differences in white matter integrity in patients with unilateral headache and neck pain vs. healthy controls [ Time Frame: Baseline ] Diffusion tensor imaging with tract based spatial statistics analyses Difference in white matter integrity

2016 Clinical Trials

133. Comparison of Two Detoxification Protocols for Treatment of Medication-overuse Headache

Pregnancy or breastfeeding Inadequate language skills to follow the patient education and filling out questionnaires. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02903329 Locations Layout table for location information Denmark Danish Headache Center (...) Identifier: Other Study ID Numbers: H-1-2012-116 First Posted: September 16, 2016 Last Update Posted: July 24, 2018 Last Verified: July 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Additional relevant MeSH terms: Layout table for MeSH terms Headache Headache Disorders, Secondary Pain Neurologic Manifestations Signs and Symptoms Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases

2016 Clinical Trials

134. Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department

interrupted the prolonged, intractable migraine spiral they had suffered for days. Furthermore, a case series of six cases of migraine treated with 5mg of haloperidol IV after a 500 to 1000ml bolus of IV fluids reported complete or substantial relief within 25 to 65 minutes and side effects were reported as minimal. The investigators hypothesize that Haloperidol is more efficacious than metoclopramide in the treatment of an acute headache or migraine in the ED in regard to a self-reported pain rating (...) scale (Numeric Pain Intensity Scale), need for additional medication, emergency department return rates, and resolution of symptoms. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 66 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment Official Title: Investigating the Efficacy of Using Haloperidol vs. Metoclopramide for Treatment of Acute Headaches

2016 Clinical Trials

135. Psilocybin for the Treatment of Cluster Headache

Identifier: Other Study ID Numbers: 1607018057 First Posted: December 5, 2016 Last Update Posted: December 20, 2018 Last Verified: December 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Additional relevant MeSH terms: Layout table for MeSH terms Headache Cluster Headache Pain Neurologic Manifestations Signs and Symptoms Trigeminal Autonomic Cephalalgias Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases (...) Headache-Trigeminal Autonomic Cephalalgia (CH-TAC), LLC Information provided by (Responsible Party): Deepak C. D'Souza, Yale University Study Details Study Description Go to Brief Summary: The purpose of this study is to investigate the effects of an oral psilocybin pulse regimen in cluster headache. Subjects will be randomized to receive oral placebo, low dose psilocybin, or high dose psilocybin in three experimental sessions, each separated by 5 days. Subjects will maintain a headache diary prior

2016 Clinical Trials

136. Body Mass Index and Post-dural Puncture Headache

Summary: Post-dural puncture headache (PDPH) is seen more frequently in pregnant women due to stress, dehydration, intra-abdominal pressure, and insufficient fluid replacement after delivery. Obesity protects against PDPH in pregnant women; increased intra-abdominal fat tissue reduced cerebrospinal fluid leakage by increasing the pressure in the epidural space. Therefore, this study investigated the influence of body mass index (BMI) on PDPH in elective caesarean section patients in whom 27G spinal (...) (Group I) and those with a BMI above 30 were accepted as obese (Group II). Dural puncture performed with a 27G Quincke spinal needle at the L3-4 or L4-5 intervertebral space and given 12.5 mg hyperbaric bupivacaine intrathecally. The patients were questioned regarding headache and low back pain 6, 12, 24, and 48 hours after the procedure, and by phone calls on days 3 and 7. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 420

2016 Clinical Trials

137. A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH)

Party: Teva Branded Pharmaceutical Products, R&D Inc. ClinicalTrials.gov Identifier: Other Study ID Numbers: TV48125-CNS-30056 2016-003278-42 ( EudraCT Number ) First Posted: October 26, 2016 Last Update Posted: March 13, 2019 Last Verified: March 2019 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Headache Cluster Headache Pain Neurologic Manifestations (...) Signs and Symptoms Trigeminal Autonomic Cephalalgias Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Antibodies, Monoclonal Immunologic Factors Physiological Effects of Drugs

2016 Clinical Trials

138. Is Detoxification Needed in Medication-overuse Headache?

. Headache days / month ≤ 6 at time of inclusion. Days with analgesics / month ≤ 6 at time of inclusion. Prophylactics are allowed. Age ≥ 18 years old. Ability to fill out headache calendar. No previous medication overuse. No significant co-morbid pain, physical or psychiatric disorders. No addiction to alcohol or drug-abuse. No pregnancy, breastfeeding or planned pregnancy within the next 12 months. Criteria for Control group 2 - Healthy volunteers: •≥ 2 days with headache in the past month at time (...) . Exclusion Criteria: Severe physical illness or psychiatric disorders. Addiction to alcohol or other drugs. Current treatment with headache prophylaxis. Patients can be included minimum 5 weeks after stop of prophylaxis. Pregnancy, breastfeeding or planned pregnancy within the next 12 months. Inability to provide reliable information about medical history. Criteria for Control group 1 - Episodic migraineurs: Episodic migraine, with/without concomitant tension-type headache, according to the ICHD-III beta

2016 Clinical Trials

139. S100B in the Care of Non-traumatic Headaches in the Emergency Department

and signed consent The patient must be insured or beneficiary of a health insurance plan The patient has nontraumatic headache pain with a visual analog scale > 3 Exclusion Criteria: The patient is participating in another study The patient is in an exclusion period determined by a previous study The patient is under judicial protection, under tutorship or curatorship The patient refuses to sign the consent It is impossible to correctly inform the patient The patient is pregnant, parturient (...) , a radiologist and an emergency physician. Condition or disease Intervention/treatment Phase Headache Biological: Plasma S100B levels at inclusion Device: Magnetic resonance imaging Not Applicable Detailed Description: The secondary objectives of this study are: A. To seek an association between S100B protein levels and the onset of pain depending on whether it is more or less than 3 hours. B. To assess the association between S100B protein levels and mortality at day 28. C. To evaluate the association

2016 Clinical Trials

140. Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout

Population Episodic cluster headache patients diagnosed according to International Classification of Headache disorders III beta (ICHD III beta) Criteria Inclusion Criteria: Age between 18 and 65 years of age Episodic cluster headache according to ICHD-III beta Ability to differentiate attacks of other primary headaches from cluster headache. 1-8 daily attacks Cluster bouts normally lasting more than 2 weeks Exclusion Criteria: Treatment with psychiatric medication other than lithium. Pregnancy (...) , Danish Headache Center ClinicalTrials.gov Identifier: Other Study ID Numbers: H-7-2014-020 Sleep study First Posted: February 20, 2018 Last Update Posted: February 20, 2018 Last Verified: February 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Keywords provided by MD, Ph.d.-student Nunu Lund, Danish Headache Center: cluster headache sleep disturbances Additional relevant MeSH terms: Layout table for MeSH terms Headache Cluster Headache Pain Neurologic

2016 Clinical Trials

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