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Headache in Pregnancy

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5141. Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery

with Decrease in Nasal symptome Visual Analogue Scale (VAS) [ Time Frame: 9 months ] nasal symptoms include general symptom, congestion, rhinorrhea, olfactory loss and headache. Secondary Outcome Measures : Percentage of Participants with Decrease in nasal endoscopy score (Lund-Kennedy score) [ Time Frame: 9 months ] Visit 1: baseline Visit 2:Day 31 post-FESS Visit 3: Day 61 post-FESS Visit 4: Day 91 post-FESS Visit 5: Day 181 post-FESS Visit 6: Day 271 post-FESS Percentage of Participants with Decrease (...) Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Diagnosis of chronic rhinosinusitis according to European position paper of rhinosinusitis and nasal polyps 2007 Diagnosis of asthma based on Global initiative for asthma 2012 All patients should provide informed consent prior to the study and agree to follow-up appointments. Exclusion Criteria: Immunodeficiency diseases, history of head and/or facial

2014 Clinical Trials

5142. Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma

- Patient neurologically normal Grade 1 - Patient alert and oriented; mild symptoms, such as headache; absent or mild symptoms or neurologic deficit, such as reflex asymmetry Grade 2 - Patient drowsy or disoriented with variable neurological deficit, such as hemiparesis Grade 3 - Patient stuporous but responding appropriately to noxious stimuli; several focal signs, such as hemiparesis Grade 4 - Patient comatose with absent motor response to painful stimuli; decerebrate or decorticate posturing. Higher (...) Presence of symptoms referable to chronic subdural hematoma, including one or more of the following: Headache; altered mental status, limb weakness, dysphasia, or focal neurological deficit Demonstration of unilateral chronic subdural hematoma on cranial imaging, including the following features: On computed tomography imaging, iso- or hypo-intensity extra-axial collection with or without presence of acute component; radiologic interpretation of magnetic resonance imaging consistent with subacute

2014 Clinical Trials

5143. Botulinum Toxin for the Treatment of Trigeminal Neuralgia

Volunteers: No Criteria Inclusion Criteria:Inclusion Criteria Age 18 - 75 yrs Male or non-pregnant/non-lactating female Subjects must have a mean attack frequency of at least 3 episodes/day of 4/10 pain Use of adequate birth-control measures as determined by investigator for females of child-bearing potential Diagnosis of Classical trigeminal neuralgia (TN) using International Classification of Headache Disorders (ICHD-2) criteria (see Appendix A in Protocol) Subjects have given written informed consent (...) Serious hepatic, respiratory, hematologic, cardiovascular or renal condition Neurologic pain other than TN, with the exception of occasional migraine or tension-type headaches. (<4 headaches per month; < 10 headache days/month) Psychiatric or medical condition that might compromise participation in study, as determined by the investigator Administration of any investigational drug within 30 days prior to screening History of substance abuse/alcoholism Contacts and Locations Go to Information from

2014 Clinical Trials

5144. Feasibility and Tolerability of Adjunct Chronotherapy in Depressed Inpatients

severe headaches, stroke, or other neurologic illness that produces either gait abnormalities or a lowered seizure threshold. Medical illness that would make wake therapy intolerable, or significant cardiac disease. Cataracts, glaucoma, or other intrinsic eye condition. Currently taking light sensitizing medications. Current pregnancy which is routinely tested for prior to admission. Mental retardation, or dementia. Untreated sleep disorder such as Obstructive sleep apnea, narcolepsy, or PLMD

2014 Clinical Trials

5145. A Study of Whether 2 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication

A Study of Whether 2 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication A Study of Whether 2 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study (...) Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of Whether 2 New Oral Formulations of a Strong Pain Killer Release the Same Amount of Drug Into the Body as the Marketed Medication The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov

2014 Clinical Trials

5146. Study of SP306 Given Intramuscularly Compared to DT BIK® Given Subcutaneously in Japanese Adolescents 11 to 12 Years Old

-vaccination) and Day 28 post-vaccination ] Pertussis antitoxin concentration were assayed by the enzyme-linked immunosorbent assay (ELISA) method Percentage of Participants Reporting Solicited Injection-site and Systemic Reactions Following a Single Booster Dose of SP306 or DT Vaccine [ Time Frame: Day 0 up to Day 7 post-vaccination ] Solicited injection-site: Pain, Erythema, Swelling; Solicited systemic reactions: Fever (Temperature), Headache, Malaise, and Myalgia. Grade 3 injection-site: Pain (...) Significant, prevents daily activity; Erythema and Swelling >100 mm. Grade 3 systemic reactions: Fever, >39˚C; Headache, Malaise, and Myalgia, Significant, prevents daily activity. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using

2014 Clinical Trials

5147. The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device

The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device (Head Position) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02079792 Recruitment Status : Completed First Posted : March 6, 2014 Last

2014 Clinical Trials

5148. Mindfulness in Mood Dysregulated Youth

patients who are either pregnant or lactating; All girls will have a urine pregnancy test prior to MR scans Any contraindication to an MRI scan (e.g., metal clips, braces or claustrophobia) Neurological disorders (e.g. epilepsy) or severe head trauma resulting in loss of consciousness for > 10 minutes or any unstable medical illness. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff (...) , involves weekly group sessions, home practice, and the core curriculum of formal mindfulness practices (e.g. body scan, sitting, movement and walking meditations). Group sessions will involve guided meditation practices, instructor-led discussion of experiences and psychoeducation. By fopstering the ability to pay close attention to thoughts, emotions and body sensations, participants learn to make better choices to deal with stress, anxiety, depression, pain and other challenges. This can allow them

2014 Clinical Trials

5149. Transforming Research and Clinical Knowledge in Traumatic Brain Injury

the clinical, neuroimaging, cognitive, genetic and proteomic biomarker characteristics for the entire spectrum of TBI from concussion to coma. TRACK-TBI will validate biomarkers and outcome measures for clinical trials, advance diagnostic and prognostic models for TBI and improve clinical trial design. We are enrolling patients within 24 hours of injury who present to a TRACK-TBI site with a brain injury that meets ACRM criteria and receives a clinically indicated head CT. Condition or disease Intervention (...) of Adult Cognition by Telephone (BTACT) Rivermead Post-Concussion Symptoms Questionnaire Pain Intensity and Interference Instruments (PROMIS-PAIN) Insomnia Severity Index (ISI) Quality of Life After Brain Injury Overall Scale (QOLIBRI-OS) Mayo-Portland Adaptability Inventory - Participation (MPAI-PART) Satisfaction with Life Scale (SWLS) 12-Item Short Form Survey (SF-12) Alcohol Use Disorders Identification Test 3-Item (AUDIT-C) 3-Item Drug Use Interview Post-Traumatic Stress Disorder Checklist 5 (PCL

2014 Clinical Trials

5150. Hemodynamic Effects of Terlipressin and High Dose Octreotide

and HR after administration to find out the effects of terlipressin or octreotide on systemic hemodynamics. Incidence rate of complications [ Time Frame: Participants will be followed for up to 24h starting from the moment of administration ] We intend to set incidence rate of complications associated with terlipressin or octreotide, to be specific, which include hypertension, abdominal pain, nausea, vomiting, diarrhea, headache, transient arrhythmia and vertigo. Participants will be followed for up (...) syndrome or renal inadequacy The patients with uncontrolled hepatic encephalopathy Pregnant and lactating women The patients who had contraindications for terlipressin or octreotide The patients who refuse to take part in this study Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov

2014 Clinical Trials

5151. Neural Substrates of Approach-Avoidance Conflict

having received any medication to treat a psychiatric disorder within the past year, have a past or present diagnosis of a psychotic or bipolar disorder, or have ever had a head injury requiring hospitalization; Weigh over 330 pounds; Are pregnant, as determined by a positive pregnancy test, or breast feeding; Report to have a facial, body, and limb flushing response to the consumption of alcohol, as determined by the Alcohol Flushing Questionnaire; Report to have a "facial flushing" response (...) closed spaces (have claustrophobia), or cannot lie comfortably on their back for up to one hour; Medical illnesses (such as diabetes or stage 2 hypertension systolic blood pressure greater than or equal to 160 mm Hg or diastolic blood pressure greater than or equal to 100 mm Hg) or neurological illnesses (carpal tunnel syndrome; migraine headaches; seizure disorders) likely to interfere with the study; Endorse more than 3 symptoms on the Yale Food Addiction Scale; Have colorblindness. Inclusion

2014 Clinical Trials

5152. Evaluation of the Prophylactic Efficacy of tDCS in Chronic Migraine

Posted: October 11, 2018 Last Verified: October 2018 Keywords provided by University Hospital, Grenoble: Chronic migraine, tDCS, Transcranial direct current stimulation Additional relevant MeSH terms: Layout table for MeSH terms Migraine Disorders Headache Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms (...) : University Hospital, Grenoble Information provided by (Responsible Party): University Hospital, Grenoble Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether TDCS is an effective prophylactic therapy of chronic migraine. Condition or disease Intervention/treatment Phase Chronic Migraine as Defined by Criteria of International Headache Society (IHS) Device: Transcranial direct current stimulation of the motor cortex Device: simulation of Transcranial

2014 Clinical Trials

5153. Energy Expenditure During Seated, Seated Cycling, and Treadmill Walking Work Conditions (EE-Work)

with a heart rate monitor fastened around their chest using an elastic strap. They will also be fitted with a portable metabolic system (COSMED). This unit fits around their waist and back, much like a backpack. The unit is attached to a face mask that fits over their mouth and nose and is secured by elastic straps which wrap around their head. The participants will first rest motionless in a chair for 20 minutes. Following this, they will complete three different simulated working conditions by typing (...) (WAPD study) You are familiar with using word processing software and comfortable using a standard computer keyboard You primarily sit while at work Exclusion Criteria: You weigh more than 250 pounds You are pregnant or lactating You have high blood pressure (greater than 159 mmHg systolic or 99 mmHg diastolic). You use tobacco or other nicotine products You have a medical condition or take medications that influence heart rate or metabolic rate (for example - beta blockers, antihistamines, anti

2014 Clinical Trials

5154. Effects of Transcranial Magnetic Stimulation (TMS) on Somatosensory Perception

month Is pregnant or breastfeeding. Has a current chronic pain condition or has had chronic pain in the past (painful condition lasting more than six months). Has a major medical condition, such as kidney, liver, cardiovascular, autonomic, pulmonary, or neurological problems (including blindness or deafness) or a chronic systemic disease (e.g. diabetes). Has a medical condition potentially affecting somatosensation (e.g. Raynaud s Disease, peripheral neuropathy, or circulatory disorder). Participant (...) questionnaires. For MRI, a magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder. A coil will be placed over their head. They will perform a task during the scan. The scanner makes loud knocking noises. Participants will get earplugs. They will be in the scanner for up to 60 minutes. In Sessions 2 and 3, participants will take Breathalyzer and urine tests. Their perception of touch will be measured. Then rTMS will be used

2014 Clinical Trials

5155. Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines

optimal medical management from migraines including triptans (Imitrex, Amerge and Relpax) Subjects who have recieved optimal medical management for migraines including anticonvulsants (Depakote, Lamictal, klonopin Exclusion Criteria: Less than 18 years of age Subjects will be excluded if they are already being treated with lidocaine (patch or other vehicle) for chronic pain Untreated Heart Failure Pregnancy Individuals unwilling to comply with study procedures and follow-up Contacts and Locations Go (...) Temporal Lobe Seizure Additional relevant MeSH terms: Layout table for MeSH terms Migraine Disorders Headache Headache Disorders Headache Disorders, Primary Brain Diseases Central Nervous System Diseases Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms Lidocaine Amitriptyline, perphenazine drug combination Amitriptyline Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Anti

2014 Clinical Trials

5156. A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas

(e.g. impaired cognition or judgment) Unable to safely comply with study procedures and reporting requirements (e.g. impairment of vision or dexterity that prevents safe operation of the bionic pancreas, impaired memory, unable to speak and read English) Current participation in another diabetes-related clinical trial that, in the judgment of the principal investigator, will compromise the results of this study or the safety of the subject Pregnancy [positive urine human chorionic gonadotropin (HCG (...) )] breast feeding, plan to become pregnant in the immediate future, or sexually active without use of contraception Need to go outside of the designated geographic boundaries during either arm of the study Current alcohol abuse (intake averaging > 3 drinks daily in last 30 days), use of marijuana within 1 month of enrollment, or other substance abuse (use within the last 6 months of controlled substances other than marijuana without a prescription) Unwilling or unable to refrain from drinking more than

2014 Clinical Trials

5157. Neurotoxin and Physical Therapy

, or with physical therapy. At Baseline, disease characteristics (as measured by the Toronto Western Spasmodic Torticollis Rating Scale, or TWSTRS, and the Clinical Global Impression of Severity, or CGIS) will be measured, along with quality of life (from the Short Health 36 Survey Form 36, or SF-36). One subscale of the TWSTRS will be videotaped to be later evaluated by blinded movement disorder specialists. A pain scale will also be completed and range of head motion will be measured using a device similar (...) using the left wrist and the right side of the head. Other Outcome Measures: Visual Analog Scale [ Time Frame: Baseline to 12 weeks ] This is a single item scale, on which participants will mark the level of pain from 0-100. Higher score represents more severe pain. Cervical Range of Motion Measurement [ Time Frame: Baseline to 12 weeks ] Participants will be asked to sit in a chair and move the head to the left, to the right, to the front, and to the back. Then, participants be asked to tilt

2014 Clinical Trials

5158. Effect of Interventions on the Progression of Knee Osteoarthritis

Details Study Description Go to Brief Summary: There has been intensive search for a substance that can have disease-modifying activity for osteoarthritis. A number of medications have been reported to be of benefit on slowing progression of knee OA. This trial will be the first head to head comparison of these medications. Patients aged between age 40 to 65 will be enrolled. Patients will be assessed clinically using two scoring systems, the WOMAC index for knee arthritis and the SF 36 for overall (...) . To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 40 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients of either sex aged between 40 to 65 years with mild to moderate osteoarthritis of the knees. Patients should have history of knee pain for at least 6

2014 Clinical Trials

5159. Pain Expectations in Subjects With Osteoarthritis

will take a verbal medical and medication history and obtain blood pressure and heart rate measurements. Verbal pain intensity report (0-10 from no pain to worst pain imaginable) will be obtained from a 5 second heat stimuli, separated by 30 seconds, delivered to a nonpainful area of skin on the arm as described in preliminary data. During pain testing, study subjects will sit in a comfortable chair in a low-ambient light room with their head positioned on a chin rest for continuous recording of pupil (...) for eligibility information Ages Eligible for Study: 18 Years to 80 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Osteoarthritis of the knee or hip Adult (ages 18-80) Moderate pain (verbal score of ≥ 4 ≤ 7 on 0-10 scale for average pain intensity with normal activity) American Society of Anesthesiologists physical status 1-3 Healthy subjects without pain Exclusion Criteria: Pregnancy; Currently taking gabapentin Currently taking

2014 Clinical Trials

5160. Phase 3 Study to Evaluate the Immunogenicity and Safety of Inactivated Split Influenza Vaccine in Healthy Korea Adults

Prefilled Syringe INJ 0.5mL by intramuscular injection Biological: IL-YANG FLU Vaccine Prefilled Syringe INJ 0.5mL IL-YANG FLU Vaccine Prefilled Syringe INJ 0.5mL by intramuscular injection Outcome Measures Go to Primary Outcome Measures : Solicited local & general Adverse Event, Unsolicited Adverse Event [ Time Frame: up to Day28(+7) ] Solicited local reaction: pain, tenderness, redness, swelling Solicited general reactions: fever, nausea/vomiting, diarrhea, headache, fatigue, myalgia Percentage (...) immunoglobulin or blood-derived products within the last 3 months prior to administration of the study vaccine, or is expecting to be treated with immunoglobulin or blood-derived products during the study. Subject who had participated in another experimental study within 30 days prior to administration of the study vaccine Woman of childbearing potential at screening or woman who plans to become pregnant during the study. A woman of childbearing potential must have a negative pregnancy test, and, unless

2014 Clinical Trials

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