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Headache in Pregnancy

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5041. Pelvic Pain in Women With Endometriosis

organs. Those undergoing tubal ligation must be at least 21 years old. Excellent health other than a three-month history of pelvic pain and documented endometriosis at laparoscopy. Chronic medications may be acceptable at the discretion of the Principal Investigator (PI). Use of antidepressants, medications for migraines and headaches, allergy medications, and treatment of bowel symptoms such as irritable bowel disease will be allowed. Do not desire pregnancy for the duration of the study. Are using (...) about their pain and previous treatments and related medical or social issues. Participants will undergo the following tests and procedures: Medical history and physical examination, including pelvic exam, blood tests, urinalysis, and diaphragm fitting. Questionnaires about pain, quality of life, sexuality, psychological attitudes, spiritual experiences, and history of headache and depression. At-home monitoring for 4 to 6 weeks of pain symptoms, menstruation and spotting, medicines taken, and urine

2003 Clinical Trials

5042. Improvement of Use Dependent Plasticity in Chronic Stroke Patients

not painful, although sometimes strong contractions of the scalp muscles can cause discomfort or a headache. Patients can ask to have the procedure discontinued at any time. For the electrical stimulation procedure, three pairs of electrodes will be placed on the skin. A quite brief pulse of current will pass between the electrodes, creating the electrical field that activates the brain. Patients will feel a brief stinging around the electrodes. Regarding the amphetamine, patients will take it orally (...) , or ischemic peripheral disease. Pregnancy. Patients and normal volunteers less than 18 years of age. Lactating women. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT00072735 Locations Layout table for location information United States, Maryland National

2003 Clinical Trials

5043. Urinary Vitamin C Loss in Diabetic Subjects

of diabetes mellitus alone or in the context of metabolic syndrome. Subjects with ischemic heart disease and/or peripheral artery disease are eligible for arm 1 of the protocol. have serum creatinine < 2.5 for healthy volunteers, be normotensive at the time of the study, with a blood pressure less than or equal to 140/90 for diabetic subjects, blood pressure less than or equal to 170/95 as long as clinically stable and in usual state of health, for example, no chest pain, shortness of breath, headache (...) at investigator discretion serious or chronic illness or history of serious or chronic illness resulting in clinical instability other than complications of diabetes pregnancy alcohol abuse, drug addiction or the use of illegal drugs positive HIV or hepatitis (B or C) screening tests (subjects will be notified of these test results). presence of other concomitant conditions which in the judgment of the investigators can influence vitamin C metabolism or vitamin C renal handling EXCLUSION CRITERIA (for arms 2

2003 Clinical Trials

5044. HerpeVac Trial for Young Women

(GMTs), and are expressed in Estimated Doses (ED), that is, the reciprocal of the dilution necessary to achieve neutralization. Antibody titers below the lowest level of quantification were not calculated . Number of Subjects Reporting Solicited Local and General Symptoms [ Time Frame: Within 7 days (Days 0-6) after vaccination ] Solicited local symptoms assessed were pain, redness and swelling. Solicited general symptoms assessed were fatigue, headache, malaise and fever (defined as oral/axillary (...) 0-6) after vaccination ] Solicited general symptoms assessed were fatigue, headache, malaise and fever (oral/axillary/tympanic). Grade 3 headache, fatigue, malaise = symptom that prevented normal activities. Grade 3 fever = temperature above 39.0 degrees Celsius. Related = symptom assessed by the investigator as causally related to the vaccination Number of Subjects Reporting Unsolicited Adverse Events (AEs) [ Time Frame: Within 31 days after vaccination ] Unsolicited AEs have been tabulated

2003 Clinical Trials

5045. Drug Therapy to Treat Minor Depression

from the Baseline score. Number of Adverse Events (Physical Symptoms) Emerging or Worsening During 12 Weeks of Treatment [ Time Frame: Change from Baseline to Week 12 ] We expect that subjects treated for Minor Depression for 12 weeks with either St. John's Wort or citalopram will have similar safety profiles to subjects treated with placebo, and will not differ by more than 20% in rates of adverse side effects (e.g., nausea, headache, insomnia, hypersomnia, diarrhea) from subjects treated (...) induction of this system poses a risk to the medical stability of the patient Pregnancy or refusal to use a medically accepted method of contraception Serious suicide or homicide risk Psychotherapy beginning less than 3 months ago Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its

2002 Clinical Trials

5046. The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept

to assess the amount and distribution of muscle and body fat. Blood vessel (brachial artery reactivity) study to measure the ability of the brachial artery to dilate and increase its blood flow. For this procedure, the subject lies on a table with electrocardiogram leads attached to the chest. A blood pressure cuff is inflated for several minutes and a drop of nasal spray of nitroglycerin is given that may cause a headache. Blood pressure and headache are monitored and treated as needed. Patients (...) of the study after full information is provided. Women must have a negative pregnancy test at screening. Study participants will be allowed to continue taking medications for chronic, stable conditions, such as hypertension and hypercholesteremia, while in the study. INCLUSION CRITERIA - for RA Patients: Active RA as defined by 9 tender and 6 swollen joints; ESR greater than 35 mm/hr OR CRP greater than 2.0 mg/dL; and, morning stiffness greater than 45 min. Actively menstruating with a normal estrogen

2002 Clinical Trials

5047. Indole-3-Carbinol in Preventing Breast Cancer in Nonsmoking Women Who Are at High Risk For Breast Cancer

allowed No serious or life-threatening drug allergies No other serious intolerances or allergies No more than 20% above or below ideal body weight No acute or unstable medical condition by physical examination or laboratory tests No chronic headaches, dysphoria, fatigue, dizziness, blurred vision, insomnia, rhinorrhea, nausea, vomiting, abdominal pain, diarrhea, constipation, or similar conditions No serious illness requiring chronic drug therapy No active malignancy Not pregnant or nursing Negative (...) pregnancy test Fertile patients must use effective barrier contraception 1 month before, during, and for 1 month after study PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: At least 2 months since prior hormonal therapy as contraception or hormone replacement therapy (HRT) No concurrent sex hormones as contraception for premenopausal women No concurrent HRT for postmenopausal women Radiotherapy: Not specified Surgery: Not specified Other

2002 Clinical Trials

5048. The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers

infection at the puncture site, and dizziness. The oral glucose tolerance test may cause temporary stomach bloating, headache, nausea, and vomiting. Condition or disease Sjogren's Syndrome Detailed Description: Sjogren's syndrome is a chronic systemic disease that primarily affects the salivary and lacrimal glands and is characterized by lymphocytic tissue infiltration and auto-antibody production. The pathogenesis of Sjogren's syndrome is unknown. We hypothesize that reduced somatostatin activity (...) (greater than 5%), use of contraceptives -BCP-, Depoprovera or Norplant), irregular menstrual cycle, lactation, blood drawing in excess of 50 ml, use of recreational drugs, modification of estrogen replacement therapy; (Within the past 6 months): chronic pattern of weight change (greater than 10%), eating disorders, uncontrolled hypo/hyperthyroidism, breast cancer, lymphoma or other malignancy, pregnancy, treatment for depression, insulinoma, VIPoma, pheochromocytoma, atrophic gastritis, active

2000 Clinical Trials

5049. Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia

or butyrate therapy any time in the last 12 months; or blood transfusion within last three months, or % hemoglobin A greater than 20%. Age less than 18 years or greater than 65 years. Current pregnancy or lactation. Inability to exercise the anterior tibialis muscle. Active cigarette smoker-defined as the inhalation of smoke from any tobacco product in the last one month. Medical conditions: diabetes mellitus; coronary artery disease; peripheral vascular disease; migraine headaches in the last 12 months

1999 Clinical Trials

5050. The Role of Hormones in Postpartum Mood Disorders

bleeding; porphyria; diabetes mellitus; malignant melanoma; gallbladder or pancreatic disease; heart or kidney disease; cerebrovascular disease (stroke); cigarette smoking; a history of suicide attempts or psychotic episodes requiring hospitalization; recurrent migraine headaches; pregnancy (patients will be warned not to become pregnant during the study and will be advised to employ barrier contraceptive methods; pregnancy-related medical conditions such as hyperemesis gravidarum, pretoxemia (...) ) Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Mental Health (NIMH) ) Study Details Study Description Go to Brief Summary: Determine whether postpartum depression is triggered by the abrupt withdrawal of estrogen and progesterone. The appearance of mood and behavioral symptoms during pregnancy and the postpartum period has been extensively reported. While there has been much speculation about possible biologically based etiologies

1999 Clinical Trials

5051. Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome

on a lung transplantation waiting list. Pregnancy or lactation Cigarette smoking in the past 6 months History of ethanol abuse or recreational drug use in the past two years History of human immunodeficiency virus (HIV) or chronic viral hepatitis infection Chronic use of high-dose steroids (greater than 10 mg prednisone/day) Prior use of pirfenidone Use of any of the following within 28 days of enrollment: investigational therapy, cytotoxic/immunosuppressive agents other than corticosteroids (including (...) but not limited to azathioprine, cyclosphosphamide, methotrexate, cyclosporine); cytokine modulators (including but not limited to etanercept and infliximab); therapies targeted to treat pulmonary fibrosis (including but not limited to D-penicillamine, colchicine, interferon gamma-1b, bosentan, N-acetylcysteine Any severe medical complication including but not be limited to uncontrolled seizures, repeated transient ischemic attacks, abnormal mental status, severe ataxia, uncontrolled migraine headaches

1999 Clinical Trials

5052. Diagnosis of Pheochromocytoma

of the following: Pregnant (based on a pregnancy test done either outside the NIH or at the NIH) or breastfeeding women Severe cardiac dysfunction Currently on dialysis -A pregnancy test is performed in women of childbearing age (up to age 55). If after enrollment to this protocol, a patient is found to have a positive pregnancy test, her participation in this protocol will be terminated.. Research scans are contraindicated in patients with proven myelodysplastic syndrome. Patients who are not willing (...) skin and soft tissue necrosis, thrombosis, fasciitis, and compartment syndrome requiring surgical intervention. -In pediatric patients: --Inclusion criteria for research PET imaging in children ---Children over 10 years old with very high suspicion of sporadic or familial pheochromocytoma/paraganglioma (e.g. the presence of new onset of hypertension or hypertensive episodes, sweating, headaches, pallor, palpitations, drug resistant hypertension, etc.) family history of pheochromocytoma

2000 Clinical Trials

5053. Treatment of Patients With Cysticercosis With Praziquantel or Albendazole

in the muscles, brain and other organs. The cysts enlarge and cause inflammation, usually in the brain. Patients may develop seizures, headache, nausea, vomiting, inability to walk, poor vision due to enlargement of the brain, and increased pressure in the brain. Other neurological problems may develop depending on the location of the cysts. The drugs praziquantel and albendazole are used to treat cysticercosis, but it is not clear if these drugs are effective in all patients, such as those with calcified (...) intervals Patients who are pregnant will be included, however, they will not be offered treatment with albendazole, praziquantel and/or methotrexate and etanercept during the pregnancy unless the clinical condition is severe, e.g. life threatening, in the opinion of the PI. They may receive corticosteroids. Patients with a positive purified protein derivative or quantiferon assay for tuberculosis (TB) and strongyloidiasis will be started/treated for these infections, per standard protocol, and shortly

1999 Clinical Trials

5054. The Safety and Effectiveness of Surgery With or Without Raloxifene for the Treatment of Pelvic Pain Caused by Endometriosis

endometriosis at laparoscopy. Chronic medications may be acceptable at the discretion of the internist associate investigator (LN). Use of antidepressants, medications for migraines and headaches, allergy medications, and treatment of bowel symptoms such as irritable bowel disease will be allowed. Do not desire pregnancy for the duration of the study. Are using abstinence, mechanical (condoms, diaphragms) or sterilization methods of contraception and are willing to continue using them throughout the study (...) . Willing and able to give informed consent. Willing and able to comply with study requirements. Less than grade III overweight or BMI less than 40 kg/m(2). EXCLUSION CRITERIA: Women with other causes of chronic pelvic pain including infectious, gastrointestinal, musculoskeletal, neurologic or psychiatric. Significant abnormalities in the physical or laboratory examination including renal and liver function more than twice the normal range. Hysterectomy or bilateral salpingo-oophorectomy. Pregnancy

1999 Clinical Trials

5055. Catecholamine Reserve and Exercise Tolerance in Healthy Volunteers and Patients With Congenital Adrenal Hyperplasia

than congenital adrenal hyperplasia except mild conditions (e.g. allergic rhinitis, migraine headaches) will be excluded provided the subjects are not acutely ill and do not require medication for this condition during the study. Acute medical conditions including intercurrent infection and fever in the preceding 7 days. Positive pregnancy test. CAH patients on flutamide. Tylenol or other acetaminophen-containing medicines (e.g. over-the-counter cold medicines) within 5 days before each test period (...) will be recruited as control subjects. All candidates will be screened with a medical history, physical examination and electrocardiogram (EKG). Body fat will be measured using an instrument called a Bod Pod. The body fat measurement has two parts: first, the subject sits quietly in a large egg-shaped capsule for about 2 to 3 minutes; then the subject breathes into a plastic tube for one minute, followed by three quick panting breaths. Women will have a urine pregnancy test; pregnant women cannot participate

2001 Clinical Trials

5056. Cocaine-Methylphendidate Interaction Study

reported when cocaine and MPD were given together included headache, nervousness, and lightheadedness. Subjective ratings of drug effect revealed that MPD did not enhance patients' response to, or desire for, cocaine. MPD appears to be a safe drug to use in cocaine addicts who continue to use cocaine at the dosages tested. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Enrollment : 8 participants Intervention Model: Crossover Assignment Primary (...) control. All female subjects will have a serum pregnancy test performed prior to the first dose of study medication. be capable of providing written informed consent to participate in this study. able to comply with protocol requirements and be likely to complete all study treatments. within 20% of ideal body weight. Exclusion Criteria: require detoxification from alcohol, opiates, or sedative-hypnotics. have a history of significant hepatic, renal, endocrine, cardiac (i.e., arrhythmia requiring

2001 Clinical Trials

5057. Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia

: --Disease Characteristics-- Histologically diagnosed severe preeclampsia at risk for eclamptic convulsions with the following criteria: Blood pressure greater than 160/110 mmHg OR Mean arterial pressure of 126 mmHg Proteinuria greater than 5 g/24 hr Epigastric pain OR Right upper quadrant pain AST/ALT greater than 70 U/L Severe headache and/or scotomata Thrombocytopenia as evidenced by: Platelet count less than 100,000/mm3 Disseminated intravascular coagulation Microangiopathic hemolytic anemia Oliguria (...) UU-FDR001061 BCM-FDR001061 First Posted: October 19, 1999 Last Update Posted: March 25, 2015 Last Verified: January 2001 Keywords provided by FDA Office of Orphan Products Development: cardiovascular and respiratory diseases hypertensive disorder pre-eclampsia rare disease Additional relevant MeSH terms: Layout table for MeSH terms Eclampsia Pre-Eclampsia Hypertension, Pregnancy-Induced Pregnancy Complications Magnesium Sulfate Nimodipine Analgesics Sensory System Agents Peripheral Nervous System

1999 Clinical Trials

5058. Biological Therapy in Treating Patients With Primary or Advanced Glioma

disease No serious cardiac arrhythmias No prior myocardial infarction Pulmonary: No major pulmonary problems Other: No history of neurologic disease (except related to brain tumor) No psychosis No impaired cognitive function No significant concurrent medical illness No active infection requiring antibiotic therapy Not pregnant Negative pregnancy test Fertile patients must use effective contraception Adequate peripheral veins to permit leukapheresis, or placement of indwelling central vascular access (...) since prior radiotherapy and recovered No concurrent radiotherapy Surgery: Prior surgery is allowed Other: Concurrent therapy with acetaminophen, anticonvulsant agents, and headache pain medications is allowed Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT

1999 Clinical Trials

5059. A Study of BufferGel in Women

with the following prior conditions are excluded: IUD, abnormal PAP smear, pregnancy, abortion, or gynecologic surgery in the last 3 months. Any of the following side effects related to Depo-provera use in the past 2 months: headaches, dizziness, abdominal pain, fatigue, or nervousness. Prior Medication: Excluded: A course of antibiotic therapy (other than treatment for malaria) in the last 14 days. Any spermicide within the past month. Initiation of Depo-provera for contraceptive purposes in the last 6 months

1999 Clinical Trials

5060. Dural puncture. Blood patch not always benign. Full Text available with Trip Pro

Dural puncture. Blood patch not always benign. 8518583 1993 07 27 2018 11 13 0959-8138 306 6888 1993 May 15 BMJ (Clinical research ed.) BMJ Dural puncture. Blood patch not always benign. 1339 Cooper G M GM Stride P C PC eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1993 Apr 3;306(6882):874-6 8490408 Analgesia, Obstetrical Blood Patch, Epidural adverse effects Female Headache etiology Humans Obstetric Labor Complications Pregnancy 1993 5 15 1993 5 15 0 1 1993 5 15 0 0 ppublish

1993 BMJ : British Medical Journal

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