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Headache in Pregnancy

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5041. Rebozo and External Cephalic Version in Breech Presentation.

of this is approximately 50%, and complications occur in about 0.5%. In addition there is discomfort and pain to the pregnant woman. The investigators will assess the effect of using the rebozo prior to the external version. Use of rebozo is a recognized technique from Mexico, where the midwife with a scarf 'shake' the pregnant woman's pelvis over several sessions, so the fetus spontaneously turns to cephalic presentation or the external version is facilitated. There are no known complications associated (...) , Hvidovre University Hospital Study Details Study Description Go to Brief Summary: Breech presentation occurs in approximately 3-5% of all pregnancies, and breech birth is more complicated and risky for the fetus than births of fetuses in the cephalic position. Therefore, it is desirable to turn the fetus from breech presentation to cephalic position before labour. This is traditionally done by external cephalic version, where the doctor manually tries to turn the fetus; the success rate

2014 Clinical Trials

5042. Safety, Tolerability and Immunogenicity Study of 2 Dose Levels of Trimeric Glycoprotein140 (gp140) in Healthy Adult Volunteers

With Local and Systemic Reactogenicity Events Over 8 Days After First Vaccination [ Time Frame: Day 8 ] Participants will be asked to note occurrences of local reactions: erythema, induration, swelling, pain/tenderness, itching, or warmth at the injection site, and systemic events: daily temperature, fatigue, headache, myalgia, arthralgia, chills, nausea, vomiting, rashes, and general itching daily for 8 days post-vaccination. These occurrences will be recorded through the memory aid provided to serve (...) as a reminder to the participants for the next clinic visit. Number of Participants With Local and Systemic Reactogenicity Events Over 8 Days After Second Vaccination [ Time Frame: Day 36 ] Participants will be asked to note occurrences of local reactions: erythema, induration, swelling, pain/tenderness, itching, or warmth at the injection site, and systemic events: daily temperature, fatigue, headache, myalgia, arthralgia, chills, nausea, vomiting, rashes, and general itching daily for 8 days post

2014 Clinical Trials

5043. Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)

and heart rhythm will be monitored before, during, and after the CT scan. They may have an electrocardiogram. Before the scan, participants will have an intravenous catheter put into their arm. It will be used to inject contrast. Participants may take a beta blocker to slow their heart rate. Participants may take nitroglycerin under their tongue. It will enlarge their heart blood vessels and improve picture quality. It may cause a flushing sensation or headache. Participants will lie on their back (...) to understand and willing to sign the Informed Consent Form EXCLUSION CRITERIA: Known allergy to iodinated contrast media Estimated GFR less than 50 ml/min Atrial fibrillation or other continuous cardiac arrhythmias Known or suspected intolerance or contraindication to beta-blocker medication (i.e. significant reactive airway disease, decompensated heart failure, Mobitz type 2 second degree or 3rd degree atrio-ventricular heart block) Inability to adequately hold breath for 5 seconds Pregnancy. Women

2014 Clinical Trials

5044. Safety and Immunogenicity of Different Schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Healthy Participants

Events (AEs) in the Immunogenicity Subset [ Time Frame: Days 7 and 14 after each vaccination ] Solicited local AEs at injection site are defined as pain, erythema and swelling. Solicited systemic AEs in infants/toddlers (15-24 months) and children (< 6 years) are defined as fever, irritability/fussiness, drowsiness and loss of appetite. Solicited systemic AEs in adults and children (≥ 6 years) are defined as fever, asthenia, headache, malaise and myalgia. Severity of Solicited Local and Systemic (...) Adverse Events (AEs) in the Immunogenicity Subset [ Time Frame: Days 7 and 14 after each vaccination ] Solicited local AEs are defined as pain, erythema and swelling. Solicited systemic AEs in infants/toddlers (15-24 months) and children (< 6 years) are defined as fever, irritability/fussiness, drowsiness and loss of appetite. Solicited systemic AEs in adults and children (≥ 6 years) are defined as fever, asthenia, headache, malaise and myalgia. Percentage of Participants in the Immunogenicity Subset

2014 Clinical Trials

5045. To Compare Conservative Management Vs. Balloon Kyphoplasty in the Treatment of VCFs in Patients With Multiple Myeloma

Sheet and study procedures The patient is able and willing to give written informed consent Exclusion Criteria: Contraindications to anaesthesia Cord Compression or large epidural mass necessitating conservative management before balloon kyphoplasty Pain unrelated to vertebral collapse Infection at the site Presence of overt instability as judged by the principle investigator Known pregnancy at time of screening Severe Cardiopulmonary insufficiency Osteoblastic lesions Any co-morbidity, (e.g (...) Sham Comparator: Arm 1 - Sham Procedure Sham Procedure & Conservative Treatment Subjects will be blinded and randomised to Arm 1 and will undergo a general anaesthetic and undergo a sham procedure. They will also be treated under conservative management alone. Below is a list of the conservative management they will be managed by their Doctor: Bisphosphonates Pain relief Systemic chemotherapy for Myeloma disease Bed rest Radiotherapy Physiotherapy This is a non interventional as conservative

2014 Clinical Trials

5046. Efficacy of the Non-invasive Brain Stimulation Techniques for Lower Limb Recovery in Stroke Patients

subjects: Male or female aged 21-80 years; Physically healthy; Be able to provide informed consent. Exclusion criteria: For subjects receiving intervention: Severe claustrophobia; pregnancy; cardiac pacemakers; orthodontics (braces); metal implant; presence of other non MRI-compatible ferromagnetic implants; history of epilepsy; sensorimotor disturbance due to other causes other than stroke; severe pain in the lower limbs affecting gait; uncontrolled medical conditions including hypertension, diabetes (...) using a standard radiofrequency head coil. Head motion was minimized by foam padding and forehead-restraining straps. changes of " Psychological and cognitive properties" from baseline to post-intervention and 4 weeks after intervention [ Time Frame: before intervention, immediately after intervention, 4 weeks after intervention ] Beck Depression Inventory Fatigue Severity Scale Forward and backward digit span changes of walking speed measured by "10 meter walk test" from baseline to post

2014 Clinical Trials

5047. An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH

Posted : October 11, 2018 Sponsor: University of Birmingham Collaborator: National Institute for Health Research, United Kingdom Information provided by (Responsible Party): Dr Alexandra Sinclair, University of Birmingham Study Details Study Description Go to Brief Summary: Idiopathic intracranial hypertension (IIH) is a condition with an unknown cause or causes. The condition is associated with raised pressure in the brain and can cause disabling daily headaches and loss of sight, which can (...) . Papilloedema [ Time Frame: 12 months ] Change in papilloedema from 0 to 12 months (and at 24 and 60 months) Headache [ Time Frame: 12 months ] Change in headache associated disability from 0 to 12 months (and at 24 and 60 months). Headache will be assessed by participant completed questionnaires. Participants will complete a daily headache diary in the week before assessments, which will evaluate the Headache Index score and use of analgesia (days/week). Headache associated disability will be evaluated

2014 Clinical Trials

5048. Acupressure for Fatigue and Low Back Pain

Minimum of 3/10 fatigue severity Ambulatory with or without assistive device Ability to operate the accelerometer (Actiwatch-S) Stable medication regiment for the previous 2 months Report of a physician's visit during the previous 24 months English-speaking Exclusion Criteria: Medically unstable (acute conditions or acute presentations of chronic conditions) Current pregnancy Radiculopathy or report of low back pain radiating to below the knee Reported history of spinal fracture, herniated lumbar disc (...) Acupressure for Fatigue and Low Back Pain Acupressure for Fatigue and Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acupressure for Fatigue and Low Back Pain The safety and scientific

2014 Clinical Trials

5049. Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain

Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oxcarbazepine Plus (...) Morphine in Patients With Refractory Cancer Pain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02078089 Recruitment Status : Terminated (Poor Accrual) First Posted : March 5, 2014 Last Update Posted : January 31, 2017 Sponsor: Costantine Albany Information provided by (Responsible Party): Costantine

2014 Clinical Trials

5050. Pharmacokinetic Study of CYCLOSET ® 0.8 mg Tablets in Children and Adolescent Type 2 Diabetes Mellitus Subjects

, endocrine, immunologic or dermatologic disease Symptoms and/or history of serious psychiatric or psychotic disorders Presence of significant heart disease or disorder according to ECG Presence of malignancy, particularly pituitary gland malignancy and prolactinoma Presence or history of migraine headache or syncope Pregnant according to a positive serum pregnancy test or lactating Females less then four months post-partum Current history of illicit drug dependency, use or alcohol abuse (greater than 3 (...) . Calculated glomerular filtration rate less than 80 mL/min based on the Schwartz Formula Presence or history of uncontrolled hypertension: systolic pressure greater than 145 mmHg and/or diastolic pressure greater than 95 mmHg, hypertensive disorders of pregnancy, hypertension post-partum and in the puerperium History of surgery that may affect drug bioavailability, including but not limited to cholecystectomy Presence of significant cardiovascular, pulmonary, hematologic, neurologic, psychiatric

2014 Clinical Trials

5051. Periduroscopy: Correlation Between the Outcome of Procedure and Histological-biochemical, Neuroinflammation and Genetic Factors.

specialist control with particular contraindications to invasive treatments Mental impaired patients History of spinal fracture Spinal tumor or infection of column; Visual alterations (glaucoma, diabetic retinopathy) Brain vascular disease Primary or secondary chronic headache For women: positive pregnancy test or pregnancy. Coagulopathy (INR>1.5) Refusal to participate Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may (...) Status : Unknown Verified February 2014 by Guido Fanelli, University of Parma. Recruitment status was: Recruiting First Posted : March 3, 2014 Last Update Posted : December 31, 2014 Sponsor: University of Parma Collaborator: IRCCS Policlinico S. Matteo Information provided by (Responsible Party): Guido Fanelli, University of Parma Study Details Study Description Go to Brief Summary: It is still unknown the pathogenesis of low back pain and a lot of hypothesis were discussed for a long time. Because

2014 Clinical Trials

5052. Comparing Triamcinolone Acetonide Mucoadhesive Films With Licorice Mucoadhesive Films

who were non-pregnant by pregnancy test and and using medically prescribed contraceptive no previous radiation therapy applied in the head and neck medically fit for a course of radical radiotherapy an ability to remain in the study for its entire duration Exclusion Criteria: pregnant women women of childbearing potential in whom medically prescribed birth control was not used concurrent chemotherapy history of heavy alcohol or drug abuse judged to be important by the investigator - concomitant (...) Information provided by (Responsible Party): Mehdi Nasr Isfahani, Isfahan University of Medical Sciences Study Details Study Description Go to Brief Summary: Abstract: Background: Complementary and alternative medicine (CAM) had proven efficacy in pain relief, correction of nutritional status and improving the performance status. However, lack of standardization is the major obstacle for any scientific evaluation of any CAM trial. Mucositis is a major complication of irradiation in head and neck (H&N

2014 Clinical Trials

5053. Muscle Injury Prevention & Rehabilitation in Military Personnel

that may limit function; 2) neurological, vascular, or cardiac problems that may limit function; 3) diabetes; 4) previous traumatic head injury or post-traumatic stress disorder; 5) a contraindication to MRI e.g.: pacemakers, metal implants which are not MRI compatible, pregnancy, and severe claustrophobia; and 6) currently performing an exercise program that specifically targets the dorsiflexor muscles. Inclusion criteria for subjects with muscle atrophy: 1) individuals ages 18-40 years with an injury (...) , uninvolved lower extremity that may limit function; 4) diabetes; 5) previous traumatic head injury or post-traumatic stress disorder; and 6) a contraindication to MRI e.g.: pacemakers, metal implants which are not MRI compatible, pregnancy, and severe claustrophobia. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer

2014 Clinical Trials

5054. Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C Patients

disease, chronic renal failure or previous gastrointestinal surgery except cholecystectomy and appendectomy; Patients with neurologic diseases (e.g. head injuries, epilepsy, multiple sclerosis, strokes, spinal cord injuries) or brain disorders prone to causing seizures; Patients experiencing impaired cognizance (mini mental score of < 15) and/or legally blind; Women who are pregnant or likely to conceive (women with potential for pregnancy must use contraceptive measures to be included); Patients (...) are available on the patient's electronic records or records provided by an external provider, we will have them complete blood testing to exclude clinically significant metabolic abnormalities). The P.I. will decide if any values that fall out of range represent clinical significance or not. Women of childbearing potential must agree to a urine pregnancy test at screening and to avoid pregnancy throughout the study. On a prospective symptom/stool diary patients reported i) presence of abdominal pain

2014 Clinical Trials

5055. Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans

with GWI versus routine clinical care plus reiki treatment. EEG measures will exhibit a positive change when fatigue is relieved and pain is alleviated for symptomatic veterans after effective treatment. Condition or disease Intervention/treatment Phase Persian Gulf Syndrome Chronic Fatigue Syndrome Other: Acupressure treatment. Other: Reiki Not Applicable Detailed Description: Symptomatic veterans will receive standardized acupressure treatment, first with one-thumb pressing applied to the head (...) of these acupoints is aimed at helping to calm and ease the subject, lighten headache and migraine, relieve fatigue, and alleviate insomnia. Finally, LI- 4 (He Gu), LI-11 (Qu Chi), HT-7(Shen Men), ST-32 (Fu Tu), SP-10 (Xue Hai), ST-36 (Zu San Li), and KI-3 (Tai Xi) acupoints will be one-thumb pressed for 10 min. Manipulations on these acupoints and meridians located on the limbs is to relax muscles, alleviate muscle and joint pain, and improve mobility. This protocol is based on our consultant's previous

2014 Clinical Trials

5056. Consistency, Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults ≥ 50 Years of Age

, Grade 3 and Related Solicited General Symptoms [ Time Frame: Within 7 days (Days 0-6) after each vaccine dose and across doses ] Assessed solicited general symptoms were fatigue, gastrointestinal (nausea, vomiting, diarrhea and/or abdominal pain), headache, myalgia, shivering and temperature [defined as oral temperature equal to or above 37.5 degrees Celsius (°C)]. Any = occurrence of the symptom regardless of intensity grade. Grade 3 symptom = symptom that prevented normal activity. Grade 3 (...) ) after each vaccine dose and across doses ] Assessed solicited local symptoms were pain, redness and swelling. Any = occurrence of the symptom regardless of intensity grade. Grade 3 pain = significant pain at rest, that prevented normal every day activities. Number of Days With Any Solicited Local Symptoms [ Time Frame: During the 7 days (Days 0-6) after each vaccine dose ] The number of days with any local symptoms reported during the solicited post-vaccination period. Number of Subjects With Any

2014 Clinical Trials

5057. A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GlaxoSmithkline (GSK) Biologicals' Investigational Vaccine GSK2838504A When Administered to Chronic Obstructive Pulmonary Disease (COPD) Patients With Persistent Airflow Obstruction.

), headache, fever [defined as oral temperature equal to or above 37.5 degrees Celsius (°C)]. Any = occurrence of the symptom regardless of intensity grade. Number of Subjects With Any Solicited General AEs [ Time Frame: During a 7-day follow-up period (from Day 60 to Day 66) following the second dose. ] Assessed solicited general symptoms are fatigue, gastrointestinal symptoms (included nausea, vomiting, diarrhoea and/or abdominal pain), headache, fever (defined as oral temperature equal to or above 37.5 (...) : NaCl Placebo Intramuscular vaccination in the deltoid region of the non-dominant arm according to protocol schedule. Outcome Measures Go to Primary Outcome Measures : Number of Subjects With Any Solicited Local Adverse Events (AEs). [ Time Frame: During a 7-day follow-up period (from Day 0 to Day 6) after first dose. ] Assessed solicited local symptoms were pain, redness and swelling. Any = occurrence of the symptom regardless of intensity grade. Number of Subjects With Any Solicited Local AEs

2014 Clinical Trials

5058. Feeling and Body Investigators

to Brief Summary: This study will provide tools to develop and pilot an intervention for Functional Abdominal Pain (FAP) using a ten session intervention with children ages 5-8. Investigators will train the subjects to be "Feeling and Body Investigators". During treatment phases the following will occur 1) gather clues (learn), 2) investigate (experience: perform interoceptive mystery missions to explore a body sensation), 3) organize body clues (contextualize: recall other contexts that evoke similar (...) changes in the viscera as fun and fascinating, rather than scary, and will develop new capacities for pain management, adaptive functioning, and emotion regulation. For the R21 Phase (assessing initial feasibility) investigators hypothesize that ≥ 80% of participants enrolled in FBI will complete treatment and that ≥ 80% of participants will complete home-based practice assignments. Condition or disease Intervention/treatment Phase Functional Abdominal Pain Behavioral: Feeling and Body Investigators

2014 Clinical Trials

5059. Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)

or 6 (on a scale of 0 - 10) on the FPS-R as evaluated by the subject. Moderate to severe pain criteria must be met at eligibility and the pre-dose pain assessment. Males or non-pregnant, non-lactating females. The subject's caregiver must have read and signed the written informed consent (including assent from subjects 18 yrs as applicable according to Investigational review board (IRB) guidelines) prior to study participation. Subjects 18 yrs old must have read and signed the written informed (...) Pharmaceuticals, Inc. ClinicalTrials.gov Identifier: Other Study ID Numbers: AR01.007 First Posted: February 28, 2014 Last Update Posted: January 24, 2017 Last Verified: January 2017 Keywords provided by Arbor Pharmaceuticals, Inc.: Acute Otitis Media Pain Ear Pain Ear Ache Ear infection middle ear infection Additional relevant MeSH terms: Layout table for MeSH terms Otitis Otitis Media Ear Diseases Otorhinolaryngologic Diseases Pharmaceutical Solutions Glycerol Carbamide Peroxide Cryoprotective Agents

2014 Clinical Trials

5060. ASIS for Botox in Upper Limb Spasticity

subdermally at Week 30 Drug: Adverse Reactions of Botox intramuscularly Adverse Reactions of Botox (onabotulinumtoxinA) intramuscularly at Week 30, in number of Headache Migraine, Facial paresis, Eyelid ptosis, Bronchitis, Neck pain Musculoskeletal stiffness, Muscular weakness Myalgia, Musculoskeletal pain, Muscle spasms, Injection site pain, and Hypertension. Other Name: Botox (onabotulinumtoxinA) Drug: Adverse Reactions of Botox subdermally Adverse Reactions of Botox (onabotulinumtoxinA) subdermally (...) at Week 30, in number of Headache Migraine, Facial paresis, Eyelid ptosis, Bronchitis, Neck pain Musculoskeletal stiffness, Muscular weakness Myalgia, Musculoskeletal pain, Muscle spasms, Injection site pain, and Hypertension. Other Name: Botox (onabotulinumtoxinA) Experimental: Adverse Reactions with Eyelid ptosis Eyelid ptosis as Adverse Reactions of Botox intramuscularly vs.Adverse Reactions of Botox subdermally at Week 30. Drug: Adverse Reactions of Botox intramuscularly Adverse Reactions of Botox

2014 Clinical Trials

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