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Headache in Pregnancy

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5001. A Phase III Study of Nimotuzumab Plus Concurrent Chemoradiotherapy in Loco-regional Esophageal Squamous Cell Carcinoma

Tumors 1.1) Eastern Cooperative Oncology Group(ECOG)Performance status of 0-1 Possible semi-liquid diet If there is a risk of pregnancy, male and female subjects must be effective contraception during treatment Normal bone marrow reserve: neutrophil (ANC) count≥1500/mm3,platelet count≥100,000 /mm3, hemoglobin≥5.6mmol/L(9g/dL) Normal renal function: serum creatinine≤1.5mg/dl and/or calculated creatinine clearance≥ 60ml/min Normal hepatic function: bilirubin level≤1.5×ULN, alanine aminotransferase (...) aspartate transaminase(ASAT)& ALST≤1.5×ULN Subjects tumor tissue available for the relevant biomarker detection Exclusion Criteria: Previous chest radiotherapy, systemic chemotherapy, and major esophageal surgery Concurrent chronic systemic immune therapy, targeted therapy, anti-vascular endothelial growth factor(VEGF)therapy or EGFR-pathway targeting therapy not indicated in this study protocol Multiple primary carcinomas of the esophagus Pregnancy (confirmed by urine β-HCG) or lactation period

2014 Clinical Trials

5002. Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients

Criteria: New diagnostic of head and neck cancer patient who need treatment with radiation involved with the oral cavity area. Never received radiotherapy or chemotherapy Karnofsky performance status > 70% Stopped smoking Able to eat and swallow medications Written informed consent Exclusion Criteria: Melatonin allergy Active oral cavity inflammation scar Pregnancy Creatinine clearance < 30 ml/min Active periodontal disease Steroids or pain killer drugs used for oral cavity pain except NSAIDs (...) with Cisplatin chemotherapy base regimen according to standard hospital protocol. Study endpoints are level of mucositis (CTCAE scale, WHO scale and MTS scores), level of xerostomia (CTCAE scale, VAS), QOL (FACT-H&N), pain (VAS 0-10) and adverse event frequency. Condition or disease Intervention/treatment Phase Head and Neck Cancer Drug: Melatonin Drug: Matched Placebo Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 39

2014 Clinical Trials

5003. Effect of Brain-Computer Interfaced-Assisted Motor Imagery for Gait Retraining in Stroke Patients

claustrophobia; pregnancy; cardiac pacemakers; orthodontics (braces); metal implant; presence of other non MR-compatible ferromagnetic implants; history of epilepsy; sensorimotor disturbance due to other causes other than stroke; severe pain in the lower limbs affecting gait; uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina; major depression and a history of psychotic disorders. Contacts and Locations Go to Information from the National Library of Medicine (...) Subjects will be seated comfortably in front of a computer screen. An EEG cap will be comfortably worn over the head of the subject to record EEG traces of any activated cortical areas. If subjects are able to activate the device and are agreeable to participate in the second phase of the study, they will be enrolled in a 4-week BCI-MI training program of 12 sessions. Subjects will be required to perform 160 trials of MI altogether with assigned rest periods (5 mins) every 40 trials. Each session

2014 Clinical Trials

5004. A Prospective Trial to Explore the Efficacy of dTMS in Subjects With Fibromyalgia

with a current primary psychiatric condition - including major depression or major personality disorders according to Diagnostic and Statistical Manual of Mental Disorders-IV criteria - or a history of substance abuse will be excluded, as well as pregnant subjects. History of any metal in the head (outside the mouth). Known history of any metallic particles in the eye, implanted cardiac pacemaker or any intracardiac lines, implanted neurostimulators, surgical clips or any medical pumps. History of head (...) for the treatment of FMS patients. In addition, the investigators attempt to assess the effect of dTMS on the perception and modulation of pain in patients suffering from FMS. Condition or disease Intervention/treatment Phase Fibromyalgia Device: dTMS Phase 2 Detailed Description: Fibromyalgia Syndrome (FMS) is a highly prevalent condition often affecting individuals in the prime of life, causing severe reduction in quality of life and productivity, as well as social isolation, anxiety, and depression. FMS has

2014 Clinical Trials

5005. Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome

, untreated major depressive disorder, epilepsy, neurodegenerative dementia, etc.) resulting in unrelated to encephalopathy impairment of consciousness and/or alteration of normal mental capacity. Patients after head injury or with advanced pulmonary, renal, or other than liver failure metabolic disorder (such as severe hypoxia, hypo/hyperglycemia, metabolic acidosis or alkalosis). Patients requiring sedation for MRI. Pregnant women. (Normal Control Group) Inclusion Criteria: Ability to understand (...) (including antidepressants, anxiolytics, or opioid/narcotic pain medications), and not have claustrophobia (Normal Control Group) Exclusion Criteria: Unwillingness or inability to comply with the requirements of this protocol, including the presence of any condition (physical, mental, or social) that is likely to affect the subject's ability to comply with the study protocol. History of alcohol consumption 1 week prior to the MRI. Illicit drug use within past 3 months. Patients requiring sedation for MRI

2014 Clinical Trials

5006. NMDA Receptors in Motor Learning in Humans

Testing for Concussions and Mild Traumatic Brain Injury (mTBI) (DETECT) System Score [ Time Frame: Baseline, Day 30 ] Using a computer, helmet with heads-up-display, headphones with audio inputs, and an input unit with two buttons ("Yes" and "No"), the DETECT system combines an immersive environment with neuropsychological tests to assess mTBI. The DETECT software consists of a series of tests evaluating information processing speed, episodic memory, and working memory. Performance is scored based (...) participants who qualify but who have profound postural instability will undergo the intervention while walking with contact guarding or, when feasible, using their leg and more involved arm to propel a wheelchair. must have a score below 16 on the Center for Epidemiologic Studies Depression Scale must receive a score greater than 25 on the Folstein Mini Mental State Exam. Exclusion Criteria: any history of more than minor head trauma, subarachnoid hemorrhage, dementia or any other neurodegenerative

2014 Clinical Trials

5007. Image-guided Cryoablation of Head, Neck and Spine Tumors

Image-guided Cryoablation of Head, Neck and Spine Tumors Image-guided Cryoablation of Head, Neck and Spine Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Image-guided Cryoablation of Head, Neck (...) provided by (Responsible Party): Thomas C. Lee, MD, Dana-Farber Cancer Institute Study Details Study Description Go to Brief Summary: This research study is evaluating a procedure called cryoablation (the removal of diseased tissue using extreme freezing temperatures) as a possible treatment for head, neck and spine tumors. Condition or disease Intervention/treatment Phase Head and Neck Neoplasms Malignant Neoplasm of Vertebral Column Procedure: Cryoablation Device: Biopsy Not Applicable Detailed

2014 Clinical Trials

5008. Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation

, seizures, febrile convulsions as a child or recurrent fainting fits will be excluded from the tDCS part of the study Any metallic implant in the neck, head, or eye that is situated within the path of the tDCS current, and anyone with any implanted electrical devices, would be excluded as there is a risk of heating with tDCS Pregnant women are excluded as a precaution as there are no data on the effect on maternal tDCS or MRI on the foetus Absolute contraindications to participation in the MRI part (...) of the study: People who suffer from claustrophobia will be excluded from the MRI part of the study if they state they are unable to tolerate the scanner environment Anyone with a metal implant or implantable device that is found to be unsafe or unknown for MRI following investigations by named researchers and staff radiographers would be excluded. Pregnant women are excluded as a precaution as there are no data on the effect on maternal tDCS or MRI on the foetus Potential contraindications

2014 Clinical Trials

5009. Transcranial Magnetic Stimulation and/or Neurofunctional Electrical Acupuncture in Myofascial Chronic Pain Patients

devices for pain control, such as vagal or deep brain stimulators; Contraindications to rTMS: metal in the head, implanted brain medical devices, previous convulsion or epilepsy, serious cranial trauma, audition problem, cochlear implant, neurostimulador implantable, spinal cord surgery, bypass valve ventriculoperitoneal peritonenal,cardiac pacemaker or other metal in the body; Pregnancy; Prior experience with acupuncture. Contacts and Locations Go to Information from the National Library of Medicine (...) . For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Providing informed consent to participate in the study ; 18 to 70 years old; Myofascial pain in the cranial- cervical- mandibular complex, with duration more than 3 months; In the last week, score higher or equal to 3cm (0 cm = 'no pain' and 10cm ='worst possible pain') on the VAS

2014 Clinical Trials

5010. Intervention to Improve Inhalative Adherence

questionnaire consisting of 36 items. It refers to the past four weeks and contains 9 domains concerning vitality, general health perception, physical functioning, social functioning, role limitations, pain, mental health and health change. The COPD Assessment Test (CAT) is a 8-item questionnaire designed to measure the impact of COPD symptoms on health status of patients. The Asthma Control Test (ACT) is a questionnaire that helps to facilitate the assessment of asthma control. ACT includes 5 items (...) . Patients with a metered dose Inhaler (e.g. Ventolin®), Diskus (e.g.Seretide®), Turbohaler (e.g.Symbicort®), Aerolizer/Breezhaler (e.g. Onbrez®), HandiHaler (e.g. Spiriva®) or Ellipta (e.g Relvar®) Exclusion Criteria: Patients who have other lung diseases than asthma and COPD Subjects with severe diseases (e.g. active carcinoma, major depression) Pregnant or lactating women Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor

2014 Clinical Trials

5011. This Study Aims to Determine the Long-term Persistence of Antibodies Against Hepatitis B and to Evaluate the Immunogenicity and Safety of Hepatitis B Vaccine in Adolescents Vaccinated in Infancy With Infanrixâ„¢ Hexa

concentration. Number of Subjects With Any Solicited Local Symptoms. [ Time Frame: During the 4-day (Day 0-3) follow-up period after the single challenge dose of Engerix-B Kinder vaccine. ] Assessed solicited local symptoms were pain, redness and swelling. Any = occurrence of the symptom regardless of intensity grade. Number of Subjects With Any Solicited General Symptoms. [ Time Frame: During the 4-day (Day 0-3) follow-up period after the single challenge dose of Engerix-B Kinder vaccine. ] Assessed (...) solicited general symptoms were fatigue, gastrointestinal, headache and temperature [defined as axillary temperature equal to oe above 37.5 degrees Celsius (°C)]. Any = occurrence of the symptom regardless of intensity grade. Number of Subjects With Any Unsolicited Adverse Events (AEs). [ Time Frame: During the 31-day (Day 0-30) follow-up period after the single challenge dose of Engerix-B Kinder vaccine. ] An unsolicited AE covers any untoward medical occurrence in a clinical investigation subject

2014 Clinical Trials

5012. Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) When Co-administered With GSK Biologicals' Diphtheria, Tetanus and Pertussis Vaccine (Boostrix®) in Adults Aged 50 Yea

period following each dose and across doses ] Assessed solicited general symptoms were fatigue, gastrointestinal (symptoms included nausea, vomiting, diarrhoea and/or abdominal pain), headache, myalgia, shivering and fever [defined as oral, axillary, rectal or tympanic temperature equal to or above (≥) 37.5 degrees Celsius (°C)]. Any = occurrence of the symptom regardless of intensity grade. Grade 3 symptoms = symptoms that prevented normal activity. Grade 3 fever = temperature above (>) 39.0 °C (...) Symptoms, by Dose [ Time Frame: During the 7-day (Days 0-6) post-vaccination period following each dose and across doses ] Assessed solicited local symptoms were pain, redness and swelling. Any = occurrence of the symptom regardless of intensity grade. Grade 3 pain = pain that prevented normal activity. Grade 3 redness/swelling = redness/swelling spreading beyond (>) 100 millimeters (mm). "0" Implied that no data was applicable for the GSK1437173A Group at Dose 3, since it received only 2 vaccine doses

2014 Clinical Trials

5013. Soft Tissue Mobilization Versus Therapeutic Ultrasound for Subjects With Neck and Arm Pain

months. Litigation associated with their neck and/or upper limb pain. Insufficient English language skills to complete the questionnaires and follow-up instructions. Inability to complete the treatment and follow-up schedule. Current pregnancy. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) Soft Tissue Mobilization Versus Therapeutic Ultrasound for Subjects With Neck and Arm Pain Soft Tissue Mobilization Versus Therapeutic Ultrasound for Subjects With Neck and Arm Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2014 Clinical Trials

5014. A Phase 1 Study of Substance P-Saporin in Terminal Cancer Patients With Intractable Pain

to 6 months from the start of SP-SAP administration. Condition or disease Intervention/treatment Phase Terminally Ill Histologically-confirmed Advanced Cancer Pain, Intractable Drug: Substance P-Saporin Phase 1 Detailed Description: Screening (-7 days to Day 0) Physical exam and medical history; Vital signs; Blood tests; Pain measurements (6 daily pain questionnaires for 7 days prior to receiving study drug); Urine tests; Pregnancy test; Electrocardiogram (EKG), a tracing of the electrical activity (...) agree to use effective contraception, or must be surgically sterile, or must be postmenopausal. Acceptable forms of birth control are: spermicide with condom, diaphragm, or cervical cap, IUD-intrauterine device, birth control pills, or abstinence. The rhythm method or Plan B are not considered acceptable forms of birth control. Male patients must agree to use effective contraception or be surgically sterile. Diagnosis of intractable chronic pain of the chest, head, neck or upper extremities. Active

2014 Clinical Trials

5015. Efficacy of Radium 223 in Radioactive Iodine Refractory Bone Metastases From Differentiated Thyroid Cancer

of 4 weeks. Radiation: Radium 223 Other Name: Xofigo Outcome Measures Go to Primary Outcome Measures : Metabolic response (PERCIST criteria) [ Time Frame: Assessed 1 months after 3 monthly injections of Radium 223 ] Metabolic response according to PERCIST criteria in up to five lesions on FDG PET/CT performed 1 month after 3 monthly injections of Radium 223 Secondary Outcome Measures : Pain response (numerical rating scale) [ Time Frame: Assessed every 30 days following the first Radium 223 up to 7 (...) months ] evaluated on a 0-to-10 numerical rating scale completed by the patients Partial pain response (improvement ≥30% and <50% pain score) [ Time Frame: Assessed every 30 days following the first Radium 223 up to 7 months ] Partial pain response is defined as an improvement ≥30% and <50% of the worst pain compared to score at baseline. Complete pain response is defined as an improvement ≥50% of the worst pain score compared to score at baseline ECOG performance status [ Time Frame: Assessed every

2014 Clinical Trials

5016. Silodosin Versus Tamsulosin for Treatment of Ureteral Stones

of a positive urine culture (defined as a single isolated bacterial species population of >100,000 CFU) Patients with chronic pain already undergoing treatment with narcotic medications Patients already taking an alpha adrenergic antagonist medication Pregnant women Prisoners No working phone number Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided (...) by (Responsible Party): James Gardner, MD, Albert Einstein Healthcare Network Study Details Study Description Go to Brief Summary: Ureteral calculi, commonly known as kidney stones, are a frequent cause of Emergency Department (ED) visits. These stones can get caught in the ureter (the tube connecting the kidney to the bladder) and cause symptoms including pain, nausea, and vomiting. As long as the obstructing stone meets certain conditions and the patient isn't too sick, the patient is usually sent home

2014 Clinical Trials

5017. Steroid Versus Platelet Rich Plasma Injection for Chronic Low Back Pain

but not limited to activity alteration, NSAIDS, physiotherapy and/or psychological counselling Exclusion criteria: Systemic infection (H/O fever, chills and/or night sweats) or localized infection at anticipated introducer entry site Spinal pathology that may impede recovery such as spondylolisthesis at L5/S1, or scoliosis Symptomatic foraminal or central canal stenosis H/O potentially confounding intervertebral disc disease or zygapophyseal joint pain Pregnancy Active radicular pain Immunosuppressive (...) Steroid Versus Platelet Rich Plasma Injection for Chronic Low Back Pain Steroid Versus Platelet Rich Plasma Injection for Chronic Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Steroid Versus

2014 Clinical Trials

5018. Epidural Analgesia on Electrophysiological Function

Healthy Pelvic Floor Disorders Drug: CSEA (ropivocaine and sufentanil) Phase 2 Phase 3 Detailed Description: Labor analgesia can relieve labor pain, reduce stress reactions, and improve blood supply to the fetus, benefiting mother and baby. Though traditional epidural analgesia has been used for more than 40 years, combined spinal-epidural analgesia (CSEA) has become popular because it provides faster-onset pain relief with minimal motor weakness. CSEA may also accelerate cervical dilation. Despite (...) have been associated with PFD, including obesity, diabetes, older age, connective tissue disorder, neurological disease, pregnancy, vaginal delivery and childbirth. PFD can lead in turn to stress urinary incontinence, overactive bladder, pelvic organ prolapse and fecal incontinence, all of which can strongly reduce women's physical and psychological health. Pelvic floor function can be analyzed by measuring the strength and degree of fatigue of pelvic floor muscles, as well as the pelvic dynamic

2014 Clinical Trials

5019. Investigation of the Putative Correlation Between Involuntary Psoas Activity During Passive Flexion of the Trunk at the Hips

or arm pain (recurrent dislocations of the glenohumeral joint, trauma in the previous 12 months, etc.) Lower back pain with irradiation of pain below the buttocks Known specific lower back pain or pain for which a differential diagnosis suggests an inflammatory, traumatic, cancerous or infectious cause Subjects under legal guardianship Known pregnancy Simultaneous participation in another biomedical research study of a drug or medical device. Contacts and Locations Go to Information from the National (...) by the subject. This lack of passivity might be concomitant with lower back pain: the impairment may be present when lower back pain is present and/or absent when lower back pain is absent. The study's primary objective is thus to determine the sensitivity and/or specificity of a clinical test for impaired hip flexor passivity in cases of lower back pain during passive flexion of the trunk (from the supine position,). The secondary objective is to show that a negative test (after administration of correcting

2014 Clinical Trials

5020. Endoscopic Transcanal Lateral Graft Tympanoplasty

of follow up. Agree to participate in the study Aaccept to be randomized to receive treatment Willing to sign an informed consent Exclusion Criteria: Medial placing or inlay surgical technique Chronic otitis media Contraindication of vasoconstriction agent (adrenaline) Allergy to analgesic agent (Xylocaine or Lidocaine) Concomitant with mastoiditis. Previous intracranial or extra-cranial complication of chronic otitis media. Pregnancy Contacts and Locations Go to Information from the National Library (...) Study Description Go to Brief Summary: Minimally invasive surgery is becoming more common in many surgical fields. The wide view of endoscope allows for minimally invasive transcanal approach instead of large postauricular opening. The investigators conduct this study to compared post operative pain score (by Visual Analogue Scales) between conventional microscope lateral placing tympanoplasty and endoscopic lateral placing tympanoplasty. Condition or disease Intervention/treatment Phase Tympanic

2014 Clinical Trials

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