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Hand Foot Syndrome in Sickle Cell Anemia

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1. Hand Foot Syndrome in Sickle Cell Anemia

Hand Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hand (...) Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Aka: Hand Foot Syndrome in Sickle Cell Anemia , Dactylitis in Sickle Cell Anemia From Related Chapters II. Epidemiology Often the first vaso- crisis finding in young children (as early as 6 months of age) Occurs in up to 50% of children with by the age of 2 years Rare over age 4 years old III. Pathophysiology Not to be confused with Hand Syndrome that occurs with certain agents in non-sickle disease Occurs in with vaso

2018 FP Notebook

2. Hand Foot Syndrome in Sickle Cell Anemia

Hand Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hand (...) Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Aka: Hand Foot Syndrome in Sickle Cell Anemia , Dactylitis in Sickle Cell Anemia From Related Chapters II. Epidemiology Often the first vaso- crisis finding in young children (as early as 6 months of age) Occurs in up to 50% of children with by the age of 2 years Rare over age 4 years old III. Pathophysiology Not to be confused with Hand Syndrome that occurs with certain agents in non-sickle disease Occurs in with vaso

2016 FP Notebook

3. Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa Full Text available with Trip Pro

entered the study. The mean age at presentation was 8.4 ± 4.9 years of age. Underweight, stunting, and wasting were found, respectively, in 47.7%, 10.5%, and 50.3% of SCA children. A history of hand-foot syndrome, more than 3 blood transfusions, being less than 12 months of age when receiving the first transfusion, more than two severe sickle crises per year, a medical history of severe infections, and the presence of hepatomegaly were associated with poor growth. When comparing sickle cell patients (...) Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa Background. The aim of this study was to investigate and determine the risk factors associated with poor growth among SCA children. Methods. A cross-sectional study was conducted in Kinshasa, the capital's country. The nutritional status was assessed using the Z scores of the anthropometric indices. Results. We gathered data on the 256 patients, 138 females (53.9%), who

2017 Anemia

4. Sickle Cell Anemia

, Sickle-cell anemia NOS , Sickle-cell disorder NOS , Sickle-cell disorders , Sickle-cell disease NOS , Anemia, Sickle Cell [Disease/Finding] , anemia cell disorders sickle , syndrome sickle cell , Anaemia;sickle cell , anemia cell disorder sickle , anemia sickle cell , anemia sickle celled , sickle cell syndrome , sickle-cell anemia , anaemia cell sickle , cell diseases sickle , cell sickle syndromes , disease hb s , hb s disease , scds , sickle cell anemias , sickle-cell disease , anemia cells (...) sickles , cell sickle syndrome , cells disease sickle , disease sickle cell , sickle cell disorder , anemia cells sickle , anemia sickle-cell , cell disorder sickle , sickle-cell anaemia , disease sickle-cell , Hb SS , Hemoglobin SS , Hemoglobin SS Disease , Hemoglobin SS disease , HbS Disease , Sickle cell anemia NOS (disorder) , Sickle cell syndrome (disorder) , Sickle cell anaemia (disorder) , Sickle-cell anaemia, unspecified , Hemoglobin S disease (disorder) , Sickle cell anemia of unspecified

2018 FP Notebook

5. Sickle cell disease

disease. Sickle cell disease is common and affects 1 in every 2000 live births in England. In the UK, sickle cell screening is offered to all newborn babies and all pregnant women. Sickle cell disease should be suspected if a person is in a high-risk ethnic group (mostly African or African-Caribbean) and: Is a child aged 9–18 months with painful dactylitis (painful swelling of the bones of the hands and feet). There may be chronic shortening of a digit due to epiphyseal damage. Has a sudden severe (...) haemoglobin variant from the other parent. If the second abnormal gene is also for Hb S, the person is said to have homozygous sickle cell disease (Hb SS), commonly called sickle cell anaemia. This is the most common and severe type of sickle cell disease. If the second abnormal gene is for a different abnormal haemoglobin, the person is said to have compound heterozygous sickle cell disorder. The variant haemoglobins that in combination with Hb S give rise to clinically significant sickle cell disease

2016 NICE Clinical Knowledge Summaries

6. Iron Deficiency and Anaemia in Adults

to check that the donor’s haemoglobin level is sufficient for them to be able to donate safely. If the person has recently been unable to meet that threshold after previously having no problems, it may give a timeframe for the onset of the anaemia. If a donation has been made within 48 hours of a blood test, then an individual will have a lower haemoglobin level (as their body replaces the red cells that have been donated). Other medical conditions It is important to record any other illnesses (...) by the liver. It acts as a regulatory hormone controlling the amount of iron in the body. In inflammation, hepcidin levels rise causing iron to be trapped within macrophages and liver cells. Therefore serum iron levels fall. This typically leads to anaemia due to an inadequate amount of serum iron being available for developing red cells. This leads to functional iron deficiency (FID), which develops under conditions where the demand exceeds iron availability. Iron homeostasis and pathophysiology

2018 Royal College of Nursing

7. Sickle Cell Anemia (Overview)

Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD causes (...) -threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome

2014 eMedicine.com

8. Sickle Cell Anemia (Diagnosis)

, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD (...) -threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome

2014 eMedicine.com

9. Sickle Cell Anemia (Follow-up)

== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal (...) regular blood transfusions (to reduce HbS to < 30%-50% total hemoglobin), hydroxyurea, or bypass surgery for advanced occlusive disease. [ ] Transfusion therapy, aimed at keeping the proportion of HbS below 30%, is now considered standard care for primary and secondary stroke prevention in children with SCD. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) showed that regular blood transfusions produced a marked (90%) reduction in first stroke in asymptomatic high-risk children who had 2

2014 eMedicine.com

10. Anemia, Sickle Cell (Follow-up)

== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal (...) regular blood transfusions (to reduce HbS to < 30%-50% total hemoglobin), hydroxyurea, or bypass surgery for advanced occlusive disease. [ ] Transfusion therapy, aimed at keeping the proportion of HbS below 30%, is now considered standard care for primary and secondary stroke prevention in children with SCD. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) showed that regular blood transfusions produced a marked (90%) reduction in first stroke in asymptomatic high-risk children who had 2

2014 eMedicine Emergency Medicine

11. Sickle Cell Anemia (Treatment)

== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal (...) regular blood transfusions (to reduce HbS to < 30%-50% total hemoglobin), hydroxyurea, or bypass surgery for advanced occlusive disease. [ ] Transfusion therapy, aimed at keeping the proportion of HbS below 30%, is now considered standard care for primary and secondary stroke prevention in children with SCD. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) showed that regular blood transfusions produced a marked (90%) reduction in first stroke in asymptomatic high-risk children who had 2

2014 eMedicine.com

12. Sickle Cell Anemia (Treatment)

== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal (...) regular blood transfusions (to reduce HbS to < 30%-50% total hemoglobin), hydroxyurea, or bypass surgery for advanced occlusive disease. [ ] Transfusion therapy, aimed at keeping the proportion of HbS below 30%, is now considered standard care for primary and secondary stroke prevention in children with SCD. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) showed that regular blood transfusions produced a marked (90%) reduction in first stroke in asymptomatic high-risk children who had 2

2014 eMedicine Pediatrics

13. Sickle Cell Anemia (Follow-up)

== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal (...) regular blood transfusions (to reduce HbS to < 30%-50% total hemoglobin), hydroxyurea, or bypass surgery for advanced occlusive disease. [ ] Transfusion therapy, aimed at keeping the proportion of HbS below 30%, is now considered standard care for primary and secondary stroke prevention in children with SCD. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) showed that regular blood transfusions produced a marked (90%) reduction in first stroke in asymptomatic high-risk children who had 2

2014 eMedicine Pediatrics

14. Sickle Cell Anemia (Overview)

Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD causes (...) -threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome

2014 eMedicine Pediatrics

15. Sickle Cell Anemia (Diagnosis)

, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD (...) -threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome

2014 eMedicine Pediatrics

16. Anemia, Sickle Cell (Overview)

, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD (...) -threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome

2014 eMedicine Emergency Medicine

17. Anemia, Sickle Cell (Diagnosis)

, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD (...) -threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome

2014 eMedicine Emergency Medicine

18. Sickle Cell Anemia, Skeletal

. Skeletal scintigraphy manifestations of hematologic disorders. Indian J Nucl Med . 2012 Jan. 27 (1):59-62. . Media Gallery Skeletal sickle cell anemia. H vertebrae. Lateral view of the spine shows angular depression of the central portion of each upper and lower endplate. Skeletal sickle cell anemia. Hand-foot syndrome. Soft tissue swelling with periosteal new-bone formation and a moth-eaten lytic process at the proximal aspect of the fourth phalanx. Skeletal sickle cell anemia. Advanced dactylitis (...) . Skeletal sickle cell anemia. Hand-foot syndrome. Soft tissue swelling with periosteal new-bone formation and a moth-eaten lytic process at the proximal aspect of the fourth phalanx. Skeletal sickle cell anemia. Expanded medullary cavity. The diploic space is markedly widened due to marrow hyperplasia. Trabeculae are oriented perpendicular to the inner table, giving a hair-on-end appearance. Ever since carriers of the mutated gene survived the deadly malaria epidemics that were thought to occur

2014 eMedicine Radiology

19. Anemia, Sickle Cell (Treatment)

== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal (...) regular blood transfusions (to reduce HbS to < 30%-50% total hemoglobin), hydroxyurea, or bypass surgery for advanced occlusive disease. [ ] Transfusion therapy, aimed at keeping the proportion of HbS below 30%, is now considered standard care for primary and secondary stroke prevention in children with SCD. The Stroke Prevention Trial in Sickle Cell Anemia (STOP) showed that regular blood transfusions produced a marked (90%) reduction in first stroke in asymptomatic high-risk children who had 2

2014 eMedicine Emergency Medicine

20. Sickle Cell Anemia

, Sickle-cell anemia NOS , Sickle-cell disorder NOS , Sickle-cell disorders , Sickle-cell disease NOS , Anemia, Sickle Cell [Disease/Finding] , anemia cell disorders sickle , syndrome sickle cell , Anaemia;sickle cell , anemia cell disorder sickle , anemia sickle cell , anemia sickle celled , sickle cell syndrome , sickle-cell anemia , anaemia cell sickle , cell diseases sickle , cell sickle syndromes , disease hb s , hb s disease , scds , sickle cell anemias , sickle-cell disease , anemia cells (...) sickles , cell sickle syndrome , cells disease sickle , disease sickle cell , sickle cell disorder , anemia cells sickle , anemia sickle-cell , cell disorder sickle , sickle-cell anaemia , disease sickle-cell , Hb SS , Hemoglobin SS , Hemoglobin SS Disease , Hemoglobin SS disease , HbS Disease , Sickle cell anemia NOS (disorder) , Sickle cell syndrome (disorder) , Sickle cell anaemia (disorder) , Sickle-cell anaemia, unspecified , Hemoglobin S disease (disorder) , Sickle cell anemia of unspecified

2015 FP Notebook

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