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Hand Foot Syndrome in Sickle Cell Anemia

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1. Hand Foot Syndrome in Sickle Cell Anemia

Hand Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hand (...) Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Aka: Hand Foot Syndrome in Sickle Cell Anemia , Dactylitis in Sickle Cell Anemia From Related Chapters II. Epidemiology Often the first vaso- crisis finding in young children (as early as 6 months of age) Occurs in up to 50% of children with by the age of 2 years Rare over age 4 years old III. Pathophysiology Not to be confused with Hand Syndrome that occurs with certain agents in non-sickle disease Occurs in with vaso

2018 FP Notebook

2. Hand Foot Syndrome in Sickle Cell Anemia

Hand Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hand (...) Foot Syndrome in Sickle Cell Anemia Hand Foot Syndrome in Sickle Cell Anemia Aka: Hand Foot Syndrome in Sickle Cell Anemia , Dactylitis in Sickle Cell Anemia From Related Chapters II. Epidemiology Often the first vaso- crisis finding in young children (as early as 6 months of age) Occurs in up to 50% of children with by the age of 2 years Rare over age 4 years old III. Pathophysiology Not to be confused with Hand Syndrome that occurs with certain agents in non-sickle disease Occurs in with vaso

2016 FP Notebook

3. Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa (PubMed)

entered the study. The mean age at presentation was 8.4 ± 4.9 years of age. Underweight, stunting, and wasting were found, respectively, in 47.7%, 10.5%, and 50.3% of SCA children. A history of hand-foot syndrome, more than 3 blood transfusions, being less than 12 months of age when receiving the first transfusion, more than two severe sickle crises per year, a medical history of severe infections, and the presence of hepatomegaly were associated with poor growth. When comparing sickle cell patients (...) Factors Associated with Growth Retardation in Children Suffering from Sickle Cell Anemia: First Report from Central Africa Background. The aim of this study was to investigate and determine the risk factors associated with poor growth among SCA children. Methods. A cross-sectional study was conducted in Kinshasa, the capital's country. The nutritional status was assessed using the Z scores of the anthropometric indices. Results. We gathered data on the 256 patients, 138 females (53.9%), who

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2017 Anemia

4. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

5. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

6. Sickle Cell Anemia (Overview)

-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine.com

7. Sickle Cell Anemia (Diagnosis)

-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine Pediatrics

8. Sickle Cell Anemia (Overview)

-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine Pediatrics

9. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

10. Anemia, Sickle Cell (Overview)

-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine Emergency Medicine

11. Anemia, Sickle Cell (Follow-up)

Anemia, Sickle Cell (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Emergency Medicine

12. Sickle Cell Anemia (Diagnosis)

-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine.com

13. Sickle Cell Anemia, Skeletal

. Skeletal sickle cell anemia. Hand-foot syndrome. Soft tissue swelling with periosteal new-bone formation and a moth-eaten lytic process at the proximal aspect of the fourth phalanx. Skeletal sickle cell anemia. Expanded medullary cavity. The diploic space is markedly widened due to marrow hyperplasia. Trabeculae are oriented perpendicular to the inner table, giving a hair-on-end appearance. Ever since carriers of the mutated gene survived the deadly malaria epidemics that were thought to occur (...) the , as well as . Next: Radiography The early plain radiographic findings of dactylitis consist of soft tissue swelling. Periosteal new-bone formation can be seen on radiographs 7-10 days later. Additionally, medullary expansion, cortical thinning, trabecular resorption, and resultant focal lucency may be seen 2-3 weeks after the onset of symptoms, but these findings usually resolve within weeks (see the images below). Skeletal sickle cell anemia. Hand-foot syndrome. Soft tissue swelling with periosteal

2014 eMedicine Radiology

14. Anemia, Sickle Cell (Treatment)

Anemia, Sickle Cell (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Emergency Medicine

15. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

16. Anemia, Sickle Cell (Diagnosis)

-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute chest syndrome (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine Emergency Medicine

17. Pediatrics, Sickle Cell Disease (Follow-up)

Pediatrics, Sickle Cell Disease (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have

2014 eMedicine Emergency Medicine

18. Pediatrics, Sickle Cell Disease (Diagnosis)

by the onset of life-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine Emergency Medicine

19. Pediatrics, Sickle Cell Disease (Treatment)

Pediatrics, Sickle Cell Disease (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have

2014 eMedicine Emergency Medicine

20. Pediatrics, Sickle Cell Disease (Overview)

by the onset of life-threatening anemia with rapid enlargement of the spleen and high reticulocyte count Infection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumonia ; adult infections are predominately with gram-negative organisms, especially Salmonella Growth retardation, delayed sexual maturation, being underweight Hand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in children Acute (...) persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia

2014 eMedicine Emergency Medicine

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