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Halo Nevus

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1. A similar local immune and oxidative stress phenotype in vitiligo and halo nevus. (PubMed)

A similar local immune and oxidative stress phenotype in vitiligo and halo nevus. Vitiligo and halo nevus are two common T-cell-mediated skin disorders. Although autoimmunity has been suggested to be involved in both diseases, the relationship between vitiligo and halo nevus is not fully understood.The aim of the current study was to investigate whether vitiligo and halo nevus share the same immunological and oxidative stress response.Infiltrations of T cells, and expressions of chemokine (...) receptors (CXCR3, CCR4, CCR5) and cytotoxic markers (Granzyme B, Perforin) in the lesions of vitiligo and halo nevus were examined by immunohistochemistry. Enzyme-linked immunosorbent assay was performed to analyze the expressions of chemokines in the serum samples and cytotoxic markers secreted by CD8+ T cells which were sorted from the peripheral blood mononuclear cells in healthy donors, vitiligo and halo nevus patients. Tissue levels of chemokine receptors and CXCR3 ligands in healthy controls

2017 Journal of dermatological science

2. Recurrent halo nevus: Dermoscopy and confocal microscopy features (PubMed)

Recurrent halo nevus: Dermoscopy and confocal microscopy features 28580411 2019 02 26 2352-5126 3 3 2017 May JAAD case reports JAAD Case Rep Recurrent halo nevus: Dermoscopy and confocal microscopy features. 256-258 10.1016/j.jdcr.2017.02.020 Porto Ana Carolina AC Cutaneous Oncology Department, AC Camargo Cancer Center, São Paulo, Brazil. Blumetti Tatiana Pinto TP Cutaneous Oncology Department, AC Camargo Cancer Center, São Paulo, Brazil. de Paula Ramos Castro Raquel R Cutaneous Oncology (...) Cancer Center, São Paulo, Brazil. eng Case Reports 2017 05 24 United States JAAD Case Rep 101665210 2352-5126 HN, halo nevi RCM, reflectance confocal microscopy RN, recurrent nevi confocal microscopy dermoscopy halo nevus melanoma nevus skin cancer 2017 6 6 6 0 2017 6 6 6 0 2017 6 6 6 1 epublish 28580411 10.1016/j.jdcr.2017.02.020 S2352-5126(17)30053-X PMC5447382 J Am Acad Dermatol. 2012 Oct;67(4):582-6 22387032 Australas J Dermatol. 2016 Mar 1;:null 26931297 J Cutan Med Surg. 2013 Jan-Feb;17(1):33-8

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2017 JAAD Case Reports

3. Factors Associated with Development of Vitiligo in Patients with Halo Nevus (PubMed)

Factors Associated with Development of Vitiligo in Patients with Halo Nevus Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients.We performed a retrospective study on consecutive patients with HN at the First Affiliated Hospital

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2017 Chinese medical journal

4. Halo Nevus

Halo Nevus Halo Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Halo Nevus Halo Nevus Aka: Halo Nevus , Halo Nevi II (...) . Pathophysiology or Halo region is depigmented, without s mediated depigmentation III. Epidemiology Onset in teen years : 1% IV. Signs White, symmetric round halo surrounding a nevus Distribution Trunk is most typical Always spares the palms and soles V. Associated Conditions risk may be increased VI. Course Repigmentation may occur spontaneously over years VII. Prognosis Rare malignant transformation (typically predictable by atypical features) VIII. Reference Habif (2003) Clinical Dermatology, 4th ed.. Mosby

2018 FP Notebook

5. Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon (PubMed)

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested (...) to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN.

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2015 The American Journal of dermatopathology

6. Dermoscopy of halo nevus in own observation (PubMed)

Dermoscopy of halo nevus in own observation Halo nevus (HN) is a rare dermatologic entity characterized by a typical whitish rim encircling the existing melanocytic nevus resembling a halo. The clinical picture is suggesting its diagnosis, but so far only several dermoscopic descriptions of halo nevus have existed in the PubMed database.To present the clinical and dermoscopic characteristics of halo nevus observed in dermoscopy.Fifteen patients were diagnosed clinically and dermoscopically (...) with halo nevus during planned routine dermoscopic examinations of all melanocytic lesions in 2007-2013. All digital images stored in the computer database were analyzed retrospectively according to the procedure described in the study. The clinical and dermoscopic parameters such as the dermoscopic pattern, color of nevus, special features and description of the surrounding halo were analyzed statistically.We analyzed 22 halo nevi (9 in females, 13 in males) in 15 patients (7 females, 8 males

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2014 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

7. Halo Nevus (Overview)

Halo Nevus (Overview) Halo Nevus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1NzQ0Ni1vdmVydmlldw== processing > Halo Nevus Updated: Feb 15, 2019 Author: Edward J (...) Zabawski, Jr, DO; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Halo Nevus Overview Background Halo nevi are common benign skin lesions that represent melanocytic nevi in which an inflammatory infiltrate develops, resulting in a zone of depigmentation surrounding the nevus. Although Sutton originally described the lesion in 1916 as leukoderma acquisita centrifugum, the lesions were noted earlier, as evidenced by their depiction in the painting The Temptation

2014 eMedicine.com

8. Halo Nevus (Treatment)

Halo Nevus (Treatment) Halo Nevus Treatment & Management: Medical Care, Consultations, Complications Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1NzQ0Ni10cmVhdG1lbnQ= processing > Halo Nevus Treatment (...) & Management Updated: Feb 15, 2019 Author: Edward J Zabawski, Jr, DO; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Halo Nevus Treatment Medical Care Halo nevi are benign, and no treatment is necessary. Next: Consultations The chief diagnostic consideration in patients with halo nevi is melanoma that is undergoing regression, although making this distinction is not usually difficult. Primary melanoma is usually solitary, whereas halo nevi are commonly multiple

2014 eMedicine.com

9. Halo Nevus (Follow-up)

Halo Nevus (Follow-up) Halo Nevus Treatment & Management: Medical Care, Consultations, Complications Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1NzQ0Ni10cmVhdG1lbnQ= processing > Halo Nevus Treatment (...) & Management Updated: Feb 15, 2019 Author: Edward J Zabawski, Jr, DO; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Halo Nevus Treatment Medical Care Halo nevi are benign, and no treatment is necessary. Next: Consultations The chief diagnostic consideration in patients with halo nevi is melanoma that is undergoing regression, although making this distinction is not usually difficult. Primary melanoma is usually solitary, whereas halo nevi are commonly multiple

2014 eMedicine.com

10. Halo Nevus (Diagnosis)

Halo Nevus (Diagnosis) Halo Nevus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1NzQ0Ni1vdmVydmlldw== processing > Halo Nevus Updated: Feb 15, 2019 Author: Edward J (...) Zabawski, Jr, DO; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Halo Nevus Overview Background Halo nevi are common benign skin lesions that represent melanocytic nevi in which an inflammatory infiltrate develops, resulting in a zone of depigmentation surrounding the nevus. Although Sutton originally described the lesion in 1916 as leukoderma acquisita centrifugum, the lesions were noted earlier, as evidenced by their depiction in the painting The Temptation

2014 eMedicine.com

11. Association of halo nevus/i and vitiligo in childhood: a retrospective observational study. (PubMed)

Association of halo nevus/i and vitiligo in childhood: a retrospective observational study. Although halo nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated.To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo.Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history

2013 Journal of the European Academy of Dermatology and Venereology

12. Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. (PubMed)

than 2 mm, subretinal fluid (F), symptoms (S) of flashes/floaters/blurred vision, orange (O) lipofuscin pigment, margin (M) less than 3 mm from optic disk, ultrasonographic hollowness (UH), halo (H) absence, and drusen (D) absence. The presence of three or more risk factors implies more than 50% chance for transformation to melanoma within 5 years. A new, online ocular oncology reading center can help judge nevus risk.Choroidal nevus is a common intraocular lesion, found predominantly in Whites (...) Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus.Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus

2017 Current Opinion in Ophthalmology

13. Halo Nevus

Halo Nevus Halo Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Halo Nevus Halo Nevus Aka: Halo Nevus , Halo Nevi II (...) . Pathophysiology or Halo region is depigmented, without s mediated depigmentation III. Epidemiology Onset in teen years : 1% IV. Signs White, symmetric round halo surrounding a nevus Distribution Trunk is most typical Always spares the palms and soles V. Associated Conditions risk may be increased VI. Course Repigmentation may occur spontaneously over years VII. Prognosis Rare malignant transformation (typically predictable by atypical features) VIII. Reference Habif (2003) Clinical Dermatology, 4th ed.. Mosby

2015 FP Notebook

14. Foxp3 Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi. (PubMed)

and CD25.We found significant increases in Foxp3(+) Tregs, and the shorter the halo nevus duration, the more Foxp3(+) Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25(+)Foxp3(+) T cells.Foxp3(+) Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3(+) Tregs were involved in the earlier developmental stages of halo (...) Foxp3 Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi. There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus.To evaluate the clinicopathologic features and the presence of Tregs in halo nevi.We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3

2012 Dermatology

15. Posterior Scleral Bowing With Choroidal Nevus on Enhanced-Depth Imaging Optical Coherence Tomography. (PubMed)

patient age was 58 years (median, 58 years; range, 36-75 years) and there were 6 men (35%) and 11 women (65%). The nevus was classified as pigmented (n = 3; 18%), nonpigmented (n = 2; 12%), and mixed pigmentation (n = 12; 71%), and with no surrounding halo (n = 7; 41%). Associated features included overlying drusen (n = 9; 53%), retinal pigment epithelial alterations (n = 9; 53%), subretinal fluid (n = 5; 29%), and orange pigment (n = 3; 18%). The nevus was clinically estimated to be of 4.91-mm basal (...) ; 95% CI, -2.95 mm to 5.51 mm; P = .01) and the foveola (difference, 2.14 mm; 95% CI, 0.80 mm to 3.48 mm; P < .001), as well as the presence of surrounding halo (difference, 36%; 95% CI, 16.86% to 59.27%; P < .001).Choroidal nevus can show focal posterior scleral bowing on EDI-OCT in 5% of cases. This finding was related to more posterior location of nevus, less/mixed pigmentation, and surrounding halo. This finding could lead to underestimation of tumor thickness as the tumor bows backward rather

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2015 JAMA ophthalmology

16. The natural history of halo nevi: A retrospective case series. (PubMed)

The natural history of halo nevi: A retrospective case series. The time period between onset of depigmentation around the halo nevus (HN) to complete resolution of the nevus and halo has not been well studied.We sought to better understand the natural history of the HN.A retrospective chart review of patients with a clinical diagnosis of HN selected from a private practice database (1994-2010) was performed. In all, 52 patients with 80 HN were identified. The current stage of the HN (...) was determined by a follow-up questionnaire and physical examination of 36 patients with 56 HN.Seven HN were excised. Of the remaining 49 HN, 51% (25) demonstrated no change in the halo or nevus after an average of 4.2 years; 14.3% (7) demonstrated partial nevus regression with persistence of the halo after an average of 6.7 years; 4.1% (2) demonstrated complete involution of the nevus with persistent halo depigmentation after an average of 7.7 years; 8.2% (4) demonstrated complete nevus involution with some

2012 Journal of American Academy of Dermatology

17. Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (PubMed)

Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus.

2010 British Journal of Dermatology

18. Halo nevus of the choroid in 150 patients: the 2010 Henry van Dyke Lecture. (PubMed)

Halo nevus of the choroid in 150 patients: the 2010 Henry van Dyke Lecture. To evaluate choroidal halo nevus.We performed a retrospective medical record review on all patients with a clinical diagnosis of choroidal halo nevus treated at the Ocular Oncology Service at Wills Eye Institute from April 1, 1974, through June 30, 2008. Their clinical characteristics and natural history were studied.The choroidal halo nevus showed 2 components, including a distinct central pigmented region surrounded (...) %) and slightly internal in 11 (7.3%). Two patients (1.3%) had multifocal halo nevi. The nevus location was superior in 31 patients (20.7%), temporal in 43 (28.7%), inferior in 29 (19.3%), nasal in 27 (18.0%), and macular in 20 (13.3%). Related features included drusen in 85 patients (56.7%), subretinal fluid in 21 (14.0%), orange pigment in 13 (8.7%), and retinal pigment epithelial atrophy in 15 (10.0%). There were no intraocular inflammatory findings. Of the 110 patients with nevi with follow-up, growth

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2010 Archives of Ophthalmology

19. Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (PubMed)

Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long-term follow-up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only (...) a few times previously.To evaluate the long-term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage

2010 British Journal of Dermatology

20. Halo naevus--a frustrated malignant maelanoma. (PubMed)

Halo naevus--a frustrated malignant maelanoma. 4552592 1972 06 11 2018 11 13 0007-1447 2 5804 1972 Apr 01 British medical journal Br Med J Halo naevus--a frustrated malignant maelanoma. 47-8 Lewis M G MG Copeman P W PW eng Journal Article England Br Med J 0372673 0007-1447 0 Antibodies AIM IM Adolescent Adult Antibodies Child Cytoplasm immunology Diagnosis, Differential Fluorescent Antibody Technique Humans Male Melanoma diagnosis immunology pathology Nevus, Pigmented diagnosis immunology

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1972 British medical journal

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