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Halo Nevus

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1. Factors Associated with Development of Vitiligo in Patients with Halo Nevus Full Text available with Trip Pro

Factors Associated with Development of Vitiligo in Patients with Halo Nevus Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients.We performed a retrospective study on consecutive patients with HN at the First Affiliated Hospital

2017 Chinese medical journal

2. Recurrent halo nevus: Dermoscopy and confocal microscopy features Full Text available with Trip Pro

Recurrent halo nevus: Dermoscopy and confocal microscopy features 28580411 2019 02 26 2352-5126 3 3 2017 May JAAD case reports JAAD Case Rep Recurrent halo nevus: Dermoscopy and confocal microscopy features. 256-258 10.1016/j.jdcr.2017.02.020 Porto Ana Carolina AC Cutaneous Oncology Department, AC Camargo Cancer Center, São Paulo, Brazil. Blumetti Tatiana Pinto TP Cutaneous Oncology Department, AC Camargo Cancer Center, São Paulo, Brazil. de Paula Ramos Castro Raquel R Cutaneous Oncology (...) Cancer Center, São Paulo, Brazil. eng Case Reports 2017 05 24 United States JAAD Case Rep 101665210 2352-5126 HN, halo nevi RCM, reflectance confocal microscopy RN, recurrent nevi confocal microscopy dermoscopy halo nevus melanoma nevus skin cancer 2017 6 6 6 0 2017 6 6 6 0 2017 6 6 6 1 epublish 28580411 10.1016/j.jdcr.2017.02.020 S2352-5126(17)30053-X PMC5447382 J Am Acad Dermatol. 2012 Oct;67(4):582-6 22387032 Australas J Dermatol. 2016 Mar 1;:null 26931297 J Cutan Med Surg. 2013 Jan-Feb;17(1):33-8

2017 JAAD Case Reports

3. A similar local immune and oxidative stress phenotype in vitiligo and halo nevus. Full Text available with Trip Pro

A similar local immune and oxidative stress phenotype in vitiligo and halo nevus. Vitiligo and halo nevus are two common T-cell-mediated skin disorders. Although autoimmunity has been suggested to be involved in both diseases, the relationship between vitiligo and halo nevus is not fully understood.The aim of the current study was to investigate whether vitiligo and halo nevus share the same immunological and oxidative stress response.Infiltrations of T cells, and expressions of chemokine (...) receptors (CXCR3, CCR4, CCR5) and cytotoxic markers (Granzyme B, Perforin) in the lesions of vitiligo and halo nevus were examined by immunohistochemistry. Enzyme-linked immunosorbent assay was performed to analyze the expressions of chemokines in the serum samples and cytotoxic markers secreted by CD8+ T cells which were sorted from the peripheral blood mononuclear cells in healthy donors, vitiligo and halo nevus patients. Tissue levels of chemokine receptors and CXCR3 ligands in healthy controls

2017 Journal of dermatological science

4. Halo Nevus

Halo Nevus Halo Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Halo Nevus Halo Nevus Aka: Halo Nevus , Halo Nevi II (...) . Pathophysiology or Halo region is depigmented, without s mediated depigmentation III. Epidemiology Onset in teen years : 1% IV. Signs White, symmetric round halo surrounding a nevus Distribution Trunk is most typical Always spares the palms and soles V. Associated Conditions risk may be increased VI. Course Repigmentation may occur spontaneously over years VII. Prognosis Rare malignant transformation (typically predictable by atypical features) VIII. Reference Habif (2003) Clinical Dermatology, 4th ed.. Mosby

2018 FP Notebook

5. Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy Full Text available with Trip Pro

Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy We present a follow-up case report of a 33-year-old lady with juvenile onset arthritis who developed halo naevi while on treatment with tocilizumab. This case report describes the development of halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy following infection with Methicillin-resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin positivity

2016 Oxford Medical Case Reports

6. Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon Full Text available with Trip Pro

Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested (...) to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN.

2015 The American Journal of dermatopathology

7. Halo naevi and café au lait macule regression in a renal transplant patient on immunosuppression. (Abstract)

Halo naevi and café au lait macule regression in a renal transplant patient on immunosuppression. A case of halo naevi and café au lait macule regression in a renal transplant patient receiving long-term immunosuppressive therapy is described. We propose the direct transfer of an auto-reactive antibody, CD8 T-cells or tumour necrosis factor α from the transplant donor to the recipient as a possible cause. We have also considered insufficient immunosuppressive therapy as a possible mechanism. ©

2014 Australasian Journal of Dermatology

8. Dermoscopy of halo nevus in own observation Full Text available with Trip Pro

Dermoscopy of halo nevus in own observation Halo nevus (HN) is a rare dermatologic entity characterized by a typical whitish rim encircling the existing melanocytic nevus resembling a halo. The clinical picture is suggesting its diagnosis, but so far only several dermoscopic descriptions of halo nevus have existed in the PubMed database.To present the clinical and dermoscopic characteristics of halo nevus observed in dermoscopy.Fifteen patients were diagnosed clinically and dermoscopically (...) with halo nevus during planned routine dermoscopic examinations of all melanocytic lesions in 2007-2013. All digital images stored in the computer database were analyzed retrospectively according to the procedure described in the study. The clinical and dermoscopic parameters such as the dermoscopic pattern, color of nevus, special features and description of the surrounding halo were analyzed statistically.We analyzed 22 halo nevi (9 in females, 13 in males) in 15 patients (7 females, 8 males

2014 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

9. Halo Nevus (Treatment)

Happle R. [Grunewald nevus]. Hautarzt . 1994 Dec. 45(12):882-3. . Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol . 1997 Oct. 37(4):620-4. . Patrizi A, Neri I, Sabattini E, Rizzoli L, Misciali C. Unusual inflammatory and hyperkeratotic halo naevus in children. Br J Dermatol . 2005 Feb. 152(2):357-60. . van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol . 2011 Apr (...) . 164(4):743-9. . Zhou H, Wu LC, Chen MK, Liao QM, Mao RX, Han JD. Factors Associated with Development of Vitiligo in Patients with Halo Nevus. Chin Med J (Engl) . 2017 Nov 20. 130 (22):2703-2708. . Fishman HC. Letter: Malignant melanoma arising with two halo nevi. Arch Dermatol . 1976 Mar. 112(3):407-8. . Jacobs JB, Edelstein LM, Snyder LM, Fortier N. Ultrastructural evidence for destruction in the halo nevus. Cancer Res . 1975 Feb. 35(2):352-7. . Herd RM, Hunter JA. Familial halo naevi. Clin Exp

2014 eMedicine.com

10. Halo Nevus (Overview)

. 1997 Oct. 37(4):620-4. . Patrizi A, Neri I, Sabattini E, Rizzoli L, Misciali C. Unusual inflammatory and hyperkeratotic halo naevus in children. Br J Dermatol . 2005 Feb. 152(2):357-60. . van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol . 2011 Apr. 164(4):743-9. . Zhou H, Wu LC, Chen MK, Liao QM, Mao RX, Han JD. Factors Associated with Development of Vitiligo in Patients with Halo Nevus. Chin Med J (Engl (...) ) . 2017 Nov 20. 130 (22):2703-2708. . Fishman HC. Letter: Malignant melanoma arising with two halo nevi. Arch Dermatol . 1976 Mar. 112(3):407-8. . Jacobs JB, Edelstein LM, Snyder LM, Fortier N. Ultrastructural evidence for destruction in the halo nevus. Cancer Res . 1975 Feb. 35(2):352-7. . Herd RM, Hunter JA. Familial halo naevi. Clin Exp Dermatol . 1998 Mar. 23(2):68-9. . Brazzelli V, Larizza D, Martinetti M, et al. Halo nevus, rather than vitiligo, is a typical dermatologic finding of turner's

2014 eMedicine.com

11. Halo Nevus (Follow-up)

Happle R. [Grunewald nevus]. Hautarzt . 1994 Dec. 45(12):882-3. . Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol . 1997 Oct. 37(4):620-4. . Patrizi A, Neri I, Sabattini E, Rizzoli L, Misciali C. Unusual inflammatory and hyperkeratotic halo naevus in children. Br J Dermatol . 2005 Feb. 152(2):357-60. . van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol . 2011 Apr (...) . 164(4):743-9. . Zhou H, Wu LC, Chen MK, Liao QM, Mao RX, Han JD. Factors Associated with Development of Vitiligo in Patients with Halo Nevus. Chin Med J (Engl) . 2017 Nov 20. 130 (22):2703-2708. . Fishman HC. Letter: Malignant melanoma arising with two halo nevi. Arch Dermatol . 1976 Mar. 112(3):407-8. . Jacobs JB, Edelstein LM, Snyder LM, Fortier N. Ultrastructural evidence for destruction in the halo nevus. Cancer Res . 1975 Feb. 35(2):352-7. . Herd RM, Hunter JA. Familial halo naevi. Clin Exp

2014 eMedicine.com

12. Halo Nevus (Diagnosis)

. 1997 Oct. 37(4):620-4. . Patrizi A, Neri I, Sabattini E, Rizzoli L, Misciali C. Unusual inflammatory and hyperkeratotic halo naevus in children. Br J Dermatol . 2005 Feb. 152(2):357-60. . van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol . 2011 Apr. 164(4):743-9. . Zhou H, Wu LC, Chen MK, Liao QM, Mao RX, Han JD. Factors Associated with Development of Vitiligo in Patients with Halo Nevus. Chin Med J (Engl (...) ) . 2017 Nov 20. 130 (22):2703-2708. . Fishman HC. Letter: Malignant melanoma arising with two halo nevi. Arch Dermatol . 1976 Mar. 112(3):407-8. . Jacobs JB, Edelstein LM, Snyder LM, Fortier N. Ultrastructural evidence for destruction in the halo nevus. Cancer Res . 1975 Feb. 35(2):352-7. . Herd RM, Hunter JA. Familial halo naevi. Clin Exp Dermatol . 1998 Mar. 23(2):68-9. . Brazzelli V, Larizza D, Martinetti M, et al. Halo nevus, rather than vitiligo, is a typical dermatologic finding of turner's

2014 eMedicine.com

13. Association of halo nevus/i and vitiligo in childhood: a retrospective observational study. (Abstract)

Association of halo nevus/i and vitiligo in childhood: a retrospective observational study. Although halo nevus (HN) is frequently observed, the relationship between vitiligo and HN in children has rarely been investigated.To investigate the association between HN and vitiligo in children and understand if HN/HNi might be a risk factor for vitiligo.Ninety-eight patients with only HN/HNi and 27 with HN/HNi and vitiligo were investigated for number and localization of HN/HNi, family history

2013 Journal of the European Academy of Dermatology and Venereology

14. Halo Nevus

Halo Nevus Halo Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Halo Nevus Halo Nevus Aka: Halo Nevus , Halo Nevi II (...) . Pathophysiology or Halo region is depigmented, without s mediated depigmentation III. Epidemiology Onset in teen years : 1% IV. Signs White, symmetric round halo surrounding a nevus Distribution Trunk is most typical Always spares the palms and soles V. Associated Conditions risk may be increased VI. Course Repigmentation may occur spontaneously over years VII. Prognosis Rare malignant transformation (typically predictable by atypical features) VIII. Reference Habif (2003) Clinical Dermatology, 4th ed.. Mosby

2015 FP Notebook

15. Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis. (Abstract)

Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis.   In analogy with melanoma-associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo.  The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo-like lesions develop directly linked to the halo phenomenon.  Forty-one patients (...) with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions.  We identified a subset of five halo naevi patients with additional subtle depigmentations. After the occurrence of multiple halo naevi, they developed leucoderma that showed a different disease pattern than vitiligo (variable asymmetric distribution, limited extent and lack of progression). Moreover, the characteristics of these halo naevi patients with associated leucoderma were

2012 Journal of the European Academy of Dermatology and Venereology

16. Halo naevus--a frustrated malignant maelanoma. Full Text available with Trip Pro

Halo naevus--a frustrated malignant maelanoma. 4552592 1972 06 11 2018 11 13 0007-1447 2 5804 1972 Apr 01 British medical journal Br Med J Halo naevus--a frustrated malignant maelanoma. 47-8 Lewis M G MG Copeman P W PW eng Journal Article England Br Med J 0372673 0007-1447 0 Antibodies AIM IM Adolescent Adult Antibodies Child Cytoplasm immunology Diagnosis, Differential Fluorescent Antibody Technique Humans Male Melanoma diagnosis immunology pathology Nevus, Pigmented diagnosis immunology

1972 British medical journal

17. Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. (Abstract)

than 2 mm, subretinal fluid (F), symptoms (S) of flashes/floaters/blurred vision, orange (O) lipofuscin pigment, margin (M) less than 3 mm from optic disk, ultrasonographic hollowness (UH), halo (H) absence, and drusen (D) absence. The presence of three or more risk factors implies more than 50% chance for transformation to melanoma within 5 years. A new, online ocular oncology reading center can help judge nevus risk.Choroidal nevus is a common intraocular lesion, found predominantly in Whites (...) Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus.Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus

2017 Current Opinion in Ophthalmology

18. Foxp3 Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi. (Abstract)

and CD25.We found significant increases in Foxp3(+) Tregs, and the shorter the halo nevus duration, the more Foxp3(+) Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25(+)Foxp3(+) T cells.Foxp3(+) Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3(+) Tregs were involved in the earlier developmental stages of halo (...) Foxp3 Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi. There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus.To evaluate the clinicopathologic features and the presence of Tregs in halo nevi.We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3

2012 Dermatology

19. Posterior Scleral Bowing With Choroidal Nevus on Enhanced-Depth Imaging Optical Coherence Tomography. Full Text available with Trip Pro

patient age was 58 years (median, 58 years; range, 36-75 years) and there were 6 men (35%) and 11 women (65%). The nevus was classified as pigmented (n = 3; 18%), nonpigmented (n = 2; 12%), and mixed pigmentation (n = 12; 71%), and with no surrounding halo (n = 7; 41%). Associated features included overlying drusen (n = 9; 53%), retinal pigment epithelial alterations (n = 9; 53%), subretinal fluid (n = 5; 29%), and orange pigment (n = 3; 18%). The nevus was clinically estimated to be of 4.91-mm basal (...) ; 95% CI, -2.95 mm to 5.51 mm; P = .01) and the foveola (difference, 2.14 mm; 95% CI, 0.80 mm to 3.48 mm; P < .001), as well as the presence of surrounding halo (difference, 36%; 95% CI, 16.86% to 59.27%; P < .001).Choroidal nevus can show focal posterior scleral bowing on EDI-OCT in 5% of cases. This finding was related to more posterior location of nevus, less/mixed pigmentation, and surrounding halo. This finding could lead to underestimation of tumor thickness as the tumor bows backward rather

2015 JAMA ophthalmology

20. Relevance of congenital melanocytic naevi in vitiligo. (Abstract)

Relevance of congenital melanocytic naevi in vitiligo. Some case reports concerning the concomitant presence of congenital melanocytic naevi (CMN), halo naevi and vitiligo have been published. However, their possible link has never been investigated in a large patient population.To evaluate the relevance of CMN in patients with vitiligo with respect to the presence of halo naevi and some general clinical variables such as age of onset, Koebner phenomenon and body surface area (BSA (...) ) involvement.In total, 1004 patients with vitiligo (nonsegmental) and 291 control patients were included in this observational study. CMN were scored in size, location and halo formation, and classified into clinical convincing or possible lesions.Convincing CMN were present in 3·3% of the patient population and in 1·0% of the control population. The presence of halo naevi was significantly higher (P = 0·01) and age of onset of vitiligo was significantly lower (P < 0·01) in the presence of CMN. Halo formation

2014 British Journal of Dermatology

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