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19561. Ethnic hair update: past and present. (Abstract)

Ethnic hair update: past and present. Hair and scalp disorders in African American patients are challenging because of the lack of pathophysiologic explanations for many of the disorders that occur in this population. To understand the clinical appearance of these disorders and to design an effective treatment plan, the dermatologist must have a clear knowledge of the basic hair-care practices and concerns of this group of patients. Given that patients of African American heritage (...) are not a homogeneous group, this overview describes many of the common hair-care practices of African Americans and how they affect patients' health. The common hair and scalp disorders are discussed, with a specific focus on inflammatory disorders that result in significant pigmentation alteration or scarring.

2003 Journal of American Academy of Dermatology

19562. Adrenomedullin: expression and possible role in human skin and hair growth. (Abstract)

Adrenomedullin: expression and possible role in human skin and hair growth. Adrenomedullin (AM) is a regulatory peptide that is synthesized and secreted by a wide number of cells and tissues. AM is a potent vasodilator, but also exerts other functions, such as regulating cell growth and antimicrobial defence. Two receptors, L1 and calcitonin receptor-like receptor (CRLR), which are able to bind AM, have been cloned and characterized.To investigate expression of AM protein and its receptors (...) in human skin and during different stages of the human hair cycle and, moreover, because of the suggested antimicrobial function of AM in skin, to investigate AM immunoreactivity (IR) in inflammatory acne lesions compared with healthy pilosebaceous follicles.We used immunohistochemistry to determine the distribution of AM and its receptors in human skin and during different stages of the human hair cycle. AM IR in inflammatory acne lesions was investigated to evaluate the antimicrobial function

2003 British Journal of Dermatology

19563. There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. (Abstract)

There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. Low iron stores are considered a possible cause of chronic diffuse telogen hair loss in women. Estimation of serum ferritin is recommended as part of the initial assessment when women present with chronic diffuse telogen hair loss, and iron supplementation therapy is commonly recommended for those found to have low iron stores.To evaluate the relationship between low serum ferritin (hair loss in women.Between 1997 and 1999, 194 consecutive women who presented to a specialist hair clinic were assessed for diffuse telogen hair loss of greater than 6 months duration. All underwent biochemical investigations that included serum ferritin and had two 4-mm punch biopsies taken from the vertex of the scalp. One biopsy was sectioned horizontally and the other vertically.Twelve women were found to have a serum ferritin of 20 micro g L-1 or less (6.2%). Androgenetic

2002 British Journal of Dermatology

19564. Hair relaxers: a benign caustic ingestion? (Abstract)

Hair relaxers: a benign caustic ingestion? Despite federally legislated safety regulations, caustic ingestions remain a significant problem in the pediatric population. The current standard of care for caustic ingestion includes upper gastrointestinal endoscopy in most cases. Hair relaxers are a common caustic ingestion at our institution, yet few data have been published describing the clinical or endoscopic outcome. We explored the relative frequency of hair relaxer ingestion, the incidence (...) of associated upper gastrointestinal injury, and the adverse clinical sequelae resulting from these ingestions.Consecutive caustic ingestions admitted to our institution between January 1990 and January 2001 were identified. The data were collected through retrospective physician chart review, were analyzed, and were pooled with the existing literature to evaluate for the presence of esophageal injury.96 charts were reviewed, 29 (30%) of which were hair relaxer ingestions that underwent

2003 Journal of Pediatric Gastroenterology and Nutrition

19565. Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse. Full Text available with Trip Pro

Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse. Meconium and hair are two biological markers of in utero exposure to illicit drugs.To compare the sensitivity of the two tests for different drugs.Motherisk laboratory which tests in utero drug exposure in Toronto.Cocaine, benzoylecgonine, opiates, cannabis, benzodiazepines, methadone, and barbiturates were measured in pairs of hair and meconium samples from the same neonates.Meconium (...) was marginally more sensitive than neonatal hair for detection of cocaine and cannabis, possibly because it may detect second trimester exposure whereas hair grows only during the third trimester of pregnancy. There was a significant correlation between hair and meconium concentrations of cocaine, cannabis, and opiates.In cases of clinical suspicion and a negative neonatal urine test, both meconium and hair are effective biological markers of in utero illicit drug exposure. Meconium may be more sensitive

2003 Archives of Disease in Childhood. Fetal and Neonatal Edition

19566. Toe tourniquet syndrome in association with maternal hair loss. (Abstract)

Toe tourniquet syndrome in association with maternal hair loss. Increased hair loss a few months after delivering an infant is a common postpartum condition known as telogen effluvium. A much less common condition involving young infants is the hair-thread tourniquet syndrome, or toe tourniquet syndrome, which involves hair or thread becoming so tightly wrapped around an appendage that pain, injury, and sometimes loss of the appendage result. This case report is the first known description (...) of the hair-thread tourniquet syndrome in association with maternal telogen effluvium. A literature review shows that accidental cases involving human hair almost always involve the toes, and usually occur at the age when mothers are experiencing excessive hair loss. This association is significant in that anticipatory guidance of new parents experiencing rapid hair loss may prevent cases of the toe tourniquet syndrome and its associated morbidity.

2003 Pediatrics

19567. Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas. (Abstract)

Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas. The hair cells are the most vulnerable elements in the cochlea, and damage to them is the most common cause of sensorineural hearing loss. Understanding the intracellular events that lead to the death of hair cells is a key to developing protective strategies. The Fas death receptor-mediated apoptotic pathway is well studied and plays an important role in the elimination of damaged cells in a number of different (...) cellular systems. We have studied the role of the Fas receptor in aminoglycoside-mediated toxicity in vitro. We employed the MRL/MpJ-Fas mouse, which does not express a functional Fas receptor.Response of Fas-deficient hair cells to gentamicin was compared with the response of normal hair cells in vitro.Basal turn organ of Corti explants from p3-5 mice were maintained in tissue culture and treated with gentamicin for 72 hours. The explants were fixed and were stained with phalloidin, and counting

2003 Laryngoscope

19568. Unbiased stereologic type I and type II hair cell counts in human utricular macula. (Abstract)

Unbiased stereologic type I and type II hair cell counts in human utricular macula. The objective of the study was to obtain unbiased estimates of the total number of type I and type II hair cells in human utricular macula from individuals with documented normal vestibular function.Application of unbiased stereology using microdissected human temporal bone specimens was conducted in an observational study.Postmortem temporal bones were obtained from 10 normal patients (age range, 42-96 y; mean (...) age, 82 y). The utricular maculae were microdissected, embedded in plastic, and cut into serial 2-microm sections. Unbiased estimates of the total number of type I and type II hair cells were obtained using the physical fractionator technique of stereology.The average total number of hair cells was 27,508 (CV = 11%) consisting of 17,326 (coefficient of variation [CV] = 11%) type I hair cells and 10,182 (CV = 13%) type II hair cells. The ratio of type I to type II hair cells was 1.70:1. In the age

2003 Laryngoscope

19569. Evidence for surviving outer hair cell function in congenitally deaf ears. (Abstract)

Evidence for surviving outer hair cell function in congenitally deaf ears. The hypotheses of the study were that congenital hearing impairment in infants can result from the isolated loss of inner hair cells of the cochlea and that this is shown by the presence of abnormal positive summating potentials on round window electrocochleography. The objectives were to establish the proportion of infants with hearing loss affected, the nature of the cochlear lesion, and its etiology. And to highlight (...) loss.Both otoacoustic emissions and abnormal positive potentials may originate from outer hair cell activity following inner hair cell loss. This may occur in more than 40% of hearing-impaired children in the neonatal intensive care unit setting. Chronic hypoxia is the most likely cause. Otoacoustic emissions testing may not be a suitable screening tool for such infants.

2003 Laryngoscope

19570. Effects of nitric oxide on morphology of isolated cochlear outer hair cells: possible involvement in sensorineural hearing loss. (Abstract)

Effects of nitric oxide on morphology of isolated cochlear outer hair cells: possible involvement in sensorineural hearing loss. One of the inflammatory mediators of otitis media, nitric oxide, can damage cochlear outer hair cells.Free radicals, including nitric oxide, have been detected in middle ear effusion. Increasing evidence implicates free radicals in the pathogenesis of otitis media and possibly in the development of sensorineural hearing loss.Isolated outer hair cells from adult (...) of 305 +/- 5 mOsm at room temperature, and with exposure time up to 90 minutes. The cells were observed using an inverted microscope, and the images were recorded and analyzed on the IMAGE Pro-Plus program.Outer hair cells exposed to either standard bathing solution or sodium nitrite (Control Groups 1 and 2) showed no significant change in cell shape or length. Cells exposed to S-nitroso-N-acetyl and l-penicillamine or 3-morpholinosynonimine exhibited ballooning and significant shortening in mean

2003 Otology and Neurotology

19571. The Effect of Laser Hair Removal on Permanent Hair Reduction

The Effect of Laser Hair Removal on Permanent Hair Reduction The Effect of Laser Hair Removal on Permanent Hair Reduction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Laser Hair Removal (...) on Permanent Hair Reduction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00279643 Recruitment Status : Completed First Posted : January 19, 2006 Last Update Posted : April 30, 2015 Sponsor: University of Michigan Information provided by (Responsible Party): Jeffrey S. Orringer, University of Michigan

2006 Clinical Trials

19572. Evaluation of the LightSheer HS Hand Piece as Compared to the LightSheer ET Hand Piece for the Intended Use of Hair Removal and Permanent Hair Reduction

Evaluation of the LightSheer HS Hand Piece as Compared to the LightSheer ET Hand Piece for the Intended Use of Hair Removal and Permanent Hair Reduction Evaluation of the LightSheer HS Hand Piece as Compared to the LightSheer ET Hand Piece for the Intended Use of Hair Removal and Permanent Hair Reduction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of the LightSheer HS Hand Piece as Compared to the LightSheer ET Hand Piece for the Intended Use of Hair Removal and Permanent Hair Reduction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read

2008 Clinical Trials

19573. Evaluation of Scalp and Hair Shaft With Biologic Markers in African American and Caucasian Hair

Evaluation of Scalp and Hair Shaft With Biologic Markers in African American and Caucasian Hair Evaluation of Scalp and Hair Shaft With Biologic Markers in African American and Caucasian Hair - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Evaluation of Scalp and Hair Shaft With Biologic Markers in African American and Caucasian Hair The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00690664 Recruitment Status : Completed First Posted : June 5, 2008 Last Update Posted : July 6, 2018 Sponsor: Wake Forest

2008 Clinical Trials

19574. The Impact of African American Women's Hair Care Practices and Hair Attitudes on Exercise Habits

The Impact of African American Women's Hair Care Practices and Hair Attitudes on Exercise Habits The Impact of African American Women's Hair Care Practices and Hair Attitudes on Exercise Habits - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. The Impact of African American Women's Hair Care Practices and Hair Attitudes on Exercise Habits The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00691782 Recruitment Status : Completed First Posted : June 5, 2008 Last Update Posted : July 6, 2018 Sponsor: Wake Forest

2008 Clinical Trials

19575. Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs Full Text available with Trip Pro

Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs The inner root sheath (IRS) allows the exit of hairs through the epidermal surface. The fine structure of monotreme and marsupial IRS and trichohyalin is not known. Using electron microscopy and immunocytochemistry, the localization of trichohyalin and transglutaminase have been studied in monotreme and marsupial hairs, and compared with trichohyalin localization (...) in placental hairs. Trichohyalin in all mammalian species studied here is recognized by a polyclonal antibody against sheep trichohyalin. This generalized immunoreactivity suggests that common epitopes are present in trichohyalin across mammals. In differentiating IRS cells, trichohyalin granules of variable dimensions are composed of an immunolabelled amorphous matrix associated with a network of 10-12-nm-thick keratin filaments. Transglutaminase labelling is present among keratin bundles and trichohyalin

2004 Journal of anatomy

19576. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression Full Text available with Trip Pro

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse transcriptase-polymerase chain reaction and immunohistology that, contrary to a previous report, human skin and normal human (...) scalp hair follicles (HFs), in particular, express both PRL and PRL receptors (PRL-R) at the mRNA and protein level. PRL and PRL-R immunoreactivity can be detected in the epithelium of human anagen VI HFs, while the HF mesenchyme is negative. During the HF transformation from growth (anagen) to apoptosis-driven regression (catagen), PRL and PRL-R immunoreactivity appear up-regulated. Treatment of organ-cultured human scalp HFs with high-dose PRL (400 ng/ml) results in a significant inhibition

2006 The American journal of pathology

19577. Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides Full Text available with Trip Pro

Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides The aim of this study was to determine optimum biomarkers to detect fetal exposure to environmental pesticides by the simultaneous analysis of maternal (hair and blood) and infant (cord blood, infant hair or meconium) matrices and to determine if a combination of these biomarkers will further increase the detection (...) rate.Pregnant women were prospectively recruited from an agricultural site in the Philippines with substantial use at home and in the farm of the following pesticides: propoxur, cyfluthrin, chlorpyrifos, cypermethrin, pretilachlor, bioallethrin, malathion, diazinon and transfluthrin. Maternal hair and blood were obtained at midgestation and at delivery and infant hair, cord blood and meconium were obtained after birth. All samples were analyzed by gas chromatography/mass spectrometry (GC/MS) for the above

2008 Environmental Research

19578. A randomized, controlled, double-blind study evaluating melanin-encapsulated liposomes as a chromophore for laser hair removal of blond, white, and gray hair. Full Text available with Trip Pro

A randomized, controlled, double-blind study evaluating melanin-encapsulated liposomes as a chromophore for laser hair removal of blond, white, and gray hair. Laser hair removal of blond and white hair is a complicated task with often unsatisfactory results as a result of a lack of laser-absorbing chromophore. In the present study, we investigated if repetitive external application of liposomal melanin (Lipoxome; Dalton Medicare B.V., Zevenbergschen Hoek, The Netherlands) enables removal (...) of blond/white and gray hair with a diode laser.Forty-two areas of blond, gray, or white facial and body hair of 16 patients were treated with a liposomal melanin spray (Lipoxome) and 3 cycles of 800 nm diode laser at intervals of 8 weeks (28-40 J/cm). A control group of 16 patients applied physiological saline spray before diode laser treatment. Hair regrowth was measured 8 weeks after each cycle and additionally 6 months after the last treatment by counting the number of terminal hairs compared

2007 Annals of plastic surgery Controlled trial quality: uncertain

19579. Oestrogen receptor antagonist and hair regrowth in dogs with hair cycle arrest (alopecia X). (Abstract)

Oestrogen receptor antagonist and hair regrowth in dogs with hair cycle arrest (alopecia X). An oestrogen receptor pathway that regulates the telogen-anagen hair follicle transition in mice has been described. The purpose of this study was to investigate whether fulvestrant, a pure oestrogen receptor antagonist, would cause hair regrowth in Pomeranian dogs with hair cycle arrest (alopecia X). Eleven Pomeranian dogs with hair cycle arrest were randomly assigned to receive two intramuscular (...) injections of either 10 mg kg(-1) fulvestrant (n = 6) or an equal volume of saline (n = 5) 1 month apart. Complete blood count, chemistry panel, and urinalysis were monitored prior to the first injection and monthly for 2 months. Dogs were evaluated each month for degree of hair growth, percentage of body affected, and quality of new hair growth. Three control dogs received fulvestrant after the completion of the study. In addition, one control dog and one treatment dog received two subcutaneous

2007 Veterinary dermatology Controlled trial quality: uncertain

19580. The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles. (Abstract)

The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles. The mechanisms involved in laser-mediated hair removal remain unclear. One means of reducing hair growth is alteration of follicular stem cells.We sought to examine the effects of laser hair removal on the immunohistochemical staining properties of human hair follicles, including the putative stem cells of the bulge region.Treatment of unwanted axillary hair was performed on one side using (...) specific laser parameters.Laser-mediated hair removal does not appear to work by frank destruction of follicular stem cells. Other mechanisms including functional alteration of these cells may underlie the clinical efficacy of the procedure.

2006 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

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