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19561. Unknown syndrome: mental retardation with postaxial polydactyly, congenital absence of hair, severe seborrhoeic dermatitis, and Perthes' disease of the hip. (PubMed)

Unknown syndrome: mental retardation with postaxial polydactyly, congenital absence of hair, severe seborrhoeic dermatitis, and Perthes' disease of the hip. We report a six year old male with mental retardation, postaxial polydactyly and syndactyly, atrichia congenita totalis, severe seborrhoeic dermatitis, recurrent staphylococcal skin sepsis, and Perthes' disease of the hip. His birth may have resulted from an incestuous mating.

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1988 Journal of Medical Genetics

19562. Hair dye use and risk of leukemia and lymphoma. (PubMed)

Hair dye use and risk of leukemia and lymphoma. Data from a population-based case-control study of incident leukemia and non-Hodgkin's lymphoma among adult men in Iowa and Minnesota were used to evaluate risk associated with hair dye use. The relative risk for ever using hair dyes was 1.8 (95% confidence interval [CI] = 1.1-2.7) among leukemia patients, and 2.0 (CI = 1.3-3.0) among cases with non-Hodgkin's lymphoma. There was a suggestion of increased risk with extent of hair dye use. Given (...) the widespread use of hair coloring products, these observations deserve more detailed evaluation in populations where the exposure is relatively common.

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1988 American Journal of Public Health

19563. Treating young men with hair loss. (PubMed)

Treating young men with hair loss. 2497819 1989 06 29 2018 11 13 0959-8138 298 6677 1989 Apr 01 BMJ (Clinical research ed.) BMJ Treating young men with hair loss. 847-8 Shrank A B AB eng Editorial England BMJ 8900488 0959-8138 AIM IM Adult Alopecia psychology therapy Hair transplantation Humans Male 1989 4 1 1989 4 1 0 1 1989 4 1 0 0 ppublish 2497819 PMC1836128 J Am Acad Dermatol. 1987 Jul;17(1):97-101 3301926 JAMA. 1979 Jun 22;241(25):2687-9 448805

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1989 BMJ : British Medical Journal

19564. A double-blind comparison of levels of terbinafine and itraconazole in plasma, skin, sebum, hair and nails during and after oral medication. (PubMed)

A double-blind comparison of levels of terbinafine and itraconazole in plasma, skin, sebum, hair and nails during and after oral medication. 9059688 1997 05 23 2019 02 01 0001-5555 77 1 1997 Jan Acta dermato-venereologica Acta Derm. Venereol. A double-blind comparison of levels of terbinafine and itraconazole in plasma, skin, sebum, hair and nails during and after oral medication. 74-6 Faergemann J J Zehender H H Boukhabza A A Smith S G SG Jones T C TC eng Clinical Trial Comparative Study (...) Letter Randomized Controlled Trial Sweden Acta Derm Venereol 0370310 0001-5555 0 Antifungal Agents 0 Naphthalenes 304NUG5GF4 Itraconazole G7RIW8S0XP Terbinafine IM Administration, Oral Adult Antifungal Agents administration & dosage analysis blood Double-Blind Method Hair chemistry Humans Itraconazole administration & dosage analysis blood Male Middle Aged Nails chemistry Naphthalenes administration & dosage analysis blood Sebum chemistry Skin chemistry Terbinafine 1997 1 1 1997 1 1 0 1 1997 1 1 0 0

1997 Acta Dermato-Venereologica Controlled trial quality: uncertain

19565. Long-term treatment of trichotillomania (hair pulling) (PubMed)

Long-term treatment of trichotillomania (hair pulling) 8510704 1993 07 15 2013 11 21 0028-4793 329 2 1993 Jul 08 The New England journal of medicine N. Engl. J. Med. Long-term treatment of trichotillomania (hair pulling) 141-2 Swedo S E SE Lenane M C MC Leonard H L HL eng Clinical Trial Letter Randomized Controlled Trial United States N Engl J Med 0255562 0028-4793 NUV44L116D Clomipramine AIM IM Behavior Therapy Clomipramine therapeutic use Combined Modality Therapy Double-Blind Method Follow

1993 The New England journal of medicine Controlled trial quality: uncertain

19566. [It is difficult to predict the effect of minoxidil liniment on hair loss in men]. (PubMed)

[It is difficult to predict the effect of minoxidil liniment on hair loss in men]. 2405223 1990 02 27 2013 11 21 0023-7205 87 1-2 1990 Jan 10 Lakartidningen Lakartidningen [It is difficult to predict the effect of minoxidil liniment on hair loss in men]. 16-7 Anderson C C Klinisk lärare, regionsjukhuset, Linköping. Berne B B Juhlin L L Skogh M M Strand A A Vahlquist A A swe Clinical Trial Journal Article Randomized Controlled Trial Svårt att förutsäga effekten av minoxidilliniment mot manligt

1990 Lakartidningen Controlled trial quality: uncertain

19567. Hair loss associated with lamivudine. (PubMed)

Hair loss associated with lamivudine. 7996976 1995 01 19 2017 09 20 0140-6736 344 8938 1994 Dec 17 Lancet (London, England) Lancet Hair loss associated with lamivudine. 1702 Fong I W IW eng Clinical Trial Letter Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Antiviral Agents 2T8Q726O95 Lamivudine 6L3XT8CB3I Zalcitabine AIM IM X Acquired Immunodeficiency Syndrome drug therapy Adult Alopecia chemically induced Antiviral Agents adverse effects Female Humans Lamivudine Male Middle

1995 Lancet (London, England) Controlled trial quality: uncertain

19568. Preoperative hair removal: a random prospective study of shaving versus clipping. (PubMed)

Preoperative hair removal: a random prospective study of shaving versus clipping. We report the results of a random, prospective study of electrical clipping versus routine razor shaving in the removal of hair immediately before operation. Two hundred patients having elective inguinal herniorrhaphy according to strict protocol were included in this study. Unsatisfactory skin preparation, as evidenced by gross cuts made in the skin during hair removal, was noted in 7% of those shaved and 4 (...) % of those clipped. Two subcutaneous wound infections occurred in the shaved group (2%) and one in the clipped group (1%). This study indicates that preoperative clipping of hair with electric barber's clippers immediately before operation is a safe, well tolerated procedure that does not increase the risk of postoperative wound infection.

1982 Southern medical journal Controlled trial quality: uncertain

19569. The influence of hair-removal methods on wound infections. (PubMed)

The influence of hair-removal methods on wound infections. The influence of preoperative shaving v clipping on wound infection rate was studied in 1,013 patients undergoing elective operations at a single hospital. Patients were prospectively randomized to be either shaved or clipped the night before or the morning of operation. The AM clipper method was associated with significantly fewer infections than were the other methods, both at discharge and at 30-day follow-up. The greatest benefit (...) was in the group with clean wounds. For each 1,000 patients treated, a savings of approximately $270,000 could be realized if the AM clipper method replaced shaving for preoperative hair removal. Preoperative shaving is deleterious, and the practice should be abandoned.

1983 Archives of Surgery Controlled trial quality: uncertain

19570. Zinc supplementation during pregnancy: zinc concentration of serum and hair from low-income women of Mexican descent. (PubMed)

Zinc supplementation during pregnancy: zinc concentration of serum and hair from low-income women of Mexican descent. The effect of zinc supplementation on concentrations of zinc in hair and serum of 213 pregnant Hispanic women attending a clinic in Los Angeles was assessed using a random, double-blind experiment. Both the treatment (T) and control (C) groups received similar vitamin and mineral supplements except that 20 mg zinc was added to the supplements for the treatment group. Nutrient (...) intakes were calculated from 24-h recalls. The initial mean dietary zinc intake of both groups was about 50% of the Recommended Dietary Allowance (9 +/- 5 mg). Initially there were no significant differences between the two groups in mean zinc levels in serum (66 +/- 11 micrograms/dl, C, and 65 +/- 12 micrograms/dl, T) or in hair (184 +/- 41 micrograms/g, C, and 175 +/- 38 micrograms/g, T). Zinc supplementation did not alter mean zinc levels in serum or hair but significantly (p less than 0.05

1983 The American journal of clinical nutrition Controlled trial quality: uncertain

19571. The effects of vitamin C supplementation on blood and hair levels of cadmium, lead, and mercury. (PubMed)

The effects of vitamin C supplementation on blood and hair levels of cadmium, lead, and mercury. Fifty-two adult male subjects were randomly assigned to one of three possible treatment groups: supplemental ascorbic acid at one of two levels, 500 mg or 1000 mg, or a placebo. Hair and blood samples were taken before vitamin C or placebo supplementation was started and at monthly intervals thereafter for three months. Samples were analyzed for cadmium, lead, and mercury. Results indicate (...) that vitamin C did not significantly affect levels of these metals in either hair or blood samples.

1987 Annals of the New York Academy of Sciences Controlled trial quality: uncertain

19572. Effect of ultraviolet light on topical minoxidil-induced hair growth in advanced male pattern baldness. (PubMed)

Effect of ultraviolet light on topical minoxidil-induced hair growth in advanced male pattern baldness. Nine healthy men with type IVa or Va male pattern baldness completed a 4-month single-blinded controlled pilot study designed to assess the effect of ultraviolet light (UVL) on topical minoxidil-induced hair growth. Subjects applied 2% topical minoxidil solution twice daily to their balding scalps and to one target area on the upper arm. These men, all of whom had either skin type II or III (...) , were randomized to also receive either incremental doses of UVB or PUVA (topical psoralen) twice weekly to one side of their scalp and to a 2.5 cm target area on the nonminoxidil-treated upper ipsilateral arm. Vellus, nonvellus, and total hair counts were done in two 1-inch in diameter circular target areas in symmetric regions of the scalp and on each upper arm at regular intervals. All nine subjects had an increase in target nonvellus hair and a net loss of vellus hair in scalp target area

1987 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

19573. Lack of effect of spironolactone on hair shaft diameter in hirsute females. (PubMed)

Lack of effect of spironolactone on hair shaft diameter in hirsute females. Because of its anti-androgenic activity spironolactone 50-200 mg daily is advocated widely for the management of female hirsutism but this practice lacks adequately controlled experimental support. In a double-blind placebo controlled study of the efficacy of spironolactone 100 mg daily in idiopathic hirsutism we were unable to demonstrate objective benefit from spironolactone treatment. The mean effect (...) of spironolactone given over a 9 month period was to increase hair shaft diameter by +15% with 95% CI (-0.4% to +29%). In addition there were no changes in circulating serum androgen concentrations.

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1989 Postgraduate medical journal Controlled trial quality: uncertain

19574. [1% econazole hair-shampoo in the treatment of pityriasis capitis; a comparative study versus zinc-pyrithione shampoo]. (PubMed)

[1% econazole hair-shampoo in the treatment of pityriasis capitis; a comparative study versus zinc-pyrithione shampoo]. On the basis of the assumption that Pityrosporum ovale is an important pathogenic factor in the aetiology of Pityriasis simplex capitis (dandruff), the Authors intended to evaluate the efficacy and tolerability of econazole (1% hair-shampoo) in the treatment of this scalp disease. Dandruff could be considered a problem more from a cosmetic than from a medical point of view (...) ; for this reason a conventional anti-dandruff hair-shampoo containing zinc-pyrithione was selected as a control. In this open controlled study, seventy patients suffering from different forms of Pityriasis simplex capitis were enrolled at the 1th Dermatological Institute, University of Milan, and randomly assigned to the econazole and zinc-pyrithione treatment groups, respectively. At the end of the four-weeks treatment (two applications/week) a marked decrease in signs (scaling, seborrhea, erythema

1990 Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia Controlled trial quality: uncertain

19575. Nuclear aberrations in hair follicle cells of patients receiving cyclophosphamide. A possible in vivo assay for human exposure to genotoxic agents. (PubMed)

Nuclear aberrations in hair follicle cells of patients receiving cyclophosphamide. A possible in vivo assay for human exposure to genotoxic agents. The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay. Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral placebo treatment. The percent (...) of cells with nuclear aberrations (indicating apoptosis, a special form of cell death) and the percent of mitotic cells, in the hair matrix, were calculated for each patient before treatment and at several time points following cyclophosphamide or placebo treatment. The mean percentages of nuclear aberrations in both the treated Low dose and High dose cyclophosphamide patients were significantly higher than those for the pre-treatment and Placebo patients. The nuclear aberrations in hair follicle cells

1990 Archives of toxicology Controlled trial quality: uncertain

19576. The biological effects of a pulsed electrostatic field with specific reference to hair. Electrotrichogenesis. (PubMed)

The biological effects of a pulsed electrostatic field with specific reference to hair. Electrotrichogenesis. This comparative, controlled study demonstrates the positive biologic effect on hair regrowth of a pulsed electrical field administered according to a regularized treatment schedule over 36 weeks. Mean hair count comparisons within the groups significantly favor the treatment group, which exhibited a 66.1% hair count increase over baseline. The control group increase over baseline (...) was 25.6%. It is notable also that 29 of the 30 treatment subjects (96.7%) exhibited regrowth or no further hair loss. The process is without side effects and untoward reactions. The rationale of this phenomenon is unclear but is considered to be due to an electrophysiologic effect on the quiescent hair follicle, similar to that documented with respect to bone fracture and soft tissue repair enhancement. The electrical pulse may cause increased cell mitosis through calcium influx, involving both

1990 International journal of dermatology Controlled trial quality: uncertain

19577. Quantitative estimation of hair growth. I. androgenetic alopecia in women: effect of minoxidil. (PubMed)

Quantitative estimation of hair growth. I. androgenetic alopecia in women: effect of minoxidil. Quantitative growth of hair over a 40-week period is reported for eight women with androgenetic alopecia. Using a random, double-blind protocol, the women were given either a 2% minoxidil solution or a placebo of vehicle only. Hair in a permanently marked site on the fronto-parietal scalp was pulled through a 1-cm-square clear plastic template, and the outline of the template was drawn on the scalp (...) . The hair was carefully hand clipped and collected at five eight-week intervals (one untreated and four treated), using great care to collect only hairs within the marked area. Subsequent measurements included the total weight of hair grown in the marked area, the total number of hairs, and, on a randomized 50-hair subsample, the weight, lengths, and optical diameters. Calculated quantities included average weight per hair, average length, and average optical width. The average total hair weight

1990 The Journal of investigative dermatology Controlled trial quality: uncertain

19578. The effectiveness of the hair-restorer "Dabao" in males with alopecia androgenetica. A clinical experiment. (PubMed)

The effectiveness of the hair-restorer "Dabao" in males with alopecia androgenetica. A clinical experiment. In a randomized, double-blind trial the effectiveness of 6 months' use of a Chinese herb extract (Dabao) as a hair-restorer was studied on 396 males with alopecia androgenetica. The effect was evaluated by nonvellus hair counts, participants' opinions and a panel's judgement of a photo-report. Twenty-three participants withdrew prematurely from the study. In both the Dabao and placebo (...) groups an increase in the amount of hair was observed; 133 and 109 hairs on a 5 cm2 marked area, a difference of 24 hairs (p = 0.03, one-sided). Participants as well as the panel reached a similar conclusion. Regarding cosmetic effect, 42% of the participants in the Dabao group and 37% in the placebo group reported positive results. The average panel score for the cosmetic result on a scale of -10 to +10 was 0.46 in the Dabao and 0.21 in the placebo group, a difference of 0.24 (p = 0.04, one-sided

1991 Journal of Clinical Epidemiology Controlled trial quality: uncertain

19579. Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. (PubMed)

Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism. Ten hirsute women with polycystic ovarian syndrome (PCO) and nine with idiopathic hirsutism (IH) underwent selective ovarian suppression with leuprolide for 5-6 months and then were randomized to receive, in addition, dexamethasone or placebo for 4 more months. Serum hormone levels and hair growth rates were determined (...) similar after ovarian suppression in the two groups. After ovarian suppression, Adiol-G was more consistently correlated with testosterone and androstenedione than was DHEAS, suggesting that Adiol-G may be a better marker than DHEAS of adrenal androgen secretion. Hair growth rates decreased by 37 +/- 6% in PCO and by 14 +/- 10% in IH (P = 0.07). The change in hair growth correlated with the change in androstenedione (r = 0.66; P = 0.002), but not significantly with the change in testosterone (r = 0.29

1990 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

19580. [The efficacy of drug therapy in structural lesions of the hair and in diffuse effluvium--comparative double blind study]. (PubMed)

[The efficacy of drug therapy in structural lesions of the hair and in diffuse effluvium--comparative double blind study]. Growth and quality of hair was studied after treatment with Pantogar, another prescription (Verum-2) and placebo for four months in 60 patients with diffuse effluvium capillorum and agnogenic structural alternations of hair. Efficacy was assessed by measurements of swelling, dye-binding and thickness for hair-quality and evaluation of hair-density and trichograms for hair (...) -growth. Statistical analysis of swelling properties and trichogram data indicated that Pantogar was effective, the second preparation improved quality of hair and retarded hair loss. Placebo was ineffective judged by the used parameters. Tolerance of the treatment was good and adverse effects could not be substantiated.

1990 Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis Controlled trial quality: uncertain

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