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161. Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions. (PubMed)

Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions. The biomechanical properties of the collagenous dermal matrix are well described but responses to mechanical force by the hair follicles have not been characterised so far. We applied a pulling force on hair follicles to visualise and quantify changes in the keratin-14 and involucrin positive cell layers of the follicles using nuclear

2019 Experimental Dermatology

162. Hair growth control by innate immunocytes: Perifollicular macrophages revisited. (PubMed)

Hair growth control by innate immunocytes: Perifollicular macrophages revisited. The role of innate immunocytes such as mast cells, γδ T cells, NK cells and macrophages (MACs) in hair growth control under physiological and pathological conditions has recently begun to be re-explored. Here, we revisit the role of resident perifollicular macrophages (pfMACs) located in the hair follicle (HF) mesenchyme (CTS). Substantial, stringently timed fluctuations in the number and localization of pfMACs (...) were first observed long ago during murine HF morphogenesis and cycling. This already suggested some involvement of these innate immunocytes, with a recognized role in tissue remodelling and in hair growth control. The relatively recent demonstration of a Wnt signalling-driven crosstalk between these immunocytes and HF epithelial stem cells in telogen HFs, which promotes anagen induction, has reinvigorated interest in the role that pfMAC plays in hair biology. Besides the apoptosis-associated

2019 Experimental Dermatology

163. The role of the microbiome in scalp hair follicle biology and disease. (PubMed)

The role of the microbiome in scalp hair follicle biology and disease. The skin surface microbiome and its role in skin diseases have received increasing attention over the past years. Beyond, there is evidence for a continuous exchange with the cutaneous immune system in healthy skin, where hair follicles provide unique anatomical niches. Especially scalp hair follicles form large tubular invaginations, which extend deeply into the skin and harbor a variety of microorganisms. The distinct (...) immunology of hair follicles with enhanced immune cell trafficking in superficial compartments in juxtaposition to immune-privileged sites crucial for hair follicle cycling and regeneration, makes this organ a highly susceptible structure. Depending on composition and penetration depth, microbiota may cause typical infections, but may also contribute to pro-inflammatory environment in chronic inflammatory scalp diseases. Involvement in hair cycle regulation and immune cell maturation has been postulated

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2019 Experimental Dermatology

164. Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway. (PubMed)

Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway. Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, creating a need for new treatments to control hair loss and prevent balding. Treatments based on plant-derived compounds could potentially prevent hair loss. Human hair follicle dermal papilla (HDP) cells, a type of specialized (...) fibroblast in the hair bulb, play an essential role in controlling hair growth and in conditions such as androgenic alopecia. We examined the effect of Bacillus/Trapa japonica fruit ferment filtrate extracts (TJFs) on HDP cells to determine whether activation of the Akt/ERK/GSK-3β signaling pathway improved HDP cell proliferation.We prepared TJFs using various methods. The extract properties were analyzed using WST-1, Lowry, and cell migration assays as well as immunofluorescence staining. We also

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2019 BMC Complementary and Alternative Medicine

165. "To Shave or Not to Shave": Pubic Hair Removal and Its Association with Relational and Sexual Satisfaction in Women and Men. (PubMed)

"To Shave or Not to Shave": Pubic Hair Removal and Its Association with Relational and Sexual Satisfaction in Women and Men. Pubic hair removal (PHR) is a widespread practice that entails certain health risks; however, there remains a lack of scientific information on the prevalence and antecedents of PHR, as well as on its association with sexual behavior and relational satisfaction.To explore women's and men's attitudes regarding PHR and their PHR practices and the associations (...) ), PHR items (ie, reasons, inclination to have or not have sex after PHR, perceived partner preferences, partner's PHR), and relationship satisfaction, assessed with the Maudsley Marital Questionnaire.Fewer men (39.1%) than women (80.3%) reported (partially) removing their pubic hair. In both men and women, the practice was associated with age, sexual activity, relationship status, and partner's PHR practice and expectations. In men, sexual and relationship satisfaction were correlated

2019 Journal Of Sexual Medicine

166. Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia. (PubMed)

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia. 5α-DHT can decrease the cell viability of the hair follicle stem cells (HFSCs) with CD34-positive and CD200-rich in bald scalp area of androgenic alopecia (AGA) patients and the apoptosis of HFSCs may be involved in the pathogenesis of AGA. The expression of Vascular (...) endothelial growth factor (VEGF) turns to be weakened or disappeared in hair follicles of AGA patients.To investigate whether VEGF is involved in the apoptosis of HFSCs induced by 5α-DHT in the patients of AGA.By 5α-DHT, apoptosis of CD200-rich and CD34-positive HFSCs was induced and apoptotic rates up to 24 hours were assessed using flow cytometry. The expression grades of Bcl-2, Akt, caspase-3 and Bax were observed through Western blot analysis.Vascular endothelial growth factor could cut 5α-DHT induced

2019 Dermatologic Surgery

167. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium. (PubMed)

Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium. An adipose-derived stem cell-conditioned medium (ADSC-CM) reportedly exerts skin-rejuvenating and hair growth-promoting effects. In the therapeutic application of ADSC-CM for alopecia, changes to the interfollicular scalp remain unclear although some evidence has indicated hair growth-promoting effects.To evaluate the effects of ADSC-CM not only on hair follicles, but also (...) on the interfollicular scalp.Forty patients (21 men, 19 women; age range, 23-74 years) with alopecia were treated by intradermal injection of ADSC-CM every month for 6 months. Eighty fixed sites on patients were investigated by trichograms, physiological examinations, and ultrasonographic examinations at 4 time points (before treatment and 2, 4, and 6 months after the initial treatment).Hair density and anagen hair rate increased significantly. As physiological parameters, transepidermal water loss value gradually

2019 Dermatologic Surgery

168. Hair cortisol concentrations as an indicator of potential HPA axis hyperactivation in risk for psychosis. (PubMed)

Hair cortisol concentrations as an indicator of potential HPA axis hyperactivation in risk for psychosis. A chronic hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis is assumed to be an important indicator of vulnerability for psychosis. Despite the considerable research on this topic, putative social origins of HPA axis hyperactivation have received little attention in the literature so far. Also, the inconsistency of previous findings calls for new and reliable methods (...) in the assessment of HPA axis activation. To address these issues, we used hair cortisol concentrations as an indicator of chronic HPA axis activation in participants at elevated risk for psychosis (clinical risk: n = 43, familial risk: n = 32) and low-risk controls (n = 35), and assessed its relation with a variety of social stressors. We also tested the interaction effect between social stressors and familial risk status on hair cortisol concentrations (moderation analysis). Participants at elevated risk

2019 Schizophrenia Research

169. Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 μm (PM 2.5) exposure using zebrafish (Danio rerio) models. (PubMed)

Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 μm (PM 2.5) exposure using zebrafish (Danio rerio) models. Particulate matter (PM) exposure has become one of the most serious problems. The aim of the present study was to evaluate the hair cell damage and possible developmental toxicity caused by PM2.5 exposure using a zebrafish model.Zebrafish embryos were exposed to various concentrations of PM2.5. Developmental toxicity was evaluated based (...) on general morphology score (GMS) system and Panzica-Kelly score, and by measurement of body length and heart rate. To evaluate hair cell damage, the average number of total hair cells within four neuromasts exposed to various concentrations of PM2.5 was compared with that of the control group.Morphological abnormalities evaluated by the GMS system and Panzica-Kelly score were rare and body length tended to be shorter in the PM2.5-exposed groups. Heart rate decreased significantly in the PM2.5-exposed

2019 International Journal of Pediatric Otorhinolaryngology

170. Electrophysiologic Characteristics of Various Degrees of Selective Outer Hair Cell Loss in Rats. (PubMed)

Electrophysiologic Characteristics of Various Degrees of Selective Outer Hair Cell Loss in Rats. The characteristics of auditory brainstem response (ABR), electrocochleogram (ECochG), and distortion product otoacoustic emissions (DPOAE) of different degrees of selective outer hair cells (OHCs) loss may be helpful for clinicians to evaluate the pathogeny, diagnosis, and rehabilitation of individuals' hearing loss.How many OHCs are necessary to maintain cochlear amplifier function remains unknown

2019 Otology and Neurotology

171. 2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. (PubMed)

2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. 2-deoxy D-glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T-cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata (...) disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell-mediated autoimmune mouse disease, alopecia areata.© 2019 John Wiley & Sons A/S. Published by John

2019 Experimental Dermatology

172. Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease. (PubMed)

Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease. While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss.We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous cGVHD.A prospective cohort of 17 adult hematopoietic cell transplantation (...) (HCT) recipients with cutaneous cGVHD was enrolled. Dermatologic examinations were performed, and punch biopsy specimens of the scalp were obtained. Biopsy specimens were analyzed with hematoxylin-eosin and immunohistochemical stains in all cases and fluorescence in situ hybridization analyses in specific cases.Clinically, 4 patterns of hair loss were described-patchy nonscarring (41.2%), diffuse nonscarring (11.8%), diffuse sclerotic (11.8%), and patchy sclerotic (5.9%). The location

2019 Journal of American Academy of Dermatology

173. Human Basal Cell Carcinoma: The Induction of Anagen Hair Follicle Differentiation. (PubMed)

Human Basal Cell Carcinoma: The Induction of Anagen Hair Follicle Differentiation. Consistent with cancer stem cell driven pattern of growth, human basal cell carcinoma (BCC) demonstrate differentiation along hair follicle (HF) lineages.Define the pattern of differentiation and therapeutic targets that promote BCC differentiation and therefore BCC cancer stem cell exhaustion.The alkaline phosphatase substrate kit (Vectastain, UK) was used to determine dermal papilla cells within the BCC stroma (...) . Autonomous HF cycle dependent gene expression was identified by analysis of the human homologues of a murine hair cycle phases differentially expressed gene set (total 2,289 genes). The findings were validated by qRT-PCR using the QuantStudio 7 Flex Real-Time PCR System (ThermoFisher Scientific) and immunofluorescence, as well as in vitro TGFβ2 stimulation of BCC cancer stem cell colonies.As in the HF, inner root sheath and matrix keratin expression observed in BCC correlated with proliferative index

2019 Clinical & Experimental Dermatology

174. Hair Follicle Differentiation Specific Keratin Expression in Human Basal Cell Carcinoma. (PubMed)

Hair Follicle Differentiation Specific Keratin Expression in Human Basal Cell Carcinoma. Identification of human basal cell carcinoma (BCC) cancer stem cells and cellular hierarchy inherently implies the presence of differentiation. By conventional histological analysis, BCC demonstrates tumour nodules that appear relatively homogenous.As BCC arise from hair follicle (HF) keratinocytes, we sought to define the pattern of HF differentiation.BCC, squamous cell carcinoma (SCC), and normal skin (...) tissues were analysed using a Illumina HumanHT-12 v4 Expression Microarray chip. The expression of individual keratins, regulatory pathways and proliferative states were analysed using RT-PCR and immunofluorescence microscopy.Microarray analysis of BCC, SCC and normal hair bearing skin revealed that BCC express a wide range of HF genes, including HF specific keratins. BCC demonstrated outer (KRT 5, 14, 16, 17 and 19) and inner (KRT25, KRT27, KRT28, KRT32, KRT35, KRT71, KRT75 and KRT85) root sheath

2019 Clinical & Experimental Dermatology

175. Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. (PubMed)

Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. The signals that induce anagen (growth) in 'quiescent' human telogen hair follicles (HFs) are as yet unknown. Their identification promises better targeted therapeutic hair growth interventions.Recognizing the central role of Wnt signalling in hair biology, the aim was to delineate the differential expression of key agonists, antagonists and target genes of this pathway during (...) the telogen-to-anagen transformation of human scalp HFs.This differential expression was studied by in situ hybridization in human telogen and early-anagen scalp HF sections.On anagen induction, gene expression of the Wnt ligands WNT3, WNT4 and WNT10B, the Wnt ligand secretion regulator WLS, and the Wnt target genes AXIN2 and LEF1, is significantly increased within the secondary hair germ and the dermal papilla. Conversely, expression of the secreted Wnt inhibitor SFRP1 (secreted frizzled-related protein

2019 British Journal of Dermatology

176. An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. (PubMed)

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. Given that unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress, new pharmacological treatment strategies by safe and effective hair growth inhibitors that do not destroy the hair follicle (HF) and its stem cells need to be developed.Since human HFs express the multifunctional, immunomodulatory glycoprotein, osteopontin (...) , we hypothesized that osteopontin-derived fragments may modulate human hair growth.This hypothesis was tested ex vivo and in vivo by using a newly generated, toxicologically well-characterized, modified osteopontin-derived peptide (FOL-005), which binds to the HF.In organ-cultured human HFs and scalp skin, and in human scalp xenotransplants onto SCID mice, FOL-005 treatment significantly promoted premature catagen development without reducing the number of keratin 15+ HF stem cells or showing

2019 British Journal of Dermatology

177. Editorial Commentary: Angles, Ratios, and Rotation-Is It Worth Splitting Hairs Over the Critical Shoulder Angle? (PubMed)

Editorial Commentary: Angles, Ratios, and Rotation-Is It Worth Splitting Hairs Over the Critical Shoulder Angle? Various radiographic indices represent lateral acromial extension over the greater tuberosity and are said to be one of the etiologic factors in rotator cuff tears. There has been much debate regarding the accuracy of these parameters based on radiographic rotation and tilt. This commentary discusses the utility of the existing parameters and the "surgical worth" of seeking another

2019 Arthroscopy

178. EMLA-induced methemoglobinemia after laser-assisted hair removal procedure. (PubMed)

EMLA-induced methemoglobinemia after laser-assisted hair removal procedure. This is the case of a 23-year-old female with a past medical history of ADHD and Depression who was evaluated in the emergency department for perioral cyanosis and hypoxia after application of the eutectic mixture of lidocaine and prilocaine (EMLA) local anesthetic prior to a laser-assisted hair removal procedure. This report illustrates a case of methemoglobinemia which is a rare but significant complication of topical

2019 American Journal of Emergency Medicine

179. The role of photobiomodulation when associated with microneedling in female pattern hair loss: A randomized, double blind, parallel group, three arm, clinical study protocol. (PubMed)

The role of photobiomodulation when associated with microneedling in female pattern hair loss: A randomized, double blind, parallel group, three arm, clinical study protocol. The female hair loss pattern was originally described as a synonym for androgenetic alopecia. It has been defined as progressive miniaturizations of the hair follicles, with a great impact on the quality of life of affected patients, causing significant psychosocial limitations. It was recently proven (...) that photobiomodulation is a safe and effective way to treat the different types of hair loss. It was also known that microneedling is a minimally invasive dermatological procedure that is applied to a wide range of dermatological conditions, including androgenic alopecia, telogen effluvium, as well as other facial and bodily conditions.The aim of this study is to verify if there is an increase in the capillary density of strands of hair, when combining 660 nm red laser photobiomodulation and microneedling

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2019 Medicine Controlled trial quality: uncertain

180. A randomized pilot study to compare hair follicle cell suspensions prepared using trypsin alone versus trypsin in combination with collagenase type I for transplantation in vitiligo. (PubMed)

A randomized pilot study to compare hair follicle cell suspensions prepared using trypsin alone versus trypsin in combination with collagenase type I for transplantation in vitiligo. Noncultured extracted hair follicle outer root sheath cell suspension (NC-EHF-ORS-CS) is an upcoming surgical technique to treat stable vitiligo. Conventionally it employs trypsin to tap the hair follicle (HF) reservoir for autologous melanocytes and their precursors for transplantation. However, a perifollicular

2019 Clinical & Experimental Dermatology Controlled trial quality: uncertain

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