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161. Platelet-rich plasma and microneedling improves hair growth in patients ofandrogenetic alopecia when used as an adjuvant to minoxidil. (Abstract)

Platelet-rich plasma and microneedling improves hair growth in patients ofandrogenetic alopecia when used as an adjuvant to minoxidil. Platelet-rich plasma (PRP) is a popular procedure for the treatment of androgenetic alopecia (AGA).To ascertain the role of minoxidil 5% lotion alone versus minoxidil 5% lotion and PRP versus minoxidil 5% lotion, PRP with microneedling in AGA.Ninety-three AGA patients with Hamilton-Norwood score 1-5 were grouped into three groups A, B, and C. Patients in group (...) and experience. Hair pull test was performed before and during follow-up.Post-treatment, hair pull test was negative in 27 patients (87.1%, P < 0.01) of group C, 20 patients (64.5%, P < 0.05) of group B, and 15 patients (48.4%) of group A. Hair growth was better appreciated in group C (26/31) compared to groups B (17/31)and A (10/31).The patients' self-satisfaction score on a Likert scale was more than seven (high satisfaction) in 24/31 patients in group C. There was a statistically significant difference

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

162. Re: Impact of Hair Removal on Surgical Site Infection Rates: A Prospective Randomized Noninferiority Trial. (Abstract)

Re: Impact of Hair Removal on Surgical Site Infection Rates: A Prospective Randomized Noninferiority Trial. 29539908 2019 01 28 2019 01 28 1527-3792 197 5 2017 05 The Journal of urology J. Urol. Re: Impact of Hair Removal on Surgical Site Infection Rates: A Prospective Randomized Noninferiority Trial. 1278 S0022-5347(17)30222-7 10.1016/j.juro.2017.02.018 Wang David S DS eng Journal Article Comment 2017 02 09 United States J Urol 0376374 0022-5347 AIM IM J Am Coll Surg. 2016 Nov;223(5):704-711 (...) 27687471 Hair Removal Humans Preoperative Care Prospective Studies Surgical Wound Infection Time Factors 2018 3 16 6 0 2018 3 16 6 0 2019 1 29 6 0 ppublish 29539908 S0022-5347(17)30222-7 10.1016/j.juro.2017.02.018

2019 The Journal of urology Controlled trial quality: uncertain

163. Re: Impact of Hair Removal on Surgical Site Infection Rates: A Prospective Randomized Noninferiority Trial. (Abstract)

Re: Impact of Hair Removal on Surgical Site Infection Rates: A Prospective Randomized Noninferiority Trial. 28505909 2019 01 29 2019 01 29 1527-3792 197 6 2017 06 The Journal of urology J. Urol. Re: Impact of Hair Removal on Surgical Site Infection Rates: A Prospective Randomized Noninferiority Trial. 1462-1463 S0022-5347(17)39267-4 10.1016/j.juro.2017.03.050 Penson David F DF eng Journal Article Comment 2017 03 15 United States J Urol 0376374 0022-5347 AIM IM J Am Coll Surg. 2016 Nov;223(5 (...) ):704-711 27687471 Hair Removal Humans Preoperative Care Prospective Studies Surgical Wound Infection Time Factors 2017 5 17 6 0 2017 5 17 6 0 2019 1 30 6 0 ppublish 28505909 S0022-5347(17)39267-4 10.1016/j.juro.2017.03.050

2019 The Journal of urology Controlled trial quality: uncertain

164. FEMALE PATTERN HAIR LOSS AND ANDROGEN EXCESS: A REPORT FROM THE MULTIDISCIPLINARY ANDROGEN EXCESS AND PCOS COMMITTEE. (Abstract)

FEMALE PATTERN HAIR LOSS AND ANDROGEN EXCESS: A REPORT FROM THE MULTIDISCIPLINARY ANDROGEN EXCESS AND PCOS COMMITTEE. To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved.An expert task force (...) appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology.Levels of evidence were assessed and graded from A to D.Peer reviewed studies evaluating FPHL published through December 2017 were reviewed. Criteria for inclusion/exclusion of the published papers were agreed upon by at least two reviewers in each area and arbitrated by a third when necessary.1. The term Female Pattern Hair Loss should be used avoiding the previous

2019 Journal of Clinical Endocrinology and Metabolism

165. Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle? Full Text available with Trip Pro

Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle? In murine skin dermal white adipose tissue (DWAT) undergoes fluctuations in size across the hair cycle, whereas changes in size, function and metabolism of dermal adipocytes (DAs) during the human scalp hair cycle remain unexplored. Transmission electron microscopy results suggest that, during anagen-catagen transition, human DAs co-opt the autophagy machinery (...) to undergo lipophagy within their lipid droplets. Wholemount staining of hair follicles (HFs) and surrounding DWAT for the autophagy marker LC3B confirms the increased presence of LC3B+ lipid droplets adjacent to catagen HFs; moreover, DWAT around catagen HFs engages in greater glycerol release compared to DWAT surrounding anagen HFs. Thus, we hypothesize that human DAs switch from lipogenesis during anagen to lipophagy together with lipolysis during catagen. We propose various experiments to further

2019 Experimental Dermatology

166. Contact sensitization to hair colors in acquired dermal macular hyperpigmentation: Results from a patch and photo patch-test study of 108 patients. (Abstract)

Contact sensitization to hair colors in acquired dermal macular hyperpigmentation: Results from a patch and photo patch-test study of 108 patients. Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis.To establish contact sensitization to hair colours as an aetiological factor for ADMH.Detailed clinical examination, skin biopsies, and patch and photo-patch testing (...) with Indian standard series and patient's own cosmetic products were performed.Thirty-nine (36.1%) patients were found to demonstrate a positive patch/photo-patch test with 35/39 reacting to their own products (all were hair colours) and 16/39 reacting to antigens from commercial series (commonly paraphenylenediamine). Fourteen patients developed delayed hyperpigmentation on positive patch-test sites at 1 month. Higher mean age, symptomatic pigmentation (pruritus, burning and photosensitivity), hair

2019 Journal of the European Academy of Dermatology and Venereology

167. An Updated Classification of Hair Follicle Morphogenesis. Full Text available with Trip Pro

An Updated Classification of Hair Follicle Morphogenesis. Hair follicle (HF) formation in developing embryonic skin requires stepwise signalling between the epithelial epidermis and mesenchymal dermis, and their specialized derivatives, the placode/germ/peg and dermal condensate/papilla, respectively. Classically, distinct stages of HF morphogenesis have been defined, in the mouse model, based on (a) changes in cell morphology and aggregation; (b) expression of few known molecular markers; (c

2019 Experimental Dermatology

168. Hair regrowth and dissemination of molluscum contagiosum: two unexpected effects with dupilumab. (Abstract)

Hair regrowth and dissemination of molluscum contagiosum: two unexpected effects with dupilumab. 30875133 2019 10 25 1468-3083 33 8 2019 08 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Hair regrowth and dissemination of molluscum contagiosum: two unexpected effects with dupilumab. e296-e298 10.1111/jdv.15571 Sevray M M Department of Dermatology, University Hospital, Brest, 29200, France. Dupré D D Department of Dermatology, University

2019 Journal of the European Academy of Dermatology and Venereology

169. Identification of titanium dioxide on the hair shaft of patients with and without frontal fibrosing alopecia: A pilot study of 20 patients. (Abstract)

Identification of titanium dioxide on the hair shaft of patients with and without frontal fibrosing alopecia: A pilot study of 20 patients. Frontal fibrosing alopecia (FFA) has increased markedly in incidence since it was first reported in 1994. A possible role of cosmetic ingredients has been suspected, especially UV blockers, since these were added to products in the late 1980s. Daily, year-round use of facial moisturizers, most of which contain a sunscreen, has been associated with FFA

2019 British Journal of Dermatology

170. Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything? (Abstract)

Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything? Studies highlighting the role of hair follicles (HFs) in wound healing have raised the challenge of bringing this knowledge to clinical applications. A successful translation is the transplantation of scalp HFs into chronic wounds to promote healing.To characterize scar formation and hair growth in nonhealing ulcers after transplantation.Nonhealing ulcers were treated with hair (...) transplantation to promote wound healing. Hair follicles were harvested from the patient's scalp and inserted into the wound bed. Wound repair and hair growth were assessed clinically. Further analyses were performed in situ, using biopsies from the central and peripheral scar.Rapid wound closure and differences of scar quality and hair growth between the central and peripheral wound areas were observed: the periphery healed with no hair shaft survival and an almost scarless appearance, the center healed

2019 Dermatologic Surgery

171. White hair in alopecia areata: Clinical forms and proposed physiopathological mechanisms. (Abstract)

White hair in alopecia areata: Clinical forms and proposed physiopathological mechanisms. Alopecia areata is a common form of non-scaring type of hair loss. It is believed to be a consequence of an immune-mediated stimulus, probably involving autoreactive T-cells against antigens present in the hair follicle. The exact antigen is still unknown; however, some authors have proposed that melanogenesis-associated molecules might trigger autoimmunity. Although transient white hair regrowth (...) is a common and well-known situation in alopecia areata, there are other different types of white hair phenomena in this context; including permanent white hair regrowth, spearing of white hair in a patchy pattern or spearing in a diffuse form giving the appearance of the so-called "overnight graying phenomena" or Canitis subita. In this review we aim to describe the different clinical aspects of white hair in alopecia areata as well as the proposed pathophysiological mechanisms involved

2019 Journal of American Academy of Dermatology

172. Building and repairing the stereocilia cytoskeleton in mammalian auditory hair cells. (Abstract)

Building and repairing the stereocilia cytoskeleton in mammalian auditory hair cells. Despite all recent achievements in identification of the molecules that are essential for the structure and mechanosensory function of stereocilia bundles in the auditory hair cells of mammalian species, we still have only a rudimentary understanding of the mechanisms of stereocilia formation, maintenance, and repair. Important molecular differences distinguishing mammalian auditory hair cells from hair cells (...) of other types and species have been recently revealed. In addition, we are beginning to solve the puzzle of the apparent life-long stability of the stereocilia bundles in these cells. New data link the stability of the cytoskeleton in the mammalian auditory stereocilia with the normal activity of mechanotransduction channels. These data suggest new ideas on how a terminally-differentiated non-regenerating hair cell in the mammalian cochlea may repair and tune its stereocilia bundle throughout the life

2019 Hearing Research

173. On Having Grey Hair. (Abstract)

On Having Grey Hair. Urologists should be aware of the importance of staying updated with the latest advances in medical research, chasing complications after surgery, being aware of postoperative results, building up a multidisciplinary team, and designing randomised trials for relevant research questions. Taken together, these key elements would allow for optimisation of patients' outcomes in everyday clinical practice.Copyright © 2019. Published by Elsevier B.V.

2019 European Urology

174. Anagen hair follicle repair: timely regenerative attempts from plastic extra-bulge epithelial cells. Full Text available with Trip Pro

Anagen hair follicle repair: timely regenerative attempts from plastic extra-bulge epithelial cells. Anagen hair follicle repair is the regenerative scheme activated to restore the structure and hair growth following injuries to anagen hair follicles. Compared with telogen-to-anagen regeneration and hair follicle neogenesis, anagen hair follicle repair is a clinically important, yet relatively unexplored regenerative feature of hair follicles. Due to their highly proliferative character (...) , germinative cells and matrix cells within hair bulbs are highly susceptible to injuries, such as chemotherapy and radiotherapy. Clinical and experimental observations suggest that damaged anagen hair follicles are able to repair themselves to resume anagen growth, bypassing premature catagen/telogen entry. Mechanistically, extra-bulge epithelial cells in the outer root sheath and the lower proximal cup are quickly mobilized for regeneration. These cells acquire stem cell-like properties, exhibiting high

2019 Experimental Dermatology

175. Wanted, dead and alive; why a multidisciplinary approach is needed to unlock hair treatment potential. Full Text available with Trip Pro

Wanted, dead and alive; why a multidisciplinary approach is needed to unlock hair treatment potential. Human recorded history is littered with attempts to improve the perceived appearance of scalp hair. Throughout history treatments have included both biological and chemical interventions. Hair "quality" or "perceived appearance" is regulated by multiple biological intervention opportunities: adding more hairs by flipping follicles from Telogen to Anagen, or delaying Anagen follicles transiting (...) into Catagen; altering hair "apparent amount" by modulating shaft diameter or shape; or, in principle, altering shaft physical properties changing its synthesis. By far the most common biological intervention strategy today is to increase the number of hairs, but to date this has proven difficult and has yielded minimal benefits. Chemical intervention primarily consists of active material surface deposition to improve shaft shine, fibre-fibre interactions, and strength. Real, perceptible benefits will best

2019 Experimental Dermatology

176. Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. (Abstract)

Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety (...) of neurodegenerative diseases and aging. Here we investigated the role of mitophagy and mitochondrial biogenesis in oxidative damage to the cochlear hair cells and age-related hearing loss. In cultured mouse House Ear Institute-Organ of Corti 1 hair cells, oxidative stress activated mitophagy but inhibited mitochondrial biogenesis and impaired mitochondrial function. Pharmacological inhibition of miR-34a/SIRT1 signaling enhanced mitophagy, mitochondrial biogenesis, and attenuated House Ear Institute-Organ of Corti

2019 Neurobiology of Aging

177. Hair growth control by innate immunocytes: Perifollicular macrophages revisited. Full Text available with Trip Pro

Hair growth control by innate immunocytes: Perifollicular macrophages revisited. The role of innate immunocytes such as mast cells, γδ T cells, NK cells and macrophages (MACs) in hair growth control under physiological and pathological conditions has recently begun to be re-explored. Here, we revisit the role of resident perifollicular macrophages (pfMACs) located in the hair follicle (HF) mesenchyme (CTS). Substantial, stringently timed fluctuations in the number and localization of pfMACs (...) were first observed long ago during murine HF morphogenesis and cycling. This already suggested some involvement of these innate immunocytes, with a recognized role in tissue remodelling and in hair growth control. The relatively recent demonstration of a Wnt signalling-driven crosstalk between these immunocytes and HF epithelial stem cells in telogen HFs, which promotes anagen induction, has reinvigorated interest in the role that pfMAC plays in hair biology. Besides the apoptosis-associated

2019 Experimental Dermatology

178. The role of the microbiome in scalp hair follicle biology and disease. Full Text available with Trip Pro

The role of the microbiome in scalp hair follicle biology and disease. The skin surface microbiome and its role in skin diseases have received increasing attention over the past years. Beyond, there is evidence for a continuous exchange with the cutaneous immune system in healthy skin, where hair follicles provide unique anatomical niches. Especially scalp hair follicles form large tubular invaginations, which extend deeply into the skin and harbor a variety of microorganisms. The distinct (...) immunology of hair follicles with enhanced immune cell trafficking in superficial compartments in juxtaposition to immune-privileged sites crucial for hair follicle cycling and regeneration, makes this organ a highly susceptible structure. Depending on composition and penetration depth, microbiota may cause typical infections, but may also contribute to pro-inflammatory environment in chronic inflammatory scalp diseases. Involvement in hair cycle regulation and immune cell maturation has been postulated

2019 Experimental Dermatology

179. Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions. (Abstract)

Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions. The biomechanical properties of the collagenous dermal matrix are well described but responses to mechanical force by the hair follicles have not been characterised so far. We applied a pulling force on hair follicles to visualise and quantify changes in the keratin-14 and involucrin positive cell layers of the follicles using nuclear

2019 Experimental Dermatology

180. Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. (Abstract)

Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. Additionally, we examined the association between hair TFV concentrations and virologic outcomes.Between 12/2012-09/2016, hair samples were (...) collected longitudinally from delivery through breastfeeding from women on ART in the PROMISE study (NCT01061151) in sub-Saharan Africa. Hair TFV levels were measured using validated methods. Using generalized estimating equations, we estimated the association between hair TFV levels and virologic suppression (<400 copies/mL) over time and assessed predictors of hair TFV levels.Hair TFV levels were measured at 370 visits in 71 women from delivery through a median of 14 months (IQR 12-15

2019 AIDS

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