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141. "Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women". (Abstract)

"Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women". Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metabolism and proliferation. Polar lipids are able to form vesicles with active compounds and to improve their bioavailability.We aimed to demonstrate potential benefits of a solution of miliacin encapsulated within polar lipids (MePL) on telogen effluvium prevention and hair condition (...) in women.After preliminary cell proliferation studies, a placebo-controlled, multicentric, randomized, double-blind trial was performed on sixty-five nonmenopausal women affected by telogen effluvium, to assess the efficacy of a 12-week oral supplementation with MePL. Telogen and anagen densities were determined by phototrichogram analysis. Scalp dryness and hair brightness were clinically evaluated using a Likert scale.MePL further enhanced cell proliferation in hair bulb from human scalp than miliacin

2019 Journal of cosmetic dermatology Controlled trial quality: predicted high

142. CD49f<sup>high</sup> Defines A Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance. (Abstract)

CD49fhigh Defines A Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance. Dermis harbor distinct mesenchymal stem cell populations, which play equally important roles as epidermal stem cells in skin homeostasis and regeneration. However, to reliably identify and directly isolate the in vivo counterpart of these cells is still challenging. Using the epidermal stem cell marker CD49f, we defined CD49fhigh distinct mesenchymal subpopulation (...) in the dermis. In vitro and in vivo differentiation assays and transcriptome analysis demonstrated that CD49fhigh cells possess neural crest-like cell characteristics. Further results showed that the formation of hair follicle-like budding structure and the expressions of key genes regulating hair follicle development were induced when hair follicle epithelial cells were co-cultured with CD49fhigh cells. Moreover, we found that CD49fhigh cells activated Notch signaling in co-cultured hair follicle

2019 Journal of Investigative Dermatology

143. Splitting hairs and challenging guidelines: Defining the role of perioperative antibiotics in pediatric appendicitis patients. (Abstract)

Splitting hairs and challenging guidelines: Defining the role of perioperative antibiotics in pediatric appendicitis patients. Ambiguity regarding timing and duration of perioperative IV antibiotics in AA and CA exists. We wanted to determine if an association existed between surgical site infections (SSI) in children with acute (AA) or complicated appendicitis (CA) and timing and duration of perioperative antibiotics.We performed a single institution, case control observational study

2019 Journal of Pediatric Surgery

144. Hair cortisol concentrations as an indicator of potential HPA axis hyperactivation in risk for psychosis. (Abstract)

Hair cortisol concentrations as an indicator of potential HPA axis hyperactivation in risk for psychosis. A chronic hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis is assumed to be an important indicator of vulnerability for psychosis. Despite the considerable research on this topic, putative social origins of HPA axis hyperactivation have received little attention in the literature so far. Also, the inconsistency of previous findings calls for new and reliable methods (...) in the assessment of HPA axis activation. To address these issues, we used hair cortisol concentrations as an indicator of chronic HPA axis activation in participants at elevated risk for psychosis (clinical risk: n = 43, familial risk: n = 32) and low-risk controls (n = 35), and assessed its relation with a variety of social stressors. We also tested the interaction effect between social stressors and familial risk status on hair cortisol concentrations (moderation analysis). Participants at elevated risk

2019 Schizophrenia Research

145. Understanding curly hair mechanics: Fibre strength. Full Text available with Trip Pro

Understanding curly hair mechanics: Fibre strength. The relationship between the geometric and mechanical profiles of hair fibres has been studied, with special focus on curly samples. Incidental observations pointed to a significantly different viscoelastic character with varying curliness. Further investigations confirmed initial observations, showing an initial distinct toe-region behaviour for curly-fibres on the stress-strain plot, which is absent for straight fibres. This behaviour (...) suggested a difference in viscoelastic nature of the curly fibre that is linked to mechanical energy stored in the fibre. Results also suggest that the strength of hair depends on two main components, and further pointed out that de facto methods of tensile testing may erode curly fibre strength during preparation. The main outcome of this study is that the tensile strength (σT), of hair fibres is composed of two (rather than one main) components, namely the toe-region (σt) and the elastic region (σε

2019 Journal of Investigative Dermatology

146. Editorial Commentary: Angles, Ratios, and Rotation-Is It Worth Splitting Hairs Over the Critical Shoulder Angle? Full Text available with Trip Pro

Editorial Commentary: Angles, Ratios, and Rotation-Is It Worth Splitting Hairs Over the Critical Shoulder Angle? Various radiographic indices represent lateral acromial extension over the greater tuberosity and are said to be one of the etiologic factors in rotator cuff tears. There has been much debate regarding the accuracy of these parameters based on radiographic rotation and tilt. This commentary discusses the utility of the existing parameters and the "surgical worth" of seeking another

2019 Arthroscopy

147. Noncultured Extracted Hair Follicle Outer Root Sheath Cell Suspension versus Noncultured Epidermal Cell Suspension in the Treatment of Stable Vitiligo. Full Text available with Trip Pro

Noncultured Extracted Hair Follicle Outer Root Sheath Cell Suspension versus Noncultured Epidermal Cell Suspension in the Treatment of Stable Vitiligo. Various treatment modalities exist for vitiligo, yet none of them are curative. Vitiligo is still considered a challenging disease to manage. Surgical treatment offers an excellent option for patients with stable vitiligo, especially those who fail to respond to medical treatment. Cell suspension techniques carry the advantage of covering large (...) surface areas.To compare noncultured extracted hair follicle outer root sheath cell suspension (NCORSHFS) and noncultured epidermal cell suspension (NCES) in producing repigmentation.Twenty patients were randomly allocated into two groups. They were objectively evaluated for the extent of repigmentation (after 1, 2, and 3 months), complications, cosmetic outcome, and satisfaction.In NCORSHFS group, 10% showed excellent pigmentation, 20% showed good pigmentation, 50% fair, and 20% poor pigmentation

2019 Journal of cutaneous and aesthetic surgery Controlled trial quality: uncertain

148. Minoxidil 1 mg Orally versus Minoxidil 5% Solution Topically for the Treatment of Female Pattern Hair Loss: A Randomized Clinical Trial. Full Text available with Trip Pro

Minoxidil 1 mg Orally versus Minoxidil 5% Solution Topically for the Treatment of Female Pattern Hair Loss: A Randomized Clinical Trial. 31473295 2019 09 01 1097-6787 2019 Aug 29 Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Minoxidil 1 mg Orally versus Minoxidil 5% Solution Topically for the Treatment of Female Pattern Hair Loss: A Randomized Clinical Trial. S0190-9622(19)32666-0 10.1016/j.jaad.2019.08.060 Ramos Paulo Müller PM Dermatologist, M.D.; MSc, Departamento de (...) Journal Article 2019 08 29 United States J Am Acad Dermatol 7907132 0190-9622 IM Female pattern hair loss androgenetic alopecia hypertrichosis minoxidil oral topical treatment 2019 02 10 2019 08 10 2019 08 22 2019 9 2 6 0 2019 9 2 6 0 2019 9 2 6 0 aheadofprint 31473295 S0190-9622(19)32666-0 10.1016/j.jaad.2019.08.060

2019 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

149. Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor. (Abstract)

Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor. Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied α1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical (...) cosmetic solution containing an α1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%.In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a shampoo containing a selective TAAR agonist, tyramine hydrochloride.A single

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

150. EMLA-induced methemoglobinemia after laser-assisted hair removal procedure. (Abstract)

EMLA-induced methemoglobinemia after laser-assisted hair removal procedure. This is the case of a 23-year-old female with a past medical history of ADHD and Depression who was evaluated in the emergency department for perioral cyanosis and hypoxia after application of the eutectic mixture of lidocaine and prilocaine (EMLA) local anesthetic prior to a laser-assisted hair removal procedure. This report illustrates a case of methemoglobinemia which is a rare but significant complication of topical

2019 American Journal of Emergency Medicine

151. Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease. (Abstract)

Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease. While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss.We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous cGVHD.A prospective cohort of 17 adult hematopoietic cell transplantation (...) (HCT) recipients with cutaneous cGVHD was enrolled. Dermatologic examinations were performed, and punch biopsy specimens of the scalp were obtained. Biopsy specimens were analyzed with hematoxylin-eosin and immunohistochemical stains in all cases and fluorescence in situ hybridization analyses in specific cases.Clinically, 4 patterns of hair loss were described-patchy nonscarring (41.2%), diffuse nonscarring (11.8%), diffuse sclerotic (11.8%), and patchy sclerotic (5.9%). The location

2019 Journal of American Academy of Dermatology

152. 2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. Full Text available with Trip Pro

2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. 2-deoxy D-glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T-cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata (...) disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell-mediated autoimmune mouse disease, alopecia areata.© 2019 John Wiley & Sons A/S. Published by John

2019 Experimental Dermatology

153. A randomized pilot study to compare hair follicle cell suspensions prepared using trypsin alone versus trypsin in combination with collagenase type I for transplantation in vitiligo. (Abstract)

A randomized pilot study to compare hair follicle cell suspensions prepared using trypsin alone versus trypsin in combination with collagenase type I for transplantation in vitiligo. Noncultured extracted hair follicle outer root sheath cell suspension (NC-EHF-ORS-CS) is an upcoming surgical technique to treat stable vitiligo. Conventionally it employs trypsin to tap the hair follicle (HF) reservoir for autologous melanocytes and their precursors for transplantation. However, a perifollicular

2019 Clinical & Experimental Dermatology Controlled trial quality: uncertain

154. Electrophysiologic Characteristics of Various Degrees of Selective Outer Hair Cell Loss in Rats. (Abstract)

Electrophysiologic Characteristics of Various Degrees of Selective Outer Hair Cell Loss in Rats. The characteristics of auditory brainstem response (ABR), electrocochleogram (ECochG), and distortion product otoacoustic emissions (DPOAE) of different degrees of selective outer hair cells (OHCs) loss may be helpful for clinicians to evaluate the pathogeny, diagnosis, and rehabilitation of individuals' hearing loss.How many OHCs are necessary to maintain cochlear amplifier function remains unknown

2019 Otology and Neurotology

155. Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. (Abstract)

Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. The signals that induce anagen (growth) in 'quiescent' human telogen hair follicles (HFs) are as yet unknown. Their identification promises better targeted therapeutic hair growth interventions.Recognizing the central role of Wnt signalling in hair biology, the aim was to delineate the differential expression of key agonists, antagonists and target genes of this pathway during (...) the telogen-to-anagen transformation of human scalp HFs.This differential expression was studied by in situ hybridization in human telogen and early-anagen scalp HF sections.On anagen induction, gene expression of the Wnt ligands WNT3, WNT4 and WNT10B, the Wnt ligand secretion regulator WLS, and the Wnt target genes AXIN2 and LEF1, is significantly increased within the secondary hair germ and the dermal papilla. Conversely, expression of the secreted Wnt inhibitor SFRP1 (secreted frizzled-related protein

2019 British Journal of Dermatology

156. An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. (Abstract)

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing FGF7 production in outer root sheath keratinocytes. Given that unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress, new pharmacological treatment strategies by safe and effective hair growth inhibitors that do not destroy the hair follicle (HF) and its stem cells need to be developed.Since human HFs express the multifunctional, immunomodulatory glycoprotein, osteopontin (...) , we hypothesized that osteopontin-derived fragments may modulate human hair growth.This hypothesis was tested ex vivo and in vivo by using a newly generated, toxicologically well-characterized, modified osteopontin-derived peptide (FOL-005), which binds to the HF.In organ-cultured human HFs and scalp skin, and in human scalp xenotransplants onto SCID mice, FOL-005 treatment significantly promoted premature catagen development without reducing the number of keratin 15+ HF stem cells or showing

2019 British Journal of Dermatology

157. Human Basal Cell Carcinoma: The Induction of Anagen Hair Follicle Differentiation. (Abstract)

Human Basal Cell Carcinoma: The Induction of Anagen Hair Follicle Differentiation. Consistent with cancer stem cell driven pattern of growth, human basal cell carcinoma (BCC) demonstrate differentiation along hair follicle (HF) lineages.Define the pattern of differentiation and therapeutic targets that promote BCC differentiation and therefore BCC cancer stem cell exhaustion.The alkaline phosphatase substrate kit (Vectastain, UK) was used to determine dermal papilla cells within the BCC stroma (...) . Autonomous HF cycle dependent gene expression was identified by analysis of the human homologues of a murine hair cycle phases differentially expressed gene set (total 2,289 genes). The findings were validated by qRT-PCR using the QuantStudio 7 Flex Real-Time PCR System (ThermoFisher Scientific) and immunofluorescence, as well as in vitro TGFβ2 stimulation of BCC cancer stem cell colonies.As in the HF, inner root sheath and matrix keratin expression observed in BCC correlated with proliferative index

2019 Clinical & Experimental Dermatology

158. Hair Follicle Differentiation Specific Keratin Expression in Human Basal Cell Carcinoma. (Abstract)

Hair Follicle Differentiation Specific Keratin Expression in Human Basal Cell Carcinoma. Identification of human basal cell carcinoma (BCC) cancer stem cells and cellular hierarchy inherently implies the presence of differentiation. By conventional histological analysis, BCC demonstrates tumour nodules that appear relatively homogenous.As BCC arise from hair follicle (HF) keratinocytes, we sought to define the pattern of HF differentiation.BCC, squamous cell carcinoma (SCC), and normal skin (...) tissues were analysed using a Illumina HumanHT-12 v4 Expression Microarray chip. The expression of individual keratins, regulatory pathways and proliferative states were analysed using RT-PCR and immunofluorescence microscopy.Microarray analysis of BCC, SCC and normal hair bearing skin revealed that BCC express a wide range of HF genes, including HF specific keratins. BCC demonstrated outer (KRT 5, 14, 16, 17 and 19) and inner (KRT25, KRT27, KRT28, KRT32, KRT35, KRT71, KRT75 and KRT85) root sheath

2019 Clinical & Experimental Dermatology

159. Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 μm (PM 2.5) exposure using zebrafish (Danio rerio) models. (Abstract)

Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 μm (PM 2.5) exposure using zebrafish (Danio rerio) models. Particulate matter (PM) exposure has become one of the most serious problems. The aim of the present study was to evaluate the hair cell damage and possible developmental toxicity caused by PM2.5 exposure using a zebrafish model.Zebrafish embryos were exposed to various concentrations of PM2.5. Developmental toxicity was evaluated based (...) on general morphology score (GMS) system and Panzica-Kelly score, and by measurement of body length and heart rate. To evaluate hair cell damage, the average number of total hair cells within four neuromasts exposed to various concentrations of PM2.5 was compared with that of the control group.Morphological abnormalities evaluated by the GMS system and Panzica-Kelly score were rare and body length tended to be shorter in the PM2.5-exposed groups. Heart rate decreased significantly in the PM2.5-exposed

2019 International Journal of Pediatric Otorhinolaryngology

160. No Association of Antenatal Synthetic Glucocorticoid Exposure and Hair Steroid Levels in Children and Adolescents. Full Text available with Trip Pro

No Association of Antenatal Synthetic Glucocorticoid Exposure and Hair Steroid Levels in Children and Adolescents. Antenatal synthetic glucocorticoid (sGC) treatment constitutes a potent programming factor of the hypothalamic-pituitary-adrenal (HPA) axis. Previous findings from our group revealed long-term changes in cortisol stress reactivity following antenatal sGC therapy. However, the few prior studies exclusively relied on spot measurements of phasic HPA-axis activity, which may (...) not adequately capture cortisol output over prolonged periods of time.To address this gap, the current study utilized hair steroid concentrations, a valid marker of integrated long-term HPA-axis activity, to investigate endocrine changes in individuals treated with antenatal sGC.This cross-sectional study comprised 76 term-born children (7-12 years) and 58 adolescents (14-18 years). Cumulated hormonal secretion in scalp hair over a 3-month period was determined for different biomarkers of tonic HPA-axis

2019 Journal of Clinical Endocrinology and Metabolism

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