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141. Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: the case of henna-based hair coloring products containing p-phenylenediamine. (PubMed)

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: the case of henna-based hair coloring products containing p-phenylenediamine. Allergic contact dermatitis reported to henna-based hair coloring products (HPs) has been associated with adulteration of henna with p-phenylenediamine (PPD).To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway (...) to evaluate allergenic potential of HPs.The following in vitro assays were used to test the sensitizing capacity of hair dye ingredients: micro-direct peptide reactivity assay (mDPRA); HaCaT keratinocytes-associated IL-18 assay; U937 cell line activation test (USENS)/IL-8 levels; blood monocyte-derived dendritic cell test; genomic allergen rapid detection (GARD skin). Those techniques with better human concordance were selected to evaluate the allergenic potential of ten HPs.Contrasting to the label's

2019 Contact Dermatitis

142. Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. (PubMed)

Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. Additionally, we examined the association between hair TFV concentrations and virologic outcomes.Between 12/2012-09/2016, hair samples were (...) collected longitudinally from delivery through breastfeeding from women on ART in the PROMISE study (NCT01061151) in sub-Saharan Africa. Hair TFV levels were measured using validated methods. Using generalized estimating equations, we estimated the association between hair TFV levels and virologic suppression (<400 copies/mL) over time and assessed predictors of hair TFV levels.Hair TFV levels were measured at 370 visits in 71 women from delivery through a median of 14 months (IQR 12-15

2019 AIDS

143. Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. (PubMed)

Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety (...) of neurodegenerative diseases and aging. Here we investigated the role of mitophagy and mitochondrial biogenesis in oxidative damage to the cochlear hair cells and age-related hearing loss. In cultured mouse House Ear Institute-Organ of Corti 1 hair cells, oxidative stress activated mitophagy but inhibited mitochondrial biogenesis and impaired mitochondrial function. Pharmacological inhibition of miR-34a/SIRT1 signaling enhanced mitophagy, mitochondrial biogenesis, and attenuated House Ear Institute-Organ of Corti

2019 Neurobiology of Aging

144. In vivo and in vitro evaluation of hair growth potential of Cacumen Platycladi, and GC-MS analysis of the active constituents of volatile oil. (PubMed)

In vivo and in vitro evaluation of hair growth potential of Cacumen Platycladi, and GC-MS analysis of the active constituents of volatile oil. Cacumen Platycladi (CP) is the leaves of Platycladus orientalis which has been traditionally used to resist alopecia and promote hair growth. However, no study has been reported on the effects of CP on proliferation of dermal papilla cells (DPCs). And there is also no complete and systematic research on hair re-growth efficacies of CP.To evaluate (...) the hair-growth activity of their extracts on the proliferation of DPCs and the promotion of hair reproduction in C57BL/6 mice.For the DPCs, different extract fractions of CP were investigated. The hair growth effect of CP volatile oil on C57BL/6 mice was evaluated for 28 days. Meanwhile, the chemical constituents of the volatile oil from Cacumen Platycladi were isolated and identified by GC-MS.The study showed that the extracts of CP could promote the proliferation of DPCs, and the activity

2019 Journal of Ethnopharmacology

145. Serum long-chain omega-3 fatty acids, hair mercury and exercise-induced myocardial ischaemia in men. (PubMed)

Serum long-chain omega-3 fatty acids, hair mercury and exercise-induced myocardial ischaemia in men. Long-chain omega-3 polyunsaturated fatty acids (PUFA) from fish have been inversely associated with coronary heart disease (CHD) risk. Fish may also contain methylmercury, which has been associated with higher CHD risk and may diminish the cardioprotective effect of long-chain omega-3 PUFA. We investigated the associations of serum long-chain omega-3 PUFA and hair mercury with the odds (...) % lower odds of myocardial ischaemia (OR 0.67, 95% CI 0.51 to 0.87, p-trend=0.006). The association was stronger among those with CHD history (OR 0.10, 95% CI 0.03 to 0.39, p-trend <0.001), than among those without (OR 0.80, 95% CI 0.57 to 1.12, p-trend=0.17) (p-interaction=0.01). Higher hair mercury concentration was associated with increased odds for myocardial ischaemia in the entire population (OR 1.62, 95% CI 1.22 to 2.14, p-trend=0.002).Higher circulating concentrations of the long-chain omega-3

2019 Heart

146. Evaluating hair growth promoting effects of candidate substance: A review of research methods. (PubMed)

Evaluating hair growth promoting effects of candidate substance: A review of research methods. Androgenetic alopecia (AGA) is the most common form of hair loss disorder. As the prevalence of AGA rises, the demand for AGA treatments is rising accordingly, prompting research to identify therapeutic candidates to treat AGA. Because AGA is caused by crosstalk among multiple hair follicle (HF) cell components, understanding the effects of candidate molecules on HF cells is essential to determining (...) therapeutic candidates for treatment. To date, research has centered on HF dermal papilla and outer root sheath cells and has indicated that the hair growth effects of candidate substances may be mediated via alterations in several signaling pathways and signature genes in these HF cells. In more integrative evaluations, the HF unit is used as an ex vivo organ culture model to verify the effects of therapeutic candidates. Animal models have also been used to evaluate the effects of candidate substances

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2019 Journal of dermatological science

147. Chemical and physical treatments damage Caucasian and Afro-ethnic hair fiber: analytical and image assays. (PubMed)

Chemical and physical treatments damage Caucasian and Afro-ethnic hair fiber: analytical and image assays. Sensory and structural characteristics of hair can be modified by chemical and physical treatments, as dyeing, brushing, but also by external factors, as sunlight radiation. However, quantitative data relating damage to the degree of hair curliness and treatments are missing.To evaluate the effect of chemical and physical treatments on different types of hair.In this study, we compared (...) the effects of bleaching/dyeing, thioglycolate-based straightening, brushing/flat iron and UVA/Vis radiation on different types of hair: Caucasian (straight dark brown, straight blond, wavy dark brown and curly dark brown) and Afro-ethnic hair.Bleaching/dyeing and UVA/Vis radiation increased combing work of Afro-ethnic hair tresses, indicating damage to the cuticle scales, which was confirmed by SEM images. Further, bleaching/dyeing caused wear on cuticles with high protein loss and reduction

2019 Journal of the European Academy of Dermatology and Venereology

148. Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families. (PubMed)

Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families. Autosomal recessive wooly hair/hypotrichosis is an inherited disorder of hair characterized by less dense, short, and tightly curled hair on the scalp and sometimes less dense to complete absence of eyebrows and eyelashes. Autosomal recessive wooly hair/hypotrichosis phenotypes are mostly associated with pathogenic sequence variants in LIPH and LPAR6 genes.To find out (...) the molecular basis of the disease, five families with autosomal recessive wooly hair/hypotrichosis were recruited for genetic analysis. Direct Sanger sequencing of LIPH and LPAR6 genes was carried out using BigDye chain termination chemistry. P2RY5 protein homology models were developed to study the effect of mutation on protein structure in a family having novel mutation.Sanger sequencing revealed a novel homozygous missense mutation (c.47A>T) in the LPAR6 gene in family A, while recurrent mutation (c

2019 International Journal of Dermatology

149. Modified basic and specific (BASP) classification for pattern hair loss. (PubMed)

Modified basic and specific (BASP) classification for pattern hair loss. In 2007, Lee et al. introduced a basic and specific (BASP) classification for pattern hair loss that was comprehensive and applicable regardless of race or gender. However, this BASP classification has several limitations. Frontal type hair loss classification is relatively crude, and a specific hair loss pattern cannot be ascertained when hair loss is associated with the temporal and occipital areas.In our modified BASP (...) classification, frontal type classification was subdivided into five instead of three grades. Basic type classification remained the same as in the previous method. In addition, information regarding the involvement of the temporal or occipital scalp was recorded. Accuracy and ease of use were evaluated and compared with the existing BASP classification in 138 patients with pattern hair loss.Temporal or occipital involvement was observed in 14 patients, accounting for 11.1% of subjects. Final type accuracy

2019 International Journal of Dermatology

150. Distribution of polyamines may be altered in different scalp regions of patients with hair loss. (PubMed)

Distribution of polyamines may be altered in different scalp regions of patients with hair loss. Hair loss, from the vertex or front of the head, generally occurs due to increased androgenic steroid levels. Androgenic steroids, particularly testosterone and dihydrotestosterone, are distributed differently across the vertex and occipital regions, and are involved in inducing ornithine decarboxylase expression. Therefore, we hypothesized that the distribution of polyamines may be altered (...) in different scalp regions. For the overall metabolic profiling of polyamines in patients with hair loss, a liquid chromatography-mass spectrometry was used. We investigated the differential polyamine levels in different regions of the hair of patients with male-pattern baldness and those with female-pattern hair loss. The levels of most polyamines were higher in the vertex region than in the occipital region, and N-acetyl polyamine levels differed significantly. We proposed to test our hypothesis

2019 Experimental Dermatology

151. Association of cicatricial alopecia with chemical hair straightening. (PubMed)

Association of cicatricial alopecia with chemical hair straightening. Exome sequencing and genome-wide association studies support a genetic basis for central centrifugal cicatricial alopecia (CCCA) and frontal fibrosing alopecia (FFA).1,2 Given recent epidemiologic trends, environmental risk factors likely interact with genetic susceptibility to promote disease.2 Hair care practices, specifically, have been suspected to contribute to hair loss disorders, namely CCCA and traction alopecia

2019 British Journal of Dermatology

152. Beyond medical therapies-clinicians' knowledge of cosmetic products in managing individuals with hair loss. (PubMed)

Beyond medical therapies-clinicians' knowledge of cosmetic products in managing individuals with hair loss. 31233630 2019 07 09 1365-2230 2019 Jun 24 Clinical and experimental dermatology Clin. Exp. Dermatol. Beyond medical therapies: clinicians' knowledge of cosmetic products in managing individuals with hair loss. 10.1111/ced.14028 Bindra H H https://orcid.org/0000-0003-4696-0640 Cardiology Department, North West London Hospitals NHS Trust, Ealing Hospital, London, UK. Sahota A A Department

2019 Clinical & Experimental Dermatology

153. Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. (PubMed)

Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. Background: Established procedures for mass casualty decontamination involve the deployment of equipment for showering with water (such as the ladder pipe system [LPS] and technical decontamination [TD]). This necessarily introduces a short, but critical delay. The incorporation of dry decontamination to the incident response process offers the potential to establish (...) a more rapid and timely intervention. Objectives: To investigate the effectiveness of various dry (DD) and wet decontamination strategies for removing a chemical warfare simulant (methyl salicylate; MS) from the hair and skin of human volunteers. Methods: The simulant was applied to volunteers via whole body exposure to an aerosol. Three decontamination protocols (dry, LPS and technical decontamination) were applied, singly and in various combinations. The efficacy of the protocols was evaluated

2019 Prehospital emergency care

154. Publisher Correction: Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability. (PubMed)

Publisher Correction: Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability. An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2019 Nature Genetics

155. SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. (PubMed)

SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. Age-related hearing loss (AHL) is typically caused by the irreversible death of hair cells (HCs). Autophagy is a constitutive pathway to strengthen cell survival under normal or stress condition. Our previous work suggested that impaired autophagy played an important role in the development of AHL in C57BL/6 mice, although the underlying mechanism of autophagy in AHL still needs to be investigated. SIRT1

2019 Neurobiology of Aging

156. On the Legacy of Genetically Altered Mouse Models to Explore Vestibular Function: Distribution of Vestibular Hair Cell Phenotypes in the Otoferlin-Null Mouse. (PubMed)

On the Legacy of Genetically Altered Mouse Models to Explore Vestibular Function: Distribution of Vestibular Hair Cell Phenotypes in the Otoferlin-Null Mouse. Early in his career, David Lim recognized the scientific impact of genetically anomalous mice exhibiting otoconia agenesis as models of drastically compromised vestibular function. While these studies focused on the mutant pallid mouse, contemporary genetic tools have produced other models with engineered functional modifications. Lim (...) genetic alteration, the otoferlin-null mouse, which has been shown to exhibit severely compromised stimulus-evoked neurotransmitter release in type I hair cells of the utricular striola. The present study, reminiscent of early investigations of Lim and colleagues that explored the utility of a genetically altered mouse to explore its utility as a model of vestibular hypofunction, endeavored to compare the expression of the hair cell marker oncomodulin in vestibular epithelia from wild-type

2019 Rhinology and Laryngology

157. Big toenail and hair samples as biomarkers for fluoride exposure - a pilot study. (PubMed)

Big toenail and hair samples as biomarkers for fluoride exposure - a pilot study. Biomarkers can aid in detecting and preventing clinical disease through the recognition of change in biological samples. The objective of this case-control study was to further the knowledge on the use of big toenail and hair samples as biomarkers for fluoride exposure.A total of 48 participants from an endemic (IC) and a non-endemic (SC) fluorosis region were included. Big toenail and hair samples were collected (...) from each participant and the fluoride concentration was determined. The results of 42 participants were reported: 21 participants (11 males and 10 females, mean age 15.66 + 2.61 years) from IC and 21 participants (11 males and 10 females, mean age 15.06 + 0.79 years) from SC.The mean fluoride concentration of big toenail (2.34 ± 0.26 mg/kg) and hair (0.24 ± 0.04 mg/kg) in the endemic region was significantly higher than the mean fluoride concentration of big toenail (0.98 ± 0.08 mg/kg) and hair

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2019 BMC Oral Health

158. Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage-hair hypoplasia via enhanced Wnt/β-catenin signaling. (PubMed)

Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage-hair hypoplasia via enhanced Wnt/β-catenin signaling. Cartilage-hair hypoplasia (CHH) is an autosomal recessive metaphyseal chondrodysplasia characterized by bone dysplasia and many other highly variable features. The responsible gene for CHH has been identified to be the RNA component of the mitochondrial RNA processing endoribonuclease (RMRP) gene. Currently, the pathogenesis of osteochondrodysplasia

2019 Journal of Bone and Mineral Research

159. Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. (PubMed)

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. Brittle and "tiger-tail" hair is the diagnostic hallmark of trichothiodystrophy (TTD), a rare recessive disease associated with a wide spectrum of clinical features including ichthyosis, intellectual disability, decreased fertility, and short stature. As a result of premature abrogation of terminal differentiation, the hair is brittle and fragile and contains reduced cysteine content. Hypersensitivity to UV light is found

2019 American Journal of Human Genetics

160. No Association of Antenatal Synthetic Glucocorticoid Exposure and Hair Steroid Levels in Children and Adolescents. (PubMed)

No Association of Antenatal Synthetic Glucocorticoid Exposure and Hair Steroid Levels in Children and Adolescents. Antenatal synthetic glucocorticoid (sGC) treatment constitutes a potent programming factor of the hypothalamic-pituitary-adrenal (HPA) axis. Previous findings from our group revealed long-term changes in cortisol stress reactivity following antenatal sGC therapy. However, the few prior studies exclusively relied on spot measurements of phasic HPA-axis activity, which may (...) not adequately capture cortisol output over prolonged periods of time.To address this gap, the current study utilized hair steroid concentrations, a valid marker of integrated long-term HPA-axis activity, to investigate endocrine changes in individuals treated with antenatal sGC.This cross-sectional study comprised 76 term-born children (7-12 years) and 58 adolescents (14-18 years). Cumulated hormonal secretion in scalp hair over a 3-month period was determined for different biomarkers of tonic HPA-axis

2019 Journal of Clinical Endocrinology and Metabolism

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