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81. Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β-catenin signalling. (Abstract)

Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β-catenin signalling. Hair growth, a complex process, has long been the subject of intense research. Recent developments in material technology have revealed boehmite as a new therapeutic modality for use in wound healing and scar reduction, indicating its beneficial effects. Nonetheless, the biological bases of the beneficial effects of boehmite remain unknown. We investigated the hair growth (...) properties of boehmite in vitro and in vivo and observed dose-dependent proliferation of human dermal papilla cells (hDPCs) in vitro and hair regrowth in a mouse model. To investigate the effects of boehmite on the promotion of cell transition to the anagen phase, we evaluated hDPC viability, alkaline phosphatase (ALP) activity, protein expression and vascular endothelial growth factor (VEGF) secretion in vitro and assessed the anagen-promoting effects of boehmite via gross observation and histological

2020 Experimental Dermatology

82. Autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study. (Abstract)

Autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study. Few effective treatments are available for male pattern hair loss (MPHL) or, especially, for female pattern hair loss (FPHL). Recently, cell-based therapies using autologous or allogeneic cells have been used clinically.We examined the safety and efficacy of autologous cell-based therapy using dermal sheath cup (DSC) cells (...) to treat MPHL and FPHL.DSCs dissected from occipital hair follicles were cultured to manufacture DSC cells. Participants with MPHL or FPHL received single injections of 7.5 × 106, 1.5 × 106, or 3.0 × 105 DSC cells or a placebo in 4 randomized separate regions on the scalp, and hair densities and diameters were measured for 3, 6, 9, and 12 months.Fifty men and 15 women aged 33 to 64 years were injected with DSC cells. Total hair density and cumulative hair diameter at the 3.0 × 105 DSC cells injection

2020 Journal of American Academy of Dermatology

83. The Trichoscopic Features of Hair Shaft Anomalies Induced by Epidermal Growth Factor Receptor Inhibitors: A Case Series. (Abstract)

The Trichoscopic Features of Hair Shaft Anomalies Induced by Epidermal Growth Factor Receptor Inhibitors: A Case Series. Although the clinical hair changes that occur under treatment with epidermal growth factor receptor inhibitors (EGFRIs) are documented, their trichoscopic features have not been reported.To evaluate the trichoscopic findings in scalp and facial hair, induced by EGFRI-treatment.Patients treated with EGFRIs at a tertiary onco-dermatology clinic in 2015-2017 were evaluated (...) for macroscopic and trichoscopic changes.The cohort included 23 patients (13 women, median age 68 years) treated with EGFRIs for an average of 13 months (range 2-40). Macroscopically, 18 patients (78%) had dry, lusterless, coarse, kinky, brittle scalp hair, and 17 (74%) had trichomegaly of the eyebrows/eyelashes. Trichoscopic findings were of hair shaft-anomalies including: pili torti, affecting scalp hair in 20 patients (87%), eyebrows in 6 (26%), and eyelashes in 8 (50%), and asymmetric-hyperpigmented

2020 Journal of American Academy of Dermatology

84. EGFL6 expression in hair follicle central isthmus is dependent on the presence of terminal Schwann cells. (Abstract)

EGFL6 expression in hair follicle central isthmus is dependent on the presence of terminal Schwann cells. Hair follicle central isthmus is surrounded by dense nerve endings and terminal Schwann cells (TSCs), forming a specialized sensory structure called lanceolate complexes. Extracellular matrix protein EGFL6 expressed from epidermis has been found closely associated with lanceolate complexes and important for proper alignment of nerve fibres and TSCs processes, and for proper response (...) to light touch. However, how EGFL6 itself is specifically induced/deposited/maintained at the central isthmus remains to be elucidated. Previous reports and our results showed that nerve endings and TSCs docking at the central isthmus during hair follicle development occur before the specific depositing of EGFL6 protein. Furthermore, we found nude mice rarely maintain the lanceolate complex, and EGFL6 is lost in their aberrant hair follicle. Instead, reconstituted hair follicle in nude mice by stem

2020 Experimental Dermatology

85. Murine dorsal hair type is genetically determined by polymorphisms in candidate genes that influence BMP and WNT signalling. Full Text available with Trip Pro

Murine dorsal hair type is genetically determined by polymorphisms in candidate genes that influence BMP and WNT signalling. Mouse dorsal coat hair types, guard, awl, auchene and zigzag, develop in three consecutive waves. To date, it is unclear if these hair types are determined genetically through expression of specific factors or can change based on their mesenchymal environment. We undertook a novel approach to this question by studying individual hair type in 67 Collaborative Cross (CC (...) ) mouse lines and found significant variation in the proportion of each type between strains. Variation in the proportion of zigzag, awl and auchene, but not guard hair, was largely due to germline genetic variation. We utilised this variation to map a quantitative trait locus (QTL) on chromosome 12 that appears to influence a decision point switch controlling the propensity for either second (awl and auchene) or third wave (zigzag) hairs to develop. This locus contains two strong candidates, Sostdc1

2020 Experimental Dermatology

86. PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology. Full Text available with Trip Pro

PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology. Peroxisome proliferator-activated receptors (PPARs) are abundantly expressed in human skin, with PPAR-γ being the most intensively investigated isoform. In various ex vivo and in vivo models, PPAR-γ-mediated signalling has recently surfaced as an essential element of hair follicle (HF) development, growth and stem cell biology. Moreover, the availability of novel, topically applicable PPAR-γ modulators (...) pharmacological modulation of PPAR-γ signalling may be employed for the management of hair growth disorders, for example, in scarring alopecia (by reducing HF inflammation as well as by promoting the survival and suppressing pathological epithelial-mesenchymal transition of keratin 15 + epithelial stem cells in the bulge) and in hirsutism/hypertrichosis (by promoting catagen development). Moreover, we explore the potential role of PPAR-γ in androgenetic alopecia, HF energy metabolism and HF ageing

2020 Experimental Dermatology

87. A "hair-raising" history of alopecia areata. Full Text available with Trip Pro

A "hair-raising" history of alopecia areata. A 3500-year-old papyrus from ancient Egypt provides a list of treatments for many diseases including "bite hair loss," most likely alopecia areata (AA). The treatment of AA remained largely unchanged for over 1500 years. In 30 CE, Celsus described AA presenting as scalp alopecia in spots or the "windings of a snake" and suggested treatment with caustic compounds and scarification. The first "modern" description of AA came in 1813, though treatment (...) ). Research progressively shifted towards identifying hair follicle-specific autoantibodies (1995). The potential role of lymphocytes in AA was made implicit with immunohistological studies (1980s). However, studies confirming their functional role were not published until the development of rodent models (1990s). Genetic studies, particularly genome-wide association studies, have now come to the forefront and open up a new era of AA investigation (2000s). Today, AA research is actively focused

2020 Experimental Dermatology

88. Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-) organs? (Abstract)

Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-) organs? Besides their many other functions, hair shafts (HS) also are a repository for potentially noxious compounds. These are neutralized by their deposition within terminally differentiated, avital epithelial cells (trichocytes) that also facilitate the interaction of potential toxins with melanin, a toxin-adsorbent biopolymer. Trichocytes are completely extruded via HS shedding during exogen, an actively (...) controlled process. This underappreciated functional property of the human hair follicle (HF) makes it a bona fide excretory (mini-) organ. Here, we ask whether the ca. 2 million HFs of the human integument operate in part as primitive, spatially dispersed kidney-like excretory organs. Despite the many obvious differences between kidneys and HFs, this provocative hypothesis is also supported by other underappreciated renal-follicular similarities such as anatomical parallels between Bowman's capsule

2020 Experimental Dermatology

89. Immune cell regulation of the hair cycle. (Abstract)

Immune cell regulation of the hair cycle. The ability to manipulate the mammalian hair cycle will lead to novel therapies and strategies to combat all forms of alopecia. Thus, in addition to the epithelial-mesenchymal interactions in the hair follicle, niche and microenvironmental signals that accompany the phases of growth, regression and rest need to be scrutinized. Immune cells are well described in skin homeostasis and wound healing and have recently been shown to play an important role (...) in the mammalian hair cycle. In this review, we will summarize our current knowledge of the role of immune cells in hair cycle control and discuss their relevance to human hair cycling disorders. Increased attention to this aspect of the hair cycle will provide new avenues to manipulate hair regeneration in humans and provide better insight into developing better ex vivo models of hair growth.© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2020 Experimental Dermatology

90. Hair abnormality in Netherton syndrome observed under polarized light microscopy. (Abstract)

Hair abnormality in Netherton syndrome observed under polarized light microscopy. Trichorrhexis invaginata, the main diagnostic feature of Netherton syndrome, is often difficult to detect, especially in adult patients.We sought to describe a characteristic feature of hairs in Netherton syndrome using a polarized light microscope and the underlying histopathologic changes.Hairs obtained from 8 patients with Netherton syndrome were observed under polarized light, and we evaluated the correlation (...) between number of band-like patterns and disease severity.Under polarized microscopy, the hair shafts of 8 patients showed a characteristic band-like pattern under polarized light that was not observed in healthy control individuals or patients with atopic dermatitis. This discontinuity of polarized light shows a band-like pattern in which the bands mostly ranged from 0.1 to 1.0 mm in width. The observed ratio of this finding was significantly higher than that of trichorrhexis invaginata observed

2020 Journal of American Academy of Dermatology

91. Exploration of potential lipid biomarkers for premature canitiesby UPLC-QTOF-MS analyses of hair follicle roots. (Abstract)

Exploration of potential lipid biomarkers for premature canitiesby UPLC-QTOF-MS analyses of hair follicle roots. The rate of premature greying, referred to as canities, varies among populations and effective treatments are lacking.However, few studies at the molecular level have been reported.Comparing lipid profiles of individuals with premature canities and healthy volunteers to explore the mechanism of premature canities.Ultra performance liquid chromatography/quadrupole time-of-flight mass (...) spectrometry(UPLC-QTOF-MS) was used to detect lipids in the hair follicle root. Multivariate data analysis wasused to show lipid changes in follicle roots.We identified lipids in the hair follicle root that differ between black and white hair and analysed key lipids contributing to white hair development. We divided the samples into three groups: PC-WH(Premature canities-White hair), PC-PH(Premature canities-Pigmented hair), Control-PH(Pigmented hair).Phosphatidylethanolamine(PE), phosphatidylcholine(PC

2020 Experimental Dermatology

92. PPD-free hair dyes: Alternative hair dyes for patients allergic to para-phenylenediamine (PPD)

PPD-free hair dyes: Alternative hair dyes for patients allergic to para-phenylenediamine (PPD) Allergy Notes: PPD-free hair dyes: Alternative hair dyes for patients allergic to para-phenylenediamine (PPD) Allergy, Asthma and Immunology News Updated Daily by Board-certified Allergist at Cleveland Clinic Florida Pages PPD-free hair dyes: Alternative hair dyes for patients allergic to para-phenylenediamine (PPD) Para-phenylenediamine is an azo dye, most commonly used in permanent hair dyes (...) as a black dye. It is also used in black rubbers, photographic developers, fabric dyes, epoxy resin curing agents, oils and greases, and gasoline. Potential cross-reactions include preservatives of the paraben family, para-aminobenzoic acid, sulfonamides (including diuretics and diabetes agents), and benzoic acid ester group anesthetics. Even if the hair product is "PPD free", other phenylenediamine variants may cause reactions. Pure, uncontaminated Lawsonia inermis (henna tree) should not cause

2019 Allergy Notes blog

93. Hair micro transplant using follicular unit extraction technique for alopecia

Hair micro transplant using follicular unit extraction technique for alopecia Hair micro transplant using follicular unit extraction technique for alopecia Hair micro transplant using follicular unit extraction technique for alopecia Macchiavello D, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L., Hernandez Vásquez A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA (...) . No evaluation of the quality of this assessment has been made for the HTA database. Citation Macchiavello D, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L., Hernandez Vásquez A. Hair micro transplant using follicular unit extraction technique for alopecia. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Documentos de Evaluación de Tecnologías Sanitarias, Informe de Respuesta Rápida N° 444, Buenos Aires, Argentina

2015 Health Technology Assessment (HTA) Database.

94. Hair pyrrole adducts serve as biomarkers for peripheral nerve impairment induced by 2,5-hexanedione and n-hexane in rats. Full Text available with Trip Pro

Hair pyrrole adducts serve as biomarkers for peripheral nerve impairment induced by 2,5-hexanedione and n-hexane in rats. Pyrrole adducts are specific reaction products of 2,5-hexadione (2,5-HD) in vivo and are considered highly relevant to the pathogenesis of peripheral nerve impairments after exposure to n-hexane, though the exact mechanism remains unclear. In this study, 40 male Wistar rats were randomly divided into three experimental groups and one control group, in which all rat's hair (...) were shaved completely at the beginning. The rats in three experimental groups were treated with 2,5-HD by gavage at dosages of 100, 200 and 300 mg/kg per day respectively, six times per week for 8 weeks. Abnormality of gait and changes in the rota-rod latency were surveilled. Pyrrole adducts in hair, urine and serum of all rats were measured at the endpoint. Results showed that the increased pyrrole adducts in hair, urine and serum accumulated in dose-response relationship. Spearman's correlation

2018 PLoS ONE

95. Statistical resolutions for large variabilities in hair mineral analysis. Full Text available with Trip Pro

Statistical resolutions for large variabilities in hair mineral analysis. Measuring biomaterials is usually subject to error. Measurement errors are classified into either random errors or biases. Random errors can be well controlled using appropriate statistical methods. But, biases due to unknown, unobserved, or temporary causes, may lead to biased conclusions. This study describes a verification method to examine whether measurement errors are random or not and to determine efficient (...) statistical methods. A number of studies have dealt with associations between hair minerals and exposures such as health, dietary or environmental conditions. Most review papers, however, emphasize the necessity for validation of hair mineral measurements, since large variations can cause highly variable results. To address these issues, we answer the following questions: How can we ascertain the reliability of measurements?How can we assess and control the variability of measurements?How do we

2018 PLoS ONE

96. Lower allergen levels in hypoallergenic Curly Horses? A comparison among breeds by measurements of horse allergens in hair and air samples. Full Text available with Trip Pro

Lower allergen levels in hypoallergenic Curly Horses? A comparison among breeds by measurements of horse allergens in hair and air samples. Exposure to horses can cause severe allergic reactions in sensitized individuals. The breed, American Bashkir Curly Horse is categorized as hypoallergenic, primarily due to reports of allergic patients experiencing fewer symptoms while handling this special breed. The possible reasons for this phenomenon could be lower allergen production and/or reduced (...) allergen release into the air because of increased sebum content in their skin and hair compared to other breeds. Therefore, the aim of the current study was to compare different horse breeds in relation to allergen content in hair and airborne dust samples.In total, 224 hair samples from 32 different horse breeds were investigated. Personal nasal filters were used to collect airborne dust during the grooming of 20 Curly Horses and 20 Quarter Horses. Quantitative analysis of all samples was performed

2018 PLoS ONE

97. Hair cortisol concentrations in a Spanish sample of healthy adults. Full Text available with Trip Pro

Hair cortisol concentrations in a Spanish sample of healthy adults. Hair cortisol concentration (HCC), as a novel promising method to retrospectively measure hypothalamic-pituitary-adrenal (HPA) axis activation, is being increasingly studied. We tested the relationships between HCC and a range of possible confounding variables in a Spanish sample of healthy adults and pregnant women.The number of healthy adults who participated in the study was 529, being 270 males and 259 females (...) , with a combined mean age of 37.88 years (SD = 15.66). Additionally, a separate sample of 62 pregnant women was also recruited with a mean age of 32.95 (SD = 3.67), and in the first trimester of pregnancy. Each participant was interviewed before the study to obtain sociodemographic and lifestyle variables, and a hair sample was taken from the posterior vertex of the head, cut as close to the scalp as possible. Assuming the average growth rate of head hair is 1 cm per month, a 3-cm segment was analysed

2018 PLoS ONE

98. Divergent genetic mechanism leads to spiny hair in rodents. Full Text available with Trip Pro

Divergent genetic mechanism leads to spiny hair in rodents. Spines, or modified hairs, have evolved multiple times in mammals, particularly in rodents. In this study, we investigated the evolution of spines in six rodent families. We first measured and compared the morphology and physical properties of hairs between paired spiny and non-spiny sister lineages. We found two distinct hair morphologies had evolved repeatedly in spiny rodents: hairs with a grooved cross-section and a second near (...) cylindrical form. Compared to the ancestral elliptical-shaped hairs, spiny hairs had higher tension and stiffness, and overall, hairs with similar morphology had similar functional properties. To examine the genetic basis of this convergent evolution, we tested whether a single amino acid change (V370A) in the Ectodysplasin A receptor (Edar) gene is associated with spiny hair, as this substitution causes thicker and straighter hair in East Asian human populations. We found that most mammals have

2018 PLoS ONE

99. Correction: Comparing hair-morphology and molecular methods to identify fecal samples from Neotropical felids. Full Text available with Trip Pro

Correction: Comparing hair-morphology and molecular methods to identify fecal samples from Neotropical felids. [This corrects the article DOI: 10.1371/journal.pone.0184073.].

2018 PLoS ONE

100. Mycorrhizal lipochitinoligosaccharides (LCOs) depolarize root hairs of Medicago truncatula. Full Text available with Trip Pro

Mycorrhizal lipochitinoligosaccharides (LCOs) depolarize root hairs of Medicago truncatula. Arbuscular Mycorrhiza and Root Nodule Symbiosis are symbiotic interactions with a high benefit for plant growth and crop production. Thus, it is of great interest to understand the developmental process of these symbioses in detail. We analysed very early symbiotic responses of Medicago truncatula root hair cells, by stimulation with lipochitinoligosaccharides specific for the induction of nodules (Nod (...) resulted only in a single transient depolarization, indicating that Myc-LCOs can repress plasma membrane responses to Nod-LCOs. In contrast to current models, the Nod-LCO-induced depolarization precedes changes in the cytosolic Ca2+ level of root hair cells. The Nod-LCO induced membrane depolarization thus is most likely independent of cytosolic Ca2+ signals and nuclear Ca2+ spiking.

2018 PLoS ONE

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