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181. Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. (Abstract)

Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders. Background: Established procedures for mass casualty decontamination involve the deployment of equipment for showering with water (such as the ladder pipe system [LPS] and technical decontamination [TD]). This necessarily introduces a short, but critical delay. The incorporation of dry decontamination to the incident response process offers the potential to establish (...) a more rapid and timely intervention. Objectives: To investigate the effectiveness of various dry (DD) and wet decontamination strategies for removing a chemical warfare simulant (methyl salicylate; MS) from the hair and skin of human volunteers. Methods: The simulant was applied to volunteers via whole body exposure to an aerosol. Three decontamination protocols (dry, LPS and technical decontamination) were applied, singly and in various combinations. The efficacy of the protocols was evaluated

2019 Prehospital emergency care

182. SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. (Abstract)

SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy. Age-related hearing loss (AHL) is typically caused by the irreversible death of hair cells (HCs). Autophagy is a constitutive pathway to strengthen cell survival under normal or stress condition. Our previous work suggested that impaired autophagy played an important role in the development of AHL in C57BL/6 mice, although the underlying mechanism of autophagy in AHL still needs to be investigated. SIRT1

2019 Neurobiology of Aging

183. Evaluating hair growth promoting effects of candidate substance: A review of research methods. Full Text available with Trip Pro

Evaluating hair growth promoting effects of candidate substance: A review of research methods. Androgenetic alopecia (AGA) is the most common form of hair loss disorder. As the prevalence of AGA rises, the demand for AGA treatments is rising accordingly, prompting research to identify therapeutic candidates to treat AGA. Because AGA is caused by crosstalk among multiple hair follicle (HF) cell components, understanding the effects of candidate molecules on HF cells is essential to determining (...) therapeutic candidates for treatment. To date, research has centered on HF dermal papilla and outer root sheath cells and has indicated that the hair growth effects of candidate substances may be mediated via alterations in several signaling pathways and signature genes in these HF cells. In more integrative evaluations, the HF unit is used as an ex vivo organ culture model to verify the effects of therapeutic candidates. Animal models have also been used to evaluate the effects of candidate substances

2019 Journal of dermatological science

184. Assessing fractional hair cell survival in archival human temporal bones. (Abstract)

Assessing fractional hair cell survival in archival human temporal bones. Histopathological analysis of hair cell survival in human temporal bone sections has historically been binarized such that each hair cell row is rated as either present or absent, thereby greatly underestimating the amount of hair cell loss. Here, we describe and validate a technique to reliably assess fractional hair cell survival in archival sections stained with hematoxylin and eosin (H&E) using high-resolution light (...) microscopy and optical sectioning.Technique validation.Hair cell counts in archival temporal bone slide sets were performed by several observers using either differential interference contrast (DIC) or confocal microscopy of the endogenous eosin fluorescence in hair cells. As a further cross-check, additional decelloidinized sections were immunostained with hair cell markers myosin VI and VIIa.Cuticular plates and stereocilia bundles are routinely resolvable in DIC imaging of archival H&E-stained human

2019 Laryngoscope

185. Deletion of Brg1 causes stereocilia bundle fusion and cuticular plate loss in vestibular hair cells. (Abstract)

Deletion of Brg1 causes stereocilia bundle fusion and cuticular plate loss in vestibular hair cells. Brg1 is an ATPase subunit of the SWI/SNF chromatin-remodeling complex, and it is indispensable for the development and homeostasis of various organs. Conditional deletion of Brg1 in cochlea hair cells (HCs) leads to multiple structural defects and profound deafness. However, the premature death of Brg1-deficient cochlea HCs hindered further study of the role of Brg1. In contrast to cochlea HCs

2019 Hearing Research

186. In vivo and in vitro evaluation of hair growth potential of Cacumen Platycladi, and GC-MS analysis of the active constituents of volatile oil. (Abstract)

In vivo and in vitro evaluation of hair growth potential of Cacumen Platycladi, and GC-MS analysis of the active constituents of volatile oil. Cacumen Platycladi (CP) is the leaves of Platycladus orientalis which has been traditionally used to resist alopecia and promote hair growth. However, no study has been reported on the effects of CP on proliferation of dermal papilla cells (DPCs). And there is also no complete and systematic research on hair re-growth efficacies of CP.To evaluate (...) the hair-growth activity of their extracts on the proliferation of DPCs and the promotion of hair reproduction in C57BL/6 mice.For the DPCs, different extract fractions of CP were investigated. The hair growth effect of CP volatile oil on C57BL/6 mice was evaluated for 28 days. Meanwhile, the chemical constituents of the volatile oil from Cacumen Platycladi were isolated and identified by GC-MS.The study showed that the extracts of CP could promote the proliferation of DPCs, and the activity

2019 Journal of Ethnopharmacology

187. Postzygotic HRAS mutation in heterochromia of straight scalp hair. (Abstract)

Postzygotic HRAS mutation in heterochromia of straight scalp hair. The growth of hair of two distinct colors in one person is a well-described phenomenon defined as heterochromia of the scalp. We studied one case with heterochromia of straight scalp hair associated with a keratinocytic epidermal nevus. Samples from lesional skin were obtained for histopathological evaluation and for DNA isolation. DNA from hair bulbs and from buccal mucosa was also isolated and molecularly analyzed. We (...) performed HRAS, NRAS and KRAS mutational analysis by Sanger sequencing using DNA from different tissues, including nevus, hair bulbs and buccal mucosa of the patient. We disclosed the HRAS heterozygous pathogenic variant c.34G>A, p.Gly12Ser in DNA from lesional skin, blond hair and, at a low level, in the mucosa of the left cheek. The mutation was not present in DNA extracted from the right oral mucosa and in normal dark colored hair. No mutations were found in NRAS or KRAS. Thus, in the present case

2019 British Journal of Dermatology

188. Hair loss among transgender and gender-nonbinary patients: a cross-sectional study. (Abstract)

Hair loss among transgender and gender-nonbinary patients: a cross-sectional study. As facial, scalp, and body hair are closely linked to gender expression and perception, hair concerns represent important considerations in gender minority patients. Diagnosis and subsequent treatment of hair conditions in this population require an understanding of gender affirming hormones, which include both masculinizing hormone therapy (MHT, i.e. testosterone use) and feminizing hormone therapy (FHT, i.e (...) . estrogen and antiandrogen use).1 Testosterone has been found to induce androgenetic alopecia (AGA) in roughly two-thirds of transmen, while estrogen/antiandrogens have been shown to increase scalp hair density in transwomen in limited case reports.2,3 In this cross-sectional study, we sought to capture the frequency of scalp hair loss and its relation to gender affirming hormone use in gender minority patients. This article is protected by copyright. All rights reserved.This article is protected

2019 British Journal of Dermatology

189. Current Approach to the Evaluation and Management of Hair-Thread Tourniquets. (Abstract)

Current Approach to the Evaluation and Management of Hair-Thread Tourniquets. Hair-thread tourniquet syndrome is a rare, painful condition that occurs when a strand of hair or thread becomes wrapped around toes, fingers, or other appendages. This causes focal edema, which eventually reduces arterial blood flow and can lead to ischemia and necrosis. A thorough physical examination and assessment of risk factors are important. Treatment involves depilatory agents or targeted incision

2019 Pediatric Emergency Care

190. Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: the case of henna-based hair coloring products containing p-phenylenediamine. (Abstract)

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: the case of henna-based hair coloring products containing p-phenylenediamine. Allergic contact dermatitis reported to henna-based hair coloring products (HPs) has been associated with adulteration of henna with p-phenylenediamine (PPD).To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway (...) to evaluate allergenic potential of HPs.The following in vitro assays were used to test the sensitizing capacity of hair dye ingredients: micro-direct peptide reactivity assay (mDPRA); HaCaT keratinocytes-associated IL-18 assay; U937 cell line activation test (USENS)/IL-8 levels; blood monocyte-derived dendritic cell test; genomic allergen rapid detection (GARD skin). Those techniques with better human concordance were selected to evaluate the allergenic potential of ten HPs.Contrasting to the label's

2019 Contact Dermatitis

191. Serum long-chain omega-3 fatty acids, hair mercury and exercise-induced myocardial ischaemia in men. (Abstract)

Serum long-chain omega-3 fatty acids, hair mercury and exercise-induced myocardial ischaemia in men. Long-chain omega-3 polyunsaturated fatty acids (PUFA) from fish have been inversely associated with coronary heart disease (CHD) risk. Fish may also contain methylmercury, which has been associated with higher CHD risk and may diminish the cardioprotective effect of long-chain omega-3 PUFA. We investigated the associations of serum long-chain omega-3 PUFA and hair mercury with the odds (...) % lower odds of myocardial ischaemia (OR 0.67, 95% CI 0.51 to 0.87, p-trend=0.006). The association was stronger among those with CHD history (OR 0.10, 95% CI 0.03 to 0.39, p-trend <0.001), than among those without (OR 0.80, 95% CI 0.57 to 1.12, p-trend=0.17) (p-interaction=0.01). Higher hair mercury concentration was associated with increased odds for myocardial ischaemia in the entire population (OR 1.62, 95% CI 1.22 to 2.14, p-trend=0.002).Higher circulating concentrations of the long-chain omega-3

2019 Heart

192. High naevus count and MC1R red hair alleles contribute synergistically to increased melanoma risk. Full Text available with Trip Pro

High naevus count and MC1R red hair alleles contribute synergistically to increased melanoma risk. A high total body naevus count is the highest risk factor for melanoma; the red hair colour phenotype of red hair, freckling and pale skin that burns easily, produced by MC1R R alleles, also predisposes to melanoma.To determine whether the known melanoma risk factors of high naevus count and red hair or MC1R R alleles act synergistically to increase melanoma risk.The Brisbane Naevus Morphology (...) to individuals with dark brown hair and 0-4 naevi, individuals with red hair and 20+ naevi had a melanoma OR 10·0 (95%CI 4·2-24·3). Individuals with MC1R R/R genotype and 20+ naevi ≥5mm had a melanoma OR 25·1 (95%CI 8·4-82·7) compared to WT/WT individuals with 0-4 naevi. The highest risk group, Australian men with MC1R R/R genotype and 20+ moles, had an absolute risk of melanoma to age 75 of 23·3%, compared to 0·8% for men with WT/WT genotype and 0-4 naevi.Patients living in a high incident UV setting

2019 British Journal of Dermatology

193. Cysteinyl-tRNA Synthetase Mutations Cause a Multi-System, Recessive Disease That Includes Microcephaly, Developmental Delay, and Brittle Hair and Nails. Full Text available with Trip Pro

Cysteinyl-tRNA Synthetase Mutations Cause a Multi-System, Recessive Disease That Includes Microcephaly, Developmental Delay, and Brittle Hair and Nails. Aminoacyl-tRNA synthetases (ARSs) are essential enzymes responsible for charging tRNA molecules with cognate amino acids. Consistent with the essential function and ubiquitous expression of ARSs, mutations in 32 of the 37 ARS-encoding loci cause severe, early-onset recessive phenotypes. Previous genetic and functional data suggest a loss (...) -of-function mechanism; however, our understanding of the allelic and locus heterogeneity of ARS-related disease is incomplete. Cysteinyl-tRNA synthetase (CARS) encodes the enzyme that charges tRNACys with cysteine in the cytoplasm. To date, CARS variants have not been implicated in any human disease phenotype. Here, we report on four subjects from three families with complex syndromes that include microcephaly, developmental delay, and brittle hair and nails. Each affected person carries bi-allelic CARS

2019 American Journal of Human Genetics

194. Frontal hairline lowering with hair transplantation in Asian women with high foreheads. (Abstract)

Frontal hairline lowering with hair transplantation in Asian women with high foreheads. People with high forehead may suffer substantially from feelings of inferiority related to facial appearance. A high forehead can make the face appear longer, larger, and even older.The study included a total of 89 patients with a chief complaint of high forehead who underwent hair transplantation to lower the frontal hairline. A five-point Likert scale was used to assess the subjective satisfaction scores (...) of patients and the objective satisfaction score of the surgeon (1: very unsatisfactory, 2: unsatisfactory, 3: average, 4: satisfactory, 5: very satisfactory). Medical charts and photographs were also reviewed.No specific postoperative complications occurred, such as folliculitis, cyst, or facial asymmetry. The average subjective satisfaction score as assessed by patients was 4.2; the average objective satisfaction score as assessed by the surgeon was 4.3.Frontal hairline lowering with hair

2019 International Journal of Dermatology

195. Hypoxia Improves Hair Inductivity of Dermal Papilla Cells via Nuclear NADPH Oxidase 4-Mediated Reactive Oxygen Species Generation. (Abstract)

Hypoxia Improves Hair Inductivity of Dermal Papilla Cells via Nuclear NADPH Oxidase 4-Mediated Reactive Oxygen Species Generation. Dermal papilla cells (DPCs) play a key role in hair regeneration and morphogenesis. Therefore, tremendous efforts have been made to promote DPCs' hair inductivity OBJECTIVES: The aim of this study was to investigate the mitogenic and hair inductive effects of hypoxia on DPCs and examine the underlying mechanism of hypoxia-induced stimulation of DPCs.Hypoxia (...) significantly increased the proliferation and delayed the senescence of DPCs via Akt phosphorylation and downstream pathways. Hypoxia upregulated the growth factor secretion of DPCs through mitogen-activated protein kinase pathway. Hypoxia-preconditioned DPCs induced the telogen-to-anagen transition in C3 H mice, and also enhanced hair neogenesis in a hair reconstitution assay. Injected GFP-labeled DPCs migrated to outer-root sheath of hair follicle, and hypoxia-preconditioning increased the survival

2019 British Journal of Dermatology

196. Skin equivalent assay: an optimized method for testing for hair growth reconstitution capacity of epidermal and dermal cells. (Abstract)

Skin equivalent assay: an optimized method for testing for hair growth reconstitution capacity of epidermal and dermal cells. Hair follicle reconstitution requires highly organized epithelial-mesenchymal interactions. Skin equivalents containing the epidermal and dermal cells with hair reconstitution capacity can reproduce these processes, but have not been established. This study was conducted to develop a hair follicle-producing three-dimensional (3D) skin equivalent assay using neonate mouse (...) . Six weeks after grafting, regenerated hair follicles were analysed. Our 3D skin equivalent culture assay reproducibly regenerated hair follicles, while MDCs precultured in the 2D model with MECs did not. Compared to the chamber assay, which produced randomly oriented hair follicles, nearly all regenerated hair follicles in our assay extruded through the skin and numerous regenerated hair follicles were higher than those in the chamber assay. Several representative genes associated with hair

2019 Experimental Dermatology

197. Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. (Abstract)

Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. The neural diathesis-stress model is useful to understand schizophrenia (SZ) and bipolar (BD) disorders. Childhood maltreatment could affect the Hypothalamic-Pituitary-Adrenal (HPA)-axis and lead to chronic changes in stress-sensitivity, which can be measured with hair cortisol concentrations (HCC), representing long-term, cumulative cortisol levels. Here we

2019 Schizophrenia Research

198. Laser hair removal for prevention of pilonidal sinus recurrence

Laser hair removal for prevention of pilonidal sinus recurrence Laser hair removal for prevention of pilonidal sinus recurrence Laser hair removal for prevention of pilonidal sinus recurrence Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Laser hair removal for prevention of pilonidal sinus recurrence. Lansdale: HAYES, Inc.. Healthcare Technology Brief (...) Publication. 2014 Authors' conclusions Pilonidal disease is a pathologic condition characterized by at least 1 abnormal pocket (sinus) or cyst located under the skin and filled with hair and skin debris. It is an acquired condition related to the presence of hair in the natal cleft, caused either by a reaction to loose hair that has penetrated and embedded in the skin or a reaction to a rupture of a hair follicle that may occur with stretching of the deep layers of skin or with the hormone-induced changes

2014 Health Technology Assessment (HTA) Database.

199. Hair Measurements of Cortisol, DHEA, and DHEA to Cortisol Ratio as Biomarkers of Chronic Stress among People Living with HIV in China: Known-Group Validation. Full Text available with Trip Pro

Hair Measurements of Cortisol, DHEA, and DHEA to Cortisol Ratio as Biomarkers of Chronic Stress among People Living with HIV in China: Known-Group Validation. Existing literature suggests that endocrine measures, including the steroid hormones of cortisol and Dehydroepiandrosterone (DHEA), as well as the DHEA to cortisol ratio in the human hair can be used as promising biomarkers of chronic stress among humans. However, data are limited regarding the validity of these measures as biomarkers (...) of chronic stress among people living with HIV (PLWH), whose endocrine system or hypothalamic pituitary adrenal (HPA) axis may be affected by HIV infection and/or antiretroviral therapy (ART) medications.Using hair sample data and self-reported survey from 60 PLWH in China, we examined the validity of three endocrine measures among Chinese PLWH using a known-groups validation strategy. High-stress group (n = 30) and low-stress group (n = 30) of PLWH were recruited through individual assessment interviews

2017 PLoS ONE

200. A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat. Full Text available with Trip Pro

A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat. The Yangtze River Delta White Goat is the only goat breed that produces high-quality brush hair, or type III hair, which is specialized for use in top-grade writing brushes. There has been little research, especially molecular research, on the traits that result in high-quality brush hair in the Yangtze River Delta White Goat. To explore the molecular mechanisms of the formation (...) of high-quality brush hair, High-throughput RNA-Seq technology was used to compare skin samples from Yangtze River Delta White Goats that produce high-quality hair and non high-quality hair for identification of the important genes and related pathways that might influence the hair quality traits. The results showed that 295 genes were expressed differentially between the goats with higher and lower hair quality, respectively. Of those genes, 132 were up-regulated, 62 were down-regulated, and 101 were

2017 PLoS ONE

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