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1. Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres. (Abstract)

Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres. Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP-derived Exos, especially those from three-dimensional (3D)-cultured DP cells, affect hair growth (...) , cycling and regeneration. Exos derived from 3D DP (3D DP-Exos) promoted the proliferation of DP cells and outer root sheath (ORS) cells and increased the expression of growth factors (IGF-1, KGF and HGF) in DP cells. 3D DP-Exo treatment also increased hair shaft elongation in cultured human hair follicles. In addition, local injections of 3D DP-Exos induced anagen from telogen and also prolonged anagen in mice. Moreover, Exo treatment in human DP spheres augmented hair follicle neogenesis when the DP

2019 Experimental Dermatology

2. What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol. Full Text available with Trip Pro

What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol. Hair is an emerging biological matrix in which to measure chronic HPA axis activity, offering a longer term view into an animal's life. We explored effects of exogenous (e.g. lifestyle, medications, social environment) and endogenous (e.g. disease, behaviour) stressors on hair cortisol concentration (HCC) in a population of Border Collies (BCs). Owners of BCs were recruited (...) and reported their dog's lifestyle, clinical history, anxiety-related behaviour, and collected a white hair sample from their dog's dorsal neck region. HCC was determined using established methods with a commercial cortisol assay kit. Samples from 135 BCs were analysed, with 91 healthy controls and 44 diagnosed with epilepsy as a model disease. Factors associated with higher HCC included psychosocial stressors (living with three or more other dogs) and lifestyle (engaging in competitive flyball); while

2019 PLoS ONE

3. Getting under the skin of hair aging: the impact of the hair follicle environment. Full Text available with Trip Pro

Getting under the skin of hair aging: the impact of the hair follicle environment. Like the skin, our hair shows striking changes with age, producing hairs with altered diameter, lustre, and texture. The biology of hair aging has focused predominately on various aspects of the hair cycle, follicle size, and the fibre produced, but surprisingly the impact of the aging scalp dermal environment on the hair follicle and fibre has been generally overlooked. Hair loss affects both sexes (...) with incidence increasing with age. In men, male pattern-balding (androgenetic alopecia) is driven by androgens and follows a specific pattern of frontotemporal and vertex regression. Women also experience female pattern hair loss (FPHL), presenting as more general, diffuse hair thinning. Hair thinning in women is commonly associated with the menopause, corresponding with other age-related changes in skin. The rapidly growing hair follicle undergoes continued renewal throughout the life span of an individual

2020 Experimental Dermatology

4. Why is hair curly?-Deductions from the structure and the biomechanics of the mature hair shaft. Full Text available with Trip Pro

Why is hair curly?-Deductions from the structure and the biomechanics of the mature hair shaft. The final shape of a head hair is predetermined through a variety of factors during its formation in the follicle. These are genetic pathways, specific growth factors, cell differentiation and segregation, etc, with spatial as well as chronological dynamics. The cortex of hair consists of two major cell groups. These are characterized by parallel (para-type) or roughly helical arrangements (ortho (...) in the transition zone of the follicle, that is, upon formation of the mature hair shaft. Furthermore, an irregular, "flat" cross section of the hair shaft is shown to be a synergistic but not determining factor of curl formation. The degree of cell type segregation along the mature hair shaft together with dynamic changes of the location of the plane of segregation, namely in a non-circular cross section can account for very complex curl patterns. Against the background of these views, we argue

2020 Experimental Dermatology

7. Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal

Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal Rapid Synthesis Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal 6 November 2018 McMaster Health Forum 1 Evidence >> Insight >> Action Rapid Synthesis: Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal 10-day response 6 November 2018 Identifying Policies, Financial Support (...) and Professional Regulations for Medically Necessary Hair Removal 2 Evidence >> Insight >> Action McMaster Health Forum The McMaster Health Forum’s goal is to generate action on the pressing health-system issues of our time, based on the best available research evidence and systematically elicited citizen values and stakeholder insights. We aim to strengthen health systems – locally, nationally, and internationally – and get the right programs, services and drugs to the people who need them. Authors Puru

2018 McMaster Health Forum

8. Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes

Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes - GOV.UK GOV.UK uses cookies to make the site simpler. Search Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes Pharmacists (...) should tell people about the risk of fire when they discuss head lice eradication options. Published 8 March 2018 From: Therapeutic area: , Contents Advice to pharmacists some products for the eradication of head lice infestations are combustible/flammable when on the hair and can ignite and cause serious harm in the presence of an open flame or other source of ignition such as when lighting cigarettes advise parents, caregivers and the person with head lice, if appropriate, that they should

2018 MHRA Drug Safety Update

9. Excessive hair growth: certain drugs implicated

Excessive hair growth: certain drugs implicated Prescrire IN ENGLISH - Spotlight ''Excessive hair growth: certain drugs implicated'', 1 May 2017 {1} {1} {1} | | > > > Excessive hair growth: certain drugs implicated Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Excessive hair growth: certain drugs implicated Some drugs expose patients (...) to excessive hair growth, which is usually reversible when treatment is discontinued. Hypertrichosis in a man or woman is characterised by an abnormal amount of hair growth on all or part of the body, usually in the form of down, and hirsutism is the growth of male hair in areas normally hairless in women (face, neck, chest, area between the pubis and navel, buttocks). Excessive hair growth can cause embarrassment, which is subjective and influenced by social, cultural and personal notions, exposing

2017 Prescrire

10. Hair distribution width - a novel trichoscopy parameter for hair miniaturization in androgenetic alopecia. (Abstract)

Hair distribution width - a novel trichoscopy parameter for hair miniaturization in androgenetic alopecia. Androgenetic alopecia (AGA) is characterized by progressive miniaturization of hair follicles on the scalp from terminal (≥30 μm)to vellus (≥30 μm) types [1]. Under trichoscopy, hair shaft diameter variation (HSDV) is defined as the percentage of vellus hair shafts within a region of interest. HSDV>20% is characteristic of AGA and is considered as a reliable means of assessing

2019 Journal of the European Academy of Dermatology and Venereology

11. Cholesterol homeostasis: links to hair follicle biology and hair disorders. Full Text available with Trip Pro

Cholesterol homeostasis: links to hair follicle biology and hair disorders. Lipids and lipid metabolism are critical factors in hair follicle (HF) biology and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms (...) by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remains largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies

2019 Experimental Dermatology

12. Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. Full Text available with Trip Pro

Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. Human skin progenitor cells will form new hair follicles, although at a low efficiency, when injected into nude mouse skin. To better study and improve upon this regenerative process, we developed an in vitro system to analyze the morphogenetic cell behavior in detail and modulate physical-chemical (...) parameters to more effectively generate hair primordia. In this three-dimensional culture, dissociated human neonatal foreskin keratinocytes self-assembled into a planar epidermal layer while fetal scalp dermal cells coalesced into stripes, then large clusters, and finally small clusters resembling dermal condensations. At sites of dermal clustering, subjacent epidermal cells protruded to form hair peg-like structures, molecularly resembling hair pegs within the sequence of follicular development

2019 Experimental Dermatology

13. Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle-dependent manner. (Abstract)

Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle-dependent manner. The dermal papilla (DP) is one of two principal mesenchymal compartments of the hair follicle (HF). We previously reported that a population of HF dermal stem cells (hfDSCs) function to regenerate the dermal sheath (DS), but intriguingly also contribute new cells to the adult DP at the onset of anagen hair growth to maintain normal cycling of HFs and support the production of large hair fibres (...) . Here, we asked whether injury altered the behaviour of hfDSCs and their progeny in order to support wound-induced hair growth (WIHG) and if the response was modulated by hair cycle stage. αSMACreERT2 :ROSAYFP mice received tamoxifen to label the DS, including hfDSCs. Full-thickness excisions were made on the dorsal skin during various stages of the hair cycle. The skin was harvested at the subsequent anagen. Interestingly, there was an increase in the magnitude of recruitment of hfDSC progeny

2019 Experimental Dermatology

14. Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter Full Text available with Trip Pro

Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter Female pattern hair loss (FPHL) is a common hair disease. However, studies of the quantitative measurement of FPHL are still limited. The aim of this study was to investigate the characteristics of hair density and hair diameter in normal women and FPHL patients, and further correlate the quantitative measurement with the clinical presentation of FPHL.An evaluation of 471 FPHL (...) patients and 236 normal women was carried out according to the Ludwig classification, and analysis was performed by using a com-puterized handheld USB camera with computer-assisted software. Various areas of the scalp, including frontal, parietal, midscalp, and occipital, were analyzed for hair density, non-vellus hair diameter, and percentage of miniaturized hair.The hair density in normal women was the highest and the lowest in the midscalp and parietal areas, respectively. The FPHL group revealed

2017 Clinical, cosmetic and investigational dermatology

15. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling Full Text available with Trip Pro

FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused (...) on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector.BALB/c mice with telogen or plucking-induced anagen HFs were exposed to total body irradiation with γ-rays at 4 to 12 Gy after intraperitoneal treatment with FGF18 or an FGF receptor inhibitor. A time course analysis was performed histologically and hair growth was observed 14 or 15 days after depilation. Skin specimens were analyzed by DNA microarrays and Western blotting.Telogen irradiation at 6 Gy

2016 Advances in radiation oncology

16. Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias Full Text available with Trip Pro

Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias Cortisol concentrations in hair are used to create hormone profiles spanning months. This method allows assessment of chronic cortisol exposure, but might be biased by hair pigmentation: dark hair was previously related to higher concentrations. It is unclear whether this association arises from local effects, such as increased hormone extractability, or whether the association represents systemic (...) differences arising from population stratification. We tested the hypothesis that hair pigmentation gene variants are associated with varying cortisol levels independent of genetic ancestry. Hormone concentrations and genotype were measured in 1674 children from the Generation R cohort at age 6. We computed a polygenic score of hair color based on 9 single nucleotide polymorphisms. This score was used to predict hair cortisol concentrations, adjusted for genetic ancestry, sex, age and corticosteroid use

2017 Scientific reports

17. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. (Abstract)

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. Alopecia is divided into two categories: androgenic alopecia and nonandrogenic alopecia. An androgen-dependent abnormality of biological functions causes alopecia in males, but the role of androgens is not yet elucidated in female pattern hair loss (FPHL). Modulation of androgenic activity is not effective in certain kinds (...) of androgenic alopecia in females, as well as in cases of nonandrogenic alopecia in males and females. The hair growth drug, minoxidil, stimulates vascular endothelial growth factor (VEGF) production as well as vascularization and hair growth in females. Yet, because minoxidil has side effects with long-term use, a safe alternative hair growth agent is needed. Whereas hair develops after birth in mammalian species, hair mostly grows in a precocial bird, in the chicken, between hatching days 14 and 15

2018 Journal of medicinal food Controlled trial quality: uncertain

18. A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair. (Abstract)

A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair. Hair loss is a complex problem that generates significant concern for those who are affected. Patients seeking medical treatments have limited options, and are increasingly turning to natural therapies. A novel nutraceutical product containing a proprietary Synergen Complex® composed of standardized (...) , active botanicals with potent anti-inflammatory, adaptogenic (anti-stress), antioxidant, and dihydrotestosterone-inhibiting properties has been developed to improve hair growth and hair quality. The objective of this 6-month randomized, double-blind, placebo-controlled study was to assess the ability of this oral supplement (Nutrafol® Women's Capsules) to strengthen and promote the growth of hair in adult women with self-perceived thinning. Enrolled subjects were randomized to receive active

2018 Journal of drugs in dermatology : JDD Controlled trial quality: predicted high

19. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity. (Abstract)

Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity. To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function.A uniquely designed 24-week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (ZPT) antidandruff shampoo or a placebo cosmetic shampoo (...) . This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff/seborrheic dermatitis (D/SD) population. Two complementary methods were used to characterize the integrity of the cuticular surface. Hair surface hydrophobicity was assessed by quantifying water wetting force using a Wilhelmy balance method. Surface structure and porosity were assessed using dynamic vapor sorption (DVS) to gravimetrically quantify

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

20. Association of Hair Loss With Health Utility Measurements Before and After Hair Transplant Surgery in Men and Women. Full Text available with Trip Pro

Association of Hair Loss With Health Utility Measurements Before and After Hair Transplant Surgery in Men and Women. Androgenetic alopecia is a highly prevalent condition across both sexes and can be surgically corrected through hair transplant. Health utility scores, which represent quantitative estimates of individual preferences for a given state of health, are a measure of health-related quality of life. The health utility scores for sex-specific alopecia and the posttransplant state have (...) not previously been quantified.To obtain health utility measurements for the objective assessment of sex-specific alopecia and hair transplant surgery and to analyze layperson perception of alopecia compared with other chronic health conditions.A prospective clinical study was conducted from August 1 to December 31, 2017, at the Harvard Decision Science Laboratory. Adult casual observers (n = 308) completed an internet-based health utility questionnaire. Health states were presented using still patient

2018 JAMA facial plastic surgery

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