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1. Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres. (PubMed)

Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres. Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP-derived Exos, especially those from three-dimensional (3D)-cultured DP cells, affect hair growth (...) , cycling and regeneration. Exos derived from 3D DP (3D DP-Exos) promoted the proliferation of DP cells and outer root sheath (ORS) cells and increased the expression of growth factors (IGF-1, KGF and HGF) in DP cells. 3D DP-Exo treatment also increased hair shaft elongation in cultured human hair follicles. In addition, local injections of 3D DP-Exos induced anagen from telogen and also prolonged anagen in mice. Moreover, Exo treatment in human DP spheres augmented hair follicle neogenesis when the DP

2019 Experimental Dermatology

2. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling (PubMed)

FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused (...) on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector.BALB/c mice with telogen or plucking-induced anagen HFs were exposed to total body irradiation with γ-rays at 4 to 12 Gy after intraperitoneal treatment with FGF18 or an FGF receptor inhibitor. A time course analysis was performed histologically and hair growth was observed 14 or 15 days after depilation. Skin specimens were analyzed by DNA microarrays and Western blotting.Telogen irradiation at 6 Gy

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2016 Advances in radiation oncology

5. Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal

Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal Rapid Synthesis Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal 6 November 2018 McMaster Health Forum 1 Evidence >> Insight >> Action Rapid Synthesis: Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal 10-day response 6 November 2018 Identifying Policies, Financial Support (...) and Professional Regulations for Medically Necessary Hair Removal 2 Evidence >> Insight >> Action McMaster Health Forum The McMaster Health Forum’s goal is to generate action on the pressing health-system issues of our time, based on the best available research evidence and systematically elicited citizen values and stakeholder insights. We aim to strengthen health systems – locally, nationally, and internationally – and get the right programs, services and drugs to the people who need them. Authors Puru

2018 McMaster Health Forum

6. Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. (PubMed)

Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. Human skin progenitor cells will form new hair follicles, although at a low efficiency, when injected into nude mouse skin. To better study and improve upon this regenerative process, we developed an in vitro system to analyze the morphogenetic cell behavior in detail and modulate physical-chemical (...) parameters to more effectively generate hair primordia. In this three-dimensional culture, dissociated human neonatal foreskin keratinocytes self-assembled into a planar epidermal layer while fetal scalp dermal cells coalesced into stripes, then large clusters, and finally small clusters resembling dermal condensations. At sites of dermal clustering, subjacent epidermal cells protruded to form hair peg-like structures, molecularly resembling hair pegs within the sequence of follicular development

2019 Experimental Dermatology

7. Hair distribution width - a novel trichoscopy parameter for hair miniaturization in androgenetic alopecia. (PubMed)

Hair distribution width - a novel trichoscopy parameter for hair miniaturization in androgenetic alopecia. Androgenetic alopecia (AGA) is characterized by progressive miniaturization of hair follicles on the scalp from terminal (≥30 μm)to vellus (≥30 μm) types [1]. Under trichoscopy, hair shaft diameter variation (HSDV) is defined as the percentage of vellus hair shafts within a region of interest. HSDV>20% is characteristic of AGA and is considered as a reliable means of assessing

2019 Journal of the European Academy of Dermatology and Venereology

8. Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle-dependent manner. (PubMed)

Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle-dependent manner. The dermal papilla (DP) is one of two principal mesenchymal compartments of the hair follicle (HF). We previously reported that a population of HF dermal stem cells (hfDSCs) function to regenerate the dermal sheath (DS), but intriguingly also contribute new cells to the adult DP at the onset of anagen hair growth to maintain normal cycling of HFs and support the production of large hair fibres (...) . Here, we asked whether injury altered the behaviour of hfDSCs and their progeny in order to support wound-induced hair growth (WIHG) and if the response was modulated by hair cycle stage. αSMACreERT2 :ROSAYFP mice received tamoxifen to label the DS, including hfDSCs. Full-thickness excisions were made on the dorsal skin during various stages of the hair cycle. The skin was harvested at the subsequent anagen. Interestingly, there was an increase in the magnitude of recruitment of hfDSC progeny

2019 Experimental Dermatology

9. Excessive hair growth: certain drugs implicated

Excessive hair growth: certain drugs implicated Prescrire IN ENGLISH - Spotlight ''Excessive hair growth: certain drugs implicated'', 1 May 2017 {1} {1} {1} | | > > > Excessive hair growth: certain drugs implicated Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Excessive hair growth: certain drugs implicated Some drugs expose patients (...) to excessive hair growth, which is usually reversible when treatment is discontinued. Hypertrichosis in a man or woman is characterised by an abnormal amount of hair growth on all or part of the body, usually in the form of down, and hirsutism is the growth of male hair in areas normally hairless in women (face, neck, chest, area between the pubis and navel, buttocks). Excessive hair growth can cause embarrassment, which is subjective and influenced by social, cultural and personal notions, exposing

2017 Prescrire

10. Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter (PubMed)

Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter Female pattern hair loss (FPHL) is a common hair disease. However, studies of the quantitative measurement of FPHL are still limited. The aim of this study was to investigate the characteristics of hair density and hair diameter in normal women and FPHL patients, and further correlate the quantitative measurement with the clinical presentation of FPHL.An evaluation of 471 FPHL (...) patients and 236 normal women was carried out according to the Ludwig classification, and analysis was performed by using a com-puterized handheld USB camera with computer-assisted software. Various areas of the scalp, including frontal, parietal, midscalp, and occipital, were analyzed for hair density, non-vellus hair diameter, and percentage of miniaturized hair.The hair density in normal women was the highest and the lowest in the midscalp and parietal areas, respectively. The FPHL group revealed

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2017 Clinical, cosmetic and investigational dermatology

11. Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias (PubMed)

Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias Cortisol concentrations in hair are used to create hormone profiles spanning months. This method allows assessment of chronic cortisol exposure, but might be biased by hair pigmentation: dark hair was previously related to higher concentrations. It is unclear whether this association arises from local effects, such as increased hormone extractability, or whether the association represents systemic (...) differences arising from population stratification. We tested the hypothesis that hair pigmentation gene variants are associated with varying cortisol levels independent of genetic ancestry. Hormone concentrations and genotype were measured in 1674 children from the Generation R cohort at age 6. We computed a polygenic score of hair color based on 9 single nucleotide polymorphisms. This score was used to predict hair cortisol concentrations, adjusted for genetic ancestry, sex, age and corticosteroid use

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2017 Scientific reports

12. Interventions for female pattern hair loss. (PubMed)

Interventions for female pattern hair loss. Female pattern hair loss (FPHL), or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and progressive follicular miniaturisation with conversion of terminal to vellus hair follicles (terminal hairs are thicker and longer, while vellus hairs are soft, fine, and short). The frontal hair line may or may (...) not be preserved. Hair loss can have a serious psychological impact on women.To determine the efficacy and safety of the available options for the treatment of female pattern hair loss in women.We updated our searches of the following databases to July 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (2015, Issue 6), MEDLINE (from 1946), EMBASE (from 1974), PsycINFO (from 1872), AMED (from 1985), LILACS (from 1982), PubMed (from 1947), and Web of Science (from 1945). We also

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2016 Cochrane

13. Health status by gender, hair color, and eye color: Red-haired women are the most divergent. (PubMed)

Health status by gender, hair color, and eye color: Red-haired women are the most divergent. Red hair is associated in women with pain sensitivity. This medical condition, and perhaps others, seems facilitated by the combination of being red-haired and female. We tested this hypothesis by questioning a large sample of Czech and Slovak respondents about the natural redness and darkness of their hair, their natural eye color, their physical and mental health (24 categories), and other personal (...) attributes (height, weight, number of children, lifelong number of sexual partners, frequency of smoking). Red-haired women did worse than other women in ten health categories and better in only three, being particularly prone to colorectal, cervical, uterine, and ovarian cancer. Red-haired men showed a balanced pattern, doing better than other men in three health categories and worse in three. Number of children was the only category where both male and female redheads did better than other respondents

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2017 PLoS ONE

14. Geometric classification of scalp hair for valid drug testing, 6 more reliable than 8 hair curl groups. (PubMed)

Geometric classification of scalp hair for valid drug testing, 6 more reliable than 8 hair curl groups. Curly hair is reported to contain higher lipid content than straight hair, which may influence incorporation of lipid soluble drugs. The use of race to describe hair curl variation (Asian, Caucasian and African) is unscientific yet common in medical literature (including reports of drug levels in hair). This study investigated the reliability of a geometric classification of hair (based on 3 (...) measurements: the curve diameter, curl index and number of waves).After ethical approval and informed consent, proximal virgin (6cm) hair sampled from the vertex of scalp in 48 healthy volunteers were evaluated. Three raters each scored hairs from 48 volunteers at two occasions each for the 8 and 6-group classifications. One rater applied the 6-group classification to 80 additional volunteers in order to further confirm the reliability of this system. The Kappa statistic was used to assess intra and inter

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2017 PLoS ONE

15. Drug-related hair loss: not only anti-cancer medication

Drug-related hair loss: not only anti-cancer medication Prescrire IN ENGLISH - Spotlight ''Drug-related hair loss: not only anti-cancer medication '', 1 May 2016 {1} {1} {1} | | > > > Drug-related hair loss: not only anti-cancer medication Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Drug-related hair loss: not only anti-cancer medication Hair (...) loss can sometimes have a profound psychological impact. It is linked to a wide range of causes, including medication, and not only anti-cancer drugs. Hair loss, both temporary and permanent, diffuse or localised, sudden or gradual, is a frequent cause for complaint. It can sometimes have a profound psychological impact. Hair loss is observed in a number of situations: hormonal disorders, dietary deficiency, auto-immune diseases, infections, inflammation, psychological or emotional trauma, tumours

2016 Prescrire

16. A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair. (PubMed)

A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair. Hair loss is a complex problem that generates significant concern for those who are affected. Patients seeking medical treatments have limited options, and are increasingly turning to natural therapies. A novel nutraceutical product containing a proprietary Synergen Complex® composed of standardized (...) , active botanicals with potent anti-inflammatory, adaptogenic (anti-stress), antioxidant, and dihydrotestosterone-inhibiting properties has been developed to improve hair growth and hair quality. The objective of this 6-month randomized, double-blind, placebo-controlled study was to assess the ability of this oral supplement (Nutrafol® Women's Capsules) to strengthen and promote the growth of hair in adult women with self-perceived thinning. Enrolled subjects were randomized to receive active

2018 Journal of drugs in dermatology : JDD

17. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. (PubMed)

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. Alopecia is divided into two categories: androgenic alopecia and nonandrogenic alopecia. An androgen-dependent abnormality of biological functions causes alopecia in males, but the role of androgens is not yet elucidated in female pattern hair loss (FPHL). Modulation of androgenic activity is not effective in certain kinds (...) of androgenic alopecia in females, as well as in cases of nonandrogenic alopecia in males and females. The hair growth drug, minoxidil, stimulates vascular endothelial growth factor (VEGF) production as well as vascularization and hair growth in females. Yet, because minoxidil has side effects with long-term use, a safe alternative hair growth agent is needed. Whereas hair develops after birth in mammalian species, hair mostly grows in a precocial bird, in the chicken, between hatching days 14 and 15

2018 Journal of medicinal food

18. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity. (PubMed)

Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity. To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function.A uniquely designed 24-week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (ZPT) antidandruff shampoo or a placebo cosmetic shampoo (...) . This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff/seborrheic dermatitis (D/SD) population. Two complementary methods were used to characterize the integrity of the cuticular surface. Hair surface hydrophobicity was assessed by quantifying water wetting force using a Wilhelmy balance method. Surface structure and porosity were assessed using dynamic vapor sorption (DVS) to gravimetrically quantify

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2018 Journal of cosmetic dermatology

19. Functional Anatomy of the Hair Follicle: the Secondary Hair Germ. (PubMed)

Functional Anatomy of the Hair Follicle: the Secondary Hair Germ. The secondary hair germ (SHG)-a transitory structure in the lower portion of the mouse telogen hair follicle (HF)-is directly involved in anagen induction and eventual HF regrowth. Some crucial aspects of SHG functioning and ontogenetic relations with other HF parts, however, remain undefined. According to recent evidence (in contrast to previous bulge-centric views), the SHG is the primary target of anagen-inducing signalling (...) to anagen-inducing signals. In general, the formation of the SHG is an evolutionary adaptation, which allowed the ancestors of modern Muridae to acquire a specific, highly synchronized pattern of hair cycling.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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2018 Experimental Dermatology

20. CME Part 2: Hair disorders in cancer survivors Persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery. (PubMed)

CME Part 2: Hair disorders in cancer survivors Persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery. With increasing survival rates across all cancers, survivors represent a growing population that is frequently affected by persistent or permanent hair growth disorders as a result of systemic therapies, radiotherapy, surgical procedures, and therapeutic transplants. These hair disorders (...) include persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, endocrine therapy-induced alopecia and hirsutism, post-surgery alopecia and localized hypertrichosis, alopecia attributed to therapeutic transplants, and to novel anticancer therapies. The information contained in this continuing medical education article should facilitate a better understanding on hair disorders in cancer survivors, so that adequate support and therapies may be provided to cancer

2018 Journal of American Academy of Dermatology

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