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1. Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres. (Abstract)

Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres. Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP-derived Exos, especially those from three-dimensional (3D)-cultured DP cells, affect hair growth (...) , cycling and regeneration. Exos derived from 3D DP (3D DP-Exos) promoted the proliferation of DP cells and outer root sheath (ORS) cells and increased the expression of growth factors (IGF-1, KGF and HGF) in DP cells. 3D DP-Exo treatment also increased hair shaft elongation in cultured human hair follicles. In addition, local injections of 3D DP-Exos induced anagen from telogen and also prolonged anagen in mice. Moreover, Exo treatment in human DP spheres augmented hair follicle neogenesis when the DP

2019 Experimental Dermatology

2. What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol. Full Text available with Trip Pro

What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol. Hair is an emerging biological matrix in which to measure chronic HPA axis activity, offering a longer term view into an animal's life. We explored effects of exogenous (e.g. lifestyle, medications, social environment) and endogenous (e.g. disease, behaviour) stressors on hair cortisol concentration (HCC) in a population of Border Collies (BCs). Owners of BCs were recruited (...) and reported their dog's lifestyle, clinical history, anxiety-related behaviour, and collected a white hair sample from their dog's dorsal neck region. HCC was determined using established methods with a commercial cortisol assay kit. Samples from 135 BCs were analysed, with 91 healthy controls and 44 diagnosed with epilepsy as a model disease. Factors associated with higher HCC included psychosocial stressors (living with three or more other dogs) and lifestyle (engaging in competitive flyball); while

2019 PLoS ONE

5. Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal

Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal Rapid Synthesis Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal 6 November 2018 McMaster Health Forum 1 Evidence >> Insight >> Action Rapid Synthesis: Identifying Policies, Financial Support and Professional Regulations for Medically Necessary Hair Removal 10-day response 6 November 2018 Identifying Policies, Financial Support (...) and Professional Regulations for Medically Necessary Hair Removal 2 Evidence >> Insight >> Action McMaster Health Forum The McMaster Health Forum’s goal is to generate action on the pressing health-system issues of our time, based on the best available research evidence and systematically elicited citizen values and stakeholder insights. We aim to strengthen health systems – locally, nationally, and internationally – and get the right programs, services and drugs to the people who need them. Authors Puru

2018 McMaster Health Forum

6. Excessive hair growth: certain drugs implicated

Excessive hair growth: certain drugs implicated Prescrire IN ENGLISH - Spotlight ''Excessive hair growth: certain drugs implicated'', 1 May 2017 {1} {1} {1} | | > > > Excessive hair growth: certain drugs implicated Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Excessive hair growth: certain drugs implicated Some drugs expose patients (...) to excessive hair growth, which is usually reversible when treatment is discontinued. Hypertrichosis in a man or woman is characterised by an abnormal amount of hair growth on all or part of the body, usually in the form of down, and hirsutism is the growth of male hair in areas normally hairless in women (face, neck, chest, area between the pubis and navel, buttocks). Excessive hair growth can cause embarrassment, which is subjective and influenced by social, cultural and personal notions, exposing

2017 Prescrire

7. Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes

Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes - GOV.UK GOV.UK uses cookies to make the site simpler. Search Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes Pharmacists (...) should tell people about the risk of fire when they discuss head lice eradication options. Published 8 March 2018 From: Therapeutic area: , Contents Advice to pharmacists some products for the eradication of head lice infestations are combustible/flammable when on the hair and can ignite and cause serious harm in the presence of an open flame or other source of ignition such as when lighting cigarettes advise parents, caregivers and the person with head lice, if appropriate, that they should

2018 MHRA Drug Safety Update

8. Cholesterol homeostasis: links to hair follicle biology and hair disorders. Full Text available with Trip Pro

Cholesterol homeostasis: links to hair follicle biology and hair disorders. Lipids and lipid metabolism are critical factors in hair follicle (HF) biology and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms (...) by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remains largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies

2019 Experimental Dermatology

9. Hair distribution width - a novel trichoscopy parameter for hair miniaturization in androgenetic alopecia. (Abstract)

Hair distribution width - a novel trichoscopy parameter for hair miniaturization in androgenetic alopecia. Androgenetic alopecia (AGA) is characterized by progressive miniaturization of hair follicles on the scalp from terminal (≥30 μm)to vellus (≥30 μm) types [1]. Under trichoscopy, hair shaft diameter variation (HSDV) is defined as the percentage of vellus hair shafts within a region of interest. HSDV>20% is characteristic of AGA and is considered as a reliable means of assessing

2019 Journal of the European Academy of Dermatology and Venereology

10. Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle-dependent manner. (Abstract)

Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle-dependent manner. The dermal papilla (DP) is one of two principal mesenchymal compartments of the hair follicle (HF). We previously reported that a population of HF dermal stem cells (hfDSCs) function to regenerate the dermal sheath (DS), but intriguingly also contribute new cells to the adult DP at the onset of anagen hair growth to maintain normal cycling of HFs and support the production of large hair fibres (...) . Here, we asked whether injury altered the behaviour of hfDSCs and their progeny in order to support wound-induced hair growth (WIHG) and if the response was modulated by hair cycle stage. αSMACreERT2 :ROSAYFP mice received tamoxifen to label the DS, including hfDSCs. Full-thickness excisions were made on the dorsal skin during various stages of the hair cycle. The skin was harvested at the subsequent anagen. Interestingly, there was an increase in the magnitude of recruitment of hfDSC progeny

2019 Experimental Dermatology

11. Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. Full Text available with Trip Pro

Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. Human skin progenitor cells will form new hair follicles, although at a low efficiency, when injected into nude mouse skin. To better study and improve upon this regenerative process, we developed an in vitro system to analyze the morphogenetic cell behavior in detail and modulate physical-chemical (...) parameters to more effectively generate hair primordia. In this three-dimensional culture, dissociated human neonatal foreskin keratinocytes self-assembled into a planar epidermal layer while fetal scalp dermal cells coalesced into stripes, then large clusters, and finally small clusters resembling dermal condensations. At sites of dermal clustering, subjacent epidermal cells protruded to form hair peg-like structures, molecularly resembling hair pegs within the sequence of follicular development

2019 Experimental Dermatology

12. Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter Full Text available with Trip Pro

Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter Female pattern hair loss (FPHL) is a common hair disease. However, studies of the quantitative measurement of FPHL are still limited. The aim of this study was to investigate the characteristics of hair density and hair diameter in normal women and FPHL patients, and further correlate the quantitative measurement with the clinical presentation of FPHL.An evaluation of 471 FPHL (...) patients and 236 normal women was carried out according to the Ludwig classification, and analysis was performed by using a com-puterized handheld USB camera with computer-assisted software. Various areas of the scalp, including frontal, parietal, midscalp, and occipital, were analyzed for hair density, non-vellus hair diameter, and percentage of miniaturized hair.The hair density in normal women was the highest and the lowest in the midscalp and parietal areas, respectively. The FPHL group revealed

2017 Clinical, cosmetic and investigational dermatology

13. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling Full Text available with Trip Pro

FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused (...) on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector.BALB/c mice with telogen or plucking-induced anagen HFs were exposed to total body irradiation with γ-rays at 4 to 12 Gy after intraperitoneal treatment with FGF18 or an FGF receptor inhibitor. A time course analysis was performed histologically and hair growth was observed 14 or 15 days after depilation. Skin specimens were analyzed by DNA microarrays and Western blotting.Telogen irradiation at 6 Gy

2016 Advances in radiation oncology

14. Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias Full Text available with Trip Pro

Predicting hair cortisol levels with hair pigmentation genes: a possible hair pigmentation bias Cortisol concentrations in hair are used to create hormone profiles spanning months. This method allows assessment of chronic cortisol exposure, but might be biased by hair pigmentation: dark hair was previously related to higher concentrations. It is unclear whether this association arises from local effects, such as increased hormone extractability, or whether the association represents systemic (...) differences arising from population stratification. We tested the hypothesis that hair pigmentation gene variants are associated with varying cortisol levels independent of genetic ancestry. Hormone concentrations and genotype were measured in 1674 children from the Generation R cohort at age 6. We computed a polygenic score of hair color based on 9 single nucleotide polymorphisms. This score was used to predict hair cortisol concentrations, adjusted for genetic ancestry, sex, age and corticosteroid use

2017 Scientific reports

15. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles Full Text available with Trip Pro

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth-modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth-promoting molecular targets. Through (...) microarray analysis we identified the Wnt inhibitor, secreted frizzled related protein 1 (SFRP1), as being down-regulated in the dermal papilla (DP) of CsA-treated human scalp hair follicles (HFs) ex vivo. Therefore, we further investigated the function of SFRP1 using a pharmacological approach and found that SFRP1 regulates intrafollicular canonical Wnt/β-catenin activity through inhibition of Wnt ligands in the human hair bulb. Conversely, inhibiting SFRP1 activity through the SFRP1 antagonist, WAY

2018 PLoS biology

16. Safety and Tolerability of Hair Stimulating Complex (HSC) in Female Pattern Hair Loss

Safety and Tolerability of Hair Stimulating Complex (HSC) in Female Pattern Hair Loss Safety and Tolerability of Hair Stimulating Complex (HSC) in Female Pattern Hair Loss - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Safety and Tolerability of Hair Stimulating Complex (HSC) in Female Pattern Hair Loss The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03662854 Recruitment Status : Active, not recruiting First Posted : September 10, 2018 Last Update Posted : February 21, 2019 Sponsor: Histogen Information

2018 Clinical Trials

17. Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea Full Text available with Trip Pro

Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea Hair cell (HC) loss is irreversible because only very limited HC regeneration has been observed in the adult mammalian cochlea. Wnt/β-catenin signaling regulates prosensory cell proliferation and differentiation during cochlear development, and Wnt activation promotes the proliferation of Lgr5+ cochlear HC progenitors in newborn mice

2018 Frontiers in molecular neuroscience

18. Nonshaved Ear Surgery: Effect of Hair on Surgical Site Infection of the Middle Ear/Mastoid Surgery and Patients’ Preference for the Hair Removal Full Text available with Trip Pro

Nonshaved Ear Surgery: Effect of Hair on Surgical Site Infection of the Middle Ear/Mastoid Surgery and Patients’ Preference for the Hair Removal This study aimed 1) to compare the rates of surgical site infection (SSI) between two groups with and without preoperative hair shaving, 2) to compare the bacterial colonization just before the skin incision between them, and 3) to evaluate people's preference for the hair shaving.The retrospective study enrolled cases in which middle ear and mastoid (...) surgery was performed with as well as without hair removal. Main measurement outcomes were the SSI rate within 3 months following the surgery, bacterial culture results obtained from the incision area just before the skin incision, and questionnaire to evaluate the preference for hair shaving from patients with chronic suppurative otitis media but without experience with the ear surgery.This study did not show any difference in the rates of SSI and bacterial colonization between two groups

2018 Journal of Audiology & Otology

19. Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss Full Text available with Trip Pro

Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss Acquired hearing loss is the predominant neurodegenerative condition associated with aging in humans. Although mutations on several genes are known to cause congenital deafness in newborns, few genes have been implicated in age-related hearing loss (ARHL), perhaps because its cause is likely polygenic. Here, we generated mice lacking lysosomal calcium (...) channel mucolipins 3 and 1 and discovered that both male and female mice suffered a polygenic form of hearing loss. Whereas mucolipin 1 is ubiquitously expressed in all cells, mucolipin 3 is expressed in a small subset of cochlear cells, hair cells (HCs) and marginal cells of the stria vascularis, and very few other cell types. Mice lacking both mucolipins 3 and 1, but not either one alone, experienced hearing loss as early as at 1 month of age. The severity of hearing impairment progressed from high

2018 The Journal of Neuroscience

20. In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells Full Text available with Trip Pro

In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells Hair growth occurs periodically in a cycle that consists of three different phases: growth, regression, and resting. The length of each phase is regulated by both intrinsic and extrinsic factors throughout life, and influenced by physiological and pathological conditions. Elongation of the resting phase and shortening of the growth phase occur during physiological ageing and in baldness, respectively (...) . In vivo discrimination of each phase of the hair cycle can be used to research for regeneration of hair follicles as well as to evaluate the efficacy of hair regrowth treatments in the same individual. Here we show that NG2+ epithelial cells in the hair follicles encompass bulge stem cells, and that the number of hair follicle NG2 cells underwent dramatic changes during the hair cycle. Transgenic rats with expression of firefly luciferase gene in NG2 cells were generated to monitor the hair cycle

2018 Scientific reports

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