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HIV related Myelopathy

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101. Human T-Cell Lymphotrophic Viruses (Follow-up)

. J Clin Oncol . 2009 Jan 20. 27(3):453-9. . . Ramos JC, Lossos IS. Newly emerging therapies targeting viral-related lymphomas. Curr Oncol Rep . 2011 Oct. 13(5):416-26. . Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, et al. Anti-CCR4 antibody mogamulizumab targets human T-lymphotropic virus type I-infected CD8+ as well as CD4+ T cells to treat associated myelopathy. J Infect Dis . 2014 Aug 7. . Nasr R, Marçais A, Hermine O, Bazarbachi A. Overview of Targeted Therapies for Adult (...) of HTLV-I-associated myelopathy/tropical spastic paraparesis: inflammatory changes occur simultaneously in the entire central nervous system. Acta Neuropathol . 2000 Sep. 100(3):245-52. . Beilke MA, Japa S, Moeller-Hadi C, Martin-Schild S. Tropical spastic paraparesis/human T leukemia virus type 1-associated myelopathy in HIV type 1-coinfected patients. Clin Infect Dis . 2005 Sep 15. 41(6):e57-63. . Berger JR, Svenningsson A, Raffanti S, Resnick L. Tropical spastic paraparesis-like illness occurring

2014 eMedicine.com

102. Neurosyphilis (Follow-up)

> Neurosyphilis Overview of Syphilis of the CNS Updated: Jul 17, 2018 Author: Richard P Knudsen, MD, FAAN, FAAP; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM Share Email Print Feedback Close Sections Sections Neurosyphilis Overview of Syphilis of the CNS Overview of Syphilis of the CNS Syphilis is a sexually transmitted disease caused by Treponema pallidum, with human beings as the only host. Syphilitic infection of the nervous system results in the most chronic, insidious meningeal inflammatory (...) process known. Invasion of the CNS occurs early in the course of untreated syphilis. Of late, there has been a drastic increase, worldwide, in the incidence of syphilis, especially in urban areas. [ ] This fact leads clinicians to heighten their degree of suspicion, being profoundly alert to the possibility of this infection within the HIV populations. [ ] Neurosyphilis, quite directly, is defined as a CSF WBC count of 20 cells/µL or greater or a reactive CSF Venereal Disease Research Laboratory (VDRL

2014 eMedicine.com

103. Arachnoiditis

, 2017 Author: Alan Holz, MD; Chief Editor: James G Smirniotopoulos, MD Share Email Print Feedback Close Sections Sections Arachnoiditis Imaging Practice Essentials Arachnoiditis is a broad term denoting inflammation of the meninges and subarachnoid space. It is characterized by thickening of the arachnoid membrane and dura mater adhesions that result in chronic lower back pain. Complications include cranial neuropathies, myelopathy, and radiculopathy. [ ] Arachnoiditis has many causes, including (...) Dec 16. 2016: . Panackal AA, Komori M, Kosa P, Khan O, Hammoud DA, Rosen LB, et al. Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. Clin Infect Dis . 2017 Feb 1. 64 (3):275-283. . Kondety SK, Chatterjee S. Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. Neurol India . 2016 Sep-Oct. 64 (5):1066-8. . Chattopadhyay I, Jha AK, Banerjee SS, Basu S. Post-procedure adhesive arachnoiditis following

2014 eMedicine Radiology

104. Somatosensory Evoked Potentials: Clinical Applications (Follow-up)

for detecting abnormalities Vascular lesions Tumors Myelomeningocele Tethered cord syndrome Infectious disorders (eg, human T-lymphocytic virus 1 and HIV) Previous Next: Brain Stem and Brain Brain stem lesions and stroke SEPs are normal in Wallenberg's syndrome but are generally abnormal when medial lemniscus is involved. SEPs are also unaffected and normal in some of the hemispheric (eg, pure motor lacunar infarctions, occipital lobe infarctions). In larger brainstem or hemispheric lesions, N20 and later (...) in the course of the disease, when distal conduction and F-wave studies may be normal Chronic acquired demyelinating neuropathies Infectious causes (eg, HIV) Toxic neuropathies Focal neuropathy The test of choice in focal neuropathy is standard NCSs. Entrapment neuropathies, such as carpal tunnel syndrome, may be found incidentally when SEPs are recorded. The use of SEP for detection of saphenous neuropathy, intercostal neuropathy, and trigeminal neuropathy has been reported. However, standard NCSs

2014 eMedicine.com

105. Transfusion-Transmitted Diseases (Follow-up)

transmitted through blood transfusion include the following: Human immunodeficiency virus (HIV) West Nile virus (WNV) Cytomegalovirus (CMV) Human T-cell lymphotrophic viruses (HTLVs) Parvovirus B19 Protozoal organisms that can be passed on through transfusion include species of the genus Plasmodium , which cause malaria. Prions, which cause Creutzfeldt-Jakob disease, are also transmissible through transfusion; they cannot be destroyed using current techniques for inactivating pathogens in the blood supply (...) of contamination. A negative culture for 24-48 hours before the product is released for transfusion is highly recommended. Previous Next: Viral Infections Human immunodeficiency virus The human immunodeficiency virus (HIV), a member of the Lentivirus family of retroviruses, is the causative agent of acquired immunodeficiency syndrome (AIDS). In the United States, more than 1.2 million people are living with HIV, and 1 in 8 of them don't know it. Individuals who engage in male-male sexual behavior accounted

2014 eMedicine.com

106. Somatosensory Evoked Potentials: Clinical Applications (Diagnosis)

for detecting abnormalities Vascular lesions Tumors Myelomeningocele Tethered cord syndrome Infectious disorders (eg, human T-lymphocytic virus 1 and HIV) Previous Next: Brain Stem and Brain Brain stem lesions and stroke SEPs are normal in Wallenberg's syndrome but are generally abnormal when medial lemniscus is involved. SEPs are also unaffected and normal in some of the hemispheric (eg, pure motor lacunar infarctions, occipital lobe infarctions). In larger brainstem or hemispheric lesions, N20 and later (...) in the course of the disease, when distal conduction and F-wave studies may be normal Chronic acquired demyelinating neuropathies Infectious causes (eg, HIV) Toxic neuropathies Focal neuropathy The test of choice in focal neuropathy is standard NCSs. Entrapment neuropathies, such as carpal tunnel syndrome, may be found incidentally when SEPs are recorded. The use of SEP for detection of saphenous neuropathy, intercostal neuropathy, and trigeminal neuropathy has been reported. However, standard NCSs

2014 eMedicine.com

107. Vitamin B-12 Associated Neurological Diseases (Diagnosis)

in infantile cobalamin deficiency appearing after treatment. Pediatr Neurol . 2001 Jul. 25(1):81-3. . Paltiel O, Falutz J, Veilleux M. Clinical correlates of subnormal vitamin B12 levels in patients infected with the human immunodeficiency virus. Am J Hematol . 1995 Aug. 49(4):318-22. . Pant SS, Asbury AK, Richardson EP Jr. The myelopathy of pernicious anemia. A neuropathological reappraisal. Acta Neurol Scand . 1968. 44:Suppl 5:1-36. . Penix LP. Ischemic strokes secondary to vitamin B12 deficiency-induced (...) and brain lesions in subacute combined degeneration. Neuroradiology . 1998 Nov. 40(11):716-9. . Kieburtz KD, Giang DW, Schiffer RB, Vakil N. Abnormal vitamin B12 metabolism in human immunodeficiency virus infection. Association with neurological dysfunction. Arch Neurol . 1991 Mar. 48(3):312-4. . Kirke PN, Molloy AM, Daly LE. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med . 1993 Nov. 86(11):703-8. . Krumholz A, Weiss HD, Goldstein PJ, Harris KC

2014 eMedicine.com

108. Polyarteritis Nodosa (Diagnosis)

, parvovirus B-19, cytomegalovirus, human T-cell leukemia virus, streptococcal species, Klebsiella species, Pseudomonas species, Yersinia species, Toxoplasma gondii , Rickettsiae, trichinosis, and sarcosporidiosis. [ , ] Recently, reports of associations with PAN and human immunodeficiency virus [ ] and cutaneous PAN and tuberculosis [ ] have been published as well. Some syndromes, including rheumatic diseases, malignancies, and infections have been associated with clinical syndromes indistinguishable from (...) in a larger 161 patient cohort with HCV-related vasculitis in France. [ ] Despite the presence of serum cryoglobulins, these patients were diagnosed with HCV-PAN on the basis of typical histopathologic features of PAN and/or the presence of microaneurysms and/or multiple stenoses on abdominal and/or renal angiography. A number of other infectious organisms have been reported in association with PAN or PAN-like diseases, but causal evidence is inconsistent. These organisms include varicella-zoster virus

2014 eMedicine.com

109. Polyarteritis Nodosa (Diagnosis)

, parvovirus B-19, cytomegalovirus, human T-cell leukemia virus, streptococcal species, Klebsiella species, Pseudomonas species, Yersinia species, Toxoplasma gondii , Rickettsiae, trichinosis, and sarcosporidiosis. [ , ] Recently, reports of associations with PAN and human immunodeficiency virus [ ] and cutaneous PAN and tuberculosis [ ] have been published as well. Some syndromes, including rheumatic diseases, malignancies, and infections have been associated with clinical syndromes indistinguishable from (...) in a larger 161 patient cohort with HCV-related vasculitis in France. [ ] Despite the presence of serum cryoglobulins, these patients were diagnosed with HCV-PAN on the basis of typical histopathologic features of PAN and/or the presence of microaneurysms and/or multiple stenoses on abdominal and/or renal angiography. A number of other infectious organisms have been reported in association with PAN or PAN-like diseases, but causal evidence is inconsistent. These organisms include varicella-zoster virus

2014 eMedicine.com

110. Raltegravir for HAM/TSP

(NINDS) ) Study Details Study Description Go to Brief Summary: Background: - Human T-cell lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an infection of the spinal cord. The infection is caused by a virus that has been known to cause cancers like leukemia and lymphoma. It causes a weakening of the legs. Researchers want to see if raltegravir, a drug for treating human immunodeficiency virus (HIV), can be used to treat HAM/TSP. They will see if the drug can (...) Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP) Study Start Date : May 21, 2013 Actual Primary Completion Date : September 25, 2018 Actual Study Completion Date : September 25, 2018 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Reduction of HTLV-1 Proviral load in HAM/TSP patients [ Time Frame: 15 months ] Eligibility Criteria Go

2013 Clinical Trials

111. Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis

) that has a negative impact on quality of life that, in the judgement of the investigator, may increase the risk of tolerability issues during dose escalation, g) Presence or history of hallucinations that, in the judgement of the investigator, may increase the safety risk to the subject, h) Known diagnosis or history consistent with positive human immunodeficiency virus (HIV) Past and Current Medications and Therapies: Have had treatment with the following to manage their MS: a) Within 1 year (...) Study Start Date : February 2013 Actual Primary Completion Date : September 2014 Actual Study Completion Date : September 2014 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: GSK239512 Arm GSK239512 once daily orally, started at 10 mcg and titrated to the maximum tolerated dose, Up to the highest dose of 80 mcg (10 mcg first week, 20 mcg second week, 40 mcg third week, 80 mcg fourth week

2013 Clinical Trials

112. Abnormal Gait and Balance Causes in the Elderly

Administration 4 Abnormal Gait and Balance Causes in the Elderly Abnormal Gait and Balance Causes in the Elderly Aka: Abnormal Gait and Balance Causes in the Elderly From Related Chapters II. Causes: Psychiatric Disorders Disorders III. Causes: Cardiovascular Disorders Arrhythmia IV. Causes: Infectious Disorders Induced (HIV-related ) V. Causes: Metabolic Disorders and VI. Causes: Musculoskeletal Disorders VII. Causes: Neurologic Disorders Cerebellar Degeneration Myelopathy Normal-pressure Vestibular (...) disorders VIII. Causes: Miscellaneous Hearing Medications IX. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Abnormal Gait and Balance Causes in the Elderly." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Motor Disorders About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency

2015 FP Notebook

113. Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)

Start Date : September 2012 Actual Primary Completion Date : January 2014 Actual Study Completion Date : June 2014 Resource links provided by the National Library of Medicine related topics: related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Intrathecal autologous stem cells Intrathecal stem cells will be administered to patients that fulfill the inclusion criteria. Biological: Intrathecal autologous stem cell Mobilization and collection of stem cells (...) Inclusion Criteria: patients with a confirmed diagnosis of ALS according to El Escorial criteria. Diagnosis-time less than four years. Over 18 years old. Forced vital capacity ≥ 40%. One year of evolution. Adequate nutritional state Exclusion Criteria: Severe bulbar ALS involucre. Inadequate nutritional status. Spondylotic myelopathy, or abnormalities in imaging study. Having concomitant neurological or psychiatric disease. Systemic disease with poor-control. History of treatment with steroids

2012 Clinical Trials

114. Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load

gene expression, and sites of viral integration. Condition or disease Intervention/treatment Phase Human T-cell Leukemia Virus Type 1 Infection Drug: Raltegravir Phase 2 Detailed Description: About 5% of HTLV-1 infected individuals develop lymphoma or myelopathy. High levels of virus replication are predictive of disease development. HTLV-1 exhibits lower levels of variation than HIV-1, suggesting that drug resistance is less likely to occur. Raltegravir was shown to inhibit HTLV-1 integration (...) : Merck Sharp & Dohme Corp. Information provided by (Responsible Party): Washington University School of Medicine Study Details Study Description Go to Brief Summary: This is a study of the effect of raltegravir on human T-cell leukemia virus type 1 (HTLV-1) viral load in asymptomatic patients. The study will enroll 14 subjects for a period of 2 months of treatment and 1 month of followup. The study will assess the effect of raltegravir on virus load in peripheral blood lymphocytes, level of virus

2012 Clinical Trials

115. Restore CLINICAL TRIAL

Cervical Radiculopathy Actual Study Start Date : May 2014 Estimated Primary Completion Date : June 2019 Estimated Study Completion Date : June 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: M6-C Artificial Cervical Disc Device: M6-C Artificial Cervical Disc Total disc replacement Active Comparator: Anterior Cervical Discectomy and Fusion Device: Anterior plate system with corticocancellous allograft (...) : Effectiveness of the Spinal Kinetics M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) [ Time Frame: 6 weeks, 3 months, 6 months, 12 months, 24 months ] Evaluate the Neck and Arm pain VAS, health-related quality of life SF-36, surgery outcomes, patient satisfaction and quantitative and qualitative radiographic assessments Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision

2012 Clinical Trials

116. C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation

C. Previous serious opportunistic or atypical infections. History of positive serology for hepatitis B. Prior history, or suspicion, of tuberculosis (TB) History of positive serology for HIV. History of clinically significant CNS trauma (e.g. traumatic brain injury, cerebral contusion, spinal cord compression). History or presence of myelopathy due to spinal cord compression by disc or vertebral disease. Past or current history of medically significant adverse effects (including allergic (...) Sponsor: Michael Levy Collaborator: ViroPharma Information provided by (Responsible Party): Michael Levy, Johns Hopkins University Study Details Study Description Go to Brief Summary: The overall objective is to evaluate the tolerability/safety and preliminary efficacy of CINRYZE® (C1 esterase inhibitor [human]) as add-on therapy for treatment of acute optic neuritis and/or transverse myelitis in NMO and NMOSD. Primary Objective: To evaluate the safety and tolerability of 3-5 doses of 1000 - 2000

2012 Clinical Trials

117. Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1

: Laboratoire Cerba Information provided by (Responsible Party): University Hospital Center of Martinique Study Details Study Description Go to Brief Summary: Only 5 to 10% of patients infected with HTLV-1 develop a disease related to infection. The two most serious diseases are adult T-cell leukemia (ATL) and Tropical spastic paraparesis /HTLV-I-associated myelopathy (TSP / HAM). Factors influencing the development of TSP / HAM in the individual HTLV-1 are not yet completely understood. Patients TSP / HAM (...) have a HTLV-1 proviral load (amount of virus) that is 6-10 times higher than seropositive asymptomatic. Various studies have shown that the development of TSP / HAM in the subject HTLV-1 and its rapid evolution is partly attributed to the failure of the immune system that regulates viral replication and expression. It has recently been shown that different versions of Single Nucleotide (human leukocyte antigen) rs12979860, located upstream of the gene for Interleukin 28B (IL28B), influenced

2012 Clinical Trials

118. Proton Radiation for Lymphoma Involving Mediastinum

: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Pilot Study Evaluating the Use of Proton Radiation for Treatment of Lymphoma Involving the Mediastinum Actual Study Start Date : February 2013 Actual Primary Completion Date : October 2016 Actual Study Completion Date : February 2017 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Proton Radiation (...) pericarditis, pneumonitis, Lhermitte's, dermatitis, mucositis, esophagitis, leukopenia, xerostomia, and thrombocytopenia. Data is shown as the number of participants that experienced the given toxicities. Late Toxicities [ Time Frame: 5 years ] Late toxicities including clinical and sub-clinical heart disease, pulmonary fibrosis, esophageal stricture, myelopathy, thyroid dysfunction and secondary cancers. 6-Month Overall Survival [ Time Frame: 6 Months ] The number of participants surviving six months

2012 Clinical Trials

119. Safety of Probiotics to Reduce Risk and Prevent or Treat Disease

and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.gov Contract No. HHSA 290-2007-10062-I Prepared by: Southern California Evidence-based Practice Center, Santa Monica, CA Investigators: Susanne Hempel, Ph.D. Sydne Newberry, Ph.D. Alicia Ruelaz, M.D. Zhen Wang, M.S. Jeremy N. V. Miles, Ph.D. Marika J. Suttorp, M.S. Breanne Johnsen, B.S. Roberta Shanman, M.L.S. Wendelin Slusser, M.D., M.P.H. Ning Fu, M.P.P. Alex Smith, M.P.H. Beth Roth, M.A. Joanna Polak, B.S. Aneesa Motala, B.A. Tanja (...) in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment. This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality

2011 EvidenceUpdates

120. Complications of Transfusion

in immunocompetent recipients, routine antibody testing of donor blood is not required. However, CMV may cause serious or fatal disease in immunocompromised patients, who should receive CMV-negative blood products that have been provided by CMV antibody-negative donors or by blood depleted of WBCs by filtration. Human T-cell lymphotropic virus 1 (HTLV-1), which can cause adult T-cell lymphoma/leukemia and HTLV-1–associated myelopathy/tropical spastic paraparesis, causes posttransfusion seroconversion in some (...) circulatory overload Transfusion-related acute lung injury (TRALI) Other complications include Allergic reactions Altered oxygen affinity Delayed hemolytic transfusion reaction Infections Post-transfusion purpura Early recognition of symptoms suggestive of a transfusion reaction and prompt reporting to the blood bank are essential. The most common symptoms are chills, rigor, fever, dyspnea, light-headedness, urticaria, itching, and flank pain. If any of these symptoms (other than localized urticaria

2013 Merck Manual (19th Edition)

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