How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

15,901 results for

HIV Course

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Extended evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E. (PubMed)

Extended evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E. The Thai Phase III Trial of ALVAC-HIV and AIDSVAX B/E showed an estimated vaccine efficacy (VE) of 31% to prevent acquisition of human immunodeficiency virus (HIV). Here we evaluated the effect of vaccination on disease progression after infection.CD4(+) T-cell counts and HIV viral load (VL) were measured serially (...) and per protocol (n = 90) cohorts. Estimated VEP (mITT) was15.8% (-21.9, 41.8) at 60 months postinfection. There was weak evidence of lower VL and higher CD4(+) count at 60 and 66 months in the vaccine group. Lower mucosal VL was observed among vaccine recipients, primarily in semen (P = .04).Vaccination did not affect the clinical course of HIV disease after infection. A potential vaccine effect on the genital mucosa warrants further study.

Full Text available with Trip Pro

2013 Journal of Infectious Diseases

142. Monocyte and myeloid dendritic cell activation occurs throughout the course of HIV-2 infection, an attenuated form of HIV disease. (PubMed)

Monocyte and myeloid dendritic cell activation occurs throughout the course of HIV-2 infection, an attenuated form of HIV disease. Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature (...) reduced viremia and slow disease progression despite the recognized ability of HIV-2 to establish viral reservoirs and overcome host restriction factors in myeloid cells. We found a heightened state of monocyte and mDC activation throughout HIV-2 infection (characterized by CD14(bright)CD16(+) expansion, as well as increased levels of soluble CD14, HLA-DR, and CD86), together with progressive mDC depletion. Importantly, HIV-2-positive patients also featured overexpression of the inhibitory molecule PD

Full Text available with Trip Pro

2013 Journal of Infectious Diseases

143. Short Course Regimens for Treatment of PKDL (Sudan)

Short Course Regimens for Treatment of PKDL (Sudan) Short Course Regimens for Treatment of PKDL (Sudan) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Short Course Regimens for Treatment of PKDL (Sudan (...) -existing clinical hearing loss based on audiometry at baseline Patients with a positive HIV test as applicable Patients / guardian not willing to participate Patients with history of allergy or hypersensitivity to the relevant study drug Patients on immunomodulators therapy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please

2017 Clinical Trials

144. Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine. (PubMed)

Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine. HIV-1 infection may impair transplacental antibody transfer to infants. The impact of highly active antiretroviral treatment (ART) given during pregnancy on transplacental antibody transport is unknown.HIV-1 infected pregnant women with CD4 counts between 200 - 500 were randomized to short-course zidovudine (ZDV) or triple ART at 32 weeks (...) gestation for prevention of mother-to-child HIV-1 transmission. Levels of maternal antibody against measles, pneumococcus and rotavirus at delivery, and antibody transfer to the baby through cord blood, were compared between trial arms.Overall, 141 and 148 women were randomized to triple ART and ZDV, respectively; cord blood was available for a subset (n = 20 in triple ART and n = 22 in ZDV). Maternal antibody levels to all pathogens during pregnancy and at delivery were not significantly different

2017 Pediatric Infectious Dsease Journal

145. Why Humanities Majors Should Take Science Courses

Why Humanities Majors Should Take Science Courses Why Humanities Majors Should Take Science Courses | PLOS Blogs Network PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis (...) that “A naturally occurring DNA segment is a product of nature and not patent-eligible merely because it has been isolated, but cDNA is patent eligible because it is not naturally occurring.” Close, but no cigar. cDNA, or complementary DNA, do form naturally when retroviruses, such as HIV, use an enzyme called reverse transcriptase to convert their genomic RNA into DNA that can then be integrated into their infected hosts. Adding to the confusion, Justice Clarence Thomas, who wrote the majority opinion

2016 PLOS Blogs Network

146. Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma

Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

147. An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers

An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2017 Clinical Trials

148. The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03335124

2017 Clinical Trials

149. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? (PubMed)

A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? 28809515 2017 12 13 2018 12 02 1535-4970 196 4 2017 08 15 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? 411-413 10.1164/rccm.201704-0759ED Randolph Adrienne G AG 0000-0002-3084-3071 1 Department of Anesthesiology, Perioperative and Pain Medicine (...) ppublish 28809515 10.1164/rccm.201704-0759ED PMC5564677 PLoS One. 2014 Mar 13;9(3):e92121 24626215 Clin Pharmacol Ther. 2001 Mar;69(3):89-95 11240971 PLoS One. 2014 Jan 29;9(1):e86242 24489704 Crit Care Med. 2016 Nov;44(11):2010-2017 27513537 Crit Care Med. 1996 May;24(5):743-52 8706448 Expert Opin Med Diagn. 2013 Jan;7(1):37-51 23335946 Crit Care Med. 2013 Jul;41(7):1761-73 23685639 Pediatr Crit Care Med. 2005 Jan;6(1):2-8 15636651 Crit Care. 2012 Oct 01;16(5):R174 23025259 Curr Opin HIV AIDS. 2010

Full Text available with Trip Pro

2017 American Journal of Respiratory and Critical Care Medicine

150. Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level (PubMed)

and potentially capture states that are unobservable with ensemble methods because they are below the limit of detection or not conducted on an appropriate time scale. Using the HIV-1 envelope glycoprotein (Env) and its interaction with receptor CD4-binding site neutralizing antibodies as a model system, we both corroborate ensemble kinetics-derived parameters and demonstrate how time-course EM can further dissect stoichiometric states of complexes that are not readily observable with other methods (...) Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level Several biophysical approaches are available to study protein-protein interactions. Most approaches are conducted in bulk solution, and are therefore limited to an average measurement of the ensemble of molecular interactions. Here, we show how single-particle EM can enrich our understanding of protein-protein interactions at the single-molecule level

Full Text available with Trip Pro

2017 The Journal of biological chemistry

151. Public health guidance on HIV and STI prevention among men who have sex with men

Public health guidance on HIV and STI prevention among men who have sex with men ECDC GUIDANCE HIV and STI prevention among men who have sex with men www.ecdc.europa.eu ECDC GUIDANCE HIV and STI prevention among men who have sex with men ii This report was commissioned by the European Centre for Disease Prevention and Control (ECDC), coordinated by Anastasia Pharris and Andrew J. Amato-Gauci with technical input from Paloma Carrillo-Santisteve, Tarik Derrough, Erika Duffell, Marco Fonzo, Yvan (...) consultants, formerly Public Health Agency of Sweden). Invaluable input was received from the guidance expert panel, which included the following persons: Rigmor C Berg, Norwegian Knowledge Center for Health Services, Norway, Torsten Berglund, Public Health Agency of Sweden (Folkhälsomydigheten), Hans Blystad, Norwegian Institute of Public Health, Department of Infectious Disease Epidemiology, Norway, Michael Bochow, Consultant, Germany, Jordi Casabona i Barbarà, Center for HIV/STI Epidemiological Studies

2015 European Centre for Disease Prevention and Control - Public Health Guidance

152. Reminder systems for people living with HIV

Reminder systems for people living with HIV Reminder systems for people living with HIV | The Ontario HIV Treatment Network The Ontario HIV Treatment Network Reminder systems for people living with HIV Reminder systems for people living with HIV , Questions What types of telephone, computer and other app-based interventions have been effective in reminding people living with HIV to attend medical appointments and adhere to antiretroviral medications? What types of telephone, computer and other (...) app-based interventions have been effective in reminding people living with HIV to test/retest for STIs and subsequently notify their partners when testing positive? Key take-home messages Text messaging, smart phone applications and cell phone counselling are all effective in promoting adherence to antiretroviral therapy (1-4). Text messaging and smart phone reminders are more effective if they are personal in nature, and if they evoke or require a response from the participant (2;4-6). Text

2015 Ontario HIV Treatment Network

153. Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary

Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 36, Issue 8, Pages 721–734 Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce (...) the full text on ScienceDirect. Abstract Objective This guideline reviews the evidence relating to the care of pregnant women living with HIV and the prevention of perinatal HIV transmission. Prenatal care of pregnancies complicated by HIV infection should include monitoring by a multidisciplinary team with experts in this area. Outcomes Outcomes evaluated include the impact of HIV on pregnancy outcome and the efficacy and safety of antiretroviral therapy and other measures to decrease the risk

2014 Society of Obstetricians and Gynaecologists of Canada

154. Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention

. Highly Active Anti-Retroviral Therapy (HAART) has brought long term survival and maximising bone health in children is increasingly important as this population reach adult life. Screening: Annual autumn screening is recommended since children with HIV in the UK have a high prevalence of vitamin D deficiency. survey (n=131) found that vitamin D deficiency is common in children with perinatally acquired HIV: 83.2% had insufficient levels ( 6yrs can be treated with short courses of high dose (...) Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Authors: Sarah Atkinson and Caroline Foster Date of preparation: February 2011 Version SMH/CF for 20,000 unit capsules Date reviewed: February 2014 Next review: February 2016 Content: 1. Algorithm for the management of vitamin D deficiency. 2. Summary of guidelines 3

2014 The Children's HIV Association

155. HIV infection and AIDS

HIV infection and AIDS HIV infection and AIDS - NICE CKS Share HIV infection and AIDS: Summary The Human Immunodeficiency Virus (HIV) is a retrovirus that preferentially infects and destroys cells of the immune system, in particular the CD4 cells (a class of T lymphocyte, also known as T helper cells). There are 2 main types of HIV: HIV-1 (the predominant type in the UK) is highly virulent and is found worldwide. HIV-2 is found mainly in West Africa but has also been reported in Portugal (...) , France, and increasingly in India and South America. Infected bodily fluid can transmit HIV: By sexual activity — through vaginal, anal, or oral sex (especially in the presence of oral disease such as ulceration or gingivitis). Vertically from mother to child — during pregnancy, childbirth, or with breastfeeding. By inoculation — via a contaminated needle, instrument, blood, or blood product; through direct exposure of mucous membranes or an open wound to infected bodily fluids; or by a human bite

2018 NICE Clinical Knowledge Summaries

156. Tenofovir DF/emtricitabine/rilpivirine as HIV post-exposure prophylaxis: results from a multicentre prospective study. (PubMed)

-occupational PEP.We conducted an observational, prospective, multicentre, open-label, non-randomized study in five French HIV centres. Adults requiring PEP according to national French guidelines were prescribed TDF/FTC/RPV one pill once a day for 28 days. Clinical and biological tolerability was assessed at week 4; occurrence of HIV seroconversion was evaluated after week 16.From March 2016 to March 2017, 163 courses of PEP were prescribed for 150 sexual exposures (44% heterosexual and 56% MSM) and 13 non (...) and no serious adverse events or hepatic or renal toxicity occurred. No HIV seroconversion occurred at week 16.The low rate of premature treatment interruption, the good tolerability and the absence of documented HIV seroconversion support the current French guidelines of a 28 day course of TDF/FTC/RPV for sexual and non-sexual PEP.© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email

2019 Journal of Antimicrobial Chemotherapy

157. Tropical Travel Trouble 009 Humongous HIV Extravaganza

from 2 hours. First line regimen in the UK is Truvada (Tenofovir (TDF) and Emtricitabine (FTC)) and Raltegravir for 28 days with an infectious disease follow up during this time. This regimen was picked due to safety and tolerability over other combinations. If further risk occurs during the last two days of the PEP course, then PEP should be continued for 48 hours after the last high-risk exposure. If more than 48 hours of PEP is missed it should be discontinued. Follow-up HIV testing (...) . Additional Resources Online ID coursesHIV and vaccines – HIV dermatology video: References Beeching N and Gill G. . 7e Wiley Blackwell 2014. BHIVA – – guidelines 2016 BHIVA/BASHH – guidelines on the use of (PrEP) 2017 BHIVA – 2018 BHIVA – 2017 Boer K, et al . Mode of delivery in HIV-infected pregnant women and prevention of mother-to-child transmission: changing practice in Western Europe. HIV Med 2010; 11:368-78. Bwakura-Dangarembizi M et al and the Antiretroviral research for Watoto (ARROW) Trial

2018 Life in the Fast Lane Blog

158. Intervene fast to prevent lasting cognitive impairment during the primary phase of HIV infection

primary phase HIV-positive participants (<1 year) over the period from 2005 to 2011. Earlier studies have hypothesized that the neural damage occurs during the phase of primary infection. The researchers seek to establish this by using MRI to examine longitudinal trajectories of brain volume and cortical thickness, and to assess the impact of the introduction of cART. Of the 65 longitudinal participants, 34 had either recently begun cART (4) or did so in the course of the trial. Cross sectional data (...) Intervene fast to prevent lasting cognitive impairment during the primary phase of HIV infection Intervene fast to prevent lasting cognitive impairment during the primary phase of HIV infection | Sexually Transmitted Infections by The impact of HIV/AIDS on cognitive function is the topic of a paper appearing in STIs as early as 1989, where some degree of neurological impairment is observed in patients who otherwise appear ‘well’ ( ). Dementia may be rarely seen nowadays, but quality-of-life

2018 Sexually Transmitted Infections blog

159. The risk network approach to HIV detection: something like contact tracing?

The risk network approach to HIV detection: something like contact tracing? The risk network approach to HIV detection: something like contact tracing? | Sexually Transmitted Infections by There has been considerable debate on the most effective and cost-effective means of accessing untested HIV- or STI-infected individuals. One frequently canvassed strategy is that of respondent driven sampling (RDS). This involves issuing suitable ‘seeds’ (e.g. recently diagnosed MSM) with coupons (...) to distribute to others in their sexual or social networks. in a recent study of black MSM in San Francisco compare RDS very favourably with time location sampling (TLS) as a method of recruitment of those most likely to be at risk. Similary, in a small study in Malawi observe the superior effectiveness of infected, over non-infected seeds in discovering untested individuals (31% vs. 11%). Much, of course, depends on the target group; so, for example, find in favour of ‘venue-based’ sampling over RDS

2018 Sexually Transmitted Infections blog

160. Piloting very early infant diagnosis of HIV in Lesotho: Acceptability and feasibility among mothers, health workers and laboratory personnel. (PubMed)

Piloting very early infant diagnosis of HIV in Lesotho: Acceptability and feasibility among mothers, health workers and laboratory personnel. Mortality associated with in-utero HIV infection rises rapidly within weeks after birth. Very early infant diagnosis of HIV (VEID)-testing within 2 weeks of birth-followed by immediate initiation of antiretroviral therapy has potential to avert mortality associated with in-utero transmission. However, our understanding of acceptability and feasibility (...) of VEID is limited.VEID was piloted in an observational prospective cohort of HIV-positive pregnant women and their infants in 13 Lesotho health facilities. Between March-July 2016, semi-structured interviews were conducted with HIV-positive women attending 6-week or 14-week postnatal visits and health workers (HWs) in 8 study facilities in 3 districts as well as with district and central laboratory staff. Interview themes included acceptability of birth and subsequent HIV testing and early treatment

Full Text available with Trip Pro

2018 PLoS ONE

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>