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141. Why Humanities Majors Should Take Science Courses

Why Humanities Majors Should Take Science Courses Why Humanities Majors Should Take Science Courses | PLOS Blogs Network PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis (...) that “A naturally occurring DNA segment is a product of nature and not patent-eligible merely because it has been isolated, but cDNA is patent eligible because it is not naturally occurring.” Close, but no cigar. cDNA, or complementary DNA, do form naturally when retroviruses, such as HIV, use an enzyme called reverse transcriptase to convert their genomic RNA into DNA that can then be integrated into their infected hosts. Adding to the confusion, Justice Clarence Thomas, who wrote the majority opinion

2016 PLOS Blogs Network

142. Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma

Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

143. An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers

An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2017 Clinical Trials

144. The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03335124

2017 Clinical Trials

145. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? (PubMed)

A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? 28809515 2017 12 13 2018 12 02 1535-4970 196 4 2017 08 15 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? 411-413 10.1164/rccm.201704-0759ED Randolph Adrienne G AG 0000-0002-3084-3071 1 Department of Anesthesiology, Perioperative and Pain Medicine (...) ppublish 28809515 10.1164/rccm.201704-0759ED PMC5564677 PLoS One. 2014 Mar 13;9(3):e92121 24626215 Clin Pharmacol Ther. 2001 Mar;69(3):89-95 11240971 PLoS One. 2014 Jan 29;9(1):e86242 24489704 Crit Care Med. 2016 Nov;44(11):2010-2017 27513537 Crit Care Med. 1996 May;24(5):743-52 8706448 Expert Opin Med Diagn. 2013 Jan;7(1):37-51 23335946 Crit Care Med. 2013 Jul;41(7):1761-73 23685639 Pediatr Crit Care Med. 2005 Jan;6(1):2-8 15636651 Crit Care. 2012 Oct 01;16(5):R174 23025259 Curr Opin HIV AIDS. 2010

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2017 American Journal of Respiratory and Critical Care Medicine

146. Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level (PubMed)

and potentially capture states that are unobservable with ensemble methods because they are below the limit of detection or not conducted on an appropriate time scale. Using the HIV-1 envelope glycoprotein (Env) and its interaction with receptor CD4-binding site neutralizing antibodies as a model system, we both corroborate ensemble kinetics-derived parameters and demonstrate how time-course EM can further dissect stoichiometric states of complexes that are not readily observable with other methods (...) Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level Several biophysical approaches are available to study protein-protein interactions. Most approaches are conducted in bulk solution, and are therefore limited to an average measurement of the ensemble of molecular interactions. Here, we show how single-particle EM can enrich our understanding of protein-protein interactions at the single-molecule level

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2017 The Journal of biological chemistry

147. Public health guidance on HIV and STI prevention among men who have sex with men

Public health guidance on HIV and STI prevention among men who have sex with men ECDC GUIDANCE HIV and STI prevention among men who have sex with men www.ecdc.europa.eu ECDC GUIDANCE HIV and STI prevention among men who have sex with men ii This report was commissioned by the European Centre for Disease Prevention and Control (ECDC), coordinated by Anastasia Pharris and Andrew J. Amato-Gauci with technical input from Paloma Carrillo-Santisteve, Tarik Derrough, Erika Duffell, Marco Fonzo, Yvan (...) consultants, formerly Public Health Agency of Sweden). Invaluable input was received from the guidance expert panel, which included the following persons: Rigmor C Berg, Norwegian Knowledge Center for Health Services, Norway, Torsten Berglund, Public Health Agency of Sweden (Folkhälsomydigheten), Hans Blystad, Norwegian Institute of Public Health, Department of Infectious Disease Epidemiology, Norway, Michael Bochow, Consultant, Germany, Jordi Casabona i Barbarà, Center for HIV/STI Epidemiological Studies

2015 European Centre for Disease Prevention and Control - Public Health Guidance

148. Reminder systems for people living with HIV

Reminder systems for people living with HIV Reminder systems for people living with HIV | The Ontario HIV Treatment Network The Ontario HIV Treatment Network Reminder systems for people living with HIV Reminder systems for people living with HIV , Questions What types of telephone, computer and other app-based interventions have been effective in reminding people living with HIV to attend medical appointments and adhere to antiretroviral medications? What types of telephone, computer and other (...) app-based interventions have been effective in reminding people living with HIV to test/retest for STIs and subsequently notify their partners when testing positive? Key take-home messages Text messaging, smart phone applications and cell phone counselling are all effective in promoting adherence to antiretroviral therapy (1-4). Text messaging and smart phone reminders are more effective if they are personal in nature, and if they evoke or require a response from the participant (2;4-6). Text

2015 Ontario HIV Treatment Network

149. Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary

Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 36, Issue 8, Pages 721–734 Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce (...) the full text on ScienceDirect. Abstract Objective This guideline reviews the evidence relating to the care of pregnant women living with HIV and the prevention of perinatal HIV transmission. Prenatal care of pregnancies complicated by HIV infection should include monitoring by a multidisciplinary team with experts in this area. Outcomes Outcomes evaluated include the impact of HIV on pregnancy outcome and the efficacy and safety of antiretroviral therapy and other measures to decrease the risk

2014 Society of Obstetricians and Gynaecologists of Canada

150. Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention

. Highly Active Anti-Retroviral Therapy (HAART) has brought long term survival and maximising bone health in children is increasingly important as this population reach adult life. Screening: Annual autumn screening is recommended since children with HIV in the UK have a high prevalence of vitamin D deficiency. survey (n=131) found that vitamin D deficiency is common in children with perinatally acquired HIV: 83.2% had insufficient levels ( 6yrs can be treated with short courses of high dose (...) Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Authors: Sarah Atkinson and Caroline Foster Date of preparation: February 2011 Version SMH/CF for 20,000 unit capsules Date reviewed: February 2014 Next review: February 2016 Content: 1. Algorithm for the management of vitamin D deficiency. 2. Summary of guidelines 3

2014 The Children's HIV Association

151. Tenofovir DF/emtricitabine/rilpivirine as HIV post-exposure prophylaxis: results from a multicentre prospective study. (PubMed)

-occupational PEP.We conducted an observational, prospective, multicentre, open-label, non-randomized study in five French HIV centres. Adults requiring PEP according to national French guidelines were prescribed TDF/FTC/RPV one pill once a day for 28 days. Clinical and biological tolerability was assessed at week 4; occurrence of HIV seroconversion was evaluated after week 16.From March 2016 to March 2017, 163 courses of PEP were prescribed for 150 sexual exposures (44% heterosexual and 56% MSM) and 13 non (...) and no serious adverse events or hepatic or renal toxicity occurred. No HIV seroconversion occurred at week 16.The low rate of premature treatment interruption, the good tolerability and the absence of documented HIV seroconversion support the current French guidelines of a 28 day course of TDF/FTC/RPV for sexual and non-sexual PEP.© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email

2019 Journal of Antimicrobial Chemotherapy

152. Tropical Travel Trouble 009 Humongous HIV Extravaganza

from 2 hours. First line regimen in the UK is Truvada (Tenofovir (TDF) and Emtricitabine (FTC)) and Raltegravir for 28 days with an infectious disease follow up during this time. This regimen was picked due to safety and tolerability over other combinations. If further risk occurs during the last two days of the PEP course, then PEP should be continued for 48 hours after the last high-risk exposure. If more than 48 hours of PEP is missed it should be discontinued. Follow-up HIV testing (...) . Additional Resources Online ID coursesHIV and vaccines – HIV dermatology video: References Beeching N and Gill G. . 7e Wiley Blackwell 2014. BHIVA – – guidelines 2016 BHIVA/BASHH – guidelines on the use of (PrEP) 2017 BHIVA – 2018 BHIVA – 2017 Boer K, et al . Mode of delivery in HIV-infected pregnant women and prevention of mother-to-child transmission: changing practice in Western Europe. HIV Med 2010; 11:368-78. Bwakura-Dangarembizi M et al and the Antiretroviral research for Watoto (ARROW) Trial

2018 Life in the Fast Lane Blog

153. Intervene fast to prevent lasting cognitive impairment during the primary phase of HIV infection

primary phase HIV-positive participants (<1 year) over the period from 2005 to 2011. Earlier studies have hypothesized that the neural damage occurs during the phase of primary infection. The researchers seek to establish this by using MRI to examine longitudinal trajectories of brain volume and cortical thickness, and to assess the impact of the introduction of cART. Of the 65 longitudinal participants, 34 had either recently begun cART (4) or did so in the course of the trial. Cross sectional data (...) Intervene fast to prevent lasting cognitive impairment during the primary phase of HIV infection Intervene fast to prevent lasting cognitive impairment during the primary phase of HIV infection | Sexually Transmitted Infections by The impact of HIV/AIDS on cognitive function is the topic of a paper appearing in STIs as early as 1989, where some degree of neurological impairment is observed in patients who otherwise appear ‘well’ ( ). Dementia may be rarely seen nowadays, but quality-of-life

2018 Sexually Transmitted Infections blog

154. The risk network approach to HIV detection: something like contact tracing?

The risk network approach to HIV detection: something like contact tracing? The risk network approach to HIV detection: something like contact tracing? | Sexually Transmitted Infections by There has been considerable debate on the most effective and cost-effective means of accessing untested HIV- or STI-infected individuals. One frequently canvassed strategy is that of respondent driven sampling (RDS). This involves issuing suitable ‘seeds’ (e.g. recently diagnosed MSM) with coupons (...) to distribute to others in their sexual or social networks. in a recent study of black MSM in San Francisco compare RDS very favourably with time location sampling (TLS) as a method of recruitment of those most likely to be at risk. Similary, in a small study in Malawi observe the superior effectiveness of infected, over non-infected seeds in discovering untested individuals (31% vs. 11%). Much, of course, depends on the target group; so, for example, find in favour of ‘venue-based’ sampling over RDS

2018 Sexually Transmitted Infections blog

155. Piloting very early infant diagnosis of HIV in Lesotho: Acceptability and feasibility among mothers, health workers and laboratory personnel. (PubMed)

Piloting very early infant diagnosis of HIV in Lesotho: Acceptability and feasibility among mothers, health workers and laboratory personnel. Mortality associated with in-utero HIV infection rises rapidly within weeks after birth. Very early infant diagnosis of HIV (VEID)-testing within 2 weeks of birth-followed by immediate initiation of antiretroviral therapy has potential to avert mortality associated with in-utero transmission. However, our understanding of acceptability and feasibility (...) of VEID is limited.VEID was piloted in an observational prospective cohort of HIV-positive pregnant women and their infants in 13 Lesotho health facilities. Between March-July 2016, semi-structured interviews were conducted with HIV-positive women attending 6-week or 14-week postnatal visits and health workers (HWs) in 8 study facilities in 3 districts as well as with district and central laboratory staff. Interview themes included acceptability of birth and subsequent HIV testing and early treatment

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2018 PLoS ONE

156. Vaccination with Fendrix of prior nonresponding patients with HIV has a high success rate. (PubMed)

HIV treatment centers participated in this retrospective study. Patients infected with HIV-1 and nonresponding to prior course of vaccination against HBV (anti-HBs <10 IU/ml) and who had Fendrix as a second, third or fourth effort to achieve seroconversion were eligible for inclusion. Primary outcome was the proportion of patients with seroconversion after revaccination with Fendrix. Univariate binary logistic regression analyses were used to determine which factors could be used as predictors (...) Vaccination with Fendrix of prior nonresponding patients with HIV has a high success rate. Patients with HIV have a poor serological conversion rate with the standard vaccination strategy against hepatitis B virus (HBV) of around 50%. Vaccination with Fendrix confers much better results in these patients. In this study, we tested the effect of revaccination with Fendrix in prior nonresponding patients with HIV and aimed to determine which factors are associated with seroconversion.Eight Dutch

2019 AIDS

157. The impact of HIV infection and MSM status on hepatitis A infection: the experience of two tertiary centres in Northern Italy during the 2017 outbreak and in the 2009-2016 period. (PubMed)

(MSM). Some reports described a different clinical course of HAV in patients infected by human immunodeficiency virus (HIV) or MSM.We consecutively collected all the hospitalized cases of hepatitis A referred to two tertiary centres in Northern Italy in 2017 and retrospectively analysed the electronic records of the 2009-2016 period (pre-2017). We evaluated demographics data, risk factors, comorbidities and laboratory results to see if MSM status or HIV infection influenced the disease. Overall 117 (...) > 1.5 at admission. MSM status and HIV infection did not affect neither the clinical course nor the severity of hepatitis A. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Journal of viral hepatitis

158. Viral diversity from next-generation sequencing of HIV-1 samples provides precise estimates of infection recency and time since infection. (PubMed)

Viral diversity from next-generation sequencing of HIV-1 samples provides precise estimates of infection recency and time since infection. HIV-1 genetic diversity increases over the course of infection, and can be used to infer time since infection (TSI) and consequently also infection recency, crucial quantities for HIV-1 surveillance and the understanding of viral pathogenesis.We considered 313 HIV-infected individuals for whom reliable estimates of infection dates and next-generation

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2019 Journal of Infectious Diseases

159. The risk network approach to HIV detection: something like contact tracing?

The risk network approach to HIV detection: something like contact tracing? The risk network approach to HIV detection: something like contact tracing? | Sexually Transmitted Infections by There has been considerable debate on the most effective and cost-effective means of accessing untested HIV- or STI-infected individuals. One frequently canvassed strategy is that of respondent driven sampling (RDS). This involves issuing suitable ‘seeds’ (e.g. recently diagnosed MSM) with coupons (...) to distribute to others in their sexual or social networks. in a recent study of black MSM in San Francisco compare RDS very favourably with time location sampling (TLS) as a method of recruitment of those most likely to be at risk. Similary, in a small study in Malawi observe the superior effectiveness of infected, over non-infected seeds in discovering untested individuals (31% vs. 11%). Much, of course, depends on the target group; so, for example, find in favour of ‘venue-based’ sampling over RDS

2018 Sexually Transmitted Infections blog

160. Metabolic syndrome and endocrine status in HIV-infected transwomen. (PubMed)

Metabolic syndrome and endocrine status in HIV-infected transwomen. HIV-infected transwomen face multiple specific issues. Economic and social marginalization, sex work, substance abuse, hormonal consumption and silicone injection may affect the course of HIV infection and lead to metabolic and endocrine complications.A matched case-control study was performed between 2013 and 2015 in a University Hospital and compared metabolic syndrome, thyroid and adrenal functions in HIV-infected transwomen (...) (i.e.; cases) and cisgender HIV-infected men (i.e.; controls) matched for age and antiretroviral therapy. The interaction between hormonal consumption, the course of HIV infection and antiretroviral therapy was also studied. Clinical and biological data (CD4 cell count, HIV RNA load, antiretroviral plasma drug concentration, HDL, triglycerides, glucose, cortisol, TSH, FT4, prolactine) were measured.292 HIV-infected patients (100 cases and 192 controls) were prospectively included

2019 AIDS

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