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HIV Course

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121. Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana (PubMed)

antiretroviral therapy throughout the course of the study, and similar chemotherapeutic regimens were recommended for all patients, regardless of subtype or HIV status (six to eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone; or cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab). There was no difference in 1-year mortality among patients not infected with HIV and patients infected with HIV (unadjusted analysis, 52.9% v 37.1%; hazard ratio [HR], 0.73; P = .33 (...) Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana Botswana has a high prevalence of HIV infection. Currently, there are few data regarding the sociodemographic factors, clinical characteristics, and outcomes of non-Hodgkin lymphoma (NHL)-an AIDS-defining cancer-in the country.This study used a prospective cancer registry to identify patients with a new diagnosis of NHL reporting for specialty cancer care

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2018 Journal of global oncology

122. mCME project V.2.0: randomised controlled trial of a revised SMS-based continuing medical education intervention among HIV clinicians in Vietnam (PubMed)

questions, (2) daily linked readings, (3) links to online CME courses and (4) feedback messages describing the performance of the participant relative to the group. Control participants had equal access to the online CME courses. Our primary endpoint was utilisation of the online CME courses; secondary endpoints were self-study behaviour, performance on a standardised medical exam and job satisfaction.From 121 total HIV clinicians in the three provinces, 106 (87.6%) enrolled, and 48/53 intervention (90 (...) %) and 47/53 control (89%) participants completed the endline evaluations. Compared with controls, intervention participants were more likely to use the CME courses (risk ratio (RR) 2.3, 95% CI 1.4 to 3.8, accounting for 83% of course use (P<0.001)). Intervention participants increased self-study behaviours over controls in terms of use of medical textbooks (P<0.01), consulting with colleagues (P<0.01), searching on the internet (P<0.001), using specialist websites (P=0.02), consulting the Vietnam HIV

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2018 BMJ global health

123. HIV prevalence and determinants of loss-to-follow-up in adolescents and young adults with tuberculosis in Cape Town. (PubMed)

HIV prevalence and determinants of loss-to-follow-up in adolescents and young adults with tuberculosis in Cape Town. TB remains a leading cause of mortality and morbidity in sub-Saharan Africa, due to the HIV epidemic. As TB treatment is lengthy, the completion of the full course of treatment may be especially challenging for young people. We therefore aimed to identify the extent of and reasons underlying loss to follow-up from TB treatment among young people in Cape Town. Accordingly, we (...) reviewed the outcomes of young people treated for TB in Cape Town during 2009-2013, across three age groups: younger adolescents (10-14 years); older adolescents; (15-19 years) and young adults (20-24 years). We employed logistic regression analysis to identify risk factors for loss from TB care. 23,737 patients aged 10-24 were treated for drug sensitive TB over the study period. Of these, the HIV co-infection prevalence was 18.5% for younger adolescents, 12.9% for older adolescents and 33.1% for young

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2019 PLoS ONE

124. Properties of a brief assessment tool for longitudinal measurement of cognition in people living with HIV. (PubMed)

Properties of a brief assessment tool for longitudinal measurement of cognition in people living with HIV. Mild cognitive impairment is common in chronic HIV infection and there is concern that it may worsen with age. Distinguishing static impairment from on-going decline is clinically important, but the field lacks well-validated cognitive measures sensitive to decline and feasible for routine clinical use. Measures capable of detecting improvement are also needed to assess interventions (...) . The objective of this study is to estimate the extent of change on repeat administration of three different forms of a brief computerized cognitive assessment battery (B-CAM) developed for assessing cognitive ability in the mildly-impaired to normal range in people living with HIV. We hypothesized no change over a six-month period in people on effective antiretroviral therapy.102 HIV+ individuals completed a set of computerized cognitive tasks on three occasions over a six-month period. Rasch analysis

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2019 PLoS ONE

125. "I am still negative": Female sex workers' perspectives on uptake and use of daily pre-exposure prophylaxis for HIV prevention in South Africa. (PubMed)

"I am still negative": Female sex workers' perspectives on uptake and use of daily pre-exposure prophylaxis for HIV prevention in South Africa. Women remain highly vulnerable to HIV infection in sub-Saharan Africa, with female sex workers (FSWs) facing some of the highest rates of HIV. Oral pre-exposure prophylaxis (PrEP) has the potential to reduce new infections among populations at highest risk and end-user perspectives of actual use in 'real-world' settings are critical to informing PrEP (...) implementation. This paper presents findings from serial in-depth interviews (IDIs) conducted with FSW participants during the course of the Treatment And Prevention for Sex workers (TAPS) Demonstration Project in South Africa, exploring the lived experiences and perceptions of taking up and using PrEP. This research provides insight into risks and responsibilities facing FSWs perceived as prominent drivers in taking up and using PrEP, how PrEP was adopted to mitigate risk or ameliorate realities

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2019 PLoS ONE

126. Individual factors associated with time to non-adherence to ART pick-up within HIV care and treatment services in three health facilities of Zambézia Province, Mozambique. (PubMed)

the benefits of joining CASGs earlier in one´s treatment course. Finally, greater efforts should be made to accelerate the scale-up of viral load capacity and HIV resistance monitoring. (...) Individual factors associated with time to non-adherence to ART pick-up within HIV care and treatment services in three health facilities of Zambézia Province, Mozambique. Mozambique has made significant gains in addressing its HIV epidemic, yet adherence to visit schedules remains a challenge. HIV programmatic gains to date could be impaired if adherence and retention to ART remains low. We investigate individual factors associated with non-adherence to ART pick-up in Mozambique.This

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2019 PLoS ONE

127. Extended evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E. (PubMed)

Extended evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E. The Thai Phase III Trial of ALVAC-HIV and AIDSVAX B/E showed an estimated vaccine efficacy (VE) of 31% to prevent acquisition of human immunodeficiency virus (HIV). Here we evaluated the effect of vaccination on disease progression after infection.CD4(+) T-cell counts and HIV viral load (VL) were measured serially (...) and per protocol (n = 90) cohorts. Estimated VEP (mITT) was15.8% (-21.9, 41.8) at 60 months postinfection. There was weak evidence of lower VL and higher CD4(+) count at 60 and 66 months in the vaccine group. Lower mucosal VL was observed among vaccine recipients, primarily in semen (P = .04).Vaccination did not affect the clinical course of HIV disease after infection. A potential vaccine effect on the genital mucosa warrants further study.

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2013 Journal of Infectious Diseases

128. Monocyte and myeloid dendritic cell activation occurs throughout the course of HIV-2 infection, an attenuated form of HIV disease. (PubMed)

Monocyte and myeloid dendritic cell activation occurs throughout the course of HIV-2 infection, an attenuated form of HIV disease. Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature (...) reduced viremia and slow disease progression despite the recognized ability of HIV-2 to establish viral reservoirs and overcome host restriction factors in myeloid cells. We found a heightened state of monocyte and mDC activation throughout HIV-2 infection (characterized by CD14(bright)CD16(+) expansion, as well as increased levels of soluble CD14, HLA-DR, and CD86), together with progressive mDC depletion. Importantly, HIV-2-positive patients also featured overexpression of the inhibitory molecule PD

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2013 Journal of Infectious Diseases

129. Short Course Regimens for Treatment of PKDL (Sudan)

Short Course Regimens for Treatment of PKDL (Sudan) Short Course Regimens for Treatment of PKDL (Sudan) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Short Course Regimens for Treatment of PKDL (Sudan (...) -existing clinical hearing loss based on audiometry at baseline Patients with a positive HIV test as applicable Patients / guardian not willing to participate Patients with history of allergy or hypersensitivity to the relevant study drug Patients on immunomodulators therapy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please

2017 Clinical Trials

130. Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine. (PubMed)

Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine. HIV-1 infection may impair transplacental antibody transfer to infants. The impact of highly active antiretroviral treatment (ART) given during pregnancy on transplacental antibody transport is unknown.HIV-1 infected pregnant women with CD4 counts between 200 - 500 were randomized to short-course zidovudine (ZDV) or triple ART at 32 weeks (...) gestation for prevention of mother-to-child HIV-1 transmission. Levels of maternal antibody against measles, pneumococcus and rotavirus at delivery, and antibody transfer to the baby through cord blood, were compared between trial arms.Overall, 141 and 148 women were randomized to triple ART and ZDV, respectively; cord blood was available for a subset (n = 20 in triple ART and n = 22 in ZDV). Maternal antibody levels to all pathogens during pregnancy and at delivery were not significantly different

2017 Pediatric Infectious Dsease Journal

131. Why Humanities Majors Should Take Science Courses

Why Humanities Majors Should Take Science Courses Why Humanities Majors Should Take Science Courses | PLOS Blogs Network PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis (...) that “A naturally occurring DNA segment is a product of nature and not patent-eligible merely because it has been isolated, but cDNA is patent eligible because it is not naturally occurring.” Close, but no cigar. cDNA, or complementary DNA, do form naturally when retroviruses, such as HIV, use an enzyme called reverse transcriptase to convert their genomic RNA into DNA that can then be integrated into their infected hosts. Adding to the confusion, Justice Clarence Thomas, who wrote the majority opinion

2016 PLOS Blogs Network

132. Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma

Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

133. An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers

An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2017 Clinical Trials

134. The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03335124

2017 Clinical Trials

135. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? (PubMed)

A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? 28809515 2017 12 13 2018 12 02 1535-4970 196 4 2017 08 15 American journal of respiratory and critical care medicine Am. J. Respir. Crit. Care Med. A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE? 411-413 10.1164/rccm.201704-0759ED Randolph Adrienne G AG 0000-0002-3084-3071 1 Department of Anesthesiology, Perioperative and Pain Medicine (...) ppublish 28809515 10.1164/rccm.201704-0759ED PMC5564677 PLoS One. 2014 Mar 13;9(3):e92121 24626215 Clin Pharmacol Ther. 2001 Mar;69(3):89-95 11240971 PLoS One. 2014 Jan 29;9(1):e86242 24489704 Crit Care Med. 2016 Nov;44(11):2010-2017 27513537 Crit Care Med. 1996 May;24(5):743-52 8706448 Expert Opin Med Diagn. 2013 Jan;7(1):37-51 23335946 Crit Care Med. 2013 Jul;41(7):1761-73 23685639 Pediatr Crit Care Med. 2005 Jan;6(1):2-8 15636651 Crit Care. 2012 Oct 01;16(5):R174 23025259 Curr Opin HIV AIDS. 2010

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2017 American Journal of Respiratory and Critical Care Medicine

136. Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level (PubMed)

and potentially capture states that are unobservable with ensemble methods because they are below the limit of detection or not conducted on an appropriate time scale. Using the HIV-1 envelope glycoprotein (Env) and its interaction with receptor CD4-binding site neutralizing antibodies as a model system, we both corroborate ensemble kinetics-derived parameters and demonstrate how time-course EM can further dissect stoichiometric states of complexes that are not readily observable with other methods (...) Time-course, negative-stain electron microscopy–based analysis for investigating protein–protein interactions at the single-molecule level Several biophysical approaches are available to study protein-protein interactions. Most approaches are conducted in bulk solution, and are therefore limited to an average measurement of the ensemble of molecular interactions. Here, we show how single-particle EM can enrich our understanding of protein-protein interactions at the single-molecule level

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2017 The Journal of biological chemistry

137. Public health guidance on HIV and STI prevention among men who have sex with men

Public health guidance on HIV and STI prevention among men who have sex with men ECDC GUIDANCE HIV and STI prevention among men who have sex with men www.ecdc.europa.eu ECDC GUIDANCE HIV and STI prevention among men who have sex with men ii This report was commissioned by the European Centre for Disease Prevention and Control (ECDC), coordinated by Anastasia Pharris and Andrew J. Amato-Gauci with technical input from Paloma Carrillo-Santisteve, Tarik Derrough, Erika Duffell, Marco Fonzo, Yvan (...) consultants, formerly Public Health Agency of Sweden). Invaluable input was received from the guidance expert panel, which included the following persons: Rigmor C Berg, Norwegian Knowledge Center for Health Services, Norway, Torsten Berglund, Public Health Agency of Sweden (Folkhälsomydigheten), Hans Blystad, Norwegian Institute of Public Health, Department of Infectious Disease Epidemiology, Norway, Michael Bochow, Consultant, Germany, Jordi Casabona i Barbarà, Center for HIV/STI Epidemiological Studies

2015 European Centre for Disease Prevention and Control - Public Health Guidance

138. Reminder systems for people living with HIV

Reminder systems for people living with HIV Reminder systems for people living with HIV | The Ontario HIV Treatment Network The Ontario HIV Treatment Network Reminder systems for people living with HIV Reminder systems for people living with HIV , Questions What types of telephone, computer and other app-based interventions have been effective in reminding people living with HIV to attend medical appointments and adhere to antiretroviral medications? What types of telephone, computer and other (...) app-based interventions have been effective in reminding people living with HIV to test/retest for STIs and subsequently notify their partners when testing positive? Key take-home messages Text messaging, smart phone applications and cell phone counselling are all effective in promoting adherence to antiretroviral therapy (1-4). Text messaging and smart phone reminders are more effective if they are personal in nature, and if they evoke or require a response from the participant (2;4-6). Text

2015 Ontario HIV Treatment Network

139. Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary

Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 36, Issue 8, Pages 721–734 Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce (...) the full text on ScienceDirect. Abstract Objective This guideline reviews the evidence relating to the care of pregnant women living with HIV and the prevention of perinatal HIV transmission. Prenatal care of pregnancies complicated by HIV infection should include monitoring by a multidisciplinary team with experts in this area. Outcomes Outcomes evaluated include the impact of HIV on pregnancy outcome and the efficacy and safety of antiretroviral therapy and other measures to decrease the risk

2014 Society of Obstetricians and Gynaecologists of Canada

140. Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention

. Highly Active Anti-Retroviral Therapy (HAART) has brought long term survival and maximising bone health in children is increasingly important as this population reach adult life. Screening: Annual autumn screening is recommended since children with HIV in the UK have a high prevalence of vitamin D deficiency. survey (n=131) found that vitamin D deficiency is common in children with perinatally acquired HIV: 83.2% had insufficient levels ( 6yrs can be treated with short courses of high dose (...) Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention Authors: Sarah Atkinson and Caroline Foster Date of preparation: February 2011 Version SMH/CF for 20,000 unit capsules Date reviewed: February 2014 Next review: February 2016 Content: 1. Algorithm for the management of vitamin D deficiency. 2. Summary of guidelines 3

2014 The Children's HIV Association

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