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HIV Course

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301. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV

AIDS acquired immunodeficiency syndrome ALT alanine aminotransferase ART antiretroviral therapy ARV antiretroviral FTC emtricitabine GRADE grading of recommendations, assessment, development and evaluation HBsAg hepatitis B surface antigen HIV human immunodeficiency virus PICO population, intervention, comparison and outcome PMTCT prevention of mother-to-child HIV transmission PrEP pre-exposure prophylaxis TB tuberculosis TDF tenofovir disoproxil fumarate UNAIDS Joint United Nations Programme (...) on HIV/AIDS WHO World Health Organization7 General HIV refers to the human immunodeficiency virus. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of HIV infections globally. Age groups and populations The following definitions for adults, adolescents, children and infants are used to ensure consistency within these guidelines. Other agencies may use different definitions. • An adult is a person older than 19 years. • An adolescent is a person 10–19 years old

2015 World Health Organisation HIV Guidelines

302. Guidelines for conducting HIV surveillance among pregnant women attending antenatal clinics based on routine programme data

and Prevention EIA enzyme immunoassay EMR electronic medical record EMTCT elimination of mother-to-child transmission EQA external quality assessment HIV human immunodeficiency virus HMIS health management information system HTC HIV testing and counselling MCH maternal and child health PDA personal digital assistant PLHIV people living with HIV PMTCT prevention of mother-to-child transmission STI sexually transmitted infections UAT unlinked anonymous testing UNAIDS Joint United Nations Programme on HIV/AIDS (...) a verified high degree of data accuracy, completeness, integrity and accessibility • To use aggregate data: requires an HMIS/routine reporting system with a verified high degree of data accuracy, completeness and integrity • Most ANC sites should be ready to participate in surveillance • Requires fieldwork to collect routine data from ANC sites ANC, antenatal clinics; EMR, electronic medical record; HIV, human immunodeficiency virus; HMIS, health management information system; PMTCT, preventing mother

2015 World Health Organisation HIV Guidelines

303. Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary

Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce Perinatal Transmission: Executive Summary - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 36, Issue 8, Pages 721–734 Guidelines for the Care of Pregnant Women Living With HIV and Interventions to Reduce (...) the full text on ScienceDirect. Abstract Objective This guideline reviews the evidence relating to the care of pregnant women living with HIV and the prevention of perinatal HIV transmission. Prenatal care of pregnancies complicated by HIV infection should include monitoring by a multidisciplinary team with experts in this area. Outcomes Outcomes evaluated include the impact of HIV on pregnancy outcome and the efficacy and safety of antiretroviral therapy and other measures to decrease the risk

2014 Society of Obstetricians and Gynaecologists of Canada

304. Consolidated guidelines on HIV testing services

electrochemiluminescence immunoassay EIA enzyme immunoassay eMTCT elimination of mother-to-child transmission EQA external quality assessment GRADE Grading of Recommendations, Assessment, Development and Evaluation HBV hepatitis B virus HCV hepatitis C virus HIV human immunodeficiency virus HIVST HIV self-testing HTS HIV testing services IVD in vitro diagnostic medical device NASBA nucleic acid sequence-based amplification NAT nucleic acid testing NGO nongovernmental organization OST opioid substitution therapy PCR (...) that there are active networks of people with high risk behaviours within the subpopulation. The future course of the epidemic is determined by the nature of the links between subpopulations with a high HIV prevalence and the general population. Numerical proxy: HIV prevalence is consistently over 5% in at least one defined subpopulation but is below 1% in pregnant women attending antenatal clinics. Confirmed: to issue an HIV status, initially reactive test results need to be confirmed according to the national

2015 World Health Organisation HIV Guidelines

305. Guidelines for HIV mortality measurement

idea of the leading causes of death. This is done to obtain the overall picture and to assess the importance of specific diseases. In 2012, an estimated 1.6 million (range 1.4 to 1.9 million) people died from HIV-related causes, including 1.2 million (range 1.1 to 1.3 million) in sub-Saharan Africa (4). These estimates are based on country data that have been analysed in statistical models, using standard methods developed to estimate the course of the HIV/AIDS epidemic. The main input is HIV (...) where HIV prevalence is high in one or more subpopulations at higher risk (i.e. >5%), but the virus is not circulating in the general population. Low-level epidemics are those where recorded infection is largely confined to members of subpopulations at higher risk of acquiring HIV (e.g. sex workers, drug injectors, men who have sex with men), with HIV prevalence levels below 1% and where HIV has not spread to significant levels within any subpopulation group. Countries with low-level

2015 World Health Organisation HIV Guidelines

306. Guideline for the management of vitamin D deficiency in HIV positive children: screening, treatment and prevention

. Highly Active Anti-Retroviral Therapy (HAART) has brought long term survival and maximising bone health in children is increasingly important as this population reach adult life. Screening: Annual autumn screening is recommended since children with HIV in the UK have a high prevalence of vitamin D deficiency. survey (n=131) found that vitamin D deficiency is common in children with perinatally acquired HIV: 83.2% had insufficient levels ( 6yrs can be treated with short courses of high dose (...) with perinatally acquired HIV-1 infection living in the UK. Poster abstract P159 2010;CHIVA Conference 2010 7. Robinson PD, Hogler W, Craig ME, et al. The re-emerging burden of rickets: a decade of experience from Sydney. Arch Dis Child 2006;91:564-8 8. Callaghan AL, Moy RJ, Booth IW, Debelle G and Shaw NJ. Incidence of symptomatic vitamin D deficiency. Arch Dis Child 2006;91:606-7 9. Tontisirin K, Clugston G. Vitamin and mineral requirements in human nutrition: second edition: World Health Organization

2014 The Children's HIV Association

307. Consolidated strategic information guidelines for HIV in the health sector

elimination of maternal-to-child transmission EQA external quality assurance EWI early warning indicator (of HIV drug resistance) GARPR Global AIDS Response Progress Reporting GIS geographic information system Global Fund Global Fund to Fight AIDS, Tuberculosis and Malaria HA Health Accounts HBV hepatitis B virus HCV hepatitis C virus HIS Health Information System HIV human immunodeficiency virus HIVDR HIV drug resistance HMIS health management information system HRH human resources for health HTS HIV (...) Consolidated strategic information guidelines for HIV in the health sector GUIDELINES HIV STRATEGIC INFORMATION FOR IMPACT MAY 2015 CONSOLIDATED STRATEGIC INFORMATION GUIDELINES FOR HIV IN THE HEALTH SECTOR CONSOLIDATED STRATEGIC INFORMATION GUIDELINES FOR HIV IN THE HEALTH SECTOR MAY 2015WHO Library Cataloguing-in-Publication Data: Consolidated strategic information guidelines for HIV in the health sector. 1.HIV Infections – prevention and control. 2.Acquired Immunodeficiency Syndrome. 3

2015 World Health Organisation HIV Guidelines

308. Short-Course Treatment Regimen of Indian Visceral Leishmaniasis with an Indian Liposomal Amphotericin B Preparation (Fungisome™). Full Text available with Trip Pro

of liposomal amphotericin B (Fungisome™) for VL caused by Leishmania donovani in India. An open-label, randomized, single-center comparative study was undertaken from 2008 to 2011, involving 120 treatment naive non-human immunodeficiency virus VL patients randomly allocated to two groups. Fungisome™ was given, in groups A (N = 60), 5 mg/kg daily for 2 days and B (N = 60), 7.5 mg/kg daily for 2 days, as intravenous infusion. Initial cure rate was 100% in both the groups after 1 month posttreatment. At 6 (...) Short-Course Treatment Regimen of Indian Visceral Leishmaniasis with an Indian Liposomal Amphotericin B Preparation (Fungisome™). India bears the burden of about half of global visceral leishmaniasis (VL) cases with emerging problems of stibanate resistance. Liposomal preparations have improved treatment outcome through shorter duration of therapy and lower toxicity compared with conventional amphotericin B. We report the efficacy of two short-course regimens of an Indian preparation

2015 American Journal of Tropical Medicine & Hygiene Controlled trial quality: uncertain

309. A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2015 Clinical Trials

310. Short-course Antimicrobial Therapy for Paediatric Respiratory Infections

), and have no evidence of empyaema or necrotizing pneumonia on chest radiograph. Exclusion Criteria: Children will be excluded if they have any of the following: cystic fibrosis, anatomic lung disease, bronchiectasis, congenital heart disease, history of repeated aspiration or velopharyngeal incompetence, malignancy, conditions requiring treatment with immune suppressants, primary immunodeficiency, advanced HIV infection, prolonged admissions (>48 h) to hospital within the past 2 months, pneumonia (...) Short-course Antimicrobial Therapy for Paediatric Respiratory Infections Short-course Antimicrobial Therapy for Paediatric Respiratory Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Short-course

2015 Clinical Trials

311. Natural Course of Chlamydia trachomatis Bacterial Load in the Time Interval between Screening and Treatment in Anogenital Samples Full Text available with Trip Pro

Natural Course of Chlamydia trachomatis Bacterial Load in the Time Interval between Screening and Treatment in Anogenital Samples Although Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection worldwide, little is known about the natural course of the bacterial load during infection. We investigated the natural course of the bacterial load in the interval between screening and returning for treatment in genital and anorectal CT-infections.CT-positive patients (...) , visiting our STI-clinic in the Netherlands from June 2011-January 2014, provided a second urogenital and/or anorectal sample when returning for treatment (diagnostic sample = T1; treatment sample = T2). Patient-record provided data about the days between samples and the date of last unsafe sex. Included patients were ≥18 years old, HIV-negative and did not report antibiotic use in the study-interval. CT load was quantified using qPCR. CT load was log-transformed, and a CT load difference (Δ-CT load

2015 PloS one

312. A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

of peripheral venous access History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies Active infection, or history of or known presence of recurrent or chronic infection such as human immunodeficiency virus (HIV), syphilis, or tuberculosis History of progressive multifocal leukoencephalopathy Contraindications to or intolerance of oral or IV corticosteroids Previous treatment with fingolimod (Gilenya®) or dimethyl fumarate (Tecfidera®) in participants whose lymphocyte (...) progressive multiple sclerosis (PPMS), progressive relapsing multiple sclerosis (PRMS), or secondary progressive multiple sclerosis (SPMS) Contraindications for MRI Known presence of other neurological disorders that may mimic multiple sclerosis Pregnancy or lactation, or intention to become pregnant during the study Requirement for chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study History of or currently active primary or secondary immunodeficiency Lack

2015 Clinical Trials

313. A Safety and Immune Study of 2 Types of GlaxoSmithKline's Varicella Vaccines Given as a 2-doses Course to Healthy Children 12-23 Months of Age.

or disease Intervention/treatment Phase Chicken-pox Illness (Varicella Virus Disease) Biological: Varilrix HSA-free Biological: Varilrix™ Phase 3 Detailed Description: GSK Biologicals has removed human serum albumin (a stabilizer) from its varicella vaccine to minimize as much as possible the use of animal or human-derived products in the production of vaccines. The study is intended to provide information on the safety and immunogenicity of GlaxoSmithKline (GSK) Biologicals' candidate varicella vaccine (...) Results First Posted: October 11, 2017 Last Update Posted: January 4, 2018 Last Verified: October 2017 Keywords provided by GlaxoSmithKline: Immunogenicity Varicella Safety Human serum albumin Healthy children 12 to 23 months Additional relevant MeSH terms: Layout table for MeSH terms Chickenpox Herpes Zoster Virus Diseases Varicella Zoster Virus Infection Herpesviridae Infections DNA Virus Infections Vaccines Immunologic Factors Physiological Effects of Drugs

2015 Clinical Trials

314. Clinical Course Study in Chronic Hepatitis B After Nucleos(t)Ide Analogue Therapy

ClinicalTrials.gov Identifier: Other Study ID Numbers: CF15240B First Posted: October 21, 2015 Last Update Posted: September 12, 2018 Last Verified: September 2018 Additional relevant MeSH terms: Layout table for MeSH terms Hepatitis, Chronic Hepatitis B Hepatitis B, Chronic Hepatitis Liver Diseases Digestive System Diseases Hepadnaviridae Infections DNA Virus Infections Virus Diseases Hepatitis, Viral, Human Entecavir Antiviral Agents Anti-Infective Agents (...) Clinical Course Study in Chronic Hepatitis B After Nucleos(t)Ide Analogue Therapy Clinical Course Study in Chronic Hepatitis B After Nucleos(t)Ide Analogue Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2015 Clinical Trials

315. Implementation of a Training Course Increased the Diagnosis of Histoplasmosis in Colombia. Full Text available with Trip Pro

Implementation of a Training Course Increased the Diagnosis of Histoplasmosis in Colombia. Histoplasmosis causes a significant mortality, especially persons living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) from developing countries where access to both appropriate diagnostic methods and antiretroviral therapy are limited. A total of 81 physicians assigned to 17 Colombian departments (states) received training in the clinical, epidemiological, and diagnostic (...) aspects of histoplasmosis. Once this training was received and during the period of October 2009-November 2012, these physicians sent biological samples for immunodiagnostic, mycological, and molecular tests from their patients with suspicion of histoplasmosis. A total of 1,536 samples from 768 patients were evaluated. Of the 768 patients studied, 463 (60%) were HIV positive, 214 (28%) HIV negative, and in 91 (12%) this diagnosis was unknown, and 538 (70%) were males. The 1,536 specimens studied

2015 American Journal of Tropical Medicine & Hygiene

316. Follicular helper T cells are major HIV-2 reservoirs and support productive infection. Full Text available with Trip Pro

Follicular helper T cells are major HIV-2 reservoirs and support productive infection. Follicular helper T cells (Tfh), CD4 lymphocytes critical for efficient antibody responses, have been shown to be key HIV-1 reservoirs. HIV-2 infection represents a unique naturally-occurring model for investigating Tfh role in HIV/AIDS, given its slow rate of CD4 decline, low to undetectable viremia and high neutralizing antibodies titers throughout the disease course. We investigated here, for the first (...) time, Tfh susceptibility to HIV-2 infection by combining in vitro infection of tonsillar Tfh with the ex vivo study of circulating Tfh from HIV-2-infected patients. We reveal that Tfh support productive HIV-2 infection and are preferential viral targets in HIV-2-infected individuals.© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

2019 Journal of Infectious Diseases

317. Text Messaging to Improve Linkage, Retention, and Health Outcomes Among HIV-Positive Young Transgender Women: Protocol for a Randomized Controlled Trial (Text Me, Girl!). Full Text available with Trip Pro

message intervention delivery; n=61) or Group B (delayed text message intervention delivery whereby participants were delivered the text-messaging intervention after a 90-day delay period; n=69). Over the course of the 90-day intervention, participants received 270 theory-based text messages that were targeted, tailored, and personalized specifically for young transgender women living with HIV. Participants received 3 messages per day in real time within a 10-hour gradual and automated delivery system (...) Text Messaging to Improve Linkage, Retention, and Health Outcomes Among HIV-Positive Young Transgender Women: Protocol for a Randomized Controlled Trial (Text Me, Girl!). Transgender women in the United States experience numerous risk factors for HIV acquisition and transmission, including increased rates of homelessness, alcohol and drug use, sex work, and nonprescribed hormone and soft tissue-filler injections. In addition, transgender women face discrimination and social/economic

2019 JMIR Research Protocols Controlled trial quality: uncertain

318. Evaluation of a Computer-Based Training Program to Teach Adults at Risk for HIV About Pre-Exposure Prophylaxis. Full Text available with Trip Pro

questions. Participants trained on each module until they met speed and accuracy criteria. The modules were divided into: Course 1 (HIV), Course 2 (PrEP), and Course 3 (HIV risk behaviors). Tests of content from all three courses were delivered before and after participants completed each course. Test scores on the content delivered in the courses improved only after participants completed training on each course. HIV and PrEP knowledge was initially low and increased following completion of each part (...) Evaluation of a Computer-Based Training Program to Teach Adults at Risk for HIV About Pre-Exposure Prophylaxis. This study developed a computer-based program to teach HIV prevention behaviors and raise awareness of pre-exposure prophylaxis (PrEP) among individuals at risk for HIV. The program was divided into modules containing educational material and multiple-choice questions. Participants received immediate feedback for responses and incentives for correct responses to multiple-choice

2019 AIDS education and prevention : official publication of the International Society for AIDS Education Controlled trial quality: uncertain

319. Updates on HIV nonoccupational postexposure prophylaxis. (Abstract)

to increase provider awareness of appropriate nPEP prescription.Research of HIV nPEP shows that it is effective when used correctly, but there needs to be increased education and awareness to increase provider prescription and patient use as well as institutional changes to help patients complete the full course of medication. (...) Updates on HIV nonoccupational postexposure prophylaxis. Adolescents and young adults continue to contribute to new HIV infections despite improved antiretroviral regimens and HIV preexposure and postexposure prophylaxis (PrEP and PEP). Knowledge about nonoccupational HIV PEP (nPEP) is relevant and important for all pediatricians as adolescents present under a variety of circumstances disclosing past sexual activity.nPEP is effective in preventing HIV infection, and newer regimens have been

2019 Current Opinion in Pediatrics

320. A Mixed Methods Evaluation of an Inclusive Sexual History Taking and HIV Prevention Curriculum for Trainees. (Abstract)

, sexually transmitted infections, and HIV risk assessment and risk reduction counseling including use of PrEP.A dedicated PrEP Clinic was created within an Academic Medical Center Outpatient HIV Clinic. Patients were primarily LGBTQ identified, but also included HIV sero-discordant couples, cisgender individuals, heterosexual invididuals, and those with experience of homelessness, sex work, and substance abuse.Thirty-four internal medicine residents completed the course between November 2017 and May (...) statistically significant increased confidence and comfort in all seven HIV prevention topic areas, with the greatest gains in safe sex counseling for LGBTQ patients and in discussing PrEP (mean changes of 1.21, 1.58 on 5-point Likert scale, respectively, p < 0.0001). Six of nine interviewees post-course had applied what they learned to patient care; five indicated their learning would benefit patients.An HIV prevention curriculum focused on cultural humility in care can improve trainee's skills in HIV risk

2019 Journal of General Internal Medicine

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