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HIV Course

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181. Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle (PubMed)

Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle HIV-1 DNA is found both integrated in the host chromosome and unintegrated in various forms: linear (DNAL) or circular (1-LTRc, 2-LTRc or products of auto-integration). Here, based on pre-established strategies, we extended and characterized in terms of sensitivity two methodologies for quantifying 1-LTRc and DNAL, respectively, the latter being able to discriminate between unprocessed or 3'-processed (...) that 3'-processing efficiency did not influence the total 2-LTRc accumulation although the nature of the LTR-LTR junction was qualitatively affected. Finally, a significant proportion of 1-LTRc was generated concomitantly with reverse transcription, although most of the 1-LTRc were produced in the nucleus.We describe the fate of viral DNA forms during HIV-1 infection. Our study reveals the interplay between various forms of the viral DNA genome, the distribution of which can be affected by mutations

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2013 Retrovirology

182. Assessment of VAC-3S Therapeutic Properties When Combined With Standard ART in the Course of HIV-1 Infection

Assessment of VAC-3S Therapeutic Properties When Combined With Standard ART in the Course of HIV-1 Infection Assessment of VAC-3S Therapeutic Properties When Combined With Standard ART in the Course of HIV-1 Infection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Assessment of VAC-3S Therapeutic Properties When Combined With Standard ART in the Course of HIV-1 Infection The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02041247 Recruitment Status : Unknown Verified June 2016 by InnaVirVax

2013 Clinical Trials

183. The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana

The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana (HHECO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01897909 Recruitment Status : Active, not recruiting First Posted : July

2013 Clinical Trials

184. Immunological and virological benefits resulted from short-course treatment during primary HIV infection: a meta-analysis. (PubMed)

Immunological and virological benefits resulted from short-course treatment during primary HIV infection: a meta-analysis. To assess the potential immunological and virological effects that result from short-course antiretroviral treatment during primary HIV infection (PHI). And to investigate whether treatment initiation time, treatment duration and follow-up time after treatment interruption would affect these post-treatment immunovirological outcomes.We systematically searched PubMed (...) . Extending treatment duration beyond 12 months did not increase efficacy.Short-course treatment during PHI was associated with immunological and virological benefits which last for at least one year after treatment interruption. The conclusions from our study would help the decision-making in the clinical management of PHI.

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2013 PloS one

185. Short communication: effect of short-course antenatal zidovudine and single-dose nevirapine on the BED capture enzyme immunoassay levels in HIV type 1 subtype C infection. (PubMed)

Short communication: effect of short-course antenatal zidovudine and single-dose nevirapine on the BED capture enzyme immunoassay levels in HIV type 1 subtype C infection. Cross-sectional prevalence studies based on immunoassays that discriminate between recent and long-term infections, such as the BED assay, have been widely used to estimate HIV incidence. However, individuals receiving highly active antiretroviral therapy tend to have lower BED levels and are associated with a higher risk (...) gestation through delivery and were randomized to receive either sdNVP or placebo during labor. Among 159 subjects, the OD-n levels decreased from baseline to delivery in 93 subjects (p=0.039), suggesting that short-course ZDV may decrease OD-n levels. sdNVP at delivery did not affect longitudinal BED OD-n levels postdelivery. However, sdNVP appeared to modify the association between CD4 count at delivery and OD-n levels postdelivery. When estimating HIV incidence with the BED assay, special care may

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2013 AIDS research and human retroviruses

186. Anogenital Human Papillomavirus Infection and HIV Infection Outcomes Among Peruvian Transgender Women: Results from a Cohort Study (PubMed)

transgender women enrolled into a 2-year, prospective cohort study: 95.6% had at least one anogenital HPV genotype at baseline, 19.1% had visible anogenital warts, and 6.0% became infected with HIV over the course of the study. Due to the high anogenital HPV prevalence, this population would likely benefit from early immunization with the HPV vaccine. (...) Anogenital Human Papillomavirus Infection and HIV Infection Outcomes Among Peruvian Transgender Women: Results from a Cohort Study Latin American transgender women are highly vulnerable to HIV infection, and although much is known about factors associated with HIV infection in this population, little is known about the association of human papilloma virus (HPV) with HIV infection. We investigated anogenital HPV and cumulative HIV incidence among 68, initially HIV uninfected, Peruvian

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2016 Transgender health

187. Susceptibility of heterosexual sub-Saharan women to HIV could be the result of cervicovaginal microbiome characteristics

these discussions is a recently published study by of a prospective cohort of 236 young HIV-negative women participating in the South African Ragon Institute’s study ( F emales R ising through E ducations, S upport and H ealth) in Kwa-Zulu Natal. The researchers were able to follow up their cohort for a total of 198.2 person-years, in the course of which 31 participants acquired HIV. The researchers distinguish four ‘cervicotypes’ in respect to FGT bacterial flora; then determine their prevalence along (...) Susceptibility of heterosexual sub-Saharan women to HIV could be the result of cervicovaginal microbiome characteristics Susceptibility of heterosexual sub-Saharan women to HIV could be the result of cervicovaginal microbiome characteristics | Sexually Transmitted Infections by Could part of the explanation for the apparent susceptibility of sub-Saharan African heterosexual women to HIV infection (eight-fold that of males) lie in the bacterial flora of their female genital tract (FGT)? Studies

2017 Sexually Transmitted Infections blog

188. Revised UK NICE Guidelines for HIV testing: why local prevalence based targeting by GPs and hospitals makes sense

departments: . This trial seems to have spectacularly failed to pick up any HIV infections that would not have been detected even without the intervention. By contrast, what is proposed by the is routine testing in areas of extremely high prevalence . Of course, patients may still refuse testing ( ) – and appear to do so all the more frequently where they belong to groups, like non-African heterosexuals, that the authors of the 2016 guidelines are so anxious to include ( ). Nevertheless, the 2014 HINTS (...) Revised UK NICE Guidelines for HIV testing: why local prevalence based targeting by GPs and hospitals makes sense Revised UK NICE Guidelines for HIV testing: why local prevalence based targeting by GPs and hospitals makes sense | Sexually Transmitted Infections by November 2016 saw the publication of revised UK for HIV testing (last updated 2011) – only a few weeks before the appearance of the annual Public Health England Report: . The latter highlights the estimated level of still undiagnosed

2017 Sexually Transmitted Infections blog

189. Location of HIV-2 emergence determined by distribution of indigenous cultural practices of male circumcision

), or performed it only late in life or very intermittently (Guinea Bissau). The complexity of this study arises from the fact that, thanks to waves of islamicization, male circumcision has been widely adopted across the region even in areas where it was traditionally prohibited. Hence investigation of the correlation with HIV-2 emergence, probably in the 1940s, required the authors to go back to ethnographic accounts preceding islamicization. Of course, the certainty of a causal link cannot be established (...) Location of HIV-2 emergence determined by distribution of indigenous cultural practices of male circumcision Location of HIV-2 emergence determined by distribution of indigenous cultural practices of male circumcision | Sexually Transmitted Infections by demonstrate a robust correlation between HIV-2 prevalence at the time of the 1980s surveys and the absence of indigenous practices of male circumcision earlier in the century. This is a complex and interdisciplinary study, involving some

2017 Sexually Transmitted Infections blog

190. Infection with hepatitis, HIV or AIDS may be significant risk factor for suicide

Infection with hepatitis, HIV or AIDS may be significant risk factor for suicide Hepatitis, HIV or AIDS may be significant risk factors for suicide Search National Elf Service Search National Elf Service » » » » Infection with hepatitis, HIV or AIDS may be significant risk factor for suicide Dec 1 2016 Posted by The role of physical illness has received little attention in psychiatric research as a potential marker of suicide risk despite emerging research evidence suggesting that as many (...) with suicidal behaviour (Okusaga, 2011). Rates of suicidal ideation have also been found to be higher in those infected with the Human Immunodeficiency Virus (HIV) (De Aledida, 2016) and hepatitis C (Lucaciu, 2015). These studies have tended to rely on cross-sectional research designs, thereby precluding clarification of whether infection lies on the causative pathway towards suicide, or alternatively, whether it is merely coincidence that patients who engage in suicidal behaviour also have brain markers

2016 The Mental Elf

191. Empirical evidence that achievement of UNAIDS 90-90-90 can deliver promised HIV elimination?

great – especially in regard to the element of engagement and retention in treatment ; ) that the question of whether the necessary interventions would really bring about the proposed goal of the elimination of HIV – of whether the modelers are right – disappears off the horizon. Results of the recent (Grabowski & Chang (G&C) from 30 communities (17,879 persons) in Uganda, over the course of 12 surveys undertaken between 1999 and 2016, show the following trends. First, an increase in viral load (...) Empirical evidence that achievement of UNAIDS 90-90-90 can deliver promised HIV elimination? Empirical evidence that achievement of UNAIDS 90-90-90 can deliver promised HIV elimination? | Sexually Transmitted Infections by The achievement of the targets would reduce levels of viral suppression amongst HIV+ people to 73% by 2020. The target is set at this ambitious level because, modelers suggest, it would bring about the elimination of HIV by 2030. In sub-Saharan Africa the challenge seems so

2017 Sexually Transmitted Infections blog

192. Gwyneth Paltrow and Goop double down on quackery by featuring an HIV/AIDS denialist and antivaccine quack at its upcoming Goop Summit

chemical is a misguided assault on their very humanity.” Elswhere in the article she claims, “Because we have barely observed the natural course of a now-labeled pathology, we attribute toxicity of medication and treatment to the disease process itself or to other incidental variables, giving pharmaceutical companies a wide birth to harm us, and even kill us.” The problem, of course, is that by 2006 we certainly had observed the natural course of untreated HIV. One of the aspects of HIV natural history (...) ” psychiatrist who denies that HIV causes AIDS, advocates treating depression “naturally,” and is rabidly antivaccine, as evidenced by […] […] #3, of course, is another bogus antivaccine that I’ve addressed on multiple other occasions. […] […] where the faithful can lap up mysticism about life after death and quackery delivered by an anti-psychiatry […] […] These dangers led to an outcry when it was announced that the second In Goop Health summit would feature Dr. Kelly Brogan, a “holistic psychiatrist” who

2017 Respectful Insolence

193. What is the potential of ‘Treatment for Prevention’ in fighting HIV/AIDS?

What is the potential of ‘Treatment for Prevention’ in fighting HIV/AIDS? What is the potential of ‘Treatment for Prevention’ in fighting HIV/AIDS? | Sexually Transmitted Infections by appears to have set the course for a global ‘treatment as prevention’ strategy. In 2015 the US revised its National HIV/AIDS Strategy (NHAS) to harmonize its goals with UNAIDS 90% targets for testing, engagement in care, and virological suppression. Though the HIV/AIDS community have been nervous about the impact (...) of the recent change of administration, the expenditure underpinning the NHAS has been retained despite 18% cuts to the Department of Health and Human Services budget ( ). It is no doubt with a view to maintaining this political course that have recently sought to quantify the benefits of the revised goals as against ‘current pace’ by using mathematical simulation to project five- and twenty-year outcomes. Given the disproportionate implication of black MSM in these effects (they face a 50% lifetime risk

2017 Sexually Transmitted Infections blog

194. Does it ever make sense to target HPV screening at HIV-infected individuals?

in older MSM living with HIV may be attributable to long-term immunologic defects in this population ( (STI)). Elevated HPV rates have also been shown in sexual minority women ( (STI)). Of course, the problem of anal cancers in MSM could be resolved through vaccination of adolescent boys. However, a recent UK study has investigated the feasibility of delivering a targeted HPV vaccination programme to adult MSM through STI clinics ( (STI)). In developing countries, there could also be a case (...) Does it ever make sense to target HPV screening at HIV-infected individuals? Does it ever make sense to target HPV screening at HIV-infected individuals? | Sexually Transmitted Infections by A number of recent studies have considered the case for HPV-related cancer prevention interventions that are targeted at specific populations. In the developed world, interventions of cervical screening and teenage vaccination aim to cover the female, or male and female, population (at a certain age

2017 Sexually Transmitted Infections blog

195. A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002-2011. (PubMed)

for overall drug resistance, and for PRO mutations in particular, over the entire course of the study, with the most rapid decrease in frequency seen after 2006. The reduced HIV-1 mutation and drug resistance trends that we observed are consistent with previous reports from multi-year studies conducted around the world. Reduced resistance can be attributed to the use of more efficacious antiretroviral drug therapy, including the introduction of multi-drug combination therapies, which limited the ability (...) A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002-2011. Puerto Rico has one of the highest rates of HIV/AIDS seen for any US state or territory, and antiretroviral therapy has been a mainstay of efforts to mitigate the HIV/AIDS public health burden on the island. We studied the evolutionary dynamics of HIV-1 mutation and antiretroviral drug resistance in Puerto Rico by monitoring the population frequency of resistance-associated mutations

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2017 PLoS ONE

196. ‘Scoping’ location: the role of ‘place’/’space’ as an influence on HIV outcomes amongst young MSM

‘Scoping’ location: the role of ‘place’/’space’ as an influence on HIV outcomes amongst young MSM ‘Scoping’ location: the role of ‘place’/’space’ as an influence on HIV outcomes amongst young MSM | Sexually Transmitted Infections by (B&S) is a review addressing the impact of location – ‘space’ and ‘place’ – on HIV prevention and care outcomes for young MSM (YMSM). It owes much to and their concern to view human behaviour in terms of ‘social location’ ‘within a context of social oppressive (...) into less physical definitions of context (i.e. ‘place’) – the evidence is more contradictory and sometimes appears counter-intuitive. For example, there are studies that find a positive correlation between social disadvantage and higher levels of adherence to HIV prevention and care recommendations. Apparently, however, income inequality (as measured by Gini ratio or male-to-female ratio of earnings) stands out across studies as an indicator of poorer YMSM outcomes. In discussing the limitations

2017 Sexually Transmitted Infections blog

197. HIV prevention through HAART: a victim of its own success?

HIV prevention through HAART: a victim of its own success? HIV prevention through HAART: a victim of its own success? | Sexually Transmitted Infections by A recent study ( (K&A)) involving a series of four cross-sectional surveys (1996-2016) at a Gay Pride event in US Atlanta Georgia adds to the mounting body of evidence that substantial changes have occurred in community-held beliefs about the safety of certain sexual behaviours in the era of HIV treatment as prevention. It might seem (...) , have remained stable or are actually rising. The obvious hypotheses, tested by K&A in this study, are that, 1., the perception of safety on the part of MSM has led to an increase in condomless anal sex, and that, 2., the growing incidence of STIs resulting from these sexual practices has itself had a direct impact in reducing the protective effects of ART. (Of course, this is not to deny that sizeable proportion of the MSM community in the US – as in Australia ( – be successfully engaged

2017 Sexually Transmitted Infections blog

198. Empirical evidence that achievement of UNAIDS 90-90-90 can deliver promised HIV elimination?

great – especially in regard to the element of engagement and retention in treatment ; ) that the question of whether the necessary interventions would really bring about the proposed goal of the elimination of HIV – of whether the modelers are right – disappears off the horizon. Results of the recent (Grabowski & Chang (G&C) from 30 communities (17,879 persons) in Uganda, over the course of 12 surveys undertaken between 1999 and 2016, show the following trends. First, an increase in viral load (...) Empirical evidence that achievement of UNAIDS 90-90-90 can deliver promised HIV elimination? Empirical evidence that achievement of UNAIDS 90-90-90 can deliver promised HIV elimination? | Sexually Transmitted Infections by The achievement of the targets would reduce levels of viral suppression amongst HIV+ people to 73% by 2020. The target is set at this ambitious level because, modelers suggest, it would bring about the elimination of HIV by 2030. In sub-Saharan Africa the challenge seems so

2017 Sexually Transmitted Infections blog

199. Consolidated guidelines on HIV testing services

that there are active networks of people with high risk behaviours within the subpopulation. The future course of the epidemic is determined by the nature of the links between subpopulations with a high HIV prevalence and the general population. Numerical proxy: HIV prevalence is consistently over 5% in at least one defined subpopulation but is below 1% in pregnant women attending antenatal clinics. Confirmed: to issue an HIV status, initially reactive test results need to be confirmed according to the national (...) Consolidated guidelines on HIV testing services GUIDELINES CONSOLIDATED GUIDELINES ON HIV TESTING SERVICES ISBN 978 92 4 150892 6 For more information, contact: World Health Organization Department of HIV 20, avenue Appia 1211 Geneva 27 Switzerland E-mail: hiv-aids@who.int http://www.who.int/hiv/pub/guidelines/ keypopulations/ JULY 2015 HIV TESTING SERVICES 5Cs: CONSENT, CONFIDENTIALITY, COUNSELLING, CORRECT RESULTS AND CONNECTION CONSOLIDATED GUIDELINES ON HIV TESTING SERVICES, 5Cs: CONSENT

2015 World Health Organisation HIV Guidelines

200. Guidelines for conducting HIV surveillance among pregnant women attending antenatal clinics based on routine programme data

. The guidance is based on the input of surveillance experts and surveillance programmes, and lessons learnt from the field. Countries may adopt or adapt this guidance as appropriate.9 Guidelines for conducting HIV surveillance based on routine programme data 1.2 HIV surveillance among pregnant women in the context of second-generation surveillance: know your epidemic Countries require information on HIV prevalence to monitor the course of their HIV epidemics and to allocate resources, and plan and evaluate (...) Guidelines for conducting HIV surveillance among pregnant women attending antenatal clinics based on routine programme data GUIDELINES CONDUCTING HIV SURVEILLANCE BASED ON ROUTINE PROGRAMME DATA AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINICS UNAIDS/WHO working group on global HIV/AIDS and STI surveillance AUGUST 2015 HIV STRATEGIC INFORMATION FOR IMPACTWHO Library Cataloguing-in-Publication Data: Guidelines for conducting HIV surveillance among pregnant women attending antenatal clinics based

2015 World Health Organisation HIV Guidelines

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