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HIV related Myelopathy

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1. HIV related Myelopathy

HIV related Myelopathy HIV related Myelopathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 HIV related Myelopathy HIV related (...) Myelopathy Aka: HIV related Myelopathy , HIV related Myelitis , Myelopathy in HIV , Myelitis in HIV , HIV-Associated Polymyositis , HIV Myopathy II. Causes Transverse myelitis (VZV) infection Spinal epidural or intradural infection Slowly progressive vacuolar myelopathy Spinal cord dysfunction (more common in advanced HIV) Progressive painless gait disturbance with Increased lower extremity motor tone and progressive weakness Consider MRI Spine HIV-Associated Polymyositis ( ) Similar to autoimmune

2018 FP Notebook

2. Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy. (PubMed)

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy. Objective: Open-label data suggest that intravenous immunoglobulin (IVIG) might improve lower-extremity strength in human immunodeficiency virus (HIV)-associated myelopathy (HIVM), a rare but debilitating neurologic complication of HIV. We sought to determine the feasibility of testing the efficacy of IVIG for HIVM (...) meaningful based on its correlations with the HDMS and the two-minute timed walk test. Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders.

2018 Innovations in clinical neuroscience

3. Diagnostic challenges in vacuolar myelopathy: a didactic case report (PubMed)

, but by no means rules out HIV-related myelopathy. Furthermore, peripheral and central viral load should always be assessed to avoid missing a possible 'CSF HIV-escape'. (...) Diagnostic challenges in vacuolar myelopathy: a didactic case report Because of the diagnostic complexity and potential pitfalls in interpreting test results, HIV-vacuolar myelopathy (HIVM) is far more often diagnosed postmortem than in vivo. In the era of highly active antiretroviral therapy (HAART), the topic of neuro-AIDS has become increasingly important. This case report covers some of the diagnostic problems encountered in vacuolar myelopathy based on magnetic resonance imaging (MRI

Full Text available with Trip Pro

2016 Spinal cord series and cases

4. Diffusion MRI in Cervical Spondylotic Myelopathy (CSM)

of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and/or lumbar stenosis, spine tumor or HIV-related myelopathy and having systemic instability or being deemed unable to tolerate standard MRI sequencing. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) Enrollment : 70 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Predictive Value of Diffusion MRI in Cervical Spondylotic Myelopathy Actual Study Start Date : January 29, 2018 Estimated Primary Completion Date : June 2022 Estimated Study Completion Date : June 2022 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Investigational subjects Patients who have been diagnosed

2017 Clinical Trials

5. HIV related Myelopathy

HIV related Myelopathy HIV related Myelopathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 HIV related Myelopathy HIV related (...) Myelopathy Aka: HIV related Myelopathy , HIV related Myelitis , Myelopathy in HIV , Myelitis in HIV , HIV-Associated Polymyositis , HIV Myopathy II. Causes Transverse myelitis (VZV) infection Spinal epidural or intradural infection Slowly progressive vacuolar myelopathy Spinal cord dysfunction (more common in advanced HIV) Progressive painless gait disturbance with Increased lower extremity motor tone and progressive weakness Consider MRI Spine HIV-Associated Polymyositis ( ) Similar to autoimmune

2015 FP Notebook

6. HIV-1 Associated Vacuolar Myelopathy (Diagnosis)

Considerations Other problems to be considered in the differential diagnosis of HIV-related VM include the following: HIV-associated transverse myelitis during seroconversion [ ] Herpes simplex (HSV) or zoster (VZV) virus infection Cytomegalovirus (CMV) infection Neurosyphilis Cervical disk syndromes Other HIV-associated conditions (eg, Kaposi sarcoma, lymphoma, toxoplasmosis) in the spinal canal Mycobacterium tuberculosis infection Compressive myelopathy (eg, tumor, abscess, herniated disc, arteriovenous (...) to print? Sections HIV-Associated Vacuolar Myelopathy Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (HIV-Associated Vacuolar Myelopathy) and HIV-Associated Vacuolar Myelopathy What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles

2014 eMedicine.com

7. HIV-1 Associated Vacuolar Myelopathy (Overview)

Considerations Other problems to be considered in the differential diagnosis of HIV-related VM include the following: HIV-associated transverse myelitis during seroconversion [ ] Herpes simplex (HSV) or zoster (VZV) virus infection Cytomegalovirus (CMV) infection Neurosyphilis Cervical disk syndromes Other HIV-associated conditions (eg, Kaposi sarcoma, lymphoma, toxoplasmosis) in the spinal canal Mycobacterium tuberculosis infection Compressive myelopathy (eg, tumor, abscess, herniated disc, arteriovenous (...) to print? Sections HIV-Associated Vacuolar Myelopathy Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (HIV-Associated Vacuolar Myelopathy) and HIV-Associated Vacuolar Myelopathy What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles

2014 eMedicine.com

8. HIV-1 Associated Vacuolar Myelopathy (Treatment)

Considerations Other problems to be considered in the differential diagnosis of HIV-related VM include the following: HIV-associated transverse myelitis during seroconversion [ ] Herpes simplex (HSV) or zoster (VZV) virus infection Cytomegalovirus (CMV) infection Neurosyphilis Cervical disk syndromes Other HIV-associated conditions (eg, Kaposi sarcoma, lymphoma, toxoplasmosis) in the spinal canal Mycobacterium tuberculosis infection Compressive myelopathy (eg, tumor, abscess, herniated disc, arteriovenous (...) to print? Sections HIV-Associated Vacuolar Myelopathy Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (HIV-Associated Vacuolar Myelopathy) and HIV-Associated Vacuolar Myelopathy What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles

2014 eMedicine.com

9. HIV-1 Associated Vacuolar Myelopathy (Follow-up)

Considerations Other problems to be considered in the differential diagnosis of HIV-related VM include the following: HIV-associated transverse myelitis during seroconversion [ ] Herpes simplex (HSV) or zoster (VZV) virus infection Cytomegalovirus (CMV) infection Neurosyphilis Cervical disk syndromes Other HIV-associated conditions (eg, Kaposi sarcoma, lymphoma, toxoplasmosis) in the spinal canal Mycobacterium tuberculosis infection Compressive myelopathy (eg, tumor, abscess, herniated disc, arteriovenous (...) to print? Sections HIV-Associated Vacuolar Myelopathy Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (HIV-Associated Vacuolar Myelopathy) and HIV-Associated Vacuolar Myelopathy What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles

2014 eMedicine.com

10. Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM)

: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Immunotherapy of Natural Killer in HTLV-1 Associated Myelopathy Study Start Date : July 2016 Estimated Primary Completion Date : October 2017 Estimated Study Completion Date : December 2017 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: cell therapy NK cells and amniotic epithelial cells Biological (...) for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Clinical diagnosis of HTLV-1 associated myelopathy Exclusion Criteria: HIV infection Hepatitis B & C viral infections Pregnant Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2016 Clinical Trials

11. A Double-Blind, Placebo Controlled Study of Intravenous Immunoglobulin for HIV-Associated Myelopathy

A Double-Blind, Placebo Controlled Study of Intravenous Immunoglobulin for HIV-Associated Myelopathy A Double-Blind, Placebo Controlled Study of Intravenous Immunoglobulin for HIV-Associated Myelopathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Double-Blind, Placebo Controlled Study of Intravenous Immunoglobulin for HIV-Associated Myelopathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01561755 Recruitment Status : Terminated (Difficulty with enrollment) First Posted : March 23, 2012

2012 Clinical Trials

12. Dementia Due to HIV Disease (Diagnosis)

inhibited and are more prone to HIV-related risk behavior (eg, unprotected intercourse), and they therefore pose a greater risk of transmission of the virus. In addition to HIV itself, other causes of neurologic complications in HIV-infected individuals include opportunistic infections, tumors, and antiretroviral drugs. Other neurologic complications that arise from primary HIV infection include vacuolar myelopathy, peripheral neuropathies, and polymyositis. For other discussions of HIV infection, see (...) . HIV-1 encephalopathy and AIDS dementia complex. Multinucleated giant cells, as shown here, are a hallmark of HIV encephalitis and harbor the virus. Image contributed by Dr Beth Levy, Saint Louis University School of Medicine, St Louis, Missouri. Previous Next: Antiretroviral and Other Therapies Currently, highly active antiretroviral therapy (HAART) is the cornerstone of treatment for HIV-related cognitive disorders. Aggressive early treatment of patients with HIV disease with antiviral

2014 eMedicine.com

13. HIV-1 Encephalopathy and AIDS Dementia Complex (Diagnosis)

, these patients are likely to be less inhibited and are more prone to HIV-related risk behavior (eg, unprotected intercourse), and they therefore pose a greater risk of transmission of the virus. In addition to HIV itself, other causes of neurologic complications in HIV-infected individuals include opportunistic infections, tumors, and antiretroviral drugs. Other neurologic complications that arise from primary HIV infection include vacuolar myelopathy, peripheral neuropathies, and polymyositis. For other (...) of treatment for HIV-related cognitive disorders. Aggressive early treatment of patients with HIV disease with antiviral medications and early suppression of viral replication prevents most of the devastating consequences of HIV dementia. [ ] Several studies have shown that early and aggressive treatment of HIV infection decreases the rate of dementia from greater than 50% to 10%. Multiple studies have shown that patients on HAART show partial reversals of neuropsychological deficits and significant

2014 eMedicine.com

14. HIV-1 Encephalopathy and AIDS Dementia Complex (Overview)

inhibited and are more prone to HIV-related risk behavior (eg, unprotected intercourse), and they therefore pose a greater risk of transmission of the virus. In addition to HIV itself, other causes of neurologic complications in HIV-infected individuals include opportunistic infections, tumors, and antiretroviral drugs. Other neurologic complications that arise from primary HIV infection include vacuolar myelopathy, peripheral neuropathies, and polymyositis. For other discussions of HIV infection, see (...) . HIV-1 encephalopathy and AIDS dementia complex. Multinucleated giant cells, as shown here, are a hallmark of HIV encephalitis and harbor the virus. Image contributed by Dr Beth Levy, Saint Louis University School of Medicine, St Louis, Missouri. Previous Next: Antiretroviral and Other Therapies Currently, highly active antiretroviral therapy (HAART) is the cornerstone of treatment for HIV-related cognitive disorders. Aggressive early treatment of patients with HIV disease with antiviral

2014 eMedicine.com

15. HIV-1 Associated CNS Complications (Overview) (Overview)

, neoplastic processes secondary to immunodeficiency or those related to treatment include: Immune Reconstitution Inflammatory Syndrome of the CNS (CNS-IRIS) [ , ] Kaposi sarcoma Fungal infections (eg, , Penicillium marneffei encephalitis) [ ] Tuberculous meningitis encephalitis In addition, HIV-infected patients are susceptible to the same neurologic diseases as patients without infection. In AIDS, a clinical presentation often cannot be explained with a single diagnosis. New-onset neurologic (...) . Other organisms, such as the JC or SV40 viruses that cause PML, may be activated directly by HIV gene products. The likelihood of a particular neurologic syndrome correlates with the clinical stage of HIV infection as reflected by viral load, immune response, and CD4 + lymphocyte counts. This, in turn, is related to the severity of immunodeficiency and autoimmunity and to serum and tissue cytokine levels. Entrance of HIV into the CNS occurs early in the course of infection, likely within days

2014 eMedicine.com

16. HIV-1 Associated Cerebrovascular Complications (Overview)

, neoplastic processes secondary to immunodeficiency or those related to treatment include: Immune Reconstitution Inflammatory Syndrome of the CNS (CNS-IRIS) [ , ] Kaposi sarcoma Fungal infections (eg, , Penicillium marneffei encephalitis) [ ] Tuberculous meningitis encephalitis In addition, HIV-infected patients are susceptible to the same neurologic diseases as patients without infection. In AIDS, a clinical presentation often cannot be explained with a single diagnosis. New-onset neurologic (...) . Other organisms, such as the JC or SV40 viruses that cause PML, may be activated directly by HIV gene products. The likelihood of a particular neurologic syndrome correlates with the clinical stage of HIV infection as reflected by viral load, immune response, and CD4 + lymphocyte counts. This, in turn, is related to the severity of immunodeficiency and autoimmunity and to serum and tissue cytokine levels. Entrance of HIV into the CNS occurs early in the course of infection, likely within days

2014 eMedicine.com

17. HIV-1 Associated Opportunistic Infections: CNS Toxoplasmosis (Overview)

study in Mexico city with 320 patients AIDS patients, the main conditions related to HIV/AIDS were brain toxoplasmosis (42%), cerebral cryptococcosis (28%), tuberculous meningitis (8.7%), lymphoma (non-Hodgkin) (3.75%), acute HIV infection (3.4%), and AIDS dementia complex (3%). [ ] The widespread use of antiretroviral treatment has decreased the incidence of toxoplasmic encephalitis. As an example, among HIV-infected patients in the United States, the annual number of toxoplasmosis-related (...) with sustained response to anti-retroviral therapy. Clin Microbiol Infect . 2006 Jul. 12(7):666-71. . Behbahani R, Moshfeghi M, Baxter JD. Therapeutic approaches for AIDS-related toxoplasmosis. Ann Pharmacother . 1995 Jul-Aug. 29(7-8):760-8. . AAN Quality Standards Subcommittee. Evaluation and management of intracranial mass lesions in AIDS. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology . 1998 Jan. 50(1):21-6. . Klepser ME, Klepser TB. Drug treatment of HIV

2014 eMedicine.com

18. Dementia Due to HIV Disease (Overview)

inhibited and are more prone to HIV-related risk behavior (eg, unprotected intercourse), and they therefore pose a greater risk of transmission of the virus. In addition to HIV itself, other causes of neurologic complications in HIV-infected individuals include opportunistic infections, tumors, and antiretroviral drugs. Other neurologic complications that arise from primary HIV infection include vacuolar myelopathy, peripheral neuropathies, and polymyositis. For other discussions of HIV infection, see (...) . HIV-1 encephalopathy and AIDS dementia complex. Multinucleated giant cells, as shown here, are a hallmark of HIV encephalitis and harbor the virus. Image contributed by Dr Beth Levy, Saint Louis University School of Medicine, St Louis, Missouri. Previous Next: Antiretroviral and Other Therapies Currently, highly active antiretroviral therapy (HAART) is the cornerstone of treatment for HIV-related cognitive disorders. Aggressive early treatment of patients with HIV disease with antiviral

2014 eMedicine.com

19. HIV-1 Encephalopathy and AIDS Dementia Complex (Treatment)

, these patients are likely to be less inhibited and are more prone to HIV-related risk behavior (eg, unprotected intercourse), and they therefore pose a greater risk of transmission of the virus. In addition to HIV itself, other causes of neurologic complications in HIV-infected individuals include opportunistic infections, tumors, and antiretroviral drugs. Other neurologic complications that arise from primary HIV infection include vacuolar myelopathy, peripheral neuropathies, and polymyositis. For other (...) of treatment for HIV-related cognitive disorders. Aggressive early treatment of patients with HIV disease with antiviral medications and early suppression of viral replication prevents most of the devastating consequences of HIV dementia. [ ] Several studies have shown that early and aggressive treatment of HIV infection decreases the rate of dementia from greater than 50% to 10%. Multiple studies have shown that patients on HAART show partial reversals of neuropsychological deficits and significant

2014 eMedicine.com

20. HIV-1 Associated Opportunistic Infections: CNS Toxoplasmosis (Treatment)

study in Mexico city with 320 patients AIDS patients, the main conditions related to HIV/AIDS were brain toxoplasmosis (42%), cerebral cryptococcosis (28%), tuberculous meningitis (8.7%), lymphoma (non-Hodgkin) (3.75%), acute HIV infection (3.4%), and AIDS dementia complex (3%). [ ] The widespread use of antiretroviral treatment has decreased the incidence of toxoplasmic encephalitis. As an example, among HIV-infected patients in the United States, the annual number of toxoplasmosis-related (...) with sustained response to anti-retroviral therapy. Clin Microbiol Infect . 2006 Jul. 12(7):666-71. . Behbahani R, Moshfeghi M, Baxter JD. Therapeutic approaches for AIDS-related toxoplasmosis. Ann Pharmacother . 1995 Jul-Aug. 29(7-8):760-8. . AAN Quality Standards Subcommittee. Evaluation and management of intracranial mass lesions in AIDS. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology . 1998 Jan. 50(1):21-6. . Klepser ME, Klepser TB. Drug treatment of HIV

2014 eMedicine.com

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