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227 results for

Gulf War Syndrome

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1. Double-Blind Placebo-Controlled Study of Rifaximin and Lactulose Hydrogen Breath Test in Gulf War Veterans with Irritable Bowel Syndrome. (PubMed)

Double-Blind Placebo-Controlled Study of Rifaximin and Lactulose Hydrogen Breath Test in Gulf War Veterans with Irritable Bowel Syndrome. Irritable bowel syndrome (IBS) occurs in up to 33% of Gulf War (GW) Veterans. Alterations in gut microflora including small intestinal bacterial overgrowth (SIBO) during deployment may play a role in development of IBS. Rifaximin is a minimally absorbed antibiotic speculated to improve IBS symptoms, in part, by restoring normal gut microflora. The aim

2018 Digestive diseases and sciences Controlled trial quality: uncertain

2. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Gulf War Illness patients exhibit increased humoral responses to the Herpesviruses-encoded dUTPase: Implications in disease pathophysiology (PubMed)

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Gulf War Illness patients exhibit increased humoral responses to the Herpesviruses-encoded dUTPase: Implications in disease pathophysiology Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) are debilitating diseases with overlapping symptomology and there are currently no validated tests for definitive diagnosis of either syndrome. While there is evidence supporting the premise that some herpesviruses (...) ) as well as significantly higher anti-human dUTPase antibodies than in controls (P = 0.0241). These results suggest that screening of patients' sera for the presence of various combinations of anti-dUTPase antibodies could be used as potential biomarkers to help identify/distinguish patients with these syndromes and better direct treatment.© 2017 Wiley Periodicals, Inc.

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2017 Journal of medical virology

3. Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects (PubMed)

Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) have similar profiles of pain, fatigue, cognitive dysfunction and exertional exhaustion. Post-exertional malaise suggests exercise alters central nervous system functions. Lumbar punctures were performed in GWI, CFS and control subjects after (i) overnight rest (nonexercise) or (ii) submaximal bicycle

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2017 Scientific reports

4. Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study. (PubMed)

Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study. Approximately 25%-35% of the 1991 Gulf War Veteran population report symptoms consistent with Gulf War Illness (GWI), a chronic, multi-symptom illness characterised by fatigue, pain, irritable bowel syndrome and problems with cognitive function. GWI is a disabling problem for Gulf War Veterans, and there remains a critical need to identify innovative, novel therapies.Gut (...) microbiota perturbation plays a key role in the symptomatology of other chronic multi-symptom illnesses, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Given similarities between ME/CFS and GWI and the presence of gastrointestinal disorders in GWI patients, Veterans with GWI may also have gut abnormalities like those seen with ME/CFS. In this longitudinal cohort study, we are comparing the diversity (structure) and the metagenomes (function) of the gut microbiome between Gulf War

2019 BMJ open

5. Gulf War Syndrome

Gulf War Syndrome Gulf War Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Gulf War Syndrome Gulf War Syndrome Aka: Gulf War (...) Syndrome , Gulf War Illnesses From Related Chapters II. Epidemiology Veterans of Persian Gulf War (8/90-6/91) 25,000 troops with unexplained symptoms post exposure III. Etiology Thought to be related to exposure Ammunition detonated in March 1991 Ammunition dump contained Likely 100,000 troops exposed IV. Symptoms Stiffness Muscle pain ral weakness Nasal and sinus congestion Excessive Memory problems Impaired concentration Word finding V. Resources Web Resources Veterans assistance: VA: 800-749-9387

2018 FP Notebook

6. Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness.

Gulf War Syndrome Device: Active tDCS Device: Sham tDCS Not Applicable Detailed Description: Gulf War Illness is a chronic and multisymptomatic disorder affecting returning military veterans of the 1990-1991 Gulf war. Pain is a major complaint of Gulf War Illness patients and is a leading cause of disability in veterans diagnosed with musculoskeletal ailments including joint and muscle pain, muscle fatigue, difficulty with lifting objects, and extremity paresthesia's. As a result, the target (...) -regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: Yes Device Product Not Approved or Cleared by U.S. FDA: No Keywords provided by Sven Vanneste, The University of Texas at Dallas: Transcranial Direct Current Stimulation Gulf War Illness Pain modulation Additional relevant MeSH terms: Layout table for MeSH terms Persian Gulf Syndrome Occupational Diseases

2018 Clinical Trials

7. Verification of exercise-induced transient postural tachycardia phenotype in Gulf War Illness (PubMed)

Tachycardia Syndrome (POTS) before and after exercise. The remaining subjects had normal ΔHR (12 ± 5 bpm) and no 1st Peak Effect, and were the Stress Test Originated Phantom Perception phenotype (STOPP). These findings indicate that about one-fourth of all Gulf War Illness study participants (24/90) developed transient postural tachycardia after the submaximal exercise stress test. The START phenotype was defined as being distinctly different from POTS. Additional studies are required to examine (...) Verification of exercise-induced transient postural tachycardia phenotype in Gulf War Illness One third of Gulf War Illness (GWI) subjects in a recent study were found to develop transient postural tachycardia after submaximal exercise stress tests. Post-exercise postural tachycardia is a previously undescribed physiological finding. A new GWI cohort was studied to verify this novel finding and characterize this cardiovascular phenomenon. Subjects followed the same protocol as before

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2018 American journal of translational research

8. Medical Correlates of Chronic Multisymptom Illness in Gulf War Veterans. (PubMed)

Medical Correlates of Chronic Multisymptom Illness in Gulf War Veterans. Chronic multisymptom illness (CMI) is more prevalent among deployed than nondeployed veterans from the first Gulf War. Objective physiologic markers of CMI are lacking. The purpose of this study is to determine whether measurable abnormalities in the autonomic nervous system or hypothalamic-pituitary adrenal axis would distinguish CMI cases (CMI+) from controls (CMI-) among deployed veterans of the 1990-1991 Gulf War.This (...) is a cross-sectional case-control cohort study that examined deployed veterans who participated in the Phase III study: National Health Survey of Gulf War Veterans and Their Families. Autonomic nervous system and hypothalamic-pituitary adrenal axis function-related measures included: 24-hour heart-rate variability, urinary catecholamines and cortisol, hypertension, insulin sensitivity, dyslipidemia, body fat, bone mineral density, and ultrasensitive C-reactive protein.Veterans of the first Gulf War

2018 American Journal of Medicine

9. Probiotic (Visbiome) for Gulf War Illness

provided by (Responsible Party): Ashok Tuteja, VA Salt Lake City Health Care System Study Details Study Description Go to Brief Summary: The overall objective is to determine whether Visbiome will improve intestinal symptoms of Irritable Bowel Syndrome (IBS) and non-intestinal symptoms (fatigue, joint pain, insomnia, general stiffness and headache) associated with IBS. All of these symptoms are part of the Gulf War (GW) illness. Condition or disease Intervention/treatment Phase Gulf War Illness Drug (...) Lake City Health Care System: GWI IBS Irritable Bowel Syndrome Gulf War Illness Probiotics

2017 Clinical Trials

10. Activity of paraoxonase/arylesterase and butyrylcholinesterase in peripheral blood of Gulf War era veterans with neurologic symptom complexes or PTSD (PubMed)

Activity of paraoxonase/arylesterase and butyrylcholinesterase in peripheral blood of Gulf War era veterans with neurologic symptom complexes or PTSD Two groups of Gulf War era veterans, one exhibiting blurred vision, balance problems/dizziness, tremors/shaking, and speech difficulty and a second group with post-traumatic stress disorder (PTSD), but not the neurologic syndrome, were assessed for organophosphate-detoxifying enzyme paraoxonase/arylesterase (PON1) and its Q/R isoforms (...) detoxified by PON1 and BuChE may not have contributed significantly to neurologic components of Gulf War Illness.

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2017 Journal of Occupational and Environmental Medicine

11. Advancing the Role of Neuroimmunity and Genetic Susceptibility in Gulf War Illness (PubMed)

Advancing the Role of Neuroimmunity and Genetic Susceptibility in Gulf War Illness 29239837 2018 09 21 2018 11 13 2352-3964 26 2017 Dec EBioMedicine EBioMedicine Advancing the Role of Neuroimmunity and Genetic Susceptibility in Gulf War Illness. 11-12 S2352-3964(17)30464-4 10.1016/j.ebiom.2017.11.021 O'Callaghan James P JP Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, United States (...) Safety and Health, Health Effects Laboratory Division, Morgantown, WV, United States. eng Journal Article 2017 11 22 Netherlands EBioMedicine 101647039 2352-3964 0 Autoantibodies 0 HLA-DRB1 Chains IM Autoantibodies immunology Brain metabolism Genetic Predisposition to Disease HLA-DRB1 Chains genetics Humans Immune System Diseases diagnosis genetics Persian Gulf Syndrome genetics immunology pathology 2017 11 21 2017 11 21 2017 12 15 6 0 2018 9 22 6 0 2017 12 15 6 0 ppublish 29239837 S2352-3964(17

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2017 EBioMedicine

12. Supporting a Neuroimmune Basis of Gulf War Illness (PubMed)

Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA. Kelly Kimberly A KA Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA. eng Letter 2016 10 26 Netherlands EBioMedicine 101647039 2352-3964 0 HLA Antigens IM Disease Susceptibility Gulf War HLA Antigens genetics immunology Humans Persian Gulf Syndrome etiology (...) Supporting a Neuroimmune Basis of Gulf War Illness 27806904 2017 02 20 2018 11 13 2352-3964 13 2016 Nov EBioMedicine EBioMedicine Supporting a Neuroimmune Basis of Gulf War Illness. 5-6 S2352-3964(16)30498-4 10.1016/j.ebiom.2016.10.037 O'Callaghan James P JP Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA. Electronic address: jdo5@cdc.gov. Michalovicz Lindsay T LT Centers for Disease

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2016 EBioMedicine

13. Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness

Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02915237 Recruitment Status : Completed First Posted : September 26, 2016 Last Update Posted : March 22, 2019 Sponsor

2016 Clinical Trials

14. Effects of Botanical Microglia Modulators in Gulf War Illness

Keywords provided by Jarred Younger, University of Alabama at Birmingham: Gulf War Syndrome Chronic Multisymptom Illnesses Medically Unexplained Illnesses Additional relevant MeSH terms: Layout table for MeSH terms Curcumin Resveratrol Pycnogenols Turmeric extract Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Antineoplastic Agents Enzyme (...) Effects of Botanical Microglia Modulators in Gulf War Illness Effects of Botanical Microglia Modulators in Gulf War Illness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Botanical Microglia

2016 Clinical Trials

15. Effect of Diet on Gulf War Illness

Veteran's intestines which then result in reduced disease symptoms. The goal of this study is to compare a low FODMAP (modified healthy) diet to a high FODMAP (typical healthy) diet for effect on Veterans with IBS and symptoms of Gulf War illness. Condition or disease Intervention/treatment Phase Irritable Bowel Syndrome Behavioral: Low FODMAP Diet Behavioral: High FODMAP Diet Not Applicable Detailed Description: Study Design This will be a prospective, blinded randomized clinical trial with two (...) Effect of Diet on Gulf War Illness Effect of Diet on Gulf War Illness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Diet on Gulf War Illness The safety and scientific validity of this study

2016 Clinical Trials

16. Mitochondrial Cocktail for Gulf War Illness

in Gulf War Illness (GWI). Condition or disease Intervention/treatment Phase Gulf War Syndrome Persian Gulf Syndrome Mitochondrial Disorders Dietary Supplement: Individualized mitochondrial cocktail Dietary Supplement: Arctic cod liver oil capsules Dietary Supplement: Placebo Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Primary Purpose: Other Estimated Primary Completion Date : September 2019 Resource links provided by the National (...) Mitochondrial Cocktail for Gulf War Illness Mitochondrial Cocktail for Gulf War Illness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Mitochondrial Cocktail for Gulf War Illness The safety and scientific

2015 Clinical Trials

17. Towards a Biopsychosocial Model of Gulf War Illness? (PubMed)

Netherlands EBioMedicine 101647039 2352-3964 IM EBioMedicine. 2016 Jan;3:79-85 26870819 Gulf War Humans Persian Gulf Syndrome psychology Veterans psychology 2015 12 21 2015 12 21 2016 2 13 6 0 2016 2 13 6 0 2016 8 25 6 0 epublish 26870810 10.1016/j.ebiom.2015.12.021 S2352-3964(15)30249-8 PMC4739450 BMC Immunol. 2015;16:57 26420016 J Neurochem. 2015 Jun;133(5):708-21 25753028 J Consult Clin Psychol. 2012 Jun;80(3):331-41 22409642 Clin Psychol Rev. 2007 Oct;27(7):842-54 17707114 Psychol Med. 1997 Sep;27(5 (...) Towards a Biopsychosocial Model of Gulf War Illness? 26870810 2016 08 24 2019 01 09 2352-3964 3 2016 Jan EBioMedicine EBioMedicine Towards a Biopsychosocial Model of Gulf War Illness? 6-7 S2352-3964(15)30249-8 10.1016/j.ebiom.2015.12.021 Wojcik Wojtek W Royal Infirmary of Edinburgh, UK. Lawrie Stephen M SM Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK. Electronic address: S.Lawrie@ed.ac.uk. eng Journal Article Comment 2015 12 23

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2015 EBioMedicine

18. Methylphenidate Plus GWI-Ntutrient Formula as a Treatment for Patients With Gulf War Illness

Methylphenidate Plus GWI-Ntutrient Formula as a Treatment for Patients With Gulf War Illness Methylphenidate Plus GWI-Nutrient Formula as a Treatment for Patients With Gulf War Illness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Methylphenidate Plus GWI-Nutrient Formula as a Treatment for Patients With Gulf War Illness The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02357030 Recruitment Status : Unknown Verified October 2015 by K-PAX Pharmaceuticals, Inc.. Recruitment status was: Recruiting First

2015 Clinical Trials

19. Thermal Clinic Treatment in Gulf War Illness

Thermal Clinic Treatment in Gulf War Illness Thermal Clinic Treatment in Gulf War Illness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thermal Clinic Treatment in Gulf War Illness (TCTGWI) The safety (...) Inc Information provided by (Responsible Party): American Society Of Thermalism And Climatology Inc Study Details Study Description Go to Brief Summary: Although thermal therapy has been utilized in the rehabilitation of war veterans since the Roman Empire, no investigations actually exist about the use of thermal therapy in GWI, This due to the fact that nobody knows that the cure for the syndrome in GWI veterans may exist in thermal therapy which is the primary objective of this investigation

2014 Clinical Trials

20. Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans

Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acupressure (...) for Pain Management and Fatigue Relief in Gulf War Veterans The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02075489 Recruitment Status : Completed First Posted : March 3, 2014 Last Update Posted : October 10, 2017 Sponsor: The Cleveland Clinic Information provided by (Responsible Party): The Cleveland

2014 Clinical Trials

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