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Grapefruit

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1. 11β-hydroxysteroid dehydrogenase type-II activity is affected by grapefruit juice and intense muscular work. Full Text available with Trip Pro

11β-hydroxysteroid dehydrogenase type-II activity is affected by grapefruit juice and intense muscular work. The enzymatic activity of 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) is key to protecting mineral corticoid receptors from cortisol and has been implicated in blood pressure regulation. Grapefruit juice (GFJ) and acidity are thought to inhibit this enzyme in vitro. This study examines the effect of GFJ and intense exercise on 11β-HSD2 enzyme activity in vivo.Eighteen subjects

2018 Archives of endocrinology and metabolism Controlled trial quality: uncertain

2. Grapefruit seed extract effectively inhibits the Candida albicans biofilms development on polymethyl methacrylate denture-base resin. Full Text available with Trip Pro

Grapefruit seed extract effectively inhibits the Candida albicans biofilms development on polymethyl methacrylate denture-base resin. This study aimed to investigate the cleansing effects of grapefruit seed extract (GSE) on biofilms of Candida albicans (C. albicans) formed on denture-base resin and the influence of GSE on the mechanical and surface characteristics of the resin. GSE solution diluted with distilled water to 0.1% (0.1% GSE) and 1% (1% GSE) and solutions with Polident® denture

2019 PLoS ONE

3. Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome. Full Text available with Trip Pro

Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome. The list of medications linked to drug-induced long QT syndrome (LQTS) is diverse. It is possible that food products too have QT-prolonging potential.We tested the effects of grapefruit juice on the QT interval with the methodology used by the pharmaceutical industry to test new drugs.This was an open-label, randomized, crossover study with blinded outcome evaluation, a thorough QT study (...) of grapefruit juice performed according to the Guidelines for the Clinical Evaluation of QT/QTc for Non-antiarrhythmic Drugs. Thirty healthy volunteers and 10 patients with congenital LQTS were studied. Healthy volunteers drank 2 L of grapefruit juice (in divided doses), or received 400 mg oral moxifloxacin, in a randomized crossover study. Patients with LQTS were tested with only grapefruit. Repeated baseline, off-drug, and on-drug (grapefruit or moxifloxacin) electrocardiograms were scanned and coded. QT

2019 Heart Rhythm Controlled trial quality: uncertain

4. Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects. (Abstract)

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects. Grapefruit juice (GFJ) is known to affect the bioavailability of drugs in different ways. Despite the influence on gastrointestinal enzymes and transporters, the influence on gastrointestinal fluid kinetics is regarded to be relevant for the absorption of several drugs. Thus

2018 Molecular pharmaceutics

5. Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects. (Abstract)

Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects. The package leaflet for dapoxetine, an effective treatment for premature ejaculation, includes a strict warning against coadministration with drugs or herbal remedies that strongly induce or inhibit the activity of Cytochrome P450 (CYP) 3A4 enzyme.To assess the effects of multiple daily consumption of grapefruit juice (GFJ) and pomegranate juice (PJ

2018 European journal of drug metabolism and pharmacokinetics Controlled trial quality: uncertain

6. Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways Full Text available with Trip Pro

Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways Tumor-specific delivery of therapeutics is challenging. One of the major hurdles for successfully delivering targeted agents by nanovectors is the filtering role of the liver in rapidly sequestering nanovectors from the circulation. Exosomes, a type of endogenous nanoparticle, circulate continuously in the peripheral blood and play a role in intercellular communication. The aim (...) of this study was to determine whether the level of endogenous exosomes has an effect on nanovector delivery efficiency of targeted agents. Methods: Exosomes were isolated from peripheral blood and intravenously (I.V.) injected into tumor-bearing mice. Subsequently, 1,1-dioctadecyl-3,3,3'3'-tetramethylindotricarbocyanine-iodide (DiR) fluorescent dye-labeled nanoparticles, including grapefruit nanovectors (GNV) and standard liposomes, were I.V. injected in the mice. The efficiency of redirecting GNVs from

2018 Theranostics

7. Does consumption of red grapefruit juice alter naringenin concentrations in milk produced by breastfeeding mothers? Full Text available with Trip Pro

Does consumption of red grapefruit juice alter naringenin concentrations in milk produced by breastfeeding mothers? The content of certain ingredients of human milk, such as flavonoids, depend on the types and amounts of plant products consumed and may vary from woman to woman. The aim of the study was to determine to what extent consumption of an average amount of grapefruit juice (250 ml) affected naringenin content in human milk. A total of 14 breastfeeding mothers were included in the study (...) . The subjects remained on a diet with restricted intake of naringenin for a total of five days except on the third day, when they drank a single serving of 250 ml of grapefruit juice. A considerable subject-to-subject variability in naringenin content was observed in both initial and subsequent determinations. Baseline concentration values, which may reflect naringenin content in the milk produced by the breastfeeding mother who eat an everyday (unmodified) diet, ranged from 420.86 nmol/l to 1568.89 nmol/l

2017 PLoS ONE

8. Genotyping by sequencing reveals the interspecific C. maxima / C. reticulata admixture along the genomes of modern citrus varieties of mandarins, tangors, tangelos, orangelos and grapefruits. Full Text available with Trip Pro

Genotyping by sequencing reveals the interspecific C. maxima / C. reticulata admixture along the genomes of modern citrus varieties of mandarins, tangors, tangelos, orangelos and grapefruits. The mandarin horticultural group is an important component of world citrus production for the fresh fruit market. This group formerly classified as C. reticulata is highly polymorphic and recent molecular studies have suggested that numerous cultivated mandarins were introgressed by C. maxima (the pummelos (...) ). C. maxima and C. reticulata are also the ancestors of sweet and sour oranges, grapefruit, and therefore of all the "small citrus" modern varieties (mandarins, tangors, tangelos) derived from sexual hybridization between these horticultural groups. Recently, NGS technologies have greatly modified how plant evolution and genomic structure are analyzed, moving from phylogenetics to phylogenomics. The objective of this work was to develop a workflow for phylogenomic inference from Genotyping

2017 PLoS ONE

9. Potentiating and synergistic effect of grapefruit juice on the antioxidant and anti-inflammatory activity of aripiprazole against hydrogen peroxide induced oxidative stress in mice. Full Text available with Trip Pro

Potentiating and synergistic effect of grapefruit juice on the antioxidant and anti-inflammatory activity of aripiprazole against hydrogen peroxide induced oxidative stress in mice. Dependence on antipsycotic drugs like aripriprazole (ARI) is increasing at alarming rate, hence, this study was undertaken to support the hypothesis that supplementation of Citrus paradisi (Grapefruit) juice having high concentration of polyphenols might potentiate and synergize the therapeutic effect of ARI

2018 BMC Complementary and Alternative Medicine

10. Bergamottin, a natural furanocoumarin abundantly present in grapefruit juice, suppresses the invasiveness of human glioma cells via inactivation of Rac1 signaling Full Text available with Trip Pro

Bergamottin, a natural furanocoumarin abundantly present in grapefruit juice, suppresses the invasiveness of human glioma cells via inactivation of Rac1 signaling The aim of the present study was to explore the effect of bergamottin, a natural furanocoumarin obtained from grapefruit juice, on the invasiveness of human glioma cells. The results revealed that treatment with bergamottin for 48 h significantly inhibited wound-healing migration and Matrigel invasion of human glioma cells, compared

2017 Oncology letters

11. Aromatherapies using Osmanthus fragrans oil and grapefruit oil are effective complementary treatments for anxious patients undergoing colonoscopy: A randomized controlled study. (Abstract)

Aromatherapies using Osmanthus fragrans oil and grapefruit oil are effective complementary treatments for anxious patients undergoing colonoscopy: A randomized controlled study. Colonoscopy can be painful and uncomfortable. Aromatherapy is often used for the relief of anxiety or discomfort. Recently, it has been reported that olfactory stimulation induces various physiological effects. We investigated the effects of aromatherapy on anxiety and abdominal discomfort during colonoscopy.The (...) investigation was carried out using a randomized controlled study. Aromatherapy was performed by vapor diffusion, and each patient was given one of the following treatments: no inhalation (control group), essential-oil-less vapor (vehicle group), lavender oil (lavender group), grapefruit oil (grapefruit group), or Osmanthus fragrans oil (Osmanthus fragrans group). Following total colonoscopy procedures, each patient estimated their anxiety and abdominal discomfort using the Numeric Rating Scale.Total

2017 Complementary Therapies In Medicine Controlled trial quality: uncertain

12. Editorial Commentary: The Grapefruit: So Much More Than an Annoying Breakfast Item-A Valuable Tool for Arthroscopic Simulation Training. Full Text available with Trip Pro

Editorial Commentary: The Grapefruit: So Much More Than an Annoying Breakfast Item-A Valuable Tool for Arthroscopic Simulation Training. As our industry is continually developing more technologically advanced and expensive virtual training equipment, the grapefruit may represent an economic and accessible approach to arthroscopic simulation. This won't replace simulators, but it could become an important tool in the armamentarium of arthroscopic educators as it provides inexpensive haptic

2017 Arthroscopy

13. Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice Full Text available with Trip Pro

Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health-care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co-consumption with conventional drugs, raising concerns for unwanted natural product-drug interactions. Assessing (...) the drug interaction liability of natural products is challenging due to the complex and variable chemical composition inherent to these products, necessitating a streamlined preclinical testing approach to prioritize precipitant individual constituents for further investigation. Such an approach was evaluated in the current work to prioritize constituents in the model natural product, grapefruit juice, as inhibitors of intestinal organic anion-transporting peptide (OATP)-mediated uptake. Using OATP2B1

2017 Biopharmaceutics & drug disposition

14. In silico analysis of the grapefruit sRNAome, transcriptome and gene regulation in response to CTV-CDVd co-infection Full Text available with Trip Pro

In silico analysis of the grapefruit sRNAome, transcriptome and gene regulation in response to CTV-CDVd co-infection Small RNA (sRNA) associated gene regulation has been shown to play a significant role during plant-pathogen interaction. In commercial citrus orchards co-infection of Citrus tristeza virus (CTV) and viroids occur naturally.A next-generation sequencing-based approach was used to study the sRNA and transcriptional response in grapefruit to the co-infection of CTV and Citrus

2017 Virology journal

15. Grapefruit: Some perspectives in pharmacology and nutrition Full Text available with Trip Pro

Grapefruit: Some perspectives in pharmacology and nutrition 28894634 2018 11 13 2146-8397 6 3 2017 Jul-Sep Journal of intercultural ethnopharmacology J Intercult Ethnopharmacol Grapefruit: Some perspectives in pharmacology and nutrition. 339-341 10.5455/jice.20170511061624 Jargin Sergei V SV Peoples' Friendship University of Russia, Russia. eng Journal Article 2017 05 30 United States J Intercult Ethnopharmacol 101653911 2146-8397 Conflict of Interest: None declared. 2017 02 23 2017 05 02 2017

2017 Journal of intercultural ethnopharmacology

16. Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast Full Text available with Trip Pro

Effects of Grapefruit Seed Extract on Oxidative Stability and Quality Properties of Cured Chicken Breast This study investigated the antioxidative and functional effects of a curing agent containing grapefruit seed extract (GSE) on the quality and storage characteristics of chicken breast. The total polyphenol and total flavonoid contents of GSE were 45.06 mg/g and 36.06 mg/g, respectively. The IC50 value of 2,2-diphenyl-1-picrylhydrazyl hydroxyl scavenging of GSE was 333.33 μg/mL. The chicken

2017 Korean journal for food science of animal resources

17. The Grapefruit: An Alternative Arthroscopic Tool Skill Platform. (Abstract)

The Grapefruit: An Alternative Arthroscopic Tool Skill Platform. To establish the construct validity of an arthroscopic training model that teaches arthroscopic tool skills including triangulation, grasping, precision biting, implant delivery and ambidexterity and uses a whole grapefruit for its training platform.For the grapefruit training model (GTM), an arthroscope and arthroscopic instruments were introduced through portals cut in the grapefruit skin of a whole prepared grapefruit. After (...) institutional review board approval, participants performed a set of tasks inside the grapefruit. Performance for each component was assessed by recording errors, achievement of criteria, and time to completion. A total of 19 medical students, orthopaedic surgery residents, and fellowship-trained orthopaedic surgeons were included in the analysis and were divided into 3 groups based on arthroscopic experience. One-way analysis of variance (ANOVA) and the post hoc Tukey test were used for statistical

2017 Arthroscopy

18. How Important Are Grapefruit (OR CBD Oil)-drug Interactions? David Bailey vs The Florida Dept. of Citrus

How Important Are Grapefruit (OR CBD Oil)-drug Interactions? David Bailey vs The Florida Dept. of Citrus How Important Are Grapefruit (OR CBD Oil)-drug Interactions? David Bailey vs The Florida Dept. of Citrus | The Skeptical Cardiologist Primary Menu Search for: , , , How Important Are Grapefruit (OR CBD Oil)-drug Interactions? David Bailey vs The Florida Dept. of Citrus Previously, the skeptical cardiologist described a patient with atrial fibrillation who was taking the blood thinner (...) apixaban (Eliquis ) and developed a nose bleed after consuming a large amount of grapefruit (see .) In researching the whole subject of grapefruit-drug interactions I came across a fascinating intellectual battle between David Bailey, the researcher who first identified a significant grapefruit-drug interaction, and clinicians and researchers, some of whom are supported by the Florida Citrus Board, who feel this interaction is not significant. What Does The Internet Tell Us? It’s always interesting

2019 The Skeptical Cardiologist

19. Grapefruit

Grapefruit Grapefruit Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Grapefruit Grapefruit Aka: Grapefruit , Grapefruit Drug (...) Interaction From Related Chapters II. Metabolism Decreases intestinal cytochrome P450 3A4 Increases level of drugs metabolized by CYP 3A4 Drugs most affected are those with low oral absorption Small Grapefruit exposure can lead to Single Grapefruit One cup of Grapefruit juice Effect onset: Within 4 hours of Grapefruit intake Effect duration: May persist 24-72 hours Grapefruit permanently binds and inactivates CYP 3A4 enzymes Enzymes replaced every 48-72 hours III. Drug Interactions: Increased serum

2018 FP Notebook

20. Is It Safe To Consume Grapefruit If You Take The Blood Thinner Apixiban (Eliquis)?

Is It Safe To Consume Grapefruit If You Take The Blood Thinner Apixiban (Eliquis)? Is It Safe To Consume Grapefruit If You Take The Blood Thinner Apixiban (Eliquis)? | The Skeptical Cardiologist Primary Menu Search for: , Is It Safe To Consume Grapefruit If You Take The Blood Thinner Apixiban (Eliquis)? A patient of mine with atrial fibrillation taking the blood thinner eliquis told me that she had eaten grapefruit for two days in a row and then developed a nose bleed. She had heard (...) of the interaction between grapefruit and certain medications and wondered if this had caused her nose bleed. I was unaware of any eliquis/grapefruit interaction but thought this was a remarkably astute observation and question and set about to research it properly. Among other things, I discovered that some researchers believe the grapefruit-drug interaction to be a widespread , underreported and highly significant problem while others feel it is overblown and a rare cause of clinically important side effects

2018 The Skeptical Cardiologist

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