How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

901 results for

GnRH Stimulation Test

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. What is the optimal GnRH antagonist protocol during ovarian stimulation for assisted reproduction technology? A systematic review and network meta-analysis comparing flexible vs fixed protocols, ganirelix vs cetrorelix and presence/absence of hormonal pre

What is the optimal GnRH antagonist protocol during ovarian stimulation for assisted reproduction technology? A systematic review and network meta-analysis comparing flexible vs fixed protocols, ganirelix vs cetrorelix and presence/absence of hormonal pre Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied (...) -clinical meta-analysis. Example: Whenever a control group serves more than one experimental group, we will correct the total number of control animals in the meta-analysis by dividing the number of animals in the control group by the number of treatment groups served. Where applicable, Holm-Bonferroni correction for testing multiple subgroup analyses will be performed. If one or more subgroup analyses cannot be performed due to insufficient data, the p-value will be adjusted accordingly. ">Other

2019 PROSPERO

2. GnRH Stimulation Test

GnRH Stimulation Test GnRH Stimulation Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 GnRH Stimulation Test GnRH Stimulation (...) Test Aka: GnRH Stimulation Test II. Indications (suspect pathologic central cause) (suspect hormonal cause) III. Technique Patient fasts overnight Administer 100 ug GnRH IV or SC Obtain Serum Gonadotropin Levels Labs (FSH) (LH) Timing Baseline prior to GnRH administration After injection at 15, 30, 45, and 60 minutes IV. Interpretation Central Two fold or higher increase in FSH and LH V. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

3. Estradiol-dependent stimulation and suppression of gonadotropin-releasing hormone (GnRH) neuron firing activity by corticotropin-releasing hormone (CRH) in female mice. (PubMed)

Estradiol-dependent stimulation and suppression of gonadotropin-releasing hormone (GnRH) neuron firing activity by corticotropin-releasing hormone (CRH) in female mice. Gonadotropin-releasing hormone (GnRH) neurons are the final central regulators of reproduction, integrating various inputs that modulate fertility. Stress typically inhibits reproduction but can be stimulatory; stress effects can also be modulated by steroid milieu. Corticotropin-releasing hormone (CRH) released during (...) the stress response may suppress reproduction independent of downstream glucocorticoids. We hypothesized CRH suppresses fertility by decreasing GnRH neuron firing activity. To test this, mice were ovariectomized (OVX) and either implanted with an estradiol capsule (OVX+E) or not treated further to examine the influence of estradiol on GnRH neuron response to CRH. Targeted extracellular recordings were used to record firing activity from green fluorescent protein-identified GnRH neurons in brain slices

Full Text available with Trip Pro

2017 Endocrinology

4. Dynamic GnRH- and hCG-testing: establishment of new diagnostic reference levels. (PubMed)

Dynamic GnRH- and hCG-testing: establishment of new diagnostic reference levels. Gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) stimulation tests may be used to evaluate the pituitary and testicular capacity. Our aim was to evaluate changes in follicular-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone after GnRH and hCG stimulation in healthy men and assess the impact of six single nucleotide polymorphisms on the responses.GnRH and hCG (...) % and 40% during GnRH testing, stimulated levels varied from 4.4 to 58.8 U/L and 0.2 to 11.8 U/L and FSH decreased in nine men. Testosterone increased approximately 110% (range: 18.7-67.6 nmol/L) during hCG testing. None of the polymorphisms had any major impact on the test results. Results from GnRH and hCG tests in patients compared with the reference group showed that the stimulated level and absolute increase in LH showed superior identification of patients compared with the relative increase

Full Text available with Trip Pro

2017 European Journal of Endocrinology

5. Progestins or GnRH antagonists for pituitary suppression during ovarian stimulation for assisted reproductive technology cycles

Progestins or GnRH antagonists for pituitary suppression during ovarian stimulation for assisted reproductive technology cycles Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) applicable, Holm-Bonferroni correction for testing multiple subgroup analyses will be performed. If one or more subgroup analyses cannot be performed due to insufficient data, the p-value will be adjusted accordingly. ">Other Subgroup analysis or meta-regression are used to explore between-study heterogeneity and can provide insight into the relationship between study characteristics (e.g. species, sex or drug class or dose) and effect size. They should be considered hypothesis-generating. Ideally

2019 PROSPERO

6. The Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Response to a Gonadotropin Releasing Hormone Analogue Test in Healthy Prepubertal Girls Aged 10 Months to 6 Years. (PubMed)

The Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Response to a Gonadotropin Releasing Hormone Analogue Test in Healthy Prepubertal Girls Aged 10 Months to 6 Years. Premature thelarche and precocious puberty are frequently diagnosed in girls even below 6 years of age and may be difficult to differentiate in the early stages. A GnRH test is often included in the diagnostic work-up, although interpretation of the GnRH test in girls below 6 years of age is challenging (...) LH responses (mean ± 2 s.d.) were 5.2 ± 4.0 and 2.9 ± 2.5 IU/L and the FSH responses were 23.3 ± 16.2 and 14.5 ± 10.3 IU/L in girls aged 0.8-3.0 years and 3.0-5.9 years respectively. This corresponds to upper cut-off limits for LH of 9.2 IU/L (<3 years) and 5.3 IU/L (3-6 years). The stimulated LH/FSH ratio was 0.23 ± 0.19 (range 0.06-0.43) and did not correlate with age.We found that LH increases up to 9.2 IU/L during GnRH test in healthy normal-weight girls below 3 years of age

Full Text available with Trip Pro

2017 European Journal of Endocrinology

7. Human chorionic gonadotrophin stimulation test as a predictor of ovarian response and pregnancy in IVF cycles stimulated with GnRH agonist gonadotrophin treatment: a pilot study. (PubMed)

Human chorionic gonadotrophin stimulation test as a predictor of ovarian response and pregnancy in IVF cycles stimulated with GnRH agonist gonadotrophin treatment: a pilot study. Recent evidence supports a specific and broad role of androgen produced by theca cells in reproductive physiology. This pilot study evaluated the usefulness of hCG theca stimulation test in predicting ovarian response and pregnancy.Prospective cohort study including 80 infertile women treated with IVF/ICSI. On Day 3 (...) = 0.03 and P = 0.02, respectively) diagnostic accuracy being 67 and 75%, respectively. The percentage increase in E(2) thus still fails in as many as 33 and 25% of patients in predicting ovarian response and pregnancy, respectively. In addition, E(2) concentrations are poorly reproducible and a wide range of variation in all serum steroids investigated-including E(2)-after hCG injection was observed.The predictive power of the hCG test is based on E(2) but not androgen response to hCG injection

Full Text available with Trip Pro

2012 Human Reproduction

8. The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life. (PubMed)

The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life. Premature thelarche in early childhood may evolve into true precocious puberty. The individuation of cases progressing to precocious puberty is challenging.We analyzed the parameters predictive for progression in girls younger than 3 years.We conducted a retrospective longitudinal study.A (...) total of 450 girls referred for premature thelarche were initially evaluated, 353 were clinically monitored at 3-month intervals, and 97 underwent endocrine and imaging assessment. Central precocious puberty (CPP) was diagnosed in girls showing LH peak response to GnRH testing >5 mU/mL with tuber cinereum hamartoma at magnetic resonance imaging, or with normal magnetic resonance imaging but progression of puberty during follow-up.We measured the progression to precocious puberty.Idiopathic premature

Full Text available with Trip Pro

2013 Journal of Clinical Endocrinology and Metabolism

9. Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF

in vitro fertilization Research question Does the live birth rate of the progestin-primed ovarian stimulation protocol comparable with the GnRH antagonist protocol for patients undergoing IVF? Design This is a multi-centre randomized trial. Research plan Population: Infertile women who have medical indication for IVF will be recruited for study if they fulfil the selection criteria. Intervention: Women will receive oral dydrogesterone 20mg daily from Day 3 till the day of ovulation trigger. Comparator (...) for eligibility information Ages Eligible for Study: 20 Years to 43 Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age of women <43 years at the time of ovarian stimulation for IVF Antral follicle count (AFC) on day 2-5 of the period > 3 Exclusion Criteria: Presence of a functional ovarian cyst with E2>100 pg/mL Taking any hormonal preparation including oral contraceptive Recipient of oocyte donation Undergoing preimplantation genetic testing

2018 Clinical Trials

10. GNRH Agonist Trigger and Modified Luteal Phase Adding a Bolus of GnRHa at the Time of Implantation: a RCT

: ovarian hyperstimulation syndrome OHSS [ Time Frame: Time Frame: from date of triggering until 2 weeks after pregnancy test] ] early and late onset Ovarian hyper stimulation syndrome Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff (...) GNRH Agonist Trigger and Modified Luteal Phase Adding a Bolus of GnRHa at the Time of Implantation: a RCT GNRH Agonist Trigger and Modified Luteal Phase Adding a Bolus of GnRHa at the Time of Implantation: a RCT - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

11. Comparison of a 'freeze-all' strategy including GnRH agonist trigger versus a 'fresh transfer' strategy including hCG trigger in assisted reproductive technology (ART): a study protocol for a randomised controlled trial. (PubMed)

. Participants will be randomised (1:1) to either (1) GnRH agonist trigger and single vitrified-warmed blastocyst transfer in a subsequent hCG triggered natural menstrual cycle or (2) hCG trigger and single blastocyst transfer in the fresh (stimulated) cycle. The primary endpoint is to compare ongoing pregnancy rates per randomised patient in the two treatment groups after the first single blastocyst transfer.The study will be performed in accordance with the ethical principles in the Helsinki Declaration (...) Comparison of a 'freeze-all' strategy including GnRH agonist trigger versus a 'fresh transfer' strategy including hCG trigger in assisted reproductive technology (ART): a study protocol for a randomised controlled trial. Pregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained after fresh embryo transfer. This is partly due to improved laboratory techniques, but may also be caused by a more physiological hormonal

Full Text available with Trip Pro

2017 BMJ open

12. GnRH agonist for protection against ovarian toxicity during chemotherapy for early breast cancer: the Anglo Celtic Group OPTION trial. (PubMed)

GnRH agonist for protection against ovarian toxicity during chemotherapy for early breast cancer: the Anglo Celtic Group OPTION trial. Chemotherapy-induced premature ovarian insufficiency (POI) impacts fertility and other aspects of women's health. The OPTION trial tested whether administration of a gonadotropin-releasing hormone agonist during chemotherapy for early breast cancer reduced the risk of POI.This was a prospective, randomized, parallel group study of the gonadotropin-releasing (...) hormone agonist goserelin administered before and during chemotherapy for breast cancer with stage I-IIIB disease. The primary outcome was amenorrhoea between 12 and 24 months after randomization, supported by elevated follicle stimulating hormone concentrations to give an additional analysis as rate of POI.A total of 227 patients were randomized and the primary analysis was conducted on 202 patients. Goserelin reduced the prevalence of amenorrhoea between 12 and 24 months to 22% versus 38

Full Text available with Trip Pro

2017 Annals of Oncology

13. Value of Cabergoline and Low Dose Aspirin in Poor Responders Undergoing ICSI-ET With GnRH Agonist Flare-Up-Protocol

. ClinicalTrials.gov Identifier: NCT03263299 Recruitment Status : Not yet recruiting First Posted : August 28, 2017 Last Update Posted : August 28, 2017 See Sponsor: Cairo University Information provided by (Responsible Party): Ahmed Maged, Cairo University Study Details Study Description Go to Brief Summary: Ovarian stimulation will be done using the Microdose flare-up regimen. The patient will receive diluted doses of the GnRH agonist leuprolide acetate 40 µg, given subcutaneously twice daily. Two days later (...) . Condition or disease Intervention/treatment Phase Invitro Fertilization Drug: cabergoline Drug: Aspirin Drug: GnRH agonist Phase 4 Detailed Description: Ovarian stimulation was done using the Microdose flare-up regimen. The patient received diluted doses of the GnRH agonist leuprolide acetate 40 µg, given subcutaneously twice daily. Two days later, stimulation is initiated by intramuscular (IM) injections of HMG (Merional, IBSA, Germany) in a dose of 300 IU/day. Follicular monitoring began from

2017 Clinical Trials

14. Dienogest Versus GnRH-a Pre-treatment in Women With Endometriosis Undergoing IVF

including number of gonadotropins consumed, number of stimulation days, number of metaphase II eggs retrieved, fertilization rate, embryo quality, miscarriage rate, clinical pregnancy rates, live birth rates and potential maternal and obstetrical complications will also be evaluated. We will also compare ongoing pregnancy rates between the groups receiving Dienogest and placebo, and GnRH agonist and placebo. Condition or disease Intervention/treatment Phase Endometriosis Drug: Dienogest 2 MG Drug (...) Dienogest Versus GnRH-a Pre-treatment in Women With Endometriosis Undergoing IVF Dienogest Versus GnRH-a Pre-treatment in Women With Endometriosis Undergoing IVF - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

15. The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies

. Therefore, a prospective comparative randomized controlled trial will be performed in order to investigate the effect of three repeated doses of GnRH agonist trigger "Triptorelin" accompanied by intensive Luteal Support on the ongoing pregnancy outcome in women who are hyper-responders to ovarian stimulation when undergoing assisted reproductive technology. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 282 participants (...) The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

16. Using kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea (PubMed)

) suggested a diagnosis of PCOS. If PCOS was the correct diagnosis, then one would expect intact hypothalamic GnRH and pituitary gonadotropin release. We used the novel hormone kisspeptin to confirm intact hypothalamic GnRH release and a GnRH stimulation test to confirm intact pituitary gonadotroph function. This case highlights that kisspeptin is a potential unique tool to test GnRH function in patients presenting with reproductive disorders.Polycystic ovarian syndrome (PCOS) can present with primary (...) amenorrhoea, and therefore, should be considered in the differential diagnosis.PCOS is a heterogeneous condition that may present in lean women with few or absent signs of hyperandrogenism.GnRH stimulation tests are useful in evaluating pituitary function; however, to date, we do not have a viable test of GnRH function. Kisspeptin has the potential to form a novel diagnostic tool for assessing hypothalamic GnRH function by monitoring gonadotropin response as a surrogate marker of GnRH release.Confirmation

Full Text available with Trip Pro

2017 Endocrinology, diabetes & metabolism case reports

17. Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor †Electronic supplementary information (ESI) available: Detailed experimental procedures and analytical characterisation of all compounds. See DOI: (PubMed)

Cu-catalysed azide alkyne cycloaddition. Our main purpose was to find a more soluble compound based on the WAY207024 lead with nanomolar potency to inhibit the GnRH receptor. A late stage diversification by the use of click chemistry was, furthermore developed to allow for expansion of the library in future optimisations. All compounds were tested in a functional assay to determine the individual potency of inhibiting stimulation of the receptor by the endogenous agonist GnRH. In conclusion, we (...) Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor †Electronic supplementary information (ESI) available: Detailed experimental procedures and analytical characterisation of all compounds. See DOI: In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-tert-butylphenyl)-4-piperazinyl-benzimidazole scaffold via

Full Text available with Trip Pro

2017 Medchemcomm

18. Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty (PubMed)

Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty Girls with precocious puberty have high luteinizing hormone (LH) levels and advanced bone age. Obese children enter puberty at earlier ages than do non-obese children. We analyzed the effects of obesity on LH secretion during gonadotropin-releasing hormone (GnRH) tests in girls with precocious puberty.A total of 981 subjects with idiopathic precocious puberty who (...) had undergone a GnRH stimulation testing between 2008 and 2014 were included in the study. Subjects were divided into three groups based on body mass index (BMI). Auxological data and gonadotropin levels after the GnRH stimulation test were compared.In Tanner stage 2 girls, peak stimulated LH levels on GnRH test were 11.9±7.5, 10.4±6.4, and 9.1±6.1 IU/L among normal-weight, overweight, and obese subjects, respectively (p=0.035 for all comparisons). In Tanner stage 3 girls, peak stimulated LH

Full Text available with Trip Pro

2016 Journal of clinical research in pediatric endocrinology

19. Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation. (PubMed)

Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation. Non-steroidal drugs that increase endogenous testosterone (T) may be used to exploit ergogenic effects of androgens in power sports. While superactive GnRH analog use is suspected, neither screening nor detection tests are developed. This study aimed to determine if (a) stimulation for 5 days by leuprolide (a superactive GnRH analog) of serum and urine steroids and urine LH is reproducible (...) at a 2 week interval, (b) nandrolone decanoate (ND) co-administration masks responses to leuprolide administration, (c) performance of urine measurement of leuprolide and M1, its major metabolite, as a detection test. Healthy men were randomized into a 4 week parallel group, open label clinical study in which all men had daily sc injections of leuprolide (1mg) for 4 days in the 1st and 3rd weeks with hormone-free 2nd and 4th weeks. In the 3rd week, men were randomized to either ND injections

2014 The Journal of steroid biochemistry and molecular biology

20. GnRH Stimulation Test

GnRH Stimulation Test GnRH Stimulation Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 GnRH Stimulation Test GnRH Stimulation (...) Test Aka: GnRH Stimulation Test II. Indications (suspect pathologic central cause) (suspect hormonal cause) III. Technique Patient fasts overnight Administer 100 ug GnRH IV or SC Obtain Serum Gonadotropin Levels Labs (FSH) (LH) Timing Baseline prior to GnRH administration After injection at 15, 30, 45, and 60 minutes IV. Interpretation Central Two fold or higher increase in FSH and LH V. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2015 FP Notebook

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>