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Glucose Tolerance Test 3 hour

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161. Pharmacokinetic and Pharmacodynamic Properties and Tolerability of Single- and multiple-dose Once-daily Empagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, in Chinese Patients With Type 2 Diabetes Mellitus. (PubMed)

Pharmacokinetic and Pharmacodynamic Properties and Tolerability of Single- and multiple-dose Once-daily Empagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, in Chinese Patients With Type 2 Diabetes Mellitus. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties and tolerability of the oral once-daily sodium glucose cotransporter 2 inhibitor empagliflozin, given in single and multiple 10 and 25 mg doses in Chinese patients with type 2 diabetes mellitus (...) concentrations within 1 to 1.5 hours (median), with plasma levels declining biphasically. Empagliflozin exposure increased roughly dose proportionally between 10 and 25 mg. Mean terminal elimination half-life values at steady state were 13.9 and 12.1 hours with empagliflozin 10 and 25 mg, respectively. Mean (SD) changes from baseline in 24-hour urinary glucose excretion (UGE) on day 1 were +87.7 (22.9) and +82.8 (18.8) g with empagliflozin 10 and 25 mg, respectively, compared with -1.0 (2.8) g with placebo

2015 Clinical therapeutics Controlled trial quality: uncertain

162. The 50g glucose challenge test does not diagnose gestational diabetes

challenge test? The conventional test for diabetes is the oral glucose tolerance test (OGTT), in which a woman has to fast for several hours before being given an oral glucose solution. Her blood is then sampled at intervals to see how well her body metabolises the additional sugar. The 50g glucose challenge test is a simpler test in which the woman does not have to fast and only has one blood sample taken, one hour after drinking 50g of glucose in solution. The review set out to work out how well (...) The 50g glucose challenge test does not diagnose gestational diabetes The 50g glucose challenge test does not diagnose gestational diabetes - The Diabetes Elf Keeping you up to date with reliable diabetes research, policy & guidance SEARCH Jan 25 2012 Posted by This systematic review found that the 50g test is not accurate enough to diagnose gestational diabetes on its own. Clinical question In pregnant women <32 weeks gestation, what is the sensitivity and specificity of the 50g glucose

2012 The Diabetes Elf

163. Challenging the Gold Standard: Pilot Study Comparing Continuous Glucose Monitoring System (CGMS), Capillary Glucose Monitors and 3 Hour Glucose Tolerance Test (GTT) to Diagnose Gestational Diabetes Mellitus (GDM)

Challenging the Gold Standard: Pilot Study Comparing Continuous Glucose Monitoring System (CGMS), Capillary Glucose Monitors and 3 Hour Glucose Tolerance Test (GTT) to Diagnose Gestational Diabetes Mellitus (GDM) Challenging the Gold Standard: Pilot Study Comparing Continuous Glucose Monitoring System (CGMS), Capillary Glucose Monitors and 3 Hour Glucose Tolerance Test (GTT) to Diagnose Gestational Diabetes Mellitus (GDM) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record (...) managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Challenging the Gold Standard: Pilot Study Comparing Continuous Glucose Monitoring System (CGMS), Capillary Glucose Monitors and 3 Hour Glucose Tolerance Test (GTT) to Diagnose Gestational Diabetes Mellitus (GDM) The safety and scientific

2010 Clinical Trials

164. The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

Start Date : October 2014 Actual Primary Completion Date : March 2017 Actual Study Completion Date : March 31, 2017 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Normal Sleepers Prediabetes patients with normal sleep duration (7-8 hours/ night) as measured objectively Other: Oral glucose tolerance Experimental: Short Sleepers Prediabetes patients with short sleep duration (<6 hours (...) /night) as measured objectively Other: Oral glucose tolerance Outcome Measures Go to Primary Outcome Measures : GLP-1 Levels in Response to Oral Glucose Tolerance Test [ Time Frame: 2 weeks ] Prediabetes patients with and without short sleep will undergo an oral glucose tolerance test with measurement of GLP-1 levels Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family

2014 Clinical Trials

165. Long-term progression of abnormal glucose tolerance and its relationship with the metabolic syndrome after kidney transplantation. (PubMed)

-diabetic renal transplant recipients underwent oral glucose tolerance tests (OGTT) in 2005 to 2006 (baseline) and then in 2011 to 2012 (follow-up). MS was identified using the International Diabetes Federation criteria and OGTT was interpreted according to the WHO classification.At follow-up, median time from transplantation was 11.1 years (range 6.2-23.8). Mean 0-hour and 2-hour plasma glucose levels were significantly higher at follow-up compared to baseline (5.7 ± 0.7 vs. 5.9 ± 0.9 mmol/L, P=0.03 (...) Long-term progression of abnormal glucose tolerance and its relationship with the metabolic syndrome after kidney transplantation. Metabolic syndrome (MS) diagnosed early after kidney transplantation is a risk factor for developing new-onset diabetes. The aim of this study was to examine whether glucose intolerance and MS identified late after transplantation influence the progression of glycemic abnormalities in kidney transplant recipients.This is a retrospective study in which 76 non

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2014 Transplantation

166. Gestational diabetes mellitus and impaired glucose tolerance pregnant women (PubMed)

density lipoprotein cholesterol (LDL-C) concentrations. GIGT patients were further divided into subgroups according to hyperglycemia appearance 1, 2 or 3 hours after glucose ingestion.GDM and GIGT correlated with age (p<0.05), family history of diabetes (p<0.05) and pre-pregnancy body mass indices (BMIs) (p<0.05). Blood pressures were higher in GDM than in GIGT and normal glucose tolerance (NGT) patients (p<0.05). The IFIs were gradually reduced (p<0.05), whereas HOMA-IR was gradually enhanced (p<0.05 (...) Gestational diabetes mellitus and impaired glucose tolerance pregnant women To evaluate correlations between insulin secretion and resistance in patients with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT).Three hundred thirty six pregnant women with an oral glucose tolerance test (OGTT) were tested and measured insulin function indices (IFI), insulin resistance indices (HOMA-IR) as well as blood serum triglycerides (TG), total cholesterol (TCH) and low

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2014 Pakistan Journal Of Medical Sciences

167. Retrospective study on the efficacy of a low-carbohydrate diet for impaired glucose tolerance (PubMed)

of the LCD on IGT. We designed a 7-day in-hospital educational program focused on the LCD for IGT.The subjects were 72 patients with IGT (36 in the LCD group and 36 in the control group) who were enrolled from April 2007-March 2012 and followed for 12 months. We retrospectively compared the LCD group with the control group.In 69.4% of the LCD group, blood glucose was normalized at 12 months and the 2-hour plasma glucose level in the oral glucose tolerance test (OGTT) was reduced by 33 mg/dL. In addition (...) Retrospective study on the efficacy of a low-carbohydrate diet for impaired glucose tolerance In recent years, the number of people with impaired glucose tolerance (IGT) has increased steadily worldwide. It is clear that the prevention of diabetes is important from the perspective of public health, medical care, and economics. It was recently reported that a low-carbohydrate diet (LCD) is useful for achieving weight loss and glycemic control, but there is no information about the effects

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2014 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

168. Estudio Parto: postpartum diabetes prevention program for hispanic women with abnormal glucose tolerance in pregnancy: a randomised controlled trial - study protocol. (PubMed)

controlled trials among adults with impaired glucose tolerance have shown that diet and physical activity reduce the risk of type 2 diabetes, such programs have not been tested in high-risk postpartum women. The overall goal of this randomised controlled trial is to test the efficacy of a culturally and linguistically modified, individually-tailored lifestyle intervention to reduce risk factors for type 2 diabetes and cardiovascular disease among postpartum Hispanic women with a history of abnormal (...) Estudio Parto: postpartum diabetes prevention program for hispanic women with abnormal glucose tolerance in pregnancy: a randomised controlled trial - study protocol. Diabetes and obesity have reached epidemic proportions in the U.S. with rates consistently higher among Hispanics as compared to non-Hispanic whites. Among Hispanic women diagnosed with gestational diabetes mellitus (GDM), 50% will go on to develop type 2 diabetes within 5 years of the index pregnancy. Although randomised

2014 BMC Pregnancy and Childbirth Controlled trial quality: uncertain

169. Effect of low-intensity ergometer aerobic training on glucose tolerance in severely impaired nondiabetic stroke patients. (PubMed)

groups participated in a 6-week rehabilitation training program with low-intensity ergometer aerobic training added only in the experimental group 3 times per week. Primary outcome variables were fasting glucose, fasting insulin, 2-hour glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) in oral glucose tolerance test before and after intervention.Before intervention, 36 of 54 (66.7%) were diagnosed with impaired glucose status or diabetic glucose tolerance totally. The average 2 (...) -hour plasma glucose level was 9.14 ± 1.39 mmol/L. After intervention, aerobic training significantly improved fasting insulin (from 8.51 ± 2.01 μU/mL to 7.11 ± 2.02 μU/mL), 2-hour glucose level (from 9.13 ± 1.14 mmol/L to 7.22 ± 1.23 mmol/L), and HOMA-IR (from 1.62 ± 1.01 to 1.29 ± .79) in the intervention group compared with the control group (P < .05). Aerobic training also significantly improved their glucose tolerance state (P < .05).Preliminary findings suggest that abnormal glucose tolerance

2014 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Controlled trial quality: uncertain

170. Impact of Sitagliptin on Carotid Intima-Media Thickness in Patients With Coronary Artery Disease and Impaired Glucose Tolerance or Mild Diabetes Mellitus. (PubMed)

progression than the control group (p = 0.02). In addition, the sitagliptin group showed greater reductions in body weight (2.2%), 2-hour glucose levels on the 75-g oral glucose tolerance test (17.3%), HbA1c (4.7%), and low-density lipoprotein cholesterol levels (7.9%) from that at baseline. In conclusion, treatment with sitagliptin for 12 months was associated with a beneficial effect in the prevention of carotid IMT progression, compared with the diet control. Copyright © 2014 Elsevier Inc. All rights (...) Impact of Sitagliptin on Carotid Intima-Media Thickness in Patients With Coronary Artery Disease and Impaired Glucose Tolerance or Mild Diabetes Mellitus. Sitagliptin has been widely used for the treatment of diabetes and shown recently to have beneficial pleiotropic outcomes on cardiovascular systems in experimental studies. However, little is known about the influence of sitagliptin on atherosclerosis-related cardiovascular diseases in a clinical setting. This study examined the effect

2014 The American journal of cardiology Controlled trial quality: uncertain

171. Estudio Parto: postpartum diabetes prevention program for hispanic women with abnormal glucose tolerance in pregnancy: a randomised controlled trial - study protocol. (PubMed)

controlled trials among adults with impaired glucose tolerance have shown that diet and physical activity reduce the risk of type 2 diabetes, such programs have not been tested in high-risk postpartum women. The overall goal of this randomised controlled trial is to test the efficacy of a culturally and linguistically modified, individually-tailored lifestyle intervention to reduce risk factors for type 2 diabetes and cardiovascular disease among postpartum Hispanic women with a history of abnormal (...) Estudio Parto: postpartum diabetes prevention program for hispanic women with abnormal glucose tolerance in pregnancy: a randomised controlled trial - study protocol. Diabetes and obesity have reached epidemic proportions in the U.S. with rates consistently higher among Hispanics as compared to non-Hispanic whites. Among Hispanic women diagnosed with gestational diabetes mellitus (GDM), 50% will go on to develop type 2 diabetes within 5 years of the index pregnancy. Although randomised

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2014 BMC pregnancy and childbirth Controlled trial quality: uncertain

172. Progression to impaired glucose tolerance or type 2 diabetes mellitus in polycystic ovary syndrome: a controlled follow-up study. (PubMed)

Progression to impaired glucose tolerance or type 2 diabetes mellitus in polycystic ovary syndrome: a controlled follow-up study. To investigate whether retesting with the oral glucose tolerance test (OGTT) is useful and necessary for all women with polycystic ovary syndrome (PCOS).Follow-up study.Tertiary medical center.Eighty-four women with PCOS and 45 healthy controls.Peripheral venous blood sampling.We performed a 75-g 2-hour OGTT in women with normal glucose tolerance (NGT) and impaired (...) glucose tolerance (IGT) at the time of the first test with and without PCOS.The average follow-up period for women with PCOS was 2.6 years (range, 2-4.17 years). Seventy-eight of these women had NGT at baseline, 11.5% converted to IGT, with an annualized incidence rate of 4.5%. Of those women with IGT at baseline (n = 6), 33.3% converted to type 2 diabetes mellitus, with an annualized incidence rate of 10.4%. In the healthy subjects, the average follow-up period was 2.6 years (range, 2-4.08 years

2014 Fertility and Sterility Controlled trial quality: uncertain

173. Maternal BMI, Peripheral Deiodinase Activity, and Plasma Glucose: Relationships among Caucasian Women in the HAPO Study. (PubMed)

women recruited in the Hyperglycemia Adverse Pregnancy Outcomes (HAPO) study, all with glucose tolerance testing [545 samples sufficient to measure thyrotropin (TSH), free thyroxine (fT4), and triiodothyronine (T3)]. Exclude highest and lowest 1% TSH values [535 available for analysis]. Assess deiodinase activity using T3/fT4 ratios. Among women with and without gestational diabetes (GDM), compare thyroid measurements, C-peptide, and other selected data. Examine relationships independent of GDM (...) glucose [z-score sum (fasting, 1, 2 hours); r=0.24, p<0.001] and with C-peptide [z-score sum (fasting, 1 hour); r=0.27, p<0.001].Higher BMI was associated with increased deiodinase activity, consistent with reports from elsewhere. Increased deiodinase activity, in turn, was associated with higher glucose. Deiodinase activity accounts for a small percentage of z score sum glucose.

2019 Journal of Clinical Endocrinology and Metabolism

174. Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians. (PubMed)

Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in non-obese Asians. The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in subjects from the nonobese Asians is not known.We conducted a cross-sectional study and measured insulin sensitivity (M value; 4-hour hyperinsulinaemic-euglycaemic clamp), insulin secretion rate (3-hour mixed meal tolerance test with oral minimal modelling), percent (...) body fat, visceral adipose tissue, intramyocellular and intrahepatic lipid contents (magnetic resonance imaging and spectroscopy), cardiorespiratory fitness (VO2 max; graded exercise test) and habitual physical activity (short International Physical Activity Questionnaire) in 60 healthy nonobese Asian subjects (BMI = 21.9 ± 1.7 kg/m2 , age = 41.8 ± 13.4 years).M was inversely associated with percent body fat (r = -0.460, P < 0.001), visceral fat (r = -0.623, P < 0.001) and liver fat (r = -0.601, P

2019 European journal of clinical investigation

175. Associations of sedentary time and self-reported television time during pregnancy with incident gestational diabetes and plasma glucose levels in women at risk of gestational diabetes in the UK. (PubMed)

and self-reported television time during pregnancy with incident GDM and plasma glucose levels among women at high risk for GDM.At 20 weeks' gestation, pregnant women (n = 188) in the North East of England with a risk factor for GDM wore an activPAL accelerometer and reported their usual television time. Participants underwent a standard oral glucose tolerance test at 24-28 weeks' gestation. Regression analyses were used to test for associations of total and prolonged sedentary time, breaks (...) Associations of sedentary time and self-reported television time during pregnancy with incident gestational diabetes and plasma glucose levels in women at risk of gestational diabetes in the UK. Sedentary time is associated with increased risk of type 2 diabetes, but the association between objectively measured sedentary time and incident gestational diabetes mellitus (GDM) has not been tested. The purpose of this paper is to test associations between objectively measured sedentary time

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2019 BMC Public Health

176. Peak OGTT glucose is associated with lower lung function in young children with cystic fibrosis. (PubMed)

Peak OGTT glucose is associated with lower lung function in young children with cystic fibrosis. Screening for Cystic Fibrosis-related diabetes is recommended in patients with CF <10 years old when there are concerns about growth and lung function. The Oral Glucose Tolerance Test (OGTT) is recommended but has not been validated in this cohort. We sought to determine whether the 2-h OGTT, the gold standard diagnostic test for CFRD, detects clinical decline in children with CF <10 years old.We (...) analysed blood glucose(BG) levels collected every 30 min during OGTT in 27 children with CF < 10 years old, comparing the 2-hour BG (BG120min), peak BG (BGmax) and Area Under the Curve(AUC) for glucose and the association with lung function and nutritional status. We also compared the OGTT results with results from Continuous Glucose Monitoring (CGM) performed in 11 participants.The BGmax was higher than the BG120min in 25/27 (93%) participants. There was a significant inverse correlation between BGmax

2019 Journal of Cystic Fibrosis

177. Sitagliptin decreases visceral fat and blood glucoses in women with polycystic ovarian syndrome. (PubMed)

participated in a double-blinded, cross-over study. They received sitagliptin 100 mg vs. placebo daily for one month separated by an eight-week washout. During each treatment, women underwent a 75-gram oral glucose tolerance test (OGTT), assessment of vascular function and body composition. Overnight GH secretion was assessed via venous sampling every 10 minutes for 12 hours and analyzed using an automated deconvolution algorithm.During OGTT, sitagliptin increased GLP-1 (p<0.001), early insulin secretion (...) Sitagliptin decreases visceral fat and blood glucoses in women with polycystic ovarian syndrome. Women with polycystic ovarian syndrome (PCOS) have decreased growth hormone (GH), which can increase visceral adiposity (VAT) and impair vascular function. GH releasing hormone, a dipeptidyl peptidase-4 (DPP4) substrate, stimulates GH secretion.We tested the hypothesis that DPP4 inhibition increases GH and improves glucose levels and vascular function in women with PCOS.Eighteen women with PCOS

2019 Journal of Clinical Endocrinology and Metabolism

178. Glucose Response during the Night Is Suppressed by Wheat Albumin in Healthy Participants: A Randomized Controlled Trial. (PubMed)

Glucose Response during the Night Is Suppressed by Wheat Albumin in Healthy Participants: A Randomized Controlled Trial. Postprandial blood glucose excursions are important for achieving optimal glycemic control. In normal-weight individuals, glucose tolerance is diminished in the evening compared to glucose tolerance in the morning. Wheat albumin (WA) has the potential to suppress the postprandial glucose response with a relatively small dose, compared to the dose required when using dietary (...) fiber. In the present study, the effect of WA on glycemic control during the night was investigated after a late evening meal. A randomly assigned crossover trial involving a single oral ingestion in healthy male participants was performed in a double-blind placebo-controlled manner. The participants ingested the placebo (PL) tablets or the WA (1.5 g)-containing tablets 3 min before an evening meal at 22:00 hour, and blood samples were drawn during the night until 07:00 hour using an intravenous

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2019 Nutrients Controlled trial quality: predicted high

179. Separate and Combined Gluco-Metabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in Healthy Individuals. (PubMed)

-regulatory hormones using the novel GIP receptor antagonist GIP(3-30)NH2 and the well-established GLP-1 receptor antagonist exendin(9-39)NH2During four-hour oral glucose tolerance tests (75 g) combined with an ad libitum meal test, 18 healthy men received on four separate days in randomized, double-blinded order intravenous infusions of A) GIP(3-30)NH2 (800 pmol/kg/min)+exendin(9-39)NH2 (0-20 min: 1,000 pmol/kg/min; 20-240 min: 450 pmol/kg/min), B) GIP(3-30)NH2, C) exendin(9-39)NH2, and D) saline (...) Separate and Combined Gluco-Metabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in Healthy Individuals. The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are secreted postprandially and contribute importantly to postprandial glucose tolerance. Here, we assessed the individual and combined contributions of endogenous GIP and GLP-1 to the postprandial changes in glucose and gluco

2019 Diabetes Controlled trial quality: uncertain

180. Glucose >200 mg/dL during Continuous Glucose Monitoring Identifies Adult Patients at Risk for Development of Cystic Fibrosis Related Diabetes (PubMed)

-gram oral glucose tolerance test (OGTT). Adherence to recommended screening has been poor, with only approximately one-quarter of adults with CF undergoing OGTT in 2014. Use of continuous glucose monitoring (CGM) for diagnosis may become an alternative. Objectives. Our objective was to determine whether abnormal CGM predicts subsequent development of CFRD, lung function, and body mass index (BMI) decline and increased rate of CF pulmonary exacerbations in adults with CF. Methods. In a prospective (...) single center pilot trial from September 2009 to September 2010, 21 adult patients due for routine OGTT were recruited to complete simultaneous 3-day CGM and 2-hour 75 gram OGTT. Subsequently, clinical information was reviewed from 2008 to 2015. Conclusions. There was a moderate correlation between interpreted results of 2-hour OGTT and CGM (p = 0.03); CGM indicated a greater level of glucose impairment than OGTT. Glucose >200 mg/dL by CGM predicted development of CFRD (p = 0.0002).

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2016 Journal of diabetes research

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