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Glucose Tolerance Test 3 hour

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141. Diagnosis & Assessment of Hypertension - Lab Tests

ventricular hypertrophy (LVH) or a prior myocardial infarction, both of which portend a higher risk of future cardiovascular events and death . Finally, both the routine and optional investigations aid in the screening for some of the modifiable causes of hypertension. For example recurrent and/or severe hypokalemia may indicate the presence of primary hyperaldosteronism. When compared with oral glucose tolerance testing, a systematic review suggests that A1C and fasting glucose levels demonstrate (...) ) (Grade D); iii. Fasting blood glucose and/or glycated hemoglobin (A1c) (Grade D); iv. Serum total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), non-HDL cholesterol, and triglycerides (Grade D); lipids may be drawn fasting or non-fasting (Grade C). v. Standard 12-lead electrocardiography (Grade C). There is little direct evidence on which to base recommendations for laboratory testing. Thus, the recommended tests have been based largely on expert opinion. However, the routine

2018 Hypertension Canada

142. Modeling of 24-Hour Glucose and Insulin Profiles in Patients With Type 2 Diabetes Mellitus Treated With Biphasic Insulin Aspart. (PubMed)

for glucose homoeostasis describing the effect of exogenous insulin would facilitate such prediction. Thus the aim of this work was to extend the previously developed integrated glucose-insulin (IGI) model to predict 24-hour glucose profiles for patients with Type 2 diabetes following exogenous insulin administration. Clinical data from two trials were included in the analysis. In both trials, 24-hour meal tolerance tests were used as the experimental setup, where exogenous insulin (biphasic insulin (...) Modeling of 24-Hour Glucose and Insulin Profiles in Patients With Type 2 Diabetes Mellitus Treated With Biphasic Insulin Aspart. Insulin therapy for diabetes patients is designed to mimic the endogenous insulin response of healthy subjects and thereby generate normal blood glucose levels. In order to control the blood glucose in insulin-treated diabetes patients, it is important to be able to predict the effect of exogenous insulin on blood glucose. A pharmacokinetic/pharmacodynamic model

2014 Journal of clinical pharmacology Controlled trial quality: uncertain

143. Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients

prominently at the front of the document: Reproduced (translated) with permission of AACC, Washington, DC. This document (PID 11774) was approved by the AACC Board of Directors in November 2017.LABORATORY MEDICINE PRACTICE GUIDELINES Executive Summary 5 Preamble 34 Introduction 38 Chapter 1: Testing for common classes of relevant over-the-counter, prescribed, and non-prescribed drugs and illicit substances abused by pain management patients 47 Chapter 2: Specimen types and detection times 52 Chapter 3 (...) at baseline and randomly, but at minimum annually for low-risk patients (American College of Occupation- al and Environmental Medicine, APS-AAPM, ASIPP, University of Michigan Health System, VA/DoD). However, in patients with 8 LABORATORY MEDICINE PRACTICE GUIDELINES risk factors for misuse/abuse, more frequent monitoring is rec- ommended, but the optimal frequency for these patients has not been determined (3). Laboratory testing and its ability to identify non- compliance in pain management regimens

2018 American Academy of Pain Medicine

144. Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes

for Study: 31 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients both sexes Age between 31 and 60 years Diagnosis of diabetes according ADA criteria: (Fasting blood glucose levels >125 mg/dl or postprandial blood glucose levels after an oral glucose tolerance test with 75 of oral glucose > 200 mg/dl, or glycosylated hemoglobin >6.5%). • Informed consent signed Exclusion Criteria: Women with confirmed or suspected pregnancy Women (...) Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

145. Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors

: Mean 24-hour glucose levels [ Time Frame: 10 weeks ] Mean 24-hour glucose levels (mg/dl) Mean 24-hour insulin levels [ Time Frame: 10 weeks ] Mean 24-hour insulin levels (mU/l) Mean 24-hour C-peptide levels [ Time Frame: 10 weeks ] Mean 24-hour C-peptide levels (pmol/l). This is also a proxy for total 24-hour insulin secretion. Insulin sensitivity [ Time Frame: 10 weeks ] Mean value of insulin sensitivity (dl/kg/min/μU/ml) across the three identical meal tolerance tests, as measured by the Oral (...) Minimal Model Beta-cell responsivity index (a measure of beta-cell function) [ Time Frame: 10 weeks ] Mean value of beta-cell responsivity across the three identical meal tolerance tests, as measured by the Oral Minimal Model Glucose AUCs [ Time Frame: 10 weeks ] Glucose area-under-the-curve (mg/dl x hr) during each of three identical meal tolerance tests within a 24-hour period Insulin AUC [ Time Frame: 10 weeks ] Insulin area-under-the-curve (mU/l x hr) during each of three identical meal tolerance

2018 Clinical Trials

146. A High-Fat Compared with a High-Carbohydrate Breakfast Enhances 24-Hour Fat Oxidation in Older Adults. (PubMed)

indirect calorimetry. Insulin and glucose measures including insulin sensitivity were determined by an oral-glucose-tolerance test. Measures were taken at baseline and after the 4-wk intervention. Group-by-time interactions were determined by 2-factor repeated-measures mixed-model ANOVA. Pearson's correlation analyses were used to determine associations of 24-h RQs with metabolic measures after the intervention.There was a significant group-by-time interaction for change in the 24-h RQ [FB (mean ± SD (...) A High-Fat Compared with a High-Carbohydrate Breakfast Enhances 24-Hour Fat Oxidation in Older Adults. The ability to oxidize fat is associated with a lower risk of chronic metabolic disease. Preclinical data in mice showed that a high-fat "breakfast" increased 24-h fat oxidation relative to a high-carbohydrate breakfast.The objectives of this study were to determine whether the timing of macronutrient intake in humans affects daily fuel utilization and to examine associations between fuel

2018 Journal of Nutrition Controlled trial quality: uncertain

147. Glucose and Insulin Measurements From the Oral Glucose Tolerance Test and Relationship to Muscle Mass. (PubMed)

Glucose and Insulin Measurements From the Oral Glucose Tolerance Test and Relationship to Muscle Mass. Diabetes is associated with decreased muscle mass. The effect of higher levels of glucose and insulin on muscle mass has not been studied in individuals without diabetes. We sought to determine the relationship of insulin and glucose measurements from the oral glucose tolerance test (OGTT) with muscle mass in persons without diabetes.We analyzed data from 587 participants in the Baltimore (...) Longitudinal Study of Aging (mean age 67.3 years, range 26-95 years) without diabetes who underwent a 2-hour OGTT, including glucose and insulin measurements taken every 20 minutes and assessment of midthigh muscle cross-sectional area by computed tomography, taken as a proxy measure of muscle mass. Linear regression models and Bayesian model averaging were used to explore the independent cross-sectional association of various OGTT-derived measures and midthigh muscle cross-sectional area, independent

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2011 Biological Sciences and Medical Sciences

148. Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis

either PTI-801 or placebo QD. Drug: Placebo Placebo Outcome Measures Go to Primary Outcome Measures : Part 1 SAD and MAD HV: Safety and tolerability measured by number of subjects who experience adverse events and potential clinically significant changes in safety labs, electrocardiograms (ECGs), physical examinations, and vital signs [ Time Frame: baseline to up to 14 days ] Part 1 SAD: Apparent terminal half-life (t1/2) of single oral dose [ Time Frame: through 72-hours post dose ] Part 1 SAD: Time (...) concentration (Tmax) [ Time Frame: through 72-hour post last dose ] Part 1 FE :Maximum plasma concentration (Cmax) [ Time Frame: through 72-hour post last dose ] Part 1 FE: Area under the concentration-time curve from time 0 to time of last measurable concentration (AUCt) [ Time Frame: through 72-hour post last dose ] Part 1 FE: AUC from time 0 to infinity (AUC0-inf) [ Time Frame: through 72-hour post last dose ] Part 1 DDI: Safety and tolerability measured by number of subjects who experience adverse

2017 Clinical Trials

149. Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease

be made for this segment of the population. PREVENTION OF CVD MORTALITY IN DIABETES MELLITUS/PREDIABETES One large RCT (details provided in Table 1) was de- signed to examine the effects of omega-3 PUFA supple- mentation on cardiovascular death among patients with or at risk for diabetes mellitus (based on impaired fast- ing glucose, impaired glucose tolerance). In the ORI- GIN trial (Outcome Reduction With Initial Glargine Inter- vention), the 12 536 patients randomized to omega-3 PUFA supplement (...) %, history of CABG within past 4 y with no intervening CVD event, severe heart failure, or cancer that might affect survival Limitations: high background dietary EPA+DHA intake (median, 210 mg/d) at baseline CABG indicates coronary artery bypass graft surgery; CI, confidence interval; CVD, cardiovascular disease; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; HbA 1c , hemoglobin A 1c ; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; LVH, left ventricular hypertrophy; MI

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2017 American Heart Association

150. Characteristics of Glucose Metabolism in Underweight Japanese Women (PubMed)

postmenopausal (50 to 65 years of age) underweight women. We also recruited young normal-weight women (n = 13) and postmenopausal normal-weight women (n = 10) to serve as references. We administered an oral glucose tolerance test (OGTT) and evaluated intramyocellular lipid (IMCL) levels and body composition using 1H-magnetic resonance spectroscopy and dual-energy X-ray absorptiometry, respectively.Young underweight women had similar glucose tolerance as young normal-weight women. However, postmenopausal (...) underweight women had a higher area under the curve (AUC) for glucose during OGTT than postmenopausal normal-weight women. In postmenopausal underweight women, 2-hour glucose levels during OGTT were negatively correlated with lean body mass (r = -0.55, P < 0.01) and insulinogenic index (r = -0.42, P = 0.02) and were positively correlated with IMCL levels (r = 0.40, P = 0.03). Compared with young underweight women, postmenopausal underweight women had a higher AUC for glucose during OGTT and a lower

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2018 Journal of the Endocrine Society

151. Oral glucose tolerance test

nauseated and experience vaso-vagal symptoms during the test. The test is invalidated by vomiting. Interpretation Results are interpreted in accordance with WHO criteria. These are as follows (for non pregnant people): Classification Fasting Two hours Normal <6.1 <7.8 Impaired fasting glucose ≥6.1 and <7.0 <7.8 Impaired glucose tolerance <7.0 7.8 and <11.0 Diabetes mellitus ≥7.0 ≥11.1 Venous plasma glucose concentrations in mmol/L. The test should not be performed in individuals who are acutely unwell (...) Oral glucose tolerance test Oral glucose tolerance test - Diabetes Investigation - Diagnosis and Treatment Oral glucose tolerance test Indications Diagnosis of diabetes mellitus and impaired glucose tolerance. Patient preparation The patient should be aware of the following: They should be on a normal carbohydrate containing diet (at least 150 g/day) for at least three days before the test. They should fast from 10pm on the evening before the test with the exception of water and any drugs

2011 Diabetes Bible

152. One-Hour Glucose During an Oral Glucose Challenge Prospectively Predicts β-Cell Deterioration and Prediabetes in Obese Hispanic Youth. (PubMed)

One-Hour Glucose During an Oral Glucose Challenge Prospectively Predicts β-Cell Deterioration and Prediabetes in Obese Hispanic Youth. In adults, 1-h glucose during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes independent of fasting and 2-h glucose concentrations. The purpose of the current investigation was to examine the utility of elevated 1-h glucose levels to prospectively predict deterioration in β-cell function and the development of prediabetes (...) in high-risk youth.Obese Latino youth with a family history of type 2 diabetes (133 male and 100 female; age 11.1 ± 1.7 years) completed a baseline OGTT and were divided into two groups based upon a 1-h glucose threshold of 155 mg/dL (<155 mg/dL, n = 151, or ≥ 155 mg/dL, n = 82). Youth were followed annually for up to 8 years for assessment of glucose tolerance, body composition by dual-energy X-ray absorptiometry, and insulin sensitivity, insulin secretion, and the disposition index by the frequently

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2013 Diabetes Care

153. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

involves measuring breathing during sleep. The evolution of measurement techniques and definitions of abnormalities justifies updating the guidelines regarding diagnostic testing, but also complicates the evaluation and summary of evidence gathered from older research studies that have included diagnostic tests with diverse sensor types and scored respiratory events using different definitions. The third edition of the International Classification of Sleep Disorders (ICSD-3) defines OSA as a PSG (...) the following criteria are met: (1) A moderate to severe degree of OSA is observed during a minimum of 2 hours of recording time on the diagnostic PSG; AND (2) At least 3 hours are available to complete CPAP titration. If these criteria are not met, a full-night diagnostic protocol should be followed. g = Clinically appropriate is defined as the absence of conditions identified by the clinician that are likely to interfere with successful diagnosis and treatment using a split-night protocol. h

2017 American Academy of Sleep Medicine

154. Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats (PubMed)

Effect of chicory seed extract on glucose tolerance test (GTT) and metabolic profile in early and late stage diabetic rats The goal was to evaluate and compare the effects of aqueous extract of the seeds of chicory, Cichorium intybus L., on glucose tolerance test (GTT) and blood biochemical indices of experimentally-induced hyperglycemic rats.Late stage and early stage of Type 2 diabetes mellitus (T2DM) were induced in rats by streptozotocin (STZ) and a combination of STZ and niacinamide (NIA (...) /STZ), respectively. Within each group, one subgroup received daily i. p. injections of chicory extract (125 mg/kg body weight, for 28 days). Body weight and fasting blood sugar (FBS) were measured weekly. Blood was analyzed for glycosylated hemoglobin (HbA1c) and sera for alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide (NO), triacylglycerol (TG), total cholesterol (TC), total protein, and insulin on days 10 and 28 after treatment. Intraperitoneal glucose tolerance

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2012 DARU Journal of Pharmaceutical Sciences

155. Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity. (PubMed)

with perinatal outcomes and the follow-up study evaluated the long-term outcomes (4697 mothers and 4832 children; study visits occurred between February 13, 2013, and December 13, 2016).Gestational diabetes was defined post hoc using criteria from the International Association of Diabetes and Pregnancy Study Groups consisting of 1 or more of the following 75-g oral glucose tolerance test results (fasting plasma glucose ≥92 mg/dL; 1-hour plasma glucose level ≥180 mg/dL; 2-hour plasma glucose level ≥153 mg/dL (...) ).Primary maternal outcome: a disorder of glucose metabolism (composite of type 2 diabetes or prediabetes). Primary outcome for children: being overweight or obese; secondary outcomes: obesity, body fat percentage, waist circumference, and sum of skinfolds (>85th percentile for latter 3 outcomes).The analytic cohort included 4697 mothers (mean [SD] age, 41.7 [5.7] years) and 4832 children (mean [SD] age, 11.4 [1.2] years; 51.0% male). The median duration of follow-up was 11.4 years. The criteria for GD

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2018 JAMA

156. Glucose Tolerance in Children With Cystic Fibrosis

between 10-20 years of age with genetically determined cystic fibrosis followed at the university children`s hospital Basel and university children`s hospital Kinderklinik Bern, Switzerland. All patients will get the diagnostics for glucose tolerance with 3 different methods (CGMS, OGTT and optionally IVGTT). Other: Diagnostics for glucose tolerance with 3 different methods. A 7-day course of subcutaneous continuous glucose monitoring system (CGMS). An oral glucose tolerance test done within the 7 day (...) the 7 day course of CGMS ] Standard oral glucose tolerance test. First phase insulin secretion and second phase insulin secretion out of IVGTT (intravenous glucose tolerance test). [ Time Frame: Within the 7 day course of CGMS ] Standard intravenous glucose tolerance test. FEV1% (forced expiratory volume at one second) out of the lung function testing [ Time Frame: Within 3 months of the 7 day course of CGMS ] Lung clearance index [ Time Frame: Within 3 months of the 7 day course of CGMS ] BMI-SDS

2015 Clinical Trials

157. Brown Seaweeds Effect on Glucose Tolerance and Appetite Response

Brown Seaweeds Effect on Glucose Tolerance and Appetite Response Brown Seaweeds Effect on Glucose Tolerance and Appetite Response - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Brown Seaweeds Effect (...) on Glucose Tolerance and Appetite Response The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02608372 Recruitment Status : Completed First Posted : November 18, 2015 Last Update Posted : August 27, 2018 Sponsor: University of Copenhagen Collaborators: Ministry of Education, Malaysia Universiti Malaysia

2015 Clinical Trials

158. Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance

of Chlorogenic Acid on Patients With Impaired Glucose Tolerance The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02621060 Recruitment Status : Unknown Verified December 2015 by Esperanza Martínez-Abundis, University of Guadalajara. Recruitment status was: Recruiting First Posted : December 3, 2015 Last Update (...) and insulin sensitivity. Condition or disease Intervention/treatment Phase Impaired Glucose Tolerance Drug: Placebo Drug: Chlorogenic acid Phase 2 Detailed Description: A randomized, double-blind, placebo-controlled clinical trial was carried out in 30 patients with a diagnosis of impaired glucose tolerance in accordance with the American Diabetes Association criteria. The patients received 400 mg capsules of Chlorogenic acid or placebo, three times daily 1/ 2 hour before meals for 90 days. Before

2015 Clinical Trials

159. Effect of 2-Week Nightly Moderate Hypoxia on Glucose Tolerance in Individuals With Type 2 Diabetes

) simulating an altitude of ~2,400 meters for 7-12 hours each night for a period of 14 days. Baseline testing measures will include a oral glucose tolerance test (OGTT) and body composition (iDXA). Post-treatment testing measures will include OGTT only. Outcome Measures Go to Primary Outcome Measures : Insulin sensitivity via oral glucose tolerance test [ Time Frame: 14 days ] Insulin sensitivity will be estimated by the Matsuda Index (unitless; calculated from the oral glucose tolerance test). Higher (...) values indicate improved insulin sensitivity. Secondary Outcome Measures : Hemoglobin A1c (%) [ Time Frame: 14 days ] Hemoglobin A1c (%) will be measured. Lower values indicate improved fasting glucose levels. 2-hour insulin area-under-the-curve via oral glucose tolerance test [ Time Frame: 14 days ] 2-hour insulin area-under-the-curve (μU/mL x hr) will be estimated from the oral glucose tolerance test 2-hour glucose area-under-the-curve via oral glucose tolerance test [ Time Frame: 14 days ] 2-hour

2015 Clinical Trials

160. Coffee Roasting and Glucose Tolerance

: Chlorogenic acid (CGA) in coffee may lower the postprandial glucose response. CGA is destroyed by dark roasting. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light (LIR) or dark (DAR) roasted coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Plasma glukose and insulin, appetite, and plasma and urine metabolic profiles will be analysed. The primary aim is to investigate whether roasting affects the postprandial glucose area (...) a carbohydrate challenge. The aim of this study was to investigate whether two coffee beverages that differ in CGA content due to different roasting degrees will affect glucose regulation differently. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light roasted (LIR) or dark roasted (DAR) coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Blood samples were drawn at baseline, 30, 60 and 120 min. Differences in glucose and insulin

2015 Clinical Trials

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