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121. A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test

A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test (DXM2) The safety and scientific validity of this study

2013 Clinical Trials

122. A1C Testing in the Diagnosis of Diabetes Mellitus

A1C Testing in the Diagnosis of Diabetes Mellitus A1C Testing in the Diagnosis of Diabetes Mellitus Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics A1C Testing in the Diagnosis of Diabetes Mellitus View/ Open Date 2006-07 Format Metadata Abstract A1C testing is highly specific compared with a two-hour oral glucose (...) tolerance test (OGTT) or a fasting plasma glucose test. However, because A1C testing is not sensitive enough to rule out diabetes if levels are normal, the test should not be used for diagnosing diabetes. (Strength of recommendation: C). URI Part of Citation American Family Physician, 74(1) 2006. Rights OpenAccess. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Collections hosted by hosted by

2019 Clinical Inquiries

123. A1C Testing in the Diagnosis of Diabetes Mellitus

A1C Testing in the Diagnosis of Diabetes Mellitus A1C Testing in the Diagnosis of Diabetes Mellitus Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics A1C Testing in the Diagnosis of Diabetes Mellitus View/ Open Date 2006-07 Format Metadata Abstract A1C testing is highly specific compared with a two-hour oral glucose (...) tolerance test (OGTT) or a fasting plasma glucose test. However, because A1C testing is not sensitive enough to rule out diabetes if levels are normal, the test should not be used for diagnosing diabetes. (Strength of recommendation: C). URI Part of Citation American Family Physician, 74(1) 2006. Rights OpenAccess. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Collections hosted by hosted by

2019 Clinical Inquiries

124. Relationship Between 1-Hour Glucose Challenge Test Results and Perinatal Outcomes. (PubMed)

Relationship Between 1-Hour Glucose Challenge Test Results and Perinatal Outcomes. To estimate the relationship between 1-hour 50 g glucose challenge test values and perinatal outcomes.This was a secondary analysis of data from a multicenter treatment trial of mild gestational diabetes mellitus. Women with glucose challenge test values of 135-199 mg/dL completed a 3-hour oral glucose tolerance test. Mild gestational diabetes mellitus was defined as fasting glucose less than 95 mg/dL and two (...) or more abnormal oral glucose tolerance test values: 1-hour 180 mg/dL or more; 2-hour 155 mg/dL or more; and 3-hour 140 mg/dL or more. Our study included untreated women with glucose challenge test values of 135-139 mg/dL and 140-199 mg/dL and a comparison group with values less than 120 mg/dL. Primary outcomes included a perinatal composite (stillbirth, neonatal death, hypoglycemia, hyperbilirubinemia, neonatal hyperinsulinemia, and birth trauma), large for gestational age (LGA, birth weight above

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2013 Obstetrics and Gynecology

125. Effect of age, hours since last food, time of day, and ketonuria on 1-hour glucose tolerance. (PubMed)

Effect of age, hours since last food, time of day, and ketonuria on 1-hour glucose tolerance. 5071315 1972 11 16 2018 11 13 0090-2918 87 7 1972 Aug-Sep Health services reports Health Serv Rep Effect of age, hours since last food, time of day, and ketonuria on 1-hour glucose tolerance. 649-57 Phillips N N Duffy T T eng Journal Article United States Health Serv Rep 0430452 0090-2918 0 Blood Glucose 0 Ketone Bodies AIM IM Adolescent Adult Age Factors Aged Blood Glucose analysis Eating Fasting (...) Female Glucose Tolerance Test standards Humans Ketone Bodies urine Middle Aged Statistics as Topic Time Factors 1972 8 1 1972 8 1 0 1 1972 8 1 0 0 ppublish 5071315 PMC1617005 Can Med Assoc J. 1969 Apr 19;100(15):692-8 5778955 J Clin Endocrinol Metab. 1970 May;30(5):602-8 4910526 Diabetologia. 1970 Aug;6(4):414-9 5452389 Public Health Rep. 1965 Mar;80:220-4 14265434 Diabetes. 1965 Jul;14:413-23 14318589 Arch Intern Med. 1963 Sep;112:338-43 14045277

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1972 Health services reports

126. CRACKCast E126 – Diabetes Mellitus and Disorders of Glucose Homeostasis

. Normally, our body’s glucose is derived from three sources—intestinal absorption from the diet, endogenous production from the breakdown of glycogen (glycogenolysis), and the formation of glucose from precursors (gluconeogenesis), including lactate, pyruvate, amino acids, and glycerol. Insulin receptors on the beta cells of the pancreas sense elevations in the blood glucose concentration and trigger insulin release into the blood. It sticks around for 3-10 minutes before it is broken down in the liver (...) , antiretroviral medications, and glucocorticoids) The 1997 National Diabetes Data Group reported discontinued use of the terms “insulin dependent diabetes mellitus” and “non–insulin-dependent diabetes mellitus” because they were confusing and clinically inaccurate. In addition, the use of Arabic numerals, 1 and 2, instead of Roman numerals is the standard. Impaired glucose tolerance (IGT) has been replaced by the term prediabetes to identify individuals at high risk for the development of diabetes

2017 CandiEM

127. Diagnostic Accuracies of Glycated Hemoglobin, Fructosamine, and Homeostasis Model Assessment of Insulin Resistance in Predicting Impaired Fasting Glucose, Impaired Glucose Tolerance, or New Onset Diabetes After Transplantation. (PubMed)

Diagnostic Accuracies of Glycated Hemoglobin, Fructosamine, and Homeostasis Model Assessment of Insulin Resistance in Predicting Impaired Fasting Glucose, Impaired Glucose Tolerance, or New Onset Diabetes After Transplantation. New onset diabetes after transplantation (NODAT) is associated with a 3-fold greater risk of cardiovascular disease events, with early identification and treatment potentially attenuating this risk. The optimal screening test to identify those with NODAT remains unclear (...) 0.81 and 0.85. Restricting to identifying IGT/NODAT using 2-hour oral glucose tolerance test (n = 66), fructosamine was the most accurate diagnostic test with adjusted AUC of 0.93 (95% CI, 0.84-0.99), but not statistically different to HBA1c with adjusted AUC of 0.88 (95% CI, 0.76-0.96).Although HBA1c is an acceptable and widely used screening test in detecting IFG/IGT or NODAT, fructosamine may be a more accurate diagnostic test but this needs to be further examined in larger cohorts.

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2015 Transplantation

128. Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus Who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum (PubMed)

Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus Who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum The aim of this study was to compare glucose intolerance in the antenatal and the postpartum periods using a 75-g oral glucose tolerance test (OGTT) in the Japanese women with gestational diabetes mellitus (GDM) using a retrospective design.Data were obtained from 85 Japanese women with GDM who delivered from (...) April 2011 through April 2015 and who underwent an OGTT 6-14 weeks postpartum. The women were divided into two groups based on the results of the postpartum OGTT: one group with normal glucose tolerance (NGT) and the other with impaired glucose tolerance (IGT) as well as impaired fasting glucose (IFG). We analyzed the associations between postpartum IGT-IFG and various factors.Antenatally, a significant difference was observed between the groups only in the 1-hour plasma glucose level of the 75-g

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2015 Japanese clinical medicine

129. Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals. (PubMed)

Prednisone affects inflammation, glucose tolerance, and bone turnover within hours of treatment in healthy individuals. Use of glucocorticoids for anti-inflammatory efficacy is limited by their side effects. This study examined, in the same individuals, prednisone's acute, dose-dependent effects on inflammation as well as biomarkers of glucose regulation and bone homeostasis.In this randomized, double-blind, parallel-design trial of healthy adults demonstrating cutaneous allergen-induced (...) hypersensitivity, patients received placebo or prednisone 10, 25 or 60 mg daily for 7 days.Effects on peripheral white blood cell (WBC) count, ex vivo whole blood lipopolysaccharide (LPS)-stimulated TNF-α release and response to cutaneous allergen challenge were assessed concurrently with biomarkers for glucose tolerance and bone turnover.Differential peripheral WBC counts changed significantly within hours of prednisone administration. Ex vivo, LPS-stimulated TNF-α was significantly reduced by all prednisone

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2012 European journal of endocrinology / European Federation of Endocrine Societies Controlled trial quality: uncertain

130. The Collaborative Assessment, OTCA12, on “C-reactive protein point-of-care testing (CRP POCT) to guide antibiotic prescribing in primary care settings for acute respiratory tract infections (RTIs)

was presented. Planned subgroup analysis (children, older adults [=65 years of age] patients attending out-of-hours (OOH) services and those in long-term care (LTC) facilities) were not possible due to limited data. Only one study included children (aged 3 months to 15 years) and no study specifically reported on CRP testing in older adults. Therefore no conclusions can be drawn on the diagnostic test accuracy of CRP testing in these subgroups and instead, results should be interpreted in terms (...) The Collaborative Assessment, OTCA12, on “C-reactive protein point-of-care testing (CRP POCT) to guide antibiotic prescribing in primary care settings for acute respiratory tract infections (RTIs) Dec2015 © EUnetHTA, 2015. Reproduction is authorised provided EUnetHTA is explicitly acknowledged 1 EUnetHTA Joint Action 3 WP4 Version 1.4, +31 January 2019] Rapid assessment of other technologies using the HTA Core Model ® for Rapid Relative Effectiveness Assessment C-REACTIVE PROTEIN POINT-OF-CARE

2019 EUnetHTA

131. HTA of C-reactive protein point-of-care testing to guide antibiotic prescribing

heterogeneity across trials in the estimated treatment effect. ? Due to limited data, it is unclear what impact CRP POCT testing has on antibiotic prescribing in children. There were no studies that met our inclusion criteria that provided data specifically on patients from long-term care facilities or out-of-hours clinics. As trials were based on short term follow-up data at three months, it is unclear whether clinicians continue to use CRP POCT as a decision support tool over the longer term. ? The use (...) of CRP POCT does not lead to an increase in adverse effects such as mortality, hospitalisations, or reconsultations. There was limited evidence regarding other outcomes of clinical effectiveness and safety. ? CRP POCT devices generally demonstrate acceptable analytical performance in a laboratory setting. When used at the point of care, however, the accuracy and precision of the devices was more variable. The overall time taken for the test to be completed ranges from just over 3 minutes to over 13

2019 Health Information and Quality Authority

132. Bone Turnover Markers in Patients with Non-Alcoholic Fatty Liver Disease and/or Type 2 Diabetes during Oral Glucose and Isoglycemic iv Glucose. (PubMed)

is uncertain but may involve the gut-bone axis.We investigated the influence of the gut on glucose-induced changes in plasma bone turnover markers in healthy controls and patients with T2D and/or biopsy-verified NAFLD.Cross-sectional cohort study.Patients with NAFLD with normal glucose tolerance, patients with NAFLD and T2D, patients with T2D without liver disease, and healthy controls.Four-hour 50-g oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI).Collagen type 1 C (...) Bone Turnover Markers in Patients with Non-Alcoholic Fatty Liver Disease and/or Type 2 Diabetes during Oral Glucose and Isoglycemic iv Glucose. Nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes (T2D) and vice versa, and both conditions are associated with an increased risk of fractures and altered bone turnover. Although patients with NAFLD typically suffer from decreased bone mineral density (BMD), T2D is associated with normal to high BMD. The pathophysiology

2018 Journal of Clinical Endocrinology and Metabolism

133. Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults. (PubMed)

, and C-peptide were assessed at baseline, minutes 15, 30, 45, 60, and every 30 minutes for 2 hours in response to a glucose tolerance test.There was a significant condition × time interaction for total BPA (P < 0.001) such that BPA increased more rapidly in BPA-50 than BPA-4 and PL (P = 0.003) and increased more rapidly in BPA-4 than PL (P < 0.001). There were no significant condition × time interactions on glucose, insulin, and C-peptide. Significant condition main effects were observed for glucose (...) such that BPA-50 was significantly lower than PL (P = 0.036) and nearly lower for BPA-4 vs PL (P = 0.056). Significant condition main effects were observed such that insulin in BPA-50 was lower than BPA-4 (P = 0.021), and C-peptide in BPA-50 was lower than BPA-4 (t18 = 3.95; Tukey-adjusted P = 0.003). Glucose, insulin, and C-peptide areas under the curve for the 3-hour profile were significantly lower in BPA-50 vs PL (P < 0.05).Orally administered BPA protocol appeared feasible and has immediate effects

2019 Journal of the Endocrine Society Controlled trial quality: uncertain

134. Influence of breastfeeding during the postpartum oral glucose tolerance test on plasma glucose and insulin. (PubMed)

Influence of breastfeeding during the postpartum oral glucose tolerance test on plasma glucose and insulin. To examine the effect of breastfeeding during the postpartum oral glucose tolerance test (OGTT) on maternal blood glucose and insulin among women with recent gestational diabetes mellitus.Participants were enrolled in the Study of Women, Infant Feeding, and Type 2 Diabetes, a prospective observational cohort study of 1,035 Kaiser Permanente Northern California members who had been (...) ) duration of breastfeeding during the OGTT was 15.3 (8.1) minutes. Compared with not having breastfed during the OGTT, having breastfed during the test was associated with lower adjusted mean (95% confidence interval) 2-hour glucose (mg/dL) by -6.2 (-11.5 to -1.0; P=.02), 2-hour insulin (microunits/mL) by -15.1 (-26.8 to -3.5; P=.01), and natural log 2-hour insulin by -0.15 (-0.25 to -0.06; P<.01), and with higher insulin sensitivity index0,120 by 0.08 (0.02-0.15; P=.02), but no differences in plasma

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2012 Obstetrics and Gynecology

135. Dose-dependent Effect of Grape Seed Extract on Glucose Control in People With Impaired Glucose Tolerance

in a fasting state for at least 10 hours, well hydrated and rested. Each OGTT Day will require blood draws throughout the visit. After evaluation of subject's health status (via anthropometric, vital sign and blood glucose measurements and in-person interview), a registered nurse will place a catheter in subject's arm for the purpose of multiple blood sample collections and take the initial blood draw (baseline: -1h) in the fasting state. 3 test capsules with 0 mg GSE, 300 mg GSE, 600 mg GSE or 900 mg GSE (...) Glucose Tolerance Test (OGTT) after administration of GSE capsules (containing 300mg, 600mg or 900mg Grape seed extract) compared to 0 mg placebo. [ Time Frame: 4 hr ] plasma metabolic markers over 4 hour Oral Glucose Tolerance Test (OGTT) Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you

2014 Clinical Trials

136. One-hour post-load hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose. (PubMed)

One-hour post-load hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose. Subjects with normal glucose tolerance (NGT) but 1-h postload glucose ≥ 155 mg/dL (NGT-1h-high) exhibit an intermediate cardiometabolic risk profile between individuals with NGT and impaired glucose tolerance (IGT).This study aimed to evaluate whether NGT-1h-high subjects have different cardiometabolic characteristics and an increased risk of type 2 diabetes compared with individuals (...) with isolated impaired fasting glucose (IFG).A cross-sectional analysis was performed on 595 nondiabetic subjects who underwent an oral glucose tolerance test and an euglycemic hyperinsulinemic clamp in an ambulatory care setting. In addition, a longitudinal analysis was performed on 392 individuals, who were reexamined after a followup of 5.2 ± 0.9 y.Insulin sensitivity, beta-cell function, and risk of developing diabetes were measured.Subjects with NGT-1h-high have a significant reduction of peripheral

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2015 Journal of Clinical Endocrinology and Metabolism

137. One-hour plasma glucose as a predictor of the development of Type 2 diabetes in Japanese adults. (PubMed)

One-hour plasma glucose as a predictor of the development of Type 2 diabetes in Japanese adults. To test the hypothesis that 1-h plasma glucose in an oral glucose tolerance test is a better predictor of the development of diabetes than 2-h plasma glucose, independently of indices of insulin secretion or action in Japanese adults.A historical cohort study was conducted in 1445 Japanese workers who did not have diabetes. The association between 1-h plasma glucose and the development of Type 2 (...) of 2-h plasma glucose was diminished and was no longer significant after adjustments for 1-h plasma glucose.One-hour plasma glucose had a greater association with the future development of Type 2 diabetes than did 2-h plasma glucose, independently of oral glucose tolerance test-derived indices of insulin action in a Japanese population.© 2015 Diabetes UK.

2015 Diabetic Medicine

138. Eight Hours of Nightly CPAP Treatment of Obstructive Sleep Apnea Improves Glucose Metabolism in Prediabetes: A Randomized Controlled Trial. (PubMed)

parallel group study, 39 participants were randomly assigned to receive either 8-hour nightly CPAP (n = 26) or oral placebo (n = 13). Sleep was polysomnographically recorded in the laboratory on each night. CPAP adherence was ensured by continuous supervision. Participants continued their daily routine activities outside the laboratory. Glucose metabolism was assessed at baseline and after 2 weeks of assigned treatment using both the oral and intravenous glucose tolerance tests. The primary outcome (...) was the overall glucose response as quantified by the area under the curve for glucose during 2-hour oral glucose tolerance testing. Secondary outcomes included fasting and 2-hour glucose and insulin, the area under the curves for insulin and insulin secretion, norepinephrine, insulin sensitivity, acute insulin response to glucose, and 24-hour blood pressure.The overall glucose response was reduced (treatment difference: -1,276.9 [mg/dl] · min [95% confidence interval, -2,392.4 to -161.5]; P = 0.03

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2015 American Journal of Respiratory and Critical Care Medicine Controlled trial quality: predicted high

139. Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep Wake Rhythm Disorder (N24SWD), and Irregular Sleep-W

). A parallel group design was used to test 28 days of daily evening exposure to a white broad-spectrum light (∼265 lux) versus a dim red light control (∼2 lux) among 47 patients (mean age 70.0 ± 6.4 years). The light source consisted of a rice paper shade over a vertical light tube, and the protocol instructed subjects to sit within 1 meter of the light source, for 2–3 hours in duration, ending 1 hour before habitual bedtime. There were no significant posttreatment group differences with respect to most (...) -Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015 R. Robert Auger, MD 1 ; Helen J. Burgess, PhD 2 ; Jonathan S. Emens, MD 3 ; Ludmila V. Deriy, PhD 4 ; Sherene M. Thomas, PhD 4 ; Katherine M. Sharkey, MD, PhD 5 1 Mayo Center for Sleep Medicine, Rochester, MN; 2 Rush University Medical Center, Chicago, IL; 3 Portland VA Medical Center, Portland, OR; 4 American

2015 American Academy of Sleep Medicine

140. Diagnosis & Assessment of Hypertension - Lab Tests

ventricular hypertrophy (LVH) or a prior myocardial infarction, both of which portend a higher risk of future cardiovascular events and death . Finally, both the routine and optional investigations aid in the screening for some of the modifiable causes of hypertension. For example recurrent and/or severe hypokalemia may indicate the presence of primary hyperaldosteronism. When compared with oral glucose tolerance testing, a systematic review suggests that A1C and fasting glucose levels demonstrate (...) ) (Grade D); iii. Fasting blood glucose and/or glycated hemoglobin (A1c) (Grade D); iv. Serum total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), non-HDL cholesterol, and triglycerides (Grade D); lipids may be drawn fasting or non-fasting (Grade C). v. Standard 12-lead electrocardiography (Grade C). There is little direct evidence on which to base recommendations for laboratory testing. Thus, the recommended tests have been based largely on expert opinion. However, the routine

2018 Hypertension Canada

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