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Glucose Tolerance Test 3 hour

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61. Clinical Trial of Efficacy and Safety of Subetta in the Treatment of Impaired Glucose Tolerance

the tablets in your mouth, not swallowing, until completely they are dissolved. Outcome Measures Go to Primary Outcome Measures : Change in 2-hour plasma glucose after a 75-g oral glucose tolerance test [ Time Frame: baseline and 12 weeks of treatment ] For oral glucose tolerance testing, the subject is given 75 g of oral glucose and measurement is taken at 2 hours post-glucose ingestion. All measurements are done in a central laboratory. Secondary Outcome Measures : Percentage of patients with 2-hour (...) , Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Outpatients aged 18 to 70 years, inclusive. Impaired glucose tolerance (plasma glucose from 7.8 to 11.0 mmol / L 2 hours after a 75 g oral glucose load when performing an oral glucose tolerance test, while fasting plasma glucose <7.0 mmol / L). HbA1c in the range of 5.7-6.4%. The body mass index is 25.0-39.9 kg / m^2. Consent to use reliable contraceptive methods during the study (for men and women

2018 Clinical Trials

62. The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults (PubMed)

, with the response to an oral glucose tolerance test (OGTT) determined <24 hours after. Inflammatory, haematological, and lipid parameters were also assessed the day after each trial. There was an effect of the trials on the insulin response to an OGTT (P=0.047), but not the glucose response. Following an acute bout of HIIT, insulin concentration during an OGTT was elevated at 60 min compared to the control trial (P=0.045), indicating more insulin was secreted, but glucose concentration was unchanged in all (...) The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults Our aim was to investigate the acute effects of a single bout of high intensity intermittent training (HIIT) on glucose tolerance and other physiological and metabolic markers in non-diabetic older adults. Fourteen healthy older adults (age, 64 ± 2 y; BMI, 25.7 ± 2.8 kg·m-2) performed two acute exercise trials: continuous moderate intensity exercise (MOD) and HIIT

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2018 International journal of exercise science

63. The Effect of Cold Exposure on Glucose Tolerance

Party): Maastricht University Study Details Study Description Go to Brief Summary: The purpose of the study is to evaluate the effect of cold exposure on an individual's glucose tolerance. Previous research has already shown that 10 days acclimation to a mild cold environment (14-15°C) can enhance insulin sensitivity. However, the duration in the cold environment was 6 hours per day which may not be practical for everyone. Therefore, the present study will investigate the effect of a shorter (...) Water-perfused suit. Outcome Measures Go to Primary Outcome Measures : Glucose and insulin concentrations in response to an oral glucose load [ Time Frame: 3 hours post glucose drink, measured 90 minutes after the cold exposure ] Secondary Outcome Measures : Energy expenditure measured using indirect calorimetry [ Time Frame: 30 minutes before and during the 1 hour of cold exposure ] Core temperature measured using a telemetric pill [ Time Frame: 30 minutes before and during the 1 hour of cold

2018 Clinical Trials

64. Effect of Medicago Sativa on Oral Glucose Tolerance in Healthy Adults

them. ] Glucose concentration after overnight fasting (10 to 12-h) determined by spectrophotometry methods. Expressed in mmol/L. 2 hour oral glucose tolerance test (2h-PG) [ Time Frame: After the acute administration of placebo and Medicago sativa. 15 days wash period between them. ] Glucose concentration after 75-g oral dextrose load, determined by spectrophotometry methods. Expressed in mmol/L First Phase of Insulin Secretion [ Time Frame: After the acute administration of placebo and Medicago (...) Ages Eligible for Study: 30 Years to 40 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Fasting plasma glucose ≤99 mg/dL. Two hours postload plasma glucose (100 a 139 mg/dL). Body mass Index: 25 -39.9 kg/m2. body weight stable over the last 3 months. Women in follicular phase of the menstrual cycle (days 3 to 8 of the cycle) at the time of laboratory tests. Sedentary. Nonsmokers. Body weight unchanged upper to 5% for at least 3 moths before

2018 Clinical Trials

65. Intermittent Fasting Improves Glucose Tolerance and Promotes Adipose Tissue Remodeling in Male Mice Fed a High Fat Diet. (PubMed)

Intermittent Fasting Improves Glucose Tolerance and Promotes Adipose Tissue Remodeling in Male Mice Fed a High Fat Diet. Obesity is associated with increased macrophage and extracellular matrix accumulation in adipose tissue, which can be partially reversed following weight loss by daily caloric restriction. This study examined the effects of 8 weeks of intermittent fasting (IF; 24-hour fast on 3 nonconsecutive days per week) in mice fed a chow or high-fat diet (HFD; 43% fat) on markers (...) of adipose tissue inflammation and fibrosis. We found that IF decreased energy intake, body weight, and fat cell size in HFD-fed mice and decreased fat mass and improved glucose tolerance in chow- and HFD-fed mice. IF decreased mRNA levels of macrophage markers (Lgals3, Itgax, Ccl2, and Ccl3) in inguinal and gonadal fat, as well as adipose tissue macrophage numbers in HFD-fed mice only, and altered genes involved in NLRP3 inflammasome pathway in both diet groups. IF increased mRNA levels of matrix

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2018 Endocrinology

66. Hepatic fat and glucose tolerance in women with recent gestational diabetes (PubMed)

and determinants thereof in women with and without recent gestational dysglycemia.Two hundred and fifty-seven women underwent an antepartum oral glucose tolerance test (OGTT), which diagnosed 97 with GDM, 40 with gestational impaired glucose tolerance (GIGT), and 120 with normal glucose tolerance (NGT). At a mean of 4.8 years post partum, they underwent an OGTT (which revealed that 52 had progressed to pre-diabetes/diabetes) and hepatic ultrasound, on which liver fat was graded as none (n=164), mild (n=66 (...) Hepatic fat and glucose tolerance in women with recent gestational diabetes Women with a history of gestational diabetes mellitus (GDM) have an elevated risk of ultimately developing pre-diabetes and diabetes later in life. They also have an increased prevalence of fatty liver, but recent studies have reported conflicting findings on whether hepatic fat affects their risk of pre-diabetes/diabetes. Thus, we sought to evaluate the associations of liver fat with glucose homeostasis

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2018 BMJ open diabetes research & care

67. Effect of Dietary Oils as FFAR Agonists on Glucose Tolerance

of 3g hydrolyzed pine nut oil and 3g olive oil 30 minutes prior to an 6-hours oral glucose tolerance test (75g glucose). Masking: Single (Participant) Primary Purpose: Treatment Official Title: Effects of Pine Nut and Olive Oil as FFA1/FFA4 and GPR119 Agonists on Glucose Tolerance in Healthy Overweight or Obese Subjects Actual Study Start Date : June 11, 2018 Estimated Primary Completion Date : December 30, 2018 Estimated Study Completion Date : December 30, 2018 Resource links provided (...) by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment No Intervention: No oil 6-hour oral glucose tolerance test Active Comparator: Hydrolyzed pine nut oil 6g hydrolyzed pine nut oil in delayed release capsules given 30 min prior to an 6-hour oral glucose tolerance test Dietary Supplement: Hydrolyzed pine nut oil Given 30 min prior to oral glucose tolerance test Active Comparator: Hydrolyzed pine nut oil and olive oil 3g hydrolyzed pine nut

2018 Clinical Trials

68. [Skin needle embedding for obese impaired glucose tolerance]. (PubMed)

were used. 0.25 g oral deltamine was prescribed three times a day in the western medication group. Thumb-tack needle for subcutaneous embedding was at bilateral Weiwanxiashu (EX-B 3), Ganshu (BL 18), Pishu (BL 20), Tianshu (ST 25) and Zusanli (ST 36) for 36 to 48 hours on Monday and Thursday, 3 months as a session, with other acupoints differentiated. All the treatment was given for 2 years. The indexes included the blood sugar indexes [fasting plasma glucose (FPG), 2 h postprandial blood glucose (...) [Skin needle embedding for obese impaired glucose tolerance]. To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT).A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management

2018 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

69. Predicting persistent impaired glucose tolerance in patients with gestational diabetes: The role of high sensitivity CRP and adiponectin. (PubMed)

education programme. Women with a GDM diagnosis ≥20 weeks were included. At the time of randomization, serum adiponectin and hsCRP levels were drawn. After delivery, women underwent a 2-hour 75-g oral glucose tolerance test at 6 to 12 weeks postpartum. Persistent impaired glucose tolerance (P-IGT) was defined as impaired fasting glucose, impaired glucose tolerance, or a diagnosis of type 2 diabetes mellitus. Regression models and receiver operator curves were used to evaluate the association between (...) interval, 1.34-8.92; P = .01) and had good diagnostic performance with an area under the curve of 0.73. There was no difference in median adiponectin levels between groups (44.8 vs 52.0, P = .57) or in odds of P-IGT (odds ratio, 0.81; 95% confidence interval, 0.33-1.99; P = .65), and area under the curve = 0.54.Midpregnancy high sensitivity CRP is a potential predictor of persistent impaired glucose tolerance diagnosed on the postpartum 2-hour 75-g oral glucose tolerance test in GDM women

2018 Diabetes/metabolism research and reviews Controlled trial quality: uncertain

70. A Slow-Digesting, Low-Glycemic Load Nutritional Beverage Improves Glucose Tolerance in Obese Pregnant Women Without Gestational Diabetes. (PubMed)

A Slow-Digesting, Low-Glycemic Load Nutritional Beverage Improves Glucose Tolerance in Obese Pregnant Women Without Gestational Diabetes. Obesity is a risk factor for gestational diabetes (gestational diabetes). Low-glycemic index diets attenuate hyperglycemia. We designed a study to determine whether a slow-digesting, low-glycemic load (SD-LGL) beverage improves glucose tolerance in obese pregnant women without GDM.This was a 3-arm comparison study comparing the effects of an SD-LGL (...) fast preceded each intervention phase. Twenty-four hour glucose was measured using continuous glucose monitoring.Consumption of the lower GL beverage was associated with improved measures of glycemia, compared with the control beverage and habitual diet at different time periods. Glucose estimates for control versus SD-LDL at 24 h (0.23 mmol/L [0.16 to 0.31], P < 0.001), daytime (0.26 mmol/L [0.18 to 0.34], P < 0.001), and nighttime (0.05 mmol/L [-0.01 to 0.11], P = 0.09). Postprandial glucose

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2018 Diabetes technology & therapeutics Controlled trial quality: uncertain

71. Post-Exercise Carbohydrate-Energy Replacement Attenuates Insulin Sensitivity and Glucose Tolerance the Following Morning in Healthy Adults (PubMed)

in a randomized, placebo-controlled, and double-blinded crossover design. A standardized low-carbohydrate evening meal was consumed in both trials before overnight recovery ahead of a two-hour oral glucose tolerance test (OGTT) the following morning to assess glycemic and insulinemic responses to feeding. Compared to the CHO-DEFICIT condition, CHO-REPLACE increased the incremental area under the plasma glucose curve by a mean difference of 68 mmol·L-1 (95% CI: 4 to 132 mmol·L-1; p = 0.040) and decreased (...) the Matsuda insulin sensitivity index by a mean difference of -2 au (95% CI: -1 to -3 au; p = 0.001). This is the first study to demonstrate that post-exercise feeding to replaceme the carbohydrate expended during exercise can attenuate glucose tolerance and insulin sensitivity the following morning. The mechanism through which exercise improves insulin sensitivity is therefore (at least in part) dependent on carbohydrate availability and so the day-to-day metabolic health benefits of exercise might

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2018 Nutrients Controlled trial quality: uncertain

72. The Influence of Sampling Site When Assessing Glucose Tolerance or Insulin Sensitivity With Oral Glucose Ingestion

Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Rest Remain rested prior to the oral glucose tolerance test Behavioral: Rest Allowed to watch television or read for one hour prior to oral glucose tolerance test Other: Dorsal Hand Vein Cannulation (heated hand technique) Other: Venous Cannulation Experimental: Exercise Complete exercise prior to the oral glucose tolerance test Behavioral: Exercise One (...) , 2016 Last Update Posted : October 25, 2016 Sponsor: University of Bath Information provided by (Responsible Party): Javier Gonzalez, University of Bath Study Details Study Description Go to Brief Summary: For decades, it has been known that post-meal blood glucose concentrations were associated with the risk of T2D, which was reflected in early diagnostic guidelines. The oral glucose tolerance test (OGTT) has been used since at least 1923 and has remained the most common test for assessing glucose

2016 Clinical Trials

73. Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

] Glucose tolerance status in individuals with impaired glucose tolerance (IGT) will be measured after 24 months of:: i) treatment with the renal SGLT2 inhibitor, dapagliflozin; (ii) treatment with the DPP4 inhibitor, saxagliptin; (iii) treatment with the thiazolidinedione, pioglitazone; (iv) treatment with the biguanide, metformin. Glucose tolerance status will be evaluated by 2-hour plasma glucose concentration (mg/dl) during the OGTT. Beta cell function in individuals with isolated impaired fasting (...) Frame: 24 months after treatment phase begins ] Glucose tolerance status in individuals with isolated impaired fasting glucose (IFG) will be quantitated after 24 months of: (i) treatment with the renal SGLT2 inhibitor, dapagliflozin; (ii) treatment with the DPP4 inhibitor, saxagliptin; (iii) treatment with the thiazolidinedione, pioglitazone; (iv) treatment with the biguanide, metformin. Glucose tolerance status will be evaluated by measuring the and 2-hour plasma glucose concentration (mg/dl

2016 Clinical Trials

74. Insulin resistance of protein anabolism accompanies that of glucose metabolism in lean, glucose-tolerant offspring of persons with type 2 diabetes (PubMed)

Insulin resistance of protein anabolism accompanies that of glucose metabolism in lean, glucose-tolerant offspring of persons with type 2 diabetes To test whether protein anabolic resistance is an early defect in type 2 diabetes (T2D).Seven lean, normoglycemic T2D offspring (T2D-O) and eight matched participants without family history (controls; C) underwent a 3-hour hyperinsulinemic (40 mU/m2/min), euglycemic (5.5 mmol/L) and isoaminoacidemic clamp. Whole-body glucose and protein kinetics were (...) measured with d-[3-3H]glucose and l-[l-13C]leucine, respectively. Plasma amino acids were measured by liquid chromatography-tandem mass spectrometry.Fasting glycemia and glucose kinetic variables did not differ between groups. Clamp decreases in glucose rate of appearance were not different, but rate of disappearance increased 29% less in T2D-O, to a significantly lower rate. Fasting leucine was higher in T2D-O, but kinetics did not differ. Clamp increases in leucine oxidation and decreases

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2016 BMJ open diabetes research & care

75. Study of Safety, Tolerability & Efficacy in Cystic Fibrosis Patients With Abnormal Glucose Tolerance

tolerance. Patients with abnormal glucose tolerance have elevated glucose level either at 1 hour or 2 hour during an Oral Glucose Tolerance Test (OGTT). The Main study will include 24 weeks of treatment with PBI-4050 or matching placebo. At the end of the treatment period, patients will have the option of participating in a 24-week Extension study. Condition or disease Intervention/treatment Phase Cystic Fibrosis Drug: PBI4050 Drug: Placebo Phase 2 Detailed Description: This is a Phase 2, multi-center (...) , double blind, placebo controlled study to evaluate the safety and tolerability of PBI-4050, and its effects on the pancreatic, pulmonary functions and on various biomarkers in Cystic Fibrosis patients with abnormal glucose tolerance. Patients with abnormal glucose tolerance have elevated glucose level either at 1 hour or 2 hour during an Oral Glucose Tolerance Test (OGTT). A total of 90 patients will be enrolled for study participation. A Data Safety Monitoring Board (DSMB) will continually review

2016 Clinical Trials

76. Continuous Glucose Monitoring and its Relationship to Hemoglobin A1c and Oral Glucose Tolerance Testing in Obese and Prediabetic Youth. (PubMed)

Continuous Glucose Monitoring and its Relationship to Hemoglobin A1c and Oral Glucose Tolerance Testing in Obese and Prediabetic Youth. The optimal screening test for diabetes and prediabetes in obese youth is controversial.We examined whether glycosylated hemoglobin (HbA1c) or the oral glucose tolerance test (OGTT) is a better predictor of free-living glycemia as measured by continuous glucose monitoring (CGM).This was a cross-sectional study of youth 10-18 years old, body mass index (BMI (...) greater than 140 and greater than 200 mg/dL. However, there were no overall differences in the strength comparisons between 2-hour glucose and HbA1c correlations to CGM outcomes.In obese youth, HbA1c and 2-hour glucose performed equally well at predicting free-living glycemia on CGM, suggesting that both are valid tests for dysglycemia screening.

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2014 Journal of Clinical Endocrinology and Metabolism

77. Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test. (PubMed)

a high fat diet.Six pigs were fed a high fat diet (36 energy% fat) for one month before oral glucose tolerance test (1 g/kg d-glucose) was performed. The experiment was designed as a cross-over study, either with or without addition of 0.5 g/kg body weight of thylakoid powder.The supplementation of thylakoids to the oral glucose tolerance test resulted in decreased blood glucose concentrations during the first hour, increased plasma cholecystokinin concentrations during the first two hours (...) Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test. Dietary chloroplast thylakoids have previously been found to reduce food intake and body weight in animal models, and to change metabolic profiles in humans in mixed-food meal studies. The aim of this study was to investigate the modulatory effects of thylakoids on glucose metabolism and appetite-regulating hormones during an oral glucose tolerance test in pigs fed

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2014 Clinical nutrition (Edinburgh, Scotland)

78. Dietary Fatty Acids Differentially Associate with Fasting Versus 2-Hour Glucose Homeostasis: Implications for The Management of Subtypes of Prediabetes (PubMed)

controls (n = 15), athletes (n = 14), and obese (n = 23), as well as people with prediabetes (n = 10) and type 2 diabetes (n = 11), were queried about their habitual diet using a Food Frequency Questionnaire. All subjects were screened by an oral glucose tolerance test (OGTT) and studied using the hyperinsulinemic/euglycemic clamp with infusion of 6,62H2-glucose. Multiple regression was performed to examine relationships between dietary fat intake and 1) fasting plasma glucose, 2) % suppression (...) of endogenous glucose production, 3) 2-hour post-OGTT plasma glucose, and 4) skeletal muscle insulin sensitivity (glucose rate of disappearance (Rd) and non-oxidative glucose disposal (NOGD)). The %kcal from saturated fat (SFA) was positively associated with fasting (β = 0.303, P = 0.018) and 2-hour plasma glucose (β = 0.415, P<0.001), and negatively related to % suppression of hepatic glucose production (β = -0.245, P = 0.049), clamp Rd (β = -0.256, P = 0.001) and NOGD (β = -0.257, P = 0.001). The %kcal

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2016 PloS one

79. A Practical Approach to the Management of Continuous Glucose Monitoring (CGM) / Real-Time Flash Glucose Scanning (FGS) in Type 1 Diabetes Mellitus in Children and Young People Under 18 years

pump where CGM data can be viewed on the pump. G5: Continuous Glucose monitoring system which can be The Dexcom G6 Continuous Glucose Monitoring System (Dexcom G6 System or G6) is a glucose monitoring system indicated for persons age 2 years and older. The Dexcom G6 System is designed to replace fingerstick The Sensor continuously measures glucose every minute and it stores this glucose data every 15 minutes. The Sensor stores up to 8 hours of glucose data, so you only needs to scan the Sensor 3 (...) wirelessly to a compatible smart phone. It is FDA approved and CE mark approved in Europe to make treatment decisions upon its results and is a newer version compared to G4. G5 is the first remote glucose monitoring system that is licenced to make dosing decisions from without checking with a finger prick. blood glucose (BG) testing for treatment decisions. FDA approved and CE Marked. in a 24-hour period to capture the complete glycaemic picture. The Reader can store approximately 90-days of glucose

2018 British Society for Paediatric Endocrinology and Diabetes

80. HCV eradication by DAA improves glucose tolerance and reduces post-load insulin resistance in nondiabetic patients with genotype 1. (PubMed)

tolerance.To this aim, we performed a prospective study assessing the effects of direct antiviral agents treatment in nondiabetic cirrhotic patients with genotypes 1a/1b and impaired glucose tolerance based on a 75-g oral glucose tolerance test. Impaired glucose tolerance was diagnosed by a 2-hour plasma glucose between 140 and 199 mg/dL. Insulin resistance was estimated by the oral glucose insulin sensitivity index, an oral glucose tolerance test-derived measure.After meeting the inclusion criteria (...) HCV eradication by DAA improves glucose tolerance and reduces post-load insulin resistance in nondiabetic patients with genotype 1. Genotype 1 chronic hepatitis C is associated with an impairment of glucose homoeostasis, especially in the advanced stages of the disease. Glucose tolerance is an independent predictor of liver-related mortality in patients with cirrhosis because of chronic hepatitis C. However, no study has demonstrated so far weather hepatitis C virus clearance affects glucose

2017 Liver International

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