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Glucose Tolerance Test 3 hour

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61. Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents. Full Text available with Trip Pro

and glucose tolerance test (OGTT) studies. In all models, group I received Tween 80, 2% v/v, Group II (GL5) treated with 5 mg/kg of glibenclamide and the remaining group: III, IV and V were given the plant extract at doses of 100 mg/kg 200 mg/kg and 400 mg/kg respectively. Blood glucose levels (BGL) were measured by collecting blood samples at different time points. Data was analyzed using one way ANOVA followed by Dunnet's post hoc test to carry out between and within group comparisons. P < 0.05 (...) extract at 200 mg/kg, has shown a significant reduction in blood glucose levels compared to negative controls and across all time points.The crude extract of O. integrifolia has shown significant antidiabetic, hypoglyceamic and oral glucose tolerating effects. The effective dose of the extract was found to be 200 mg/kg in time dependent manner.

2015 BMC Complementary and Alternative Medicine

62. A Research Study of How Different Amounts of a New Medicine NNC0148-0287 C (Insulin 287) Works on the Blood Sugar of People Who Are Japanese With Type 1 Diabetes When Given Once a Week

will have 24 visits with the study doctor. There will be 3 glucose clamps where the participants' blood sugar is tested over time. The participants cannot be in the study if the study doctor thinks that there are risks for their health. Condition or disease Intervention/treatment Phase Diabetes Mellitus, Type 1 Drug: Insulin 287 Drug: Insulin glargine U100 Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 24 participants (...) at how insulin 287 works, if it is safe and the side effects in people who are Japanese with type 1 diabetes. The study will test how insulin goes through your blood, how long it stays there and how the blood sugar is lowered. Insulin 287 is a new medicine. Insulin glargine is already approved to treat diabetes. The study doctors can prescribe insulin glargine. The participants will get both of the insulins in a random order. The participants will get 8 weekly doses of insulin 287 and 14 daily doses

2018 Clinical Trials

63. Blood Sugar Take Care and Glucose Metabolism

with gestational diabetes mellitus Hypertensive (≥140/90) Known HDL cholesterol level 35 mg/dl Known triglyceride level ≥250 mg/dl On previous testing, had impaired glucose tolerance or impaired fasting glucose History of vascular disease Stable body weight (<5% change) in the last 3 months Agree to use contraception throughout study period, unless postmenopausal or surgically sterile (females only) Able to understand the nature and purpose of the study including potential risks and side effects Willing (...) : STEP 2 1. Fasting glucose between 95 and 130 mg/dl, based on portable glucometer reading SUBJECT INCLUSION CRITERIA: STEP 3 Impaired fasting glucose, based on the American Diabetes Association definition of fasting serum glucose between 100 and 125 mg/dl Impaired glucose tolerance, based on the American Diabetes Association definition of serum glucose between 140 and 199 mg/dl 2 hours after a 75 g glucose load Contacts and Locations Go to Information from the National Library of Medicine To learn

2012 Clinical Trials

64. Differential effects of split and continuous sleep on neurobehavioral function and glucose tolerance in sleep-restricted adolescents. Full Text available with Trip Pro

(TIB), participants underwent either 5 nights of continuous 6.5-h TIB (n = 29) or 5-hour nocturnal TIB with a 1.5-hour afternoon nap (n = 29). After two recovery nights of 9-hour TIB, participants were sleep restricted for another three nights. Sleep was assessed using polysomnography (PSG). Cognitive performance and mood were evaluated three times per day. Oral glucose tolerance tests (OGTT) were conducted on mornings after baseline sleep, recovery sleep, and the third day of each sleep (...) Differential effects of split and continuous sleep on neurobehavioral function and glucose tolerance in sleep-restricted adolescents. Many adolescents are exposed to sleep restriction on school nights. We assessed how different apportionment of restricted sleep (continuous vs. split sleep) influences neurobehavioral function and glucose levels.Adolescents, aged 15-19 years, were evaluated in a dormitory setting using a parallel-group design. Following two baseline nights of 9-hour time-in-bed

2019 Sleep Controlled trial quality: uncertain

65. Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. Full Text available with Trip Pro

Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m2 ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm (...) ) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd).TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions

2019 Obesity Controlled trial quality: uncertain

66. Maternal night-eating pattern and glucose tolerance during pregnancy: study protocol for a longitudinal study. Full Text available with Trip Pro

physical activity, sedentary behaviour, sleep and light exposure are captured using the accelerometer at 18-24 weeks' gestation. Continuous glucose monitoring at 18-24 weeks' gestation, oral glucose tolerance test and insulin test at 24-28 weeks' gestation are performed to assess glycaemic outcomes. Multivariable generalised linear models will be used to analyse the association of maternal night-eating pattern (consumption of meal and snack during 1900-0659 hours) with glycaemic measures (...) with glucose tolerance in the second trimester of pregnancy, and to investigate how lifestyle factors may be related to night-eating pattern.This is an observational longitudinal study that targets to recruit 200 pregnant women at 18-24 weeks' gestation from the KK Women's and Children's Hospital in Singapore. Data collection includes sociodemographics, lifestyle habits and obstetric information. Maternal dietary intake is collected using the 4-day food diary and food frequency questionnaire; while 24-hour

2019 BMJ open

67. Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. (Abstract)

women with PCOS (age: 27 ± 1 yr, BMI: 41.3 ± 1.1 kg/m-2) were assigned to heat therapy (HT) or time control (CON). HT participants underwent 30 one-hour hot tub sessions over 8-10 wk, while CON participants completed all testing but did not undergo heat therapy. Before (Pre), at the mid-point (Mid), and following (Post) 8-10 wk of heat therapy, metabolic health was assessed using a 2-h oral glucose tolerance test, a subcutaneous abdominal fat biopsy (Pre-Post only), and other blood markers relating (...) Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. Polycystic ovary syndrome (PCOS) is associated with high rates of obesity and metabolic dysfunction. Repeated passive heat exposure (termed heat therapy) is a novel lifestyle intervention for improving health in obese women with PCOS. The purpose of this study was to examine changes in metabolic function in obese women with PCOS following heat therapy. Eighteen age- and BMI-matched obese

2019 American journal of physiology. Endocrinology and metabolism Controlled trial quality: uncertain

68. Plasma Metabolomics to Identify and Stratify Patients with Impaired Glucose Tolerance. (Abstract)

Plasma Metabolomics to Identify and Stratify Patients with Impaired Glucose Tolerance. Impaired glucose tolerance (IGT) is one of the pre-symptomatic states of type 2 diabetes mellitus and requires an oral glucose tolerance test (OGTT) for diagnosis. Our aims were two-fold: 1) characterize signatures of small molecules predicting the OGTT-response and 2) identify metabolic subgroups of participants with IGT.Plasma samples from 827 participants of the Study of Health in Pomerania free (...) of diabetes were measured utilizing mass spectrometry and proton-nuclear magnetic resonance spectroscopy. Linear regression analyses were used to screen for metabolites significantly associated with the OGTT-response after two hours adjusting for baseline glucose and insulin levels, as well as important confounders. A signature predictive for IGT was established using regularized logistic regression. All IGT cases (N=159) were selected and subjected to unsupervised clustering using a k-means approach.In

2019 Journal of Clinical Endocrinology and Metabolism

69. Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects. Full Text available with Trip Pro

) in healthy individuals.Subjects participated in a three step hyperinsulinemic (+10, +20, +40 mU/m2·min) euglycemic clamp before and after a 48 hour glucose infusion to increase plasma glucose concentration by ∼40 mg/dl above baseline. Endogenous glucose production (EGP) was measured with 3-3H-glucose before and after chronic glucose infusion.Sixteen NGT subjects (8 with and 8 without family history [FH] of diabetes) participated in the study.EGP.Basal EGP increased following 48 hours of glucose infusion (...) Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects. Chronic hyperglycemia worsens skeletal muscle insulin resistance and beta cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity is not clear.To examine the effect of sustained physiologic hyperglycemia (similar to that observed in type 2 diabetic individuals) on endogenous (primarily reflects hepatic) glucose production (EGP

2019 Journal of Clinical Endocrinology and Metabolism

70. Newly detected abnormal glucose regulation and long-term prognosis after acute myocardial infarction: Comparison of an oral glucose tolerance test and glycosylated haemoglobin A1c. (Abstract)

Newly detected abnormal glucose regulation and long-term prognosis after acute myocardial infarction: Comparison of an oral glucose tolerance test and glycosylated haemoglobin A1c. An oral glucose tolerance test (OGTT) and/or glycosylated haemoglobin A1c (HbA1c) in patients with acute myocardial infarction (AMI) identify patients with increased mortality risk, but no comparison of the long-term prognostic values has yet been investigated.This study was a prospective cohort enrolling patients (...) was observed (Hazard Ratio (HR) 1.60 [1.09-2.34]). However, when adjusting for known DM, no significance was detected. An OGTT did not show a significantly increased mortality, if used separately. A combined estimate showed a significantly increased mortality in patients categorized as newly diagnosed DM by OGTT and HbA1c<6.5% (HR 1.56 [95% CI 1.07-2.30]) compared to patients categorized as normal/impaired fasting glycaemia/impaired glucose tolerance by OGTT and HbA1c <6.5%. Approximately 50

2016 International journal of cardiology

71. Continuous glucose monitoring (CGM real-time) and flash glucose monitoring (FGM) as personal, standalone systems in patients with diabetes mellitus treated with insulin

Action 3 WP4 83 A total of 281 thousand men and 317 thousand women worldwide died with DM in 2011, most from CVD. The healthcare expenditure for DM in Europe was about 75 billion Euros in 2011 and is projected to increase to 90 billion by 2030 [7]. In 2012, the total burden of deaths from high blood glucose has been estimated to be up to 3.7 million, with 1.5 million deaths directly related to diabetes, and an additional 2.2 million deaths from cardiovascular diseases, chronic kidney disease (...) July 2018 EUnetHTA Joint Action 3 WP4 84 Current clinical management of diabetes mellitus [A0024] – How is diabetes mellitus currently diagnosed according to published guidelines and in practice? In individual European countries, responsible bodies and expert societies are responsible for pub- lishing national guidelines on diabetes diagnosis. General Diagnostic Tests for Diabetes [79] Diabetes can be diagnosed based on plasma glucose criteria, either based on the fasting plasma glucose, 2-h PG

2018 EUnetHTA

72. Diagnostic Ability of Elevated 1- hour Glucose Challenge Test Full Text available with Trip Pro

Diagnostic Ability of Elevated 1- hour Glucose Challenge Test To determine whether a threshold of a 1-h glucose challenge test (GCT) eliminates the need for a 3-h glucose tolerance test (GTT).A retrospective cohort of patients undergoing GTT after GCT was ⩾140 mg dl(-1). Gestational diabetes mellitus (GDM) was diagnosed using National Diabetes Data Group (NDDG) and Carpenter-Coustan (CC) criteria. Sensitivity, specificity and predictive values were calculated for 1-h GCT values of 160 to 220 mg (...)  dl(-1).Of 6218 patients, 988 (15.9%) had an elevated GCT and 753 (12.1%) underwent a GTT. In all, 165 (2.7%) were diagnosed with GDM using NDDG criteria, and 250 (4.0%) by CC criteria. The positive predictive value of a 1-h of GCT ⩾200 mg dl(-1) for GDM was 68.6% by NDDG and 80.0% for GDM by CC criteria.Although the predictive value of an elevated 1-h ⩽200 mg dl(-1) for GDM was high, 1 in 3 to 1 in 5 women would be overdiagnosed with GDM if the 3-h GTT was omitted.

2016 Journal of perinatology : official journal of the California Perinatal Association

73. CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study Full Text available with Trip Pro

with elevated CRP level (each P < 1.2 × 10-6). Allele C at rs3093059 was associated with fasting glucose (β = 0.20, P = 0.045) and G at rs1205 was associated with 2-hour glucose (β = 0.46, P = 0.00090) post oral glucose tolerance test, but only the latter passed Bonferroni correction. No polymorphism was associated with diabetes. Since 2-hour glucose is an indicator of glucose tolerance, this study indicated CRP gene is associated with glucose intolerance. (...) CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin

2017 Scientific reports

74. Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults Full Text available with Trip Pro

following 3 h of intermittent hypoxia in healthy humans independent of any effect on insulin sensitivity. Eight (7M/1F, 21-34 years) healthy subjects completed two study visits randomized to 3 h of intermittent hypoxia or continuous normoxia, followed by an oral glucose tolerance test. Intermittent hypoxia consisted of 25 hypoxic events per hour where oxygen saturation (SpO2) was significantly reduced (Normoxia: 97 ± 1%, Hypoxia: 90 ± 2%, P < 0.01). Venous plasma glucose concentrations were measured (...) glucose tolerance test (P > 0.05). Circulating glucose is increased after 3 h of intermittent hypoxia in healthy humans, independent of any lasting changes in insulin sensitivity. These novel findings could explain, in part, the high prevalence of diabetes in patients with sleep apnea and warrant future studies to identify underlying mechanisms.© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

2017 Physiological reports

75. Reply to Kawada One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. (Abstract)

, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Yamagishi M M Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. eng Letter Comment England Diabet Med 8500858 0742-3071 0 Blood Glucose IM Diabet Med. 2017 May;34(5):733 28173621 Diabet Med. 2016 Oct;33(10 ):1399-405 26482027 Blood Glucose Diabetes Mellitus, Type 2 Diabetes, Gestational Glucose Tolerance Test Humans 2017 02 03 2017 2 9 6 0 2018 4 11 6 0 (...) Reply to Kawada One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 28173616 2018 04 10 2018 12 02 1464-5491 34 5 2017 05 Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. Reply to Kawada: One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 734 10.1111/dme.13329 Oka R R Department of Internal Medicine, Hokuriku Central Hospital. Aizawa T T Diabetes Centre, Aizawa Hospital. Yoneda T T Department of Cardiovascular and Internal Medicine

2017 Diabetic Medicine

76. One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. (Abstract)

26482027 Diabet Med. 2017 May;34(5):734 28173616 Blood Glucose Diabetes Mellitus, Type 2 Diabetes, Gestational Glucose Tolerance Test Humans 2016 12 06 2017 02 03 2017 2 9 6 0 2018 4 11 6 0 2017 2 8 6 0 ppublish 28173621 10.1111/dme.13330 (...) One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 28173621 2018 04 10 2018 12 02 1464-5491 34 5 2017 05 Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 733 10.1111/dme.13330 Kawada T T Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan. eng Letter Comment England Diabet Med 8500858 0742-3071 0 Blood Glucose IM Diabet Med. 2016 Oct;33(10 ):1399-405

2017 Diabetic Medicine

77. A Slow-Digesting, Low-Glycemic Load Nutritional Beverage Improves Glucose Tolerance in Obese Pregnant Women Without Gestational Diabetes. Full Text available with Trip Pro

A Slow-Digesting, Low-Glycemic Load Nutritional Beverage Improves Glucose Tolerance in Obese Pregnant Women Without Gestational Diabetes. Obesity is a risk factor for gestational diabetes (gestational diabetes). Low-glycemic index diets attenuate hyperglycemia. We designed a study to determine whether a slow-digesting, low-glycemic load (SD-LGL) beverage improves glucose tolerance in obese pregnant women without GDM.This was a 3-arm comparison study comparing the effects of an SD-LGL (...) fast preceded each intervention phase. Twenty-four hour glucose was measured using continuous glucose monitoring.Consumption of the lower GL beverage was associated with improved measures of glycemia, compared with the control beverage and habitual diet at different time periods. Glucose estimates for control versus SD-LDL at 24 h (0.23 mmol/L [0.16 to 0.31], P < 0.001), daytime (0.26 mmol/L [0.18 to 0.34], P < 0.001), and nighttime (0.05 mmol/L [-0.01 to 0.11], P = 0.09). Postprandial glucose

2018 Diabetes technology & therapeutics Controlled trial quality: uncertain

78. [Skin needle embedding for obese impaired glucose tolerance]. (Abstract)

were used. 0.25 g oral deltamine was prescribed three times a day in the western medication group. Thumb-tack needle for subcutaneous embedding was at bilateral Weiwanxiashu (EX-B 3), Ganshu (BL 18), Pishu (BL 20), Tianshu (ST 25) and Zusanli (ST 36) for 36 to 48 hours on Monday and Thursday, 3 months as a session, with other acupoints differentiated. All the treatment was given for 2 years. The indexes included the blood sugar indexes [fasting plasma glucose (FPG), 2 h postprandial blood glucose (...) [Skin needle embedding for obese impaired glucose tolerance]. To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT).A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management

2018 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

79. Predicting persistent impaired glucose tolerance in patients with gestational diabetes: The role of high sensitivity CRP and adiponectin. (Abstract)

education programme. Women with a GDM diagnosis ≥20 weeks were included. At the time of randomization, serum adiponectin and hsCRP levels were drawn. After delivery, women underwent a 2-hour 75-g oral glucose tolerance test at 6 to 12 weeks postpartum. Persistent impaired glucose tolerance (P-IGT) was defined as impaired fasting glucose, impaired glucose tolerance, or a diagnosis of type 2 diabetes mellitus. Regression models and receiver operator curves were used to evaluate the association between (...) interval, 1.34-8.92; P = .01) and had good diagnostic performance with an area under the curve of 0.73. There was no difference in median adiponectin levels between groups (44.8 vs 52.0, P = .57) or in odds of P-IGT (odds ratio, 0.81; 95% confidence interval, 0.33-1.99; P = .65), and area under the curve = 0.54.Midpregnancy high sensitivity CRP is a potential predictor of persistent impaired glucose tolerance diagnosed on the postpartum 2-hour 75-g oral glucose tolerance test in GDM women

2018 Diabetes/metabolism research and reviews Controlled trial quality: uncertain

80. Effect of Dietary Oils as FFAR Agonists on Glucose Tolerance

of 3g hydrolyzed pine nut oil and 3g olive oil 30 minutes prior to an 6-hours oral glucose tolerance test (75g glucose). Masking: Single (Participant) Primary Purpose: Treatment Official Title: Effects of Pine Nut and Olive Oil as FFA1/FFA4 and GPR119 Agonists on Glucose Tolerance in Healthy Overweight or Obese Subjects Actual Study Start Date : June 11, 2018 Estimated Primary Completion Date : December 30, 2018 Estimated Study Completion Date : December 30, 2018 Resource links provided (...) by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment No Intervention: No oil 6-hour oral glucose tolerance test Active Comparator: Hydrolyzed pine nut oil 6g hydrolyzed pine nut oil in delayed release capsules given 30 min prior to an 6-hour oral glucose tolerance test Dietary Supplement: Hydrolyzed pine nut oil Given 30 min prior to oral glucose tolerance test Active Comparator: Hydrolyzed pine nut oil and olive oil 3g hydrolyzed pine nut

2018 Clinical Trials

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