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Glucose Tolerance Test 3 hour

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41. Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins. (PubMed)

Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins. The associations of body mass index (BMI) and liver fat (LF) with circulating prandial metabolomic markers are incompletely understood.We aimed to characterize circulating metabolite excursions during an oral glucose tolerance test (OGTT) and evaluate whether the metabolomic signatures of BMI discordance coassociate with LF content.We measured 80 metabolite parameters by nuclear (...) magnetic resonance, together with glucose and insulin, during a 2-hour OGTT in 64 monozygotic (MZ) and 73 dizygotic (DZ) twin pairs (aged 22.8 to 36.2 years). Metabolite excursions during the OGTT were compared within BMI-discordant (intrapair difference, BMI ≥ 3 kg/m2) cotwins separately within MZ and DZ pairs. Insulin-based indices were calculated from the OGTT. LF was measured by magnetic resonance spectroscopy in 25 BMI-discordant MZ pairs. Metabolite profiles were compared with respect to LF

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2016 Journal of Clinical Endocrinology and Metabolism

42. One hour post-OGTT glucose improves the early prediction of type 2 diabetes by clinical and metabolic markers. (PubMed)

oral glucose tolerance test (OGTT).We measured PG and INS levels at 0, 30, 60, and 120 minutes during an OGTT in 543 participants in the Botnia Prospective Study, 146 of whom progressed to type 2 diabetes within a 10-year follow-up period. Using combinations of variables, we evaluated 1527 predictive models for progression to type 2 diabetes.The 1-hour PG outperformed every individual marker except 30-minute PG or mannose, whose predictive performances were lower but not significantly worse. HbA1c (...) One hour post-OGTT glucose improves the early prediction of type 2 diabetes by clinical and metabolic markers. Early prediction of dysglycemia is crucial to prevent progression to type 2 diabetes. The 1-hour postload plasma glucose (PG) is reported to be a better predictor of dysglycemia than fasting plasma glucose (FPG), 2-hour PG, or glycated hemoglobin (HbA1c).To evaluate the predictive performance of clinical markers, metabolites, HbA1c, and PG and serum insulin (INS) levels during a 75-g

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2018 Journal of Clinical Endocrinology and Metabolism

43. Improved Glucose Profile in Patients With Type 2 Diabetes With a New, High-Protein, Diabetes-Specific Tube Feed During 4 Hours of Continuous Feeding. (PubMed)

, ambulant, nonhospitalized patients with type 2 diabetes received the DSF or an isocaloric, fiber-containing SF via a nasogastric tube. After overnight fasting, the formula was continuously administered to the patients during 4 hours. Plasma glucose and insulin concentrations were determined during the 4-hour period and in the subsequent 4 hours during which no formula was provided.During the 4-hour feeding period, DSF compared with SF resulted in a lower mean delta glucose concentration in the 3- to 4 (...) . No significant differences in tolerance were observed.Administration of a new, high-protein DSF during 4 hours of continuous feeding resulted in lower glucose and insulin levels compared with a fiber-containing SF in ambulant, nonhospitalized patients with type 2 diabetes. These data suggest that a DSF may contribute to lower glucose levels in these patients.

2018 JPEN. Journal of parenteral and enteral nutrition Controlled trial quality: uncertain

44. Strong Association Between Insulin-Mediated Glucose Uptake and the 2-Hour, Not the Fasting Plasma Glucose Concentration in the Normal Glucose Tolerance Range. (PubMed)

glucose intolerance received a 75-g oral glucose tolerance test and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG and NGT individuals and was related to fasting and 2-hour plasma glucose concentrations in each group.TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2-hour plasma glucose (PG; r = 0.40, P < .0001) but not with the fasting PG. When IFG and NGT individuals were (...) Strong Association Between Insulin-Mediated Glucose Uptake and the 2-Hour, Not the Fasting Plasma Glucose Concentration in the Normal Glucose Tolerance Range. The aim of this study was to examine the relationship between whole-body insulin-mediated glucose disposal and the fasting plasma glucose concentration in nondiabetic individuals.Two hundred fifty-three nondiabetic subjects with normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance, and combined

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2014 Journal of Clinical Endocrinology and Metabolism

45. Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects. (PubMed)

) in healthy individuals.Subjects participated in a three step hyperinsulinemic (+10, +20, +40 mU/m2·min) euglycemic clamp before and after a 48 hour glucose infusion to increase plasma glucose concentration by ∼40 mg/dl above baseline. Endogenous glucose production (EGP) was measured with 3-3H-glucose before and after chronic glucose infusion.Sixteen NGT subjects (8 with and 8 without family history [FH] of diabetes) participated in the study.EGP.Basal EGP increased following 48 hours of glucose infusion (...) Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects. Chronic hyperglycemia worsens skeletal muscle insulin resistance and beta cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity is not clear.To examine the effect of sustained physiologic hyperglycemia (similar to that observed in type 2 diabetic individuals) on endogenous (primarily reflects hepatic) glucose production (EGP

2019 Journal of Clinical Endocrinology and Metabolism

46. Plasma Metabolomics to Identify and Stratify Patients with Impaired Glucose Tolerance. (PubMed)

Plasma Metabolomics to Identify and Stratify Patients with Impaired Glucose Tolerance. Impaired glucose tolerance (IGT) is one of the pre-symptomatic states of type 2 diabetes mellitus and requires an oral glucose tolerance test (OGTT) for diagnosis. Our aims were two-fold: 1) characterize signatures of small molecules predicting the OGTT-response and 2) identify metabolic subgroups of participants with IGT.Plasma samples from 827 participants of the Study of Health in Pomerania free (...) of diabetes were measured utilizing mass spectrometry and proton-nuclear magnetic resonance spectroscopy. Linear regression analyses were used to screen for metabolites significantly associated with the OGTT-response after two hours adjusting for baseline glucose and insulin levels, as well as important confounders. A signature predictive for IGT was established using regularized logistic regression. All IGT cases (N=159) were selected and subjected to unsupervised clustering using a k-means approach.In

2019 Journal of Clinical Endocrinology and Metabolism

47. Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. (PubMed)

Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m2 ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm (...) ) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd).TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions

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2019 Obesity Controlled trial quality: uncertain

48. Maternal night-eating pattern and glucose tolerance during pregnancy: study protocol for a longitudinal study. (PubMed)

physical activity, sedentary behaviour, sleep and light exposure are captured using the accelerometer at 18-24 weeks' gestation. Continuous glucose monitoring at 18-24 weeks' gestation, oral glucose tolerance test and insulin test at 24-28 weeks' gestation are performed to assess glycaemic outcomes. Multivariable generalised linear models will be used to analyse the association of maternal night-eating pattern (consumption of meal and snack during 1900-0659 hours) with glycaemic measures (...) with glucose tolerance in the second trimester of pregnancy, and to investigate how lifestyle factors may be related to night-eating pattern.This is an observational longitudinal study that targets to recruit 200 pregnant women at 18-24 weeks' gestation from the KK Women's and Children's Hospital in Singapore. Data collection includes sociodemographics, lifestyle habits and obstetric information. Maternal dietary intake is collected using the 4-day food diary and food frequency questionnaire; while 24-hour

2019 BMJ open

49. Differential effects of split and continuous sleep on neurobehavioral function and glucose tolerance in sleep-restricted adolescents. (PubMed)

(TIB), participants underwent either 5 nights of continuous 6.5-h TIB (n = 29) or 5-hour nocturnal TIB with a 1.5-hour afternoon nap (n = 29). After two recovery nights of 9-hour TIB, participants were sleep restricted for another three nights. Sleep was assessed using polysomnography (PSG). Cognitive performance and mood were evaluated three times per day. Oral glucose tolerance tests (OGTT) were conducted on mornings after baseline sleep, recovery sleep, and the third day of each sleep (...) Differential effects of split and continuous sleep on neurobehavioral function and glucose tolerance in sleep-restricted adolescents. Many adolescents are exposed to sleep restriction on school nights. We assessed how different apportionment of restricted sleep (continuous vs. split sleep) influences neurobehavioral function and glucose levels.Adolescents, aged 15-19 years, were evaluated in a dormitory setting using a parallel-group design. Following two baseline nights of 9-hour time-in-bed

2019 Sleep Controlled trial quality: uncertain

50. Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. (PubMed)

women with PCOS (age: 27 ± 1 yr, BMI: 41.3 ± 1.1 kg/m-2) were assigned to heat therapy (HT) or time control (CON). HT participants underwent 30 one-hour hot tub sessions over 8-10 wk, while CON participants completed all testing but did not undergo heat therapy. Before (Pre), at the mid-point (Mid), and following (Post) 8-10 wk of heat therapy, metabolic health was assessed using a 2-h oral glucose tolerance test, a subcutaneous abdominal fat biopsy (Pre-Post only), and other blood markers relating (...) Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. Polycystic ovary syndrome (PCOS) is associated with high rates of obesity and metabolic dysfunction. Repeated passive heat exposure (termed heat therapy) is a novel lifestyle intervention for improving health in obese women with PCOS. The purpose of this study was to examine changes in metabolic function in obese women with PCOS following heat therapy. Eighteen age- and BMI-matched obese

2019 American journal of physiology. Endocrinology and metabolism Controlled trial quality: uncertain

51. Glucose Tolerance Test 3 hour

Glucose Tolerance Test 3 hour Glucose Tolerance Test 3 hour Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Glucose Tolerance Test 3 (...) hour Glucose Tolerance Test 3 hour Aka: Glucose Tolerance Test 3 hour , Glucose Tolerance Test , Three Hour Glucose Tolerance Test II. Indications Diagnosis of Failed III. Protocol g patient ingests 100 gram oral drink (e.g. Glucola Drink) measured at 4 times g baseline before oral Hour 1 after oral Hour 2 after oral Hour 3 after oral IV. Interpretation Diagnosis suggestive of Two or more values below are abnormal Carpenter and Coustan guidelines are the standard of care now Replaces the NDDG

2015 FP Notebook

52. One-hour post-load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and Hypertension. (PubMed)

One-hour post-load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and Hypertension. The relationship between 1- and 2-h glucose levels following an oral glucose tolerance test (OGTT) and long-term mortality was evaluated.Over a 33-year period, 2138 individuals were followed for all-cause mortality. Fasting and post-OGTT glucose parameters categorized the cohort according to baseline glycaemic status. Four categories (...) were established according to 1- and 2-h glucose levels (in mmol/l): group A = 1 h ≤ 8.8 and 2 h < 7.8; group B = 1 h > 8.6 and 2 h < 7.8; group C = 1 h ≤ 8.6 and 2 h = 7.8-11.1 (impaired glucose tolerance); group D = 1 h > 8.6 and 2 h = 7.8-11.1 (impaired glucose tolerance). Individuals with diabetes at baseline were excluded from the cohort.By August 2013, 51% of the study cohort had died. The worst prognosis occurred in group D (73.8% mortality), followed by groups C (67.5%), B and A (57.9

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2016 Diabetic Medicine

53. Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent. (PubMed)

Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent. To estimate the prevalence of abnormal glucose tolerance (AGT) among Indian women with polycystic ovary syndrome (PCOS) and analyze the role of oral glucose tolerance (OGTT) test on its estimation.Cross-sectional clinical study.Tertiary care center.A total of 2,014 (...) plasma glucose/impaired glucose tolerance) using American Diabetes Association criteria. The glucose intolerance showed a rising trend with advancing age (30.3%, 35.4%, 51%, and 58.8% in the second, third, fourth, and fifth decades, respectively) and increasing BMI. Family history of diabetes mellitus was present in 54.6% (953/1,746) subjects, and it did not correlate with any of the studied parameters except waist circumference and BMI. Sensitivity was better with 2-hour post-OGTT glucose values

2015 Fertility and Sterility

54. Reply to Kawada One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. (PubMed)

, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Yamagishi M M Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. eng Letter Comment England Diabet Med 8500858 0742-3071 0 Blood Glucose IM Diabet Med. 2017 May;34(5):733 28173621 Diabet Med. 2016 Oct;33(10 ):1399-405 26482027 Blood Glucose Diabetes Mellitus, Type 2 Diabetes, Gestational Glucose Tolerance Test Humans 2017 02 03 2017 2 9 6 0 2018 4 11 6 0 (...) Reply to Kawada One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 28173616 2018 04 10 2018 12 02 1464-5491 34 5 2017 05 Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. Reply to Kawada: One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 734 10.1111/dme.13329 Oka R R Department of Internal Medicine, Hokuriku Central Hospital. Aizawa T T Diabetes Centre, Aizawa Hospital. Yoneda T T Department of Cardiovascular and Internal Medicine

2017 Diabetic Medicine

55. One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. (PubMed)

26482027 Diabet Med. 2017 May;34(5):734 28173616 Blood Glucose Diabetes Mellitus, Type 2 Diabetes, Gestational Glucose Tolerance Test Humans 2016 12 06 2017 02 03 2017 2 9 6 0 2018 4 11 6 0 2017 2 8 6 0 ppublish 28173621 10.1111/dme.13330 (...) One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 28173621 2018 04 10 2018 12 02 1464-5491 34 5 2017 05 Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. One-hour plasma glucose as a predictor of Type 2 diabetes mellitus. 733 10.1111/dme.13330 Kawada T T Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan. eng Letter Comment England Diabet Med 8500858 0742-3071 0 Blood Glucose IM Diabet Med. 2016 Oct;33(10 ):1399-405

2017 Diabetic Medicine

56. CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study (PubMed)

with elevated CRP level (each P < 1.2 × 10-6). Allele C at rs3093059 was associated with fasting glucose (β = 0.20, P = 0.045) and G at rs1205 was associated with 2-hour glucose (β = 0.46, P = 0.00090) post oral glucose tolerance test, but only the latter passed Bonferroni correction. No polymorphism was associated with diabetes. Since 2-hour glucose is an indicator of glucose tolerance, this study indicated CRP gene is associated with glucose intolerance. (...) CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin

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2017 Scientific reports

57. Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults (PubMed)

following 3 h of intermittent hypoxia in healthy humans independent of any effect on insulin sensitivity. Eight (7M/1F, 21-34 years) healthy subjects completed two study visits randomized to 3 h of intermittent hypoxia or continuous normoxia, followed by an oral glucose tolerance test. Intermittent hypoxia consisted of 25 hypoxic events per hour where oxygen saturation (SpO2) was significantly reduced (Normoxia: 97 ± 1%, Hypoxia: 90 ± 2%, P < 0.01). Venous plasma glucose concentrations were measured (...) glucose tolerance test (P > 0.05). Circulating glucose is increased after 3 h of intermittent hypoxia in healthy humans, independent of any lasting changes in insulin sensitivity. These novel findings could explain, in part, the high prevalence of diabetes in patients with sleep apnea and warrant future studies to identify underlying mechanisms.© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

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2017 Physiological reports

58. Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values. (PubMed)

PCPG levels to achieve HbA1c targets recommended by the American Diabetes Association (ADA), International Diabetes Federation (IDF), and American College of Endocrinology (ACE).The data of all healthy individuals with HbA1c values less than 7.0% (N = 457) who underwent oral glucose tolerance tests between 1986 and 2002 for either screening as potential research volunteers (93%) or diagnostic purposes (7%) were analyzed.Of 404 individuals with normal HbA1c levels (<6.0%), 60% had normal glucose (...) tolerance, 33% had impaired glucose tolerance, 1% had isolated impaired FPG, and 6% had type 2 diabetes mellitus. Of 161 individuals without normal glucose tolerance, 80% had normal FPG levels. Both FPG and 2-hour PCPG levels increased as HbA1c increased and were significantly correlated (r = 0.63, P<.001), but the 2-hour PCPG level increased at a rate 4 times greater than FPG and accounted for a greater proportion of HbA1c. People who met the IDF and ACE HbA1c targets (<6.5%) had significantly lower 2

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2017 Archives of Internal Medicine

59. Continuous glucose monitoring (CGM real-time) and flash glucose monitoring (FGM) as personal, standalone systems in patients with diabetes mellitus treated with insulin

July 2018 EUnetHTA Joint Action 3 WP4 84 Current clinical management of diabetes mellitus [A0024] – How is diabetes mellitus currently diagnosed according to published guidelines and in practice? In individual European countries, responsible bodies and expert societies are responsible for pub- lishing national guidelines on diabetes diagnosis. General Diagnostic Tests for Diabetes [79] Diabetes can be diagnosed based on plasma glucose criteria, either based on the fasting plasma glucose, 2-h PG (...) is reasonable. • To test for type 2 diabetes, fasting plasma glucose, 2-h PG after 75-g oral glucose tolerance test, and haemoglobin A1C are equally appropriate. • In patients with diabetes, other cardiovascular disease risk factors should be identified and treated. • Testing for type 2 diabetes should be considered in children and adolescents who are over- weight or obese (BMI > 85th percentile for age and sex, weight for height > 85 th percentile, or weight > 120% of ideal for height) and who have

2018 EUnetHTA

60. Exogenous Ketones and Glucose Tolerance

and Interventions Go to Arm Intervention/treatment Experimental: Ketone monoester Acute morning dose of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (0.45 ml/kg body weight) Dietary Supplement: Ketone monoester Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior a 2-hour oral glucose tolerance test. Placebo Comparator: Placebo Acute morning dose of flavour-matched placebo. Dietary Supplement: Placebo Acute ingestion of a taste-matched placebo prior a 2-hour oral glucose tolerance test. Outcome (...) Measures Go to Primary Outcome Measures : Glucose area under the curve [ Time Frame: 2-hour ] Area under the curve for glucose during oral glucose tolerance test Secondary Outcome Measures : Insulin area under the curve [ Time Frame: 2-hour ] Insulin area under the curve during oral glucose tolerance test Free fatty acids area under the curve [ Time Frame: 2-hour ] Non-esterified fatty acids area under the curve during oral glucose tolerance test Caspase-1 activation [ Time Frame: 15 minutes ] Caspase

2018 Clinical Trials

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