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Glucose Tolerance Test 3 hour

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41. Intestinal glucose absorption is a key determinant of 1-hour post-load plasma glucose levels in non-diabetic subjects. (Abstract)

Intestinal glucose absorption is a key determinant of 1-hour post-load plasma glucose levels in non-diabetic subjects. One-hour post-load hyperglycemia, defined as 1-hour plasma glucose (1hPG) ≥155 mg/dl during an oral glucose tolerance test (OGTT), has been proposed as an independent predictor of type 2 diabetes. Recent evidence suggests that 1-hour hyperglycemia can be explained by enhanced duodenal glucose absorption, which in turn may increase the rate of appearance of oral glucose (...) in the systemic circulation (RaO). However, the impact of RaO on 1hPG and 1-hour glucose excursions (glucose iAUC1h) is still unknown.We quantified the relative contribution of post-load RaO to 1hPG and glucose iAUC1h with respect to other major glucose homeostatic mechanisms in non-diabetic subjects.Model-derived β-cell function, insulin clearance, glucose metabolic fluxes, and peripheral and hepatic insulin sensitivity were measured during a 75-g OGTT by a double tracer method in 23 non-diabetic

2018 Journal of Clinical Endocrinology and Metabolism

42. Letter: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53) (Full text)

Letter: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53) 26124998 2015 06 30 2018 11 13 2233-6079 39 3 2015 Jun Diabetes & metabolism journal Diabetes Metab J Letter: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53). 268-9 10.4093/dmj

2015 Diabetes & metabolism journal PubMed abstract

43. Response: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53) (Full text)

Response: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53) 26124999 2015 06 30 2018 11 13 2233-6079 39 3 2015 Jun Diabetes & metabolism journal Diabetes Metab J Response: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53). 270-1 10.4093

2015 Diabetes & metabolism journal PubMed abstract

44. Oral Glucose Tolerance and Related Factors in a Normal Population Sample—I. Blood Sugar, Plasma Insulin, Glyceride, and Cholesterol Measurements and the Effects of Age and Sex (Full text)

Oral Glucose Tolerance and Related Factors in a Normal Population Sample—I. Blood Sugar, Plasma Insulin, Glyceride, and Cholesterol Measurements and the Effects of Age and Sex Oral glucose tolerance tests were performed on 220 people, a representative sample of the employees of a large pharmaceutical company. Blood sugar and plasma immunoreactive insulin levels were measured on each sample of venous blood obtained before and at half-hourly intervals for two hours after 50 g. of glucose (...) by mouth; plasma cholesterol and glycerides were measured on the fasting sample only.Women had higher mean insulin levels throughout the test, though their mean blood sugar levels were higher only at 90 and 120 minutes. In both sexes there were positive correlations between age and the levels of blood sugar, plasma cholesterol, and plasma glycerides. Though the levels of glucose rose with age, those of insulin did not.

1969 British medical journal PubMed abstract

45. Two-hour post-challenge hyperglycemia, but not fasting plasma glucose, associated with severity of coronary artery disease in patients with angina. (Full text)

and were in stable condition after discharge were recruited. A standard 75-g oral glucose tolerance test (OGTT) was performed at outpatient visits approximately 2-4 weeks after hospital discharge, and fasting and post-challenge blood glucose were measured. Twenty-six volunteers in our hospital staff served as the healthy group. CAD severity was graded using the SYNTAX and Jeopardy scoring systems.The subjects in the angina group had a higher body mass index, higher fasting glucose, and higher 2-h (...) Two-hour post-challenge hyperglycemia, but not fasting plasma glucose, associated with severity of coronary artery disease in patients with angina. Postprandial hyperglycemia plays a pivotal role in cardiovascular disease. However, few studies have investigated associations between the severity of coronary artery disease (CAD) and postprandial glucose levels in angina patients without known diabetes before coronary angiography.Subjects who were admitted for coronary angiography due to angina

2018 PLoS ONE PubMed abstract

46. Hypoglycemia during oral glucose tolerance test among post-bariatric surgery pregnant patients: incidence and perinatal significance. (Abstract)

Hypoglycemia during oral glucose tolerance test among post-bariatric surgery pregnant patients: incidence and perinatal significance. While hypoglycemia during an oral glucose tolerance test (OGTT) has been shown to occur in a considerable portion of nonpregnant post-bariatric surgery (BS) patients, its incidence among pregnant post-BS patients evaluated for gestational diabetes has only been sparsely studied.We investigated OGTT results and pregnancy outcomes in pregnant women who underwent 3 (...) types of bariatric procedures before pregnancy.A university hospital.From medical records, data were collected on glucose measurements during a 100-g, 3-hour OGTT, as well as maternal and fetal outcomes.Of 119 post-BS pregnant patients included in the study, 55 underwent laparoscopic sleeve gastrectomy, 34 laparoscopic adjustable gastric banding, and 30 laparoscopic Roux-en-Y gastric bypass surgery. Hypoglycemia (<55 mg/dL) was encountered in 59 (49.6%) patients during the OGTT. Among them

2017 Surgery for Obesity and Related Diseases

47. Mitochondrial DNA copy number augments performance of A1C and oral glucose tolerance testing in the prediction of type 2 diabetes (Full text)

Mitochondrial DNA copy number augments performance of A1C and oral glucose tolerance testing in the prediction of type 2 diabetes Here, we tested the performance of the mitochondrial DNA copy number (mtDNA-CN) in predicting future type 2 diabetes (n = 1108). We used the baseline clinical data (age, sex, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure) and the mtDNA-CN, hemoglobin A1c (A1C) levels and results of oral glucose tolerance test (OGTT) including fasting (...) plasma glucose, 1-hour glucose, and 2-hour glucose levels, to predict future diabetes. We built a prediction model using the baseline data and the diabetes status at biannual follow-up of 8 years. The mean area under curve (AUC) for all follow-ups of the full model including all variables was 0.92 ± 0.04 (mean ± standard deviation), while that of the model excluding the mtDNA-CN was 0.90 ± 0.03. The sensitivity of the f4ull model was much greater than that of the model not including mtDNA-CN

2017 Scientific reports PubMed abstract

48. Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population (Full text)

Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population To find the association between biochemical hypoglycemia on a 2-hour screening oral glucose tolerance test (OGTT) and insulin resistance.Subjects of this study were sampled from the China National Diabetes and Metabolic Disorders Study that was conducted during 2007 and 2008. Blood samples were drawn at 0, 30, and 120 minutes after the glucose load. Biochemical hypoglycemia was defined (...) as 2-hour glucose < 3.0 mmol/l.In total, 26,606 participants were included, and 141 participants were diagnosed with biochemical hypoglycemia on a 2-hour OGTT. Compared to participants with normal glucose tolerance (NGT), participants with biochemical hypoglycemia presented with a younger age, lower BMI, lower levels of fasting glucose, and lower levels of 30-minute and 2-hour OGTT glucose. In terms of insulin resistance, participants with biochemical hypoglycemia showed higher levels of Matsuda

2017 Journal of diabetes research PubMed abstract

49. Effect of Ethyl Acetate Extract of Melothria Perpusilla on Oral Glucose Tolerance Test in Albino Rats (Full text)

. The same set of six animals were used for the experiment throughout and successive tests were conducted after a drug wash out period of 10 days. Fasting blood glucose samples were measured using glucometer. A 2% gum acacia suspension {10 ml/kg per oral (p.o.)} was given in all six albino rats followed by the oral glucose load of 3g/kg. Glucose concentrations were estimated at one hour and two hour after the glucose load. Using the same set of animals, similar tests were repeated with the test dose (...) of 250 mg/kg and 500 mg/kg of EAEMP and glibenclamide (0.5 mg/kg p.o.). In this experiment, glucose was given immediately at the dose of 3 g/kg p.o. after the treatments. Drug wash out period of 10 days was maintained in between the successive tests to avoid the interference of action of the drug with the other. The non parametric data were analysed by Kruskal Wallis test.EAEMP produced a significant increase in the oral glucose tolerance test when compared with control and standard.Treatment

2017 Journal of clinical and diagnostic research : JCDR PubMed abstract

50. Effect of liraglutide on myocardial glucose uptake and blood flow in stable chronic heart failure patients: A double-blind, randomized, placebo-controlled LIVE sub-study. (Abstract)

ventricular ejection fraction ≤45% and without type 2 diabetes were randomized to liraglutide (N = 18) 1.8 mg once daily or placebo (N = 18) for 24 weeks in a double-blinded design. Changes in MGU during an oral glucose tolerance test (OGTT) and changes in MBF and MFR from baseline to follow-up were measured quantitatively by 18F-FDG and 15O-H2O positron emission tomography. Compared with placebo, liraglutide reduced weight (P = 0.03), HbA1c (P = 0.03) and the 2-hour glucose value during the OGTT (P (...) Effect of liraglutide on myocardial glucose uptake and blood flow in stable chronic heart failure patients: A double-blind, randomized, placebo-controlled LIVE sub-study. The glucagon-like peptide-1 analog liraglutide increases heart rate and may be associated with more cardiac events in chronic heart failure (CHF) patients. We studied whether this could be ascribed to effects on myocardial glucose uptake (MGU), myocardial blood flow (MBF) and MBF reserve (MFR).CHF patients with left

2017 Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Controlled trial quality: predicted high

51. The Acute Effect of Moderate Intensity Stair-Climbing on Postprandial Blood Glucose

provided by (Responsible Party): Jochen Kressler, San Diego State University Study Details Study Description Go to Brief Summary: This study aims to investigate the effect of moderate intensity stair-climbing bouts of various durations on postprandial blood glucose. Participants will perform a standard oral glucose tolerance test (OGTT) using 75g of dextrose and with fingerstick blood glucose measurements at baseline and every 15 minutes after consuming the drink for one hour. On separate subsequent (...) -climbing Active Comparator: 10 minutes Oral glucose tolerance test with 10 minutes stair-climbing Other: Stair-climbing Short bouts of moderate intensity stair-climbing Outcome Measures Go to Primary Outcome Measures : Postprandial Blood Glucose [ Time Frame: 1 hour ] Postprandial blood glucose after various durations of stair-climbing Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor

2017 Clinical Trials

52. Use of Sitagliptin With Closed-Loop Technology to Decrease Postprandial Blood Glucose in Type 1 Diabetes (Full text)

system.This was a randomized, double-blinded, placebo controlled, crossover design trial. The participants were18-35 years old, had T1DM, and an HbA1c of ≤ 8.5%. A dose determination study included eight subjects with T1DM. There were three study visits. Four hours after receiving study drug (placebo, sitagliptin 50 mg, sitagliptin 100 mg), subjects underwent a mixed meal tolerance test with assessment of hormone concentrations. In a second study, 15 subjects underwent two visits receiving either placebo (...) or 100 mg of sitagliptin plus an insulin only closed-loop system for 25 hours with timed meals. Blood glucose and other hormone concentrations were analyzed using repeated measures ANOVA.For the dose determination study, sitagliptin 100 mg resulted in reduced postprandial blood glucose ( P = .006). For the closed-loop study, glucose concentrations were lower in the treatment group, most prominently during the first two study meals ( P = .03). There was no difference in glucagon concentrations

2017 Journal of diabetes science and technology Controlled trial quality: uncertain PubMed abstract

53. Control of Blood Glucose Fluctuation With Usage of Polyherbal

(impaired fasting glucose or impaired glucose tolerance) or diabetes and meeting one of the following criteria Fasting Plasma Glucose ≥100 mg/dL, fasting defined as no caloric intake for at least 8 hours, AND Glycosylated haemoglobin (A1C) ≥ 6 %. The test should be performed in a laboratory using a method that is National Accreditation Board for Testing and Calibration Laboratories certified and standardized within last 3 months. Exclusion Criteria: Any one of the following Patients on Insulin therapy (...) , catharanthus A unique combination of 3 herbs that lower blood sugars Other Name: Sugar Balance (SB) Placebo Comparator: Placebo Placebo will contain an inert substance Drug: Placebo Similar looking inactive powder Outcome Measures Go to Primary Outcome Measures : Mean amplitude glycemic excursion [ Time Frame: 14 days ] To demonstrate that the difference in mean amplitude glycemic excursions among patients receiving polyherbal medication will be less than 1mmol/dL or 18mg/dL for a sampling frequency: 1

2017 Clinical Trials

54. Modest Salt Reduction Lowers Blood Pressure and Albumin Excretion in Impaired Glucose Tolerance and Type 2 Diabetes Mellitus: A Randomized Double-Blind Trial. (Full text)

of salt restriction with salt or placebo tablets, each for 6 weeks, in 46 individuals with diet-controlled type 2 diabetes mellitus or impaired glucose tolerance and untreated normal or high normal blood pressure (BP). From salt to placebo, 24-hour urinary sodium was reduced by 49±9 mmol (2.9 g salt). This reduction in salt intake led to fall in clinic BP from 136/81±2/1 mm Hg to 131/80±2/1 mm Hg, (systolic BP; P<0.01). Mean ambulatory 24-hour BP was reduced by 3/2±1/1 mm Hg (systolic BP, P<0.01 (...) Modest Salt Reduction Lowers Blood Pressure and Albumin Excretion in Impaired Glucose Tolerance and Type 2 Diabetes Mellitus: A Randomized Double-Blind Trial. The role of salt restriction in patients with impaired glucose tolerance and diabetes mellitus is controversial, with a lack of well controlled, longer term, modest salt reduction trials in this group of patients, in spite of the marked increase in cardiovascular risk. We carried out a 12-week randomized double-blind, crossover trial

2016 Hypertension Controlled trial quality: uncertain PubMed abstract

55. The one-hour post-load plasma glucose predicts progression to prediabetes in a multiethnic cohort of obese youths. (Abstract)

The one-hour post-load plasma glucose predicts progression to prediabetes in a multiethnic cohort of obese youths. One-hour post-load hyperglycaemia has been proposed as an independent predictor of type 2 diabetes in adults. We examined whether 1-hour plasma glucose (1hPG) during an oral glucose tolerance test (OGTT) can predict changes in the glucose tolerance status of a multi-ethnic cohort of youths with normal glucose tolerance (NGT).A total of 202 obese youths with NGT (33.7% Caucasian (...) , 31.1% Hispanic, 32.2% African American) underwent a 3-hour OGTT at baseline and after a 2-year follow-up period. Whole-body insulin sensitivity, insulin secretion, β-cell function and insulin clearance were estimated by modeling plasma glucose, insulin and C-peptide levels.Obese youths with 1hPG ≥7.4 mmol/L (or 133 mg/dL; n = 83) exhibited higher body mass index (BMI), plasma triglycerides and fasting and post-load glucose concentrations than individuals with 1hPG <7.4 mmol/L. Also, 1hPG ≥7.4 mmol

2019 obesity & metabolism

56. The ability of exercise to meaningfully improve glucose tolerance in people living with prediabetes: A meta-analysis. (Abstract)

glucose tolerance beyond the smallest worthwhile difference in individuals with prediabetes. It was hypothesized that the majority of implemented exercise programs designed for individuals with prediabetes would not result in meaningful improvements in glucose tolerance.Searches were performed in MEDLINE, The Cumulative Index to Nursing and Allied Health Literature, SPORTDiscus, and the Cochrane Library. Included studies reported glucose tolerance using a 2-hour oral glucose tolerance test at baseline (...) The ability of exercise to meaningfully improve glucose tolerance in people living with prediabetes: A meta-analysis. Individuals with prediabetes are likely to progress to Type 2 diabetes. Although exercise training is an established method to improve glycemic control, the degree to which this translates into meaningful improvements, particularly in individuals with prediabetes, is unclear. The purpose of this meta-analysis was to investigate the ability of exercise training to improve 2-hour

2020 Scandinavian journal of medicine & science in sports

57. The Prognostic Value of Fasting Plasma Glucose, Two-Hour Postload Glucose, and HbA<sub>1c</sub> in Patients With Coronary Artery Disease: A Report From EUROASPIRE IV: A Survey From the European Society of Cardiology. (Full text)

The Prognostic Value of Fasting Plasma Glucose, Two-Hour Postload Glucose, and HbA1c in Patients With Coronary Artery Disease: A Report From EUROASPIRE IV: A Survey From the European Society of Cardiology. Three tests are recommended for identifying dysglycemia: fasting glucose (FPG), 2-h postload glucose (2h-PG) from an oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). This study explored the prognostic value of these screening tests in patients with coronary (...) artery disease (CAD).FPG, 2h-PG, and HbA1c were used to screen 4,004 CAD patients without a history of diabetes (age 18-80 years) for dysglycemia. The prognostic value of these tests was studied after 2 years of follow-up. The primary end point included cardiovascular mortality, nonfatal myocardial infarction, stroke, or hospitalization for heart failure and a secondary end point of incident diabetes.Complete information including all three glycemic parameters was available in 3,775 patients (94.3

2017 Diabetes Care PubMed abstract

58. One hour post-OGTT glucose improves the early prediction of type 2 diabetes by clinical and metabolic markers. (Full text)

oral glucose tolerance test (OGTT).We measured PG and INS levels at 0, 30, 60, and 120 minutes during an OGTT in 543 participants in the Botnia Prospective Study, 146 of whom progressed to type 2 diabetes within a 10-year follow-up period. Using combinations of variables, we evaluated 1527 predictive models for progression to type 2 diabetes.The 1-hour PG outperformed every individual marker except 30-minute PG or mannose, whose predictive performances were lower but not significantly worse. HbA1c (...) One hour post-OGTT glucose improves the early prediction of type 2 diabetes by clinical and metabolic markers. Early prediction of dysglycemia is crucial to prevent progression to type 2 diabetes. The 1-hour postload plasma glucose (PG) is reported to be a better predictor of dysglycemia than fasting plasma glucose (FPG), 2-hour PG, or glycated hemoglobin (HbA1c).To evaluate the predictive performance of clinical markers, metabolites, HbA1c, and PG and serum insulin (INS) levels during a 75-g

2018 Journal of Clinical Endocrinology and Metabolism PubMed abstract

59. Improved Glucose Profile in Patients With Type 2 Diabetes With a New, High-Protein, Diabetes-Specific Tube Feed During 4 Hours of Continuous Feeding. (Abstract)

, ambulant, nonhospitalized patients with type 2 diabetes received the DSF or an isocaloric, fiber-containing SF via a nasogastric tube. After overnight fasting, the formula was continuously administered to the patients during 4 hours. Plasma glucose and insulin concentrations were determined during the 4-hour period and in the subsequent 4 hours during which no formula was provided.During the 4-hour feeding period, DSF compared with SF resulted in a lower mean delta glucose concentration in the 3- to 4 (...) . No significant differences in tolerance were observed.Administration of a new, high-protein DSF during 4 hours of continuous feeding resulted in lower glucose and insulin levels compared with a fiber-containing SF in ambulant, nonhospitalized patients with type 2 diabetes. These data suggest that a DSF may contribute to lower glucose levels in these patients.

2018 JPEN. Journal of parenteral and enteral nutrition Controlled trial quality: uncertain

60. Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent. (Abstract)

Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent. To estimate the prevalence of abnormal glucose tolerance (AGT) among Indian women with polycystic ovary syndrome (PCOS) and analyze the role of oral glucose tolerance (OGTT) test on its estimation.Cross-sectional clinical study.Tertiary care center.A total of 2,014 (...) plasma glucose/impaired glucose tolerance) using American Diabetes Association criteria. The glucose intolerance showed a rising trend with advancing age (30.3%, 35.4%, 51%, and 58.8% in the second, third, fourth, and fifth decades, respectively) and increasing BMI. Family history of diabetes mellitus was present in 54.6% (953/1,746) subjects, and it did not correlate with any of the studied parameters except waist circumference and BMI. Sensitivity was better with 2-hour post-OGTT glucose values

2015 Fertility and Sterility

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