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Glucose Challenge Test

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1. A Modified Two-Step Screening Strategy for Gestational Diabetes Mellitus Based on the 2013 WHO Criteria by Combining the Glucose Challenge Test and Clinical Risk Factors (PubMed)

A Modified Two-Step Screening Strategy for Gestational Diabetes Mellitus Based on the 2013 WHO Criteria by Combining the Glucose Challenge Test and Clinical Risk Factors This study determines if a modified two-step screening strategy with a glucose challenge test (GCT) ≥ 7.2 mmol/L and clinical risk factors improves the diagnostic accuracy for gestational diabetes mellitus (GDM), based on 2013 WHO criteria, while limiting the number of oral glucose tolerance tests (OGTT). This was a prospective (...) multicentric cohort study with 1811 participants receiving both GCT and 75 g OGTT in pregnancy. Participants and health care providers were blinded for GCT. Characteristics were analyzed across four glucose tolerance groups: abnormal (≥7.2 mmol/L), GCT GDM (n = 165), normal GCT GDM (n = 63), abnormal GCT normal glucose tolerant (NGT) (n = 472); normal GCT NGT (n = 1113). Compared to normal GCT NGT women, normal GCT GDM women had increased rates of obesity (23.8% vs. 10.5%, p < 0.001), ethnic minority

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2018 Journal of clinical medicine

2. Glucose challenge test for detecting gestational diabetes mellitus: a systematic review

Glucose challenge test for detecting gestational diabetes mellitus: a systematic review Glucose challenge test for detecting gestational diabetes mellitus: a systematic review Glucose challenge test for detecting gestational diabetes mellitus: a systematic review van Leeuwen M, Louwerse MD, Opmeer BC, Limpens J, Serlie MJ, Reitsma JB, Mol BW CRD summary The authors concluded that higher accuracy measures were needed for the 50g glucose challenge test to be used as a definite diagnostic test (...) in place of the oral glucose tolerance test. This was a well-conducted review but limitations in the evidence available and potential for missing unpublished studies make the reliability and generalisability of the pooled results uncertain. Authors' objectives To determine the diagnostic accuracy of the 50g glucose challenge test for gestational diabetes mellitus. Searching MEDLINE and EMBASE were searched without methodological filter or other restrictions up to October 2010. Search terms were

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2012 DARE.

3. Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes (PubMed)

Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes 28724164 2019 02 08 1098-8785 34 14 2017 Dec American journal of perinatology Am J Perinatol Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes. 1464-1469 10.1055/s-0037-1604243 Tita Alan T N ATN Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama. Lai Yinglei Y The Biostatistics Center, The George

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2017 American journal of perinatology

4. Male grower pigs fed cereal soluble dietary fibres display biphasic glucose response and delayed glycaemic response after an oral glucose tolerance test. (PubMed)

) and oat β-glucan (BG) were fed individually and in combination to determine the effect on glucose tolerance in jugular vein catheterized grower pigs. Five groups of Large White male grower pigs were fed highly digestible diets containing either 10% AX, 10% BG, 5% AX with 5% BG, a model cereal whole wheat flour (WWF), or a control wheat starch diet (WS) with no SDF. Blood was collected via jugular vein catheters over 240 minutes following a feed challenge and an oral glucose tolerance test (OGTT (...) Male grower pigs fed cereal soluble dietary fibres display biphasic glucose response and delayed glycaemic response after an oral glucose tolerance test. Acute and sustained soluble dietary fibre (SDF) consumption are both associated with improved glucose tolerance in humans and animal models (e.g. porcine). However, the effects on glucose tolerance in grower pigs, adapted to diets with a combination of SDF have not been studied previously. In this experiment, cereal SDF wheat arabinoxylan (AX

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2018 PLoS ONE

5. How high is too high in cutoff levels from 50-g glucose challenge test (PubMed)

How high is too high in cutoff levels from 50-g glucose challenge test To determine the highest 50-g glucose challenge test (GCT) value that indicates no further diagnostic test is needed to confirm a diagnosis of gestational diabetes mellitus (GDM) under the criteria of National Diabetes Data Group (NDDG) or the Carpenter and Coustan (C&C) and fasting glucose thresholds from the International Association of Diabetes and Pregnancy Study Group (IADPSG).We collected the 50-g GCT results from (...) 16,560 pregnancies and identified 2,457 gravidas with positive 50-g GCT (≥130 mg/dL) values who underwent the 100-g glucose tolerance test. We investigated GDM prevalence in pregnancies with positive 50-g GCT according to the respective diagnostic thresholds and determined the 50-g GCT cutoff values with 100% positive predictive value for GDM under each diagnostic threshold.Twelve point five percent (306/2,457), 20.0% (492/2,457), and 9.6% (235/2,457) met the diagnostic criteria of GDM

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2016 Obstetrics & gynecology science

6. Glucose challenge test screening for prediabetes and early diabetes. (PubMed)

Glucose challenge test screening for prediabetes and early diabetes. To test the hypothesis that a 50-g oral glucose challenge test with 1-h glucose measurement would have superior performance compared with other opportunistic screening methods.In this prospective study in a Veterans Health Administration primary care clinic, the following test performances, measured by area under receiver-operating characteristic curves, were compared: 50-g oral glucose challenge test; random glucose (...) ; and HbA1c level, using a 75-g oral glucose tolerance test as the 'gold standard'.The study population was comprised of 1535 people (mean age 56 years, BMI 30.3 kg/m2 , 94% men, 74% black). By oral glucose tolerance test criteria, diabetes was present in 10% and high-risk prediabetes was present in 22% of participants. The plasma glucose challenge test provided area under receiver-operating characteristic curves of 0.85 (95% CI 0.78-0.91) to detect diabetes and 0.76 (95% CI 0.72-0.80) to detect high-risk

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2016 Diabetic Medicine

7. Glucose Challenge Test

Glucose Challenge Test Glucose Challenge Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Glucose Challenge Test Glucose Challenge (...) Test Aka: Glucose Challenge Test II. Indication: Gestational DiabetesScreening Test All pregnant patients at 24-28 weeks gestation Test with initial s if indicated patient of Age over 30 years Prior history of Prior pregnancy complication ( ) (PIH) Polyhydramnios Congenital defect III. Protocol Patient ingests 50 gram oral (e.g. Glucola Drink) measured after 1 hour IV. Interpretation >130 mg/dl (7.2 mmol/L) suggests gestation diabetes Obtain if positive Empiric for GCT >200 mg/dl (without a 3 hour

2018 FP Notebook

8. Diagnostic Ability of Elevated 1- hour Glucose Challenge Test (PubMed)

Diagnostic Ability of Elevated 1- hour Glucose Challenge Test To determine whether a threshold of a 1-h glucose challenge test (GCT) eliminates the need for a 3-h glucose tolerance test (GTT).A retrospective cohort of patients undergoing GTT after GCT was ⩾140 mg dl(-1). Gestational diabetes mellitus (GDM) was diagnosed using National Diabetes Data Group (NDDG) and Carpenter-Coustan (CC) criteria. Sensitivity, specificity and predictive values were calculated for 1-h GCT values of 160 to 220 mg

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2016 Journal of perinatology : official journal of the California Perinatal Association

9. Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance (PubMed)

Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance Insulin resistance (IR) predisposes to type 2 diabetes and cardiovascular disease but its causes are incompletely understood. Metabolic challenges like the oral glucose tolerance test (OGTT) can reveal pathogenic mechanisms. We aimed to discover associations of IR with metabolite trajectories during OGTT. In 470 non-diabetic men (age 70.6 ± 0.6 years), plasma samples obtained at 0, 30 and 120 minutes (...) , and no associations with L-carnitine or C2-, C8-, C14- or C16-carnitine. Concentrations of C10- and C12-carnitine decreased during OGTT with a blunted decline in participants with worse insulin resistance. Associations persisted after adjustment for obesity, fasting insulin and fasting glucose. In mouse 3T3-L1 adipocytes exposed to different acylcarnitines, we observed blunted insulin-stimulated glucose uptake after treatment with C10- or C12-carnitine. In conclusion, our results identify medium-chain

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2018 Scientific reports

10. Chronic oscillating glucose challenges disarrange innate immune homeostasis to potentiate the variation of neutrophil–lymphocyte ratio in rats with or without hidden diabetes mellitus (PubMed)

Chronic oscillating glucose challenges disarrange innate immune homeostasis to potentiate the variation of neutrophil–lymphocyte ratio in rats with or without hidden diabetes mellitus The neutrophil-lymphocyte ratio (NLR) has been considered as an inflammatory marker in various disorders, but it is not clear whether the NLR is also elevated with hidden diabetes (HD), which is normal in fasting blood glucose (FBG) but abnormal in the oral glucose tolerance test (OGTT).An HD animal model for 27 (...) days and an animal model with oscillating glucose (OG) for 7 days were applied on adult female Sprague-Dawley rats. OGTT, leukogram analysis, histology, and immunohistochemistry were carried out.In HD rats, the percentage of neutrophils increased but the percentage of lymphocytes decreased; hence, the NLR rose relative to sham. This may be a result of the OG levels often experienced by diabetic subjects, as normal rats given OG (6 g/kg/6 h) for 7 days had significantly reduced lymphocyte numbers

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2018 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

11. Clinical Implications of Using Post-Challenge Plasma Glucose Levels for Early Diagnosis of Type 2 Diabetes Mellitus in Older Individuals (PubMed)

Clinical Implications of Using Post-Challenge Plasma Glucose Levels for Early Diagnosis of Type 2 Diabetes Mellitus in Older Individuals The aim of this study was to explore the differences in the clinical characteristics and diagnostic rates of diabetes mellitus (DM) according to various criteria in different age groups and to evaluate the efficacy of each criterion for screening older patients.We studied 515 patients and measured the fasting plasma glucose level (FPG), 2-hour plasma glucose (...) level after the 75 g oral glucose tolerance test (2-hour postload glucose [2-h PG]), and glycosylated hemoglobin (HbA1c) for re-evaluation of hyperglycemia without a history of diabetes. Patients with newly diagnosed DM were grouped by age as younger (<65 years) or older (≥65 years).Older patients had significantly lower HbA1c, FPG, and 2-h PG levels and a higher homeostatic level of pancreatic β-cell function compared with younger patients (P<0.001). The older group had the lowest diagnostic rate

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2018 Diabetes & metabolism journal

12. Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats (PubMed)

Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats Better choices of dietary lipid sources and substitution of refined by fortified oils could reduce the intake of saturated fatty acids (FA) and increase the intake of omega 3 FA concomitantly to healthy bioactive compounds.The development of obesity and metabolic disturbances was explored in rats fed during 11 weeks with a high fat diet (HFD) in which the amount of saturated (...) and polyunsaturated FA was respectively reduced and increased, using rapeseed oil as lipid source. This oil was used in a refined form (R) or fortified (10 fold increase in concentration) with endogenous micronutrients (coenzyme Q10 + tocopherol only (RF) only and also with canolol (RFC)). The effect of substituting palm by rapeseed oil was analysed using a student t test, oil fortification was analysed using ANOVA statistical test.Despite a similar weight gain, diets R, RF and RFC improved glucose tolerance

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2018 Nutrition & metabolism

13. Physical activity is associated with lower insulin and C-peptide during glucose challenge in children and adolescents with family background of diabetes. (PubMed)

was negatively associated with insulin and C-peptide during challenge with an oral glucose tolerance test. MVPA was also significantly positively associated with the insulin sensitivity index, whereas no consistently significant associations were found between MVPA and BMI, blood pressure or cytokine levels.Our findings indicate that physical activity may have beneficial effects on insulin and C-peptide metabolism in children and adolescents with a family background of diabetes, but show no evidence (...) Physical activity is associated with lower insulin and C-peptide during glucose challenge in children and adolescents with family background of diabetes. Children and adolescents with a family history of diabetes are at increased risk of overweight, but little is known about the potentially beneficial effects of physical activity on these children. The objective of this study was to investigate the association between moderate to vigorous physical activity (MVPA) and metabolic and inflammatory

2018 Diabetic Medicine

14. Non-Suppressed Glucagon after Glucose Challenge as a Potential Predictor for Glucose Tolerance. (PubMed)

Non-Suppressed Glucagon after Glucose Challenge as a Potential Predictor for Glucose Tolerance. Glucagon levels are classically suppressed after glucose challenge. It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes. We investigated the association of postchallenge change in glucagon during oral glucose tolerance tests (OGTTs), hypothesizing that higher postchallenge glucagon levels are observed in subjects with impaired (...) glucose tolerance (IGT). Glucagon levels were measured during OGTT in a total of 4,194 individuals without diabetes in three large European cohorts. Longitudinal changes in glucagon suppression were investigated in 50 participants undergoing a lifestyle intervention. Only 66-79% of participants showed suppression of glucagon at 120 min (fold change glucagon120/0 <1) during OGTT, whereas 21-34% presented with increasing glucagon levels (fold change glucagon120/0 ≥1). Participants with nonsuppressed

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2016 Diabetes

15. High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population (PubMed)

High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population The prevalence of Type 2 Diabetes (T2D) mellitus in the past decades, has reached epidemic proportions. Several lines of evidence support the role of genetic variation in the pathogenesis of T2D and insulin resistance. Elucidating these factors could contribute to developing new medical treatments and tools (...) diet (18% fat). Briefly, 8 week old mice were maintained on HFD until 20 weeks of age, and subsequently assessed by intraperitoneal glucose tolerance test (IPGTT). Biweekly body weight (BW), body length (BL), waist circumstance (WC), and body mass index (BMI) were measured. On statistical analysis, trait measurements taken at 20 weeks of age showed significant sex by diet interaction across the different lines and traits. Consequently, males and females were analyzed, separately. Differences among

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2016 BMC genetics

16. Racial Differences in the Natriuretic Peptide Response to Glucose Challenge

Differences in Natriuretic Peptides Response to Glucose Challenge Actual Study Start Date : March 1, 2017 Actual Primary Completion Date : October 1, 2018 Actual Study Completion Date : October 1, 2018 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: African-American Healthy self-identified African-American participants will be enrolled and each will undergo a physical exam and screening tests to determine (...) Racial Differences in the Natriuretic Peptide Response to Glucose Challenge Racial Differences in the Natriuretic Peptide Response to Glucose Challenge - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Racial

2017 Clinical Trials

17. Gut-training: The impact of two weeks repetitive gut-challenge during exercise on gastrointestinal status, glucose availability, fuel kinetics, and running performance. (PubMed)

% V̇O2max whilst consuming gel-discs containing 30 g carbohydrates (2:1 glucose/fructose, 10% w/v) every 20 min and a 1 h distance test. Participants were then randomly assigned to a carbohydrate gel-disc (CHO-S), carbohydrate food (CHO-F), or placebo (PLA) gut-training group for 2 weeks of repetitive gut-challenge intervention. Participants then repeated a second gut-challenge trial (GC2). Gastrointestinal symptoms reduced in GC2 on CHO-S (60%; p = 0.008) and CHO-F (63%; p = 0.046); reductions were (...) Gut-training: The impact of two weeks repetitive gut-challenge during exercise on gastrointestinal status, glucose availability, fuel kinetics, and running performance. Due to gastrointestinal tract adaptability, the study aimed to determine the impact of gut-training protocol over 2 weeks on gastrointestinal status, blood glucose availability, fuel kinetics, and running performance. Endurance runners (n = 25) performed a gut-challenge trial (GC1), consisting of 2 h running exercise at 60

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2017 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

18. The Effects of an 8-week Vegan Diet on TMAO Levels and Post-challenge Glucose Levels in Individuals With Dysglycaemia

/treatment Phase Diabetes Mellitus, Type 2 Heart Diseases Other: Adoption of a vegan diet Not Applicable Detailed Description: Study Design Interventional single group prospective trial in a patient population with identified dysglycaemia within the past 36 months defined as 2h post-challenge glucose ≥7.8 mmol/L after a standard oral glucose tolerance test or HbA1c ≥5.7% (39-46 mmol/mol). This phase clinical trial will evaluate the efficacy and underlining mechanisms of a vegan diet in promoting (...) The Effects of an 8-week Vegan Diet on TMAO Levels and Post-challenge Glucose Levels in Individuals With Dysglycaemia The Effects of an 8-week Vegan Diet on TMAO Levels and Post-challenge Glucose Levels in Individuals With Dysglycaemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

19. Characterization of Metabolic and Brain Effects of Rising Glucagon During an Oral Glucose Challenge

Glucose Challenge Actual Study Start Date : February 10, 2017 Estimated Primary Completion Date : November 2018 Estimated Study Completion Date : February 2019 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Intravenous glucagon Low-dose glucagon infusion (0.5 pmol/min/kg body weight) over 150 minutes during a standardized 75 g oral glucose tolerance test Drug: Intravenous glucagon Randomized (...) application of glucagon or saline during oral glucose tolerance test Placebo Comparator: Intravenous saline Saline infusion over 150 minutes during a standardized 75 g oral glucose tolerance test Drug: Intravenous saline Randomized application of glucagon or saline during oral glucose tolerance test Outcome Measures Go to Primary Outcome Measures : Brain activity [ Time Frame: change from baseline to 120 minutes after oral glucose challenge ] Resting-state brain activity assessed by fMRI Secondary Outcome

2017 Clinical Trials

20. A Practical Approach to the Management of Continuous Glucose Monitoring (CGM) / Real-Time Flash Glucose Scanning (FGS) in Type 1 Diabetes Mellitus in Children and Young People Under 18 years

wirelessly to a compatible smart phone. It is FDA approved and CE mark approved in Europe to make treatment decisions upon its results and is a newer version compared to G4. G5 is the first remote glucose monitoring system that is licenced to make dosing decisions from without checking with a finger prick. blood glucose (BG) testing for treatment decisions. FDA approved and CE Marked. in a 24-hour period to capture the complete glycaemic picture. The Reader can store approximately 90-days of glucose (...) for calibration G4: Blood glucose reading has to be entered manually into the Dexcom receiver or Animas Vibe pump. G5: Blood glucose reading has to be entered manually into the Dexcom receiver/Smart phone device. If you have not used the calibration code, you must manually calibrate your G6 daily, using values obtained from a blood glucose meter and fingersticks. The Reader can also be used as a manual blood glucose or blood ketone testing device. It is compatible with FreeStyle Optium test strips

2018 British Society for Paediatric Endocrinology and Diabetes

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