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Gigantism

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2. Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study. (PubMed)

Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study. A multicenter, open-label, phase 2 study was conducted to investigate the efficacy and safety of long-acting pasireotide formulation in Japanese patients with acromegaly or pituitary gigantism. Medically naïve or inadequately controlled patients (on somatostatin analogues or dopamine agonists) were included. Primary end (...) point was the proportion of all patients who achieved biochemical control (mean growth hormone [GH] levels<2.5μg/L and normalized insulin-like growth factor-1 [IGF-1]) at month 3. Thirty-three patients (acromegaly, n=32; pituitary gigantism, n=1) were enrolled and randomized 1:1:1 to receive open-label pasireotide 20mg, 40mg, or 60mg. The median age was 52 years (range, 31-79) and 20 patients were males. At month 3, 18.2% of patients (6/33; 90% confidence interval: 8.2%, 32.8%) had biochemical

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2018 Endocrine journal

3. Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges (PubMed)

Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges Parotid gland surgery can be challenging due to intricate relationship between the gland and facial nerve. Besides complete removal of the lesion, the main focus of surgery is centered on the facial nerve. Surgery can be technically demanding especially when the tumor is large or involves the deep lobe. We report a patient with a 30-year history of gigantic parotid mass, which initial fine-needle

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2018 Oman medical journal

4. Dental Management of a Young Child Affected by Galactosialidosis and a Gigantic Abdominal Growth (PubMed)

Dental Management of a Young Child Affected by Galactosialidosis and a Gigantic Abdominal Growth Galactosialidosis (GS) is a rare form of lysosomal storage disease that involves a broad spectrum of skeletal and soft tissue abnormalities. We report here on a 4-year 7-month-old boy with mild mental retardation, exhibiting multiple caries cavities and associated infectious foci and macroglossia. A huge abdominal enlargement due to peritoneal ascites was evident. Behavioral management and patient

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2018 Case reports in dentistry

5. A Gigantic Anal Mass: Buschke–Löwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome (PubMed)

A Gigantic Anal Mass: Buschke–Löwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome Buschke-Löwenstein tumor of anorectal and perianal area is a rare but highly aggressive tumor, frequently associated with human papillomavirus (HPV) types 6 and 11. It often grows over years in immunocompetent patients and can be highly destructive to local tissue. We present a case of a 61-year-old male with HIV infection who presented with worsening pain and swelling

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2018 Case reports in infectious diseases

6. Unusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism (PubMed)

Unusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism Early-onset acromegaly causing gigantism is often associated with aryl-hydrocarbon-interacting receptor protein (AIP) mutation, especially if there is a positive family history. A15y male presented with tiredness and visual problems. He was 201 cm tall with a span of 217 cm. He had typical facial features of acromegaly, elevated IGF-1, secondary hypogonadism and a large macroadenoma. His paternal aunt

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2018 Endocrinology, diabetes & metabolism case reports

7. Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date (PubMed)

Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date Gastrointestinal stromal tumors are uncommon when compared to all gastrointestinal neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. The largest gastrointestinal stromal tumor ever recorded in literature weighed approximately 6.1 kg and measured 39 cm × 27 cm × 14 cm. About two-thirds of GISTs are malignant. The tumor size, mitotic rate, cellularity, and nuclear pleomorphism

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2018 Case reports in surgery

8. El ocaso de los Gigantes

El ocaso de los Gigantes El ocaso de los gigantes | Primum non nocere 2019 Desde octubre de 2003. Decano de los blogs sanitaren español. Blog de medicina, atención primaria y mucho más….. o mucho menos. médico general británico, un apasionado defensor del del Reino Unido (en inglés National Health Service – NHS) y del socialismo. Su aportación más conocida en medicina fue la ley de cuidados inversos que formulo en un publicado en la revista Lancet en 1971, y cuyo resumen dice así: La

2018 Primum non nocere blog

9. Gigantism in a McCune-Albright’s syndrome with calcified GH-releasing pituitary adenoma: Case report and literature review (PubMed)

Gigantism in a McCune-Albright’s syndrome with calcified GH-releasing pituitary adenoma: Case report and literature review McCune-Albright's syndrome (MAS) is a rare disorder that is characterized by café-au-lait macules, fibrous dysplasia of the skull and endocrinopathies like excessive secretion of growth hormone by a hyper-functional pituitary adenoma (PA).We describe the case of a 43-year-old male with history of Gigantism in 1990 secondary to a GH-secreting pituitary macroadenoma (...) and bone formation.This is a rare case of MAS. Gigantism within the context of a pituitary calcification raises special diagnostic and therapeutic challenges. The cause of the excessive secretion of GH in MAS is not well understood concluding that it seems to be a different etiology of patients with Acromegaly and Gigantism in non-MAS patients.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

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2018 International journal of surgery case reports

10. Gigantic mammary Paget’s disease of a very elderly woman (PubMed)

Gigantic mammary Paget’s disease of a very elderly woman Recently, surgical stress due to breast cancer has been reduced, more so for elderly patients. However, an expanded resection is still required in some situations.We present a case of a 90-year-old woman with a 15 × 15 cm2 erythema and localized skin ulceration with hemorrhage in her right breast. A punch biopsy indicated mammary Paget's disease. Computed tomography showed that the tumor was only located on the surface of the breast

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2018 Surgical Case Reports

11. Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast (PubMed)

Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast 29521304 2018 10 29 2018 11 14 2542-5641 131 6 2018 Mar 20 Chinese medical journal Chin. Med. J. Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast. 751-752 10.4103/0366-6999.226898 Gao Yan-Hong YH Department of Ultrasound, Wuhan General Hospital of the People's Liberation Army, Wuhan, Hubei 430070, China. Xiang Hui-Juan HJ Department of Ultrasound, Wuhan General Hospital of the People's Liberation Army

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2018 Chinese medical journal

12. The causes and consequences of pituitary gigantism. (PubMed)

The causes and consequences of pituitary gigantism. In the general population, height is determined by a complex interplay between genetic and environmental factors. Pituitary gigantism is a rare but very important subgroup of patients with excessive height, as it has an identifiable and clinically treatable cause. The disease is caused by chronic growth hormone and insulin-like growth factor 1 secretion from a pituitary somatotrope adenoma that forms before the closure of the epiphyses (...) . If not controlled effectively, this hormonal hypersecretion could lead to extremely elevated final adult height. The past 10 years have seen marked advances in the understanding of pituitary gigantism, including the identification of genetic causes in ~50% of cases, such as mutations in the AIP gene or chromosome Xq26.3 duplications in X-linked acrogigantism syndrome. Pituitary gigantism has a male preponderance, and patients usually have large pituitary adenomas. The large tumour size, together with the young

2018 Nature reviews. Endocrinology

13. How sauropods gobbled their way to gigantism

How sauropods gobbled their way to gigantism How sauropods gobbled their way to gigantism | PLOS Blogs Network PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy (...) for sauropods then is pretty important as it can tell us about how feeding links to evolutionary constraints on gigantic body sizes in land-dwelling animals. Thankfully, computer-assisted engineering studies of biological organisms has really taken off in the last few years, especially in dinosaur studies. The field, generally known as biomechanics, applies our knowledge of materials and their physical properties to ask questions about how animals behaved in different ways, such as how fast they could run

2016 PLOS Blogs Network

14. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction & stability and is associated with gigantism. (PubMed)

In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction & stability and is associated with gigantism. Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events.Observational, inferential and experimental study, including: AIP mutation testing (...) affected (nine gigantism/four acromegaly/two non-functioning pituitary adenoma patients and one prospectively diagnosed acromegaly patient) and nine unaffected carriers. All pedigrees shared a 2.79 Mbp haploblock around AIP with additional haploblocks privately shared between subsets of the pedigrees, indicating the existence of an evolutionarily recent common ancestor, the 'English founder', with an estimated median tMRCA of 47 generations (corresponding to 1175 years) with a confidence interval (9

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2017 European Journal of Endocrinology

15. Assessment of Unusual Gigantic Jets observed during the Monsoon season: First observations from Indian Subcontinent (PubMed)

Assessment of Unusual Gigantic Jets observed during the Monsoon season: First observations from Indian Subcontinent Gigantic Jets are electric discharges from thunderstorm cloud tops to the bottom of ionosphere at ~90 km altitude and electrically connect the troposphere and lower ionosphere. Since their first report in 2002, sporadic observations have been reported from ground and space based observations. Here we report first observations of Gigantic Jets in Indian subcontinent over the Indo (...) the leading edge of a slowly drifting complex convective cloud close to the highest regions at ~17 km altitude. A horizontal displacement of ~10 km developed at ~50 km altitude before connecting to the lower ionosphere. Modeling of these Gigantic jets suggests that Gigantic Jets may bend when initiated at the edge of clouds with misaligned vertical charge distribution.

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2017 Scientific reports

16. Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection (PubMed)

Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection Primary hepatic leiomyosarcoma (PHL) is an extremely rare tumor. The tumor has no specific presentations and often diagnosis is delayed until it reaches a significant size. We report the case of a 69-year-old female presented with a huge PHL. Due to size of the tumor and to be operable, the patient subjected to right portal vein embolization (PVE) and selective embolization of segment V. Four

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2017 Annals of Hepato-Biliary-Pancreatic Surgery

17. Gigantic Thrombus of the Left Atrium in Mitral Stenosis (PubMed)

Gigantic Thrombus of the Left Atrium in Mitral Stenosis Excess dilatation of the left atrium >65 mm is known in the literature as gigantic atrium. This dilation is most commonly encountered in the mitral insufficiency of rheumatic etiology, but also in severe prolapses of the mitral valve, permanent atrial fibrillation, and at the left right shunt with cardiac insufficiency.In this paper is presented a case study of echocardiographically verified giant thrombus in left atrium in a 50 years old (...) female patient aged 50 hospitalized because of tiredness, choking, heartburn and urinary tract symptoms. The patient had rheumatic fever at age of 18 years. At age of 35, she was diagnosed with mitral stenosis. In permanent atrial fibrillation with anamnestic data on the previous cerebrovascular stroke (CVI) and the repeated transitional ischemic seizures. Echocardiographic examination confirmed severe mitral stenosis with moderate aortic insufficiency and gigantic left atrium (LA) with gigantic

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2017 Medical Archives

18. Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo) (PubMed)

Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo) Seed size is one of the most important traits in leguminous crops. We obtained a recessive mutant of blackgram that had greatly enlarged leaves, stems and seeds. The mutant produced 100% bigger leaves, 50% more biomass and 70% larger seeds though it produced 40% less number of seeds. We designated the mutant as multiple-organ-gigantism (mog) and found the mog phenotype was due to increase in cell numbers

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2017 Breeding science

19. A Rare Case of Extra Gigantic Digit of Sole (PubMed)

A Rare Case of Extra Gigantic Digit of Sole 28713720 2018 11 13 2228-7914 6 2 2017 May World journal of plastic surgery World J Plast Surg A Rare Case of Extra Gigantic Digit of Sole. 246-247 Satish Chetan C Sanjeevani Hospital, Bangalore, India. Reddy Subhash S Sanjeevani Hospital, Bangalore, India. eng Journal Article Iran World J Plast Surg 101639130 2228-7914 Gigantic digit India Sole 2017 7 18 6 0 2017 7 18 6 0 2017 7 18 6 1 ppublish 28713720 PMC5506364 Birth Defects Orig Artic Ser

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2017 World journal of plastic surgery

20. Tyrannosauroid integument reveals conflicting patterns of gigantism and feather evolution (PubMed)

Tyrannosauroid integument reveals conflicting patterns of gigantism and feather evolution Recent evidence for feathers in theropods has led to speculations that the largest tyrannosaurids, including Tyrannosaurus rex, were extensively feathered. We describe fossil integument from Tyrannosaurus and other tyrannosaurids (Albertosaurus, Daspletosaurus, Gorgosaurus and Tarbosaurus), confirming that these large-bodied forms possessed scaly, reptilian-like skin. Body size evolution in tyrannosauroids (...) reveals two independent occurrences of gigantism; specifically, the large sizes in Yutyrannus and tyrannosaurids were independently derived. These new findings demonstrate that extensive feather coverings observed in some early tyrannosauroids were lost by the Albian, basal to Tyrannosauridae. This loss is unrelated to palaeoclimate but possibly tied to the evolution of gigantism, although other mechanisms exist.© 2017 The Author(s).

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2017 Biology letters

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