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Gigantism

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2. Anesthetic management of gigantic pheochromocytoma resection with inferior vena cava and right atrium tumor thrombosis: a case report. Full Text available with Trip Pro

Anesthetic management of gigantic pheochromocytoma resection with inferior vena cava and right atrium tumor thrombosis: a case report. This report describes one case of anesthetic management about surgical resection of a malignant phaeochromocytoma with tumor extension into vena cava and right atrium in a patient. Report for anesthetic management is limited in these patients under surgical resection until now.In September 2015, a 24-year-old male presented to the department of cardiology

2019 BMC Anesthesiology

3. Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges Full Text available with Trip Pro

Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges Parotid gland surgery can be challenging due to intricate relationship between the gland and facial nerve. Besides complete removal of the lesion, the main focus of surgery is centered on the facial nerve. Surgery can be technically demanding especially when the tumor is large or involves the deep lobe. We report a patient with a 30-year history of gigantic parotid mass, which initial fine-needle

2018 Oman medical journal

4. Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date Full Text available with Trip Pro

Gigantic GIST: A Case of the Largest Gastrointestinal Stromal Tumor Found to Date Gastrointestinal stromal tumors are uncommon when compared to all gastrointestinal neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. The largest gastrointestinal stromal tumor ever recorded in literature weighed approximately 6.1 kg and measured 39 cm × 27 cm × 14 cm. About two-thirds of GISTs are malignant. The tumor size, mitotic rate, cellularity, and nuclear pleomorphism

2018 Case reports in surgery

5. Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast Full Text available with Trip Pro

Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast 29521304 2018 10 29 2018 11 14 2542-5641 131 6 2018 Mar 20 Chinese medical journal Chin. Med. J. Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast. 751-752 10.4103/0366-6999.226898 Gao Yan-Hong YH Department of Ultrasound, Wuhan General Hospital of the People's Liberation Army, Wuhan, Hubei 430070, China. Xiang Hui-Juan HJ Department of Ultrasound, Wuhan General Hospital of the People's Liberation Army

2018 Chinese medical journal

6. Dental Management of a Young Child Affected by Galactosialidosis and a Gigantic Abdominal Growth Full Text available with Trip Pro

Dental Management of a Young Child Affected by Galactosialidosis and a Gigantic Abdominal Growth Galactosialidosis (GS) is a rare form of lysosomal storage disease that involves a broad spectrum of skeletal and soft tissue abnormalities. We report here on a 4-year 7-month-old boy with mild mental retardation, exhibiting multiple caries cavities and associated infectious foci and macroglossia. A huge abdominal enlargement due to peritoneal ascites was evident. Behavioral management and patient

2018 Case reports in dentistry

7. A Gigantic Anal Mass: Buschke–Löwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome Full Text available with Trip Pro

A Gigantic Anal Mass: Buschke–Löwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome Buschke-Löwenstein tumor of anorectal and perianal area is a rare but highly aggressive tumor, frequently associated with human papillomavirus (HPV) types 6 and 11. It often grows over years in immunocompetent patients and can be highly destructive to local tissue. We present a case of a 61-year-old male with HIV infection who presented with worsening pain and swelling

2018 Case reports in infectious diseases

8. Regional endothermy as a trigger for gigantism in some extinct macropredatory sharks. Full Text available with Trip Pro

Regional endothermy as a trigger for gigantism in some extinct macropredatory sharks. Otodontids include some of the largest macropredatory sharks that ever lived, the most extreme case being Otodus (Megaselachus) megalodon. The reasons underlying their gigantism, distribution patterns and extinction have been classically linked with climatic factors and the evolution, radiation and migrations of cetaceans during the Paleogene. However, most of these previous proposals are based on the idea (...) of otodontids as ectothermic sharks regardless of the ecological, energetic and body size constraints that this implies. Interestingly, a few recent studies have suggested the possible existence of endothermy in these sharks thus opening the door to a series of new interpretations. Accordingly, this work proposes that regional endothermy was present in otodontids and some closely related taxa (cretoxyrhinids), playing an important role in the evolution of gigantism and in allowing an active mode of live

2017 PLoS ONE

9. The causes and consequences of pituitary gigantism. (Abstract)

The causes and consequences of pituitary gigantism. In the general population, height is determined by a complex interplay between genetic and environmental factors. Pituitary gigantism is a rare but very important subgroup of patients with excessive height, as it has an identifiable and clinically treatable cause. The disease is caused by chronic growth hormone and insulin-like growth factor 1 secretion from a pituitary somatotrope adenoma that forms before the closure of the epiphyses (...) . If not controlled effectively, this hormonal hypersecretion could lead to extremely elevated final adult height. The past 10 years have seen marked advances in the understanding of pituitary gigantism, including the identification of genetic causes in ~50% of cases, such as mutations in the AIP gene or chromosome Xq26.3 duplications in X-linked acrogigantism syndrome. Pituitary gigantism has a male preponderance, and patients usually have large pituitary adenomas. The large tumour size, together with the young

2018 Nature reviews. Endocrinology

10. Gigantism in a McCune-Albright’s syndrome with calcified GH-releasing pituitary adenoma: Case report and literature review Full Text available with Trip Pro

Gigantism in a McCune-Albright’s syndrome with calcified GH-releasing pituitary adenoma: Case report and literature review McCune-Albright's syndrome (MAS) is a rare disorder that is characterized by café-au-lait macules, fibrous dysplasia of the skull and endocrinopathies like excessive secretion of growth hormone by a hyper-functional pituitary adenoma (PA).We describe the case of a 43-year-old male with history of Gigantism in 1990 secondary to a GH-secreting pituitary macroadenoma (...) and bone formation.This is a rare case of MAS. Gigantism within the context of a pituitary calcification raises special diagnostic and therapeutic challenges. The cause of the excessive secretion of GH in MAS is not well understood concluding that it seems to be a different etiology of patients with Acromegaly and Gigantism in non-MAS patients.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

2018 International journal of surgery case reports

11. Gigantic mammary Paget’s disease of a very elderly woman Full Text available with Trip Pro

Gigantic mammary Paget’s disease of a very elderly woman Recently, surgical stress due to breast cancer has been reduced, more so for elderly patients. However, an expanded resection is still required in some situations.We present a case of a 90-year-old woman with a 15 × 15 cm2 erythema and localized skin ulceration with hemorrhage in her right breast. A punch biopsy indicated mammary Paget's disease. Computed tomography showed that the tumor was only located on the surface of the breast

2018 Surgical Case Reports

12. Unusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism Full Text available with Trip Pro

Unusual AIP mutation and phenocopy in the family of a young patient with acromegalic gigantism Early-onset acromegaly causing gigantism is often associated with aryl-hydrocarbon-interacting receptor protein (AIP) mutation, especially if there is a positive family history. A15y male presented with tiredness and visual problems. He was 201 cm tall with a span of 217 cm. He had typical facial features of acromegaly, elevated IGF-1, secondary hypogonadism and a large macroadenoma. His paternal aunt

2018 Endocrinology, diabetes & metabolism case reports

13. Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study. Full Text available with Trip Pro

Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study. A multicenter, open-label, phase 2 study was conducted to investigate the efficacy and safety of long-acting pasireotide formulation in Japanese patients with acromegaly or pituitary gigantism. Medically naïve or inadequately controlled patients (on somatostatin analogues or dopamine agonists) were included. Primary end (...) point was the proportion of all patients who achieved biochemical control (mean growth hormone [GH] levels<2.5μg/L and normalized insulin-like growth factor-1 [IGF-1]) at month 3. Thirty-three patients (acromegaly, n=32; pituitary gigantism, n=1) were enrolled and randomized 1:1:1 to receive open-label pasireotide 20mg, 40mg, or 60mg. The median age was 52 years (range, 31-79) and 20 patients were males. At month 3, 18.2% of patients (6/33; 90% confidence interval: 8.2%, 32.8%) had biochemical

2018 Endocrine journal Controlled trial quality: uncertain

14. Gigantic Thrombus of the Left Atrium in Mitral Stenosis Full Text available with Trip Pro

Gigantic Thrombus of the Left Atrium in Mitral Stenosis Excess dilatation of the left atrium >65 mm is known in the literature as gigantic atrium. This dilation is most commonly encountered in the mitral insufficiency of rheumatic etiology, but also in severe prolapses of the mitral valve, permanent atrial fibrillation, and at the left right shunt with cardiac insufficiency.In this paper is presented a case study of echocardiographically verified giant thrombus in left atrium in a 50 years old (...) female patient aged 50 hospitalized because of tiredness, choking, heartburn and urinary tract symptoms. The patient had rheumatic fever at age of 18 years. At age of 35, she was diagnosed with mitral stenosis. In permanent atrial fibrillation with anamnestic data on the previous cerebrovascular stroke (CVI) and the repeated transitional ischemic seizures. Echocardiographic examination confirmed severe mitral stenosis with moderate aortic insufficiency and gigantic left atrium (LA) with gigantic

2017 Medical Archives

15. Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection Full Text available with Trip Pro

Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection Primary hepatic leiomyosarcoma (PHL) is an extremely rare tumor. The tumor has no specific presentations and often diagnosis is delayed until it reaches a significant size. We report the case of a 69-year-old female presented with a huge PHL. Due to size of the tumor and to be operable, the patient subjected to right portal vein embolization (PVE) and selective embolization of segment V. Four

2017 Annals of Hepato-Biliary-Pancreatic Surgery

16. Assessment of Unusual Gigantic Jets observed during the Monsoon season: First observations from Indian Subcontinent Full Text available with Trip Pro

Assessment of Unusual Gigantic Jets observed during the Monsoon season: First observations from Indian Subcontinent Gigantic Jets are electric discharges from thunderstorm cloud tops to the bottom of ionosphere at ~90 km altitude and electrically connect the troposphere and lower ionosphere. Since their first report in 2002, sporadic observations have been reported from ground and space based observations. Here we report first observations of Gigantic Jets in Indian subcontinent over the Indo (...) the leading edge of a slowly drifting complex convective cloud close to the highest regions at ~17 km altitude. A horizontal displacement of ~10 km developed at ~50 km altitude before connecting to the lower ionosphere. Modeling of these Gigantic jets suggests that Gigantic Jets may bend when initiated at the edge of clouds with misaligned vertical charge distribution.

2017 Scientific reports

17. Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo) Full Text available with Trip Pro

Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo) Seed size is one of the most important traits in leguminous crops. We obtained a recessive mutant of blackgram that had greatly enlarged leaves, stems and seeds. The mutant produced 100% bigger leaves, 50% more biomass and 70% larger seeds though it produced 40% less number of seeds. We designated the mutant as multiple-organ-gigantism (mog) and found the mog phenotype was due to increase in cell numbers

2017 Breeding science

18. High-precision chronology for Central American maize diversification from El Gigante rockshelter, Honduras Full Text available with Trip Pro

High-precision chronology for Central American maize diversification from El Gigante rockshelter, Honduras The first steps toward maize (Zea mays subspecies mays) domestication occurred in the Balsas region of Mexico by ∼9,000 calendar years B.P. (cal B.P.), but it remains unclear when maize was productive enough to be a staple grain in the Americas. Molecular and microbotanical data provide a partial picture of the timing and nature of morphological change, with genetic data indicating (...) that alleles for some domestication traits were not yet fixed by 5,300 cal B.P. in the highlands of Mexico. Here, we report 88 radiocarbon dates on the botanical remains from El Gigante rockshelter (Honduras) to establish a Bayesian chronology over the past ∼11,000 y spanning the transition to maize-based food production. Botanical remains are remarkably well preserved and include over 10,000 maize macrofossils. We directly dated 37 maize cobs to establish the appearance and local change of maize

2017 Proceedings of the National Academy of Sciences of the United States of America

19. Human versus Robots in the Discovery and Crystallization of Gigantic Polyoxometalates Full Text available with Trip Pro

Human versus Robots in the Discovery and Crystallization of Gigantic Polyoxometalates The discovery of new gigantic molecules formed by self-assembly and crystal growth is challenging as it combines two contingent events; first is the formation of a new molecule, and second its crystallization. Herein, we construct a workflow that can be followed manually or by a robot to probe the envelope of both events and employ it for a new polyoxometalate cluster, Na6 [Mo120 Ce6 O366 H12 (H2 O)78 ]⋅200 H2

2017 Angewandte Chemie (International ed. in English)

20. A Rare Case of Extra Gigantic Digit of Sole Full Text available with Trip Pro

A Rare Case of Extra Gigantic Digit of Sole 28713720 2018 11 13 2228-7914 6 2 2017 May World journal of plastic surgery World J Plast Surg A Rare Case of Extra Gigantic Digit of Sole. 246-247 Satish Chetan C Sanjeevani Hospital, Bangalore, India. Reddy Subhash S Sanjeevani Hospital, Bangalore, India. eng Journal Article Iran World J Plast Surg 101639130 2228-7914 Gigantic digit India Sole 2017 7 18 6 0 2017 7 18 6 0 2017 7 18 6 1 ppublish 28713720 PMC5506364 Birth Defects Orig Artic Ser

2017 World journal of plastic surgery

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