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Giant Cell Arteritis

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2. Tocilizumab for treating giant cell arteritis

Tocilizumab for treating giant cell arteritis T T ocilizumab for treating giant cell ocilizumab for treating giant cell arteritis arteritis T echnology appraisal guidance Published: 18 April 2018 nice.org.uk/guidance/ta518 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful consideration (...) to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. T ocilizumab for treating giant cell arteritis (TA518) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 21Contents Contents 1 Recommendations 4 2 Information about tocilizumab 5 3 Committee discussion 6 A new treatment option 6 Subgroups 6

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

3. Giant cell arteritis

Giant cell arteritis Giant cell arteritis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Giant cell arteritis Last reviewed: February 2019 Last updated: December 2018 Summary Giant cell arteritis (GCA) is a common form of vasculitis in people aged 50 years or older. The extracranial branches of the carotid artery are usually affected. Irreversible blindness is the most common serious consequence. Aortic aneurysms (...) and corticosteroid-sparing benefit in the treatment of GCA. Definition Giant cell arteritis (GCA) is a granulomatous vasculitis of large and medium-sized arteries. It primarily affects branches of the external carotid artery, and it is the most common form of systemic vasculitis in adults. GCA typically occurs in people 50 years of age or older and is more common in women. Symptoms of polymyalgia rheumatica are frequently present. The most common serious consequence of GCA is irreversible loss of vision due

2018 BMJ Best Practice

4. Giant cell arteritis

Giant cell arteritis Giant cell arteritis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Giant cell arteritis Last reviewed: February 2019 Last updated: December 2018 Summary Giant cell arteritis (GCA) is a common form of vasculitis in people aged 50 years or older. The extracranial branches of the carotid artery are usually affected. Irreversible blindness is the most common serious consequence. Aortic aneurysms (...) and corticosteroid-sparing benefit in the treatment of GCA. Definition Giant cell arteritis (GCA) is a granulomatous vasculitis of large and medium-sized arteries. It primarily affects branches of the external carotid artery, and it is the most common form of systemic vasculitis in adults. GCA typically occurs in people 50 years of age or older and is more common in women. Symptoms of polymyalgia rheumatica are frequently present. The most common serious consequence of GCA is irreversible loss of vision due

2018 BMJ Best Practice

5. The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study

The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry (...) - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Ultrasound was more sensitive but less specific than temporal artery biopsy in diagnosing giant cell arteritis and there is scope for reducing the role of biopsy. {{author}} {{($index , , , , , , , , , , , , , , , , , & . Raashid Luqmani 1, * , Ellen Lee 2

2016 NIHR HTA programme

6. Actemra - tocilizumab - Giant cell arteritis (GCA)

Actemra - tocilizumab - Giant cell arteritis (GCA) tocilizumab | CADTH.ca Find the information you need tocilizumab tocilizumab Last Updated: April 30, 2018 Result type: Reports Project Number: SR0534-000 Product Line: Generic Name: tocilizumab Brand Name: Actemra Manufacturer: Hoffmann-La Roche Limited Indications: Giant cell arteritis (GCA) Submission Type: New Indication Project Status: Complete Biosimilar: No Date Recommendation Issued: March 27, 2018 Recommendation Type: Reimburse (...) plans March 06, 2018 Embargo period ended and validation of redacted CDR review report(s) received March 20, 2018 CDEC Final Recommendation issued to applicant and drug plans March 27, 2018 CDEC Final Recommendation posted March 29, 2018 Final CDR review report(s) and patient input posted April 24, 2018 Tags nervous system, giant cell arteritis, cardiovascular, giant cell arteritis Files Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2017 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

7. Magnetic resonance angiography in giant cell arteritis: results of a randomized controlled trial of tocilizumab in giant cell arteritis. (PubMed)

Magnetic resonance angiography in giant cell arteritis: results of a randomized controlled trial of tocilizumab in giant cell arteritis. To analyse magnetic resonance angiographic (MRA) vessel wall signals from a randomized controlled trial of tocilizumab (TCZ) to treat GCA.Participants were assigned in a 2:1 ratio to receive either TCZ + glucocorticoids (GCs) or placebo + GC infusions at 4-week intervals for 52 weeks. GCs were started at 1 mg/kg/day, then tapered to 0.1 mg/kg/day at week 12

2018 Rheumatology (Oxford, England)

8. Giant---cell arteritis---related mortality in France: A multiple---cause---of---death analysis Giant---cell arteritis---related mortality in France. (PubMed)

Giant---cell arteritis---related mortality in France: A multiple---cause---of---death analysis Giant---cell arteritis---related mortality in France. Giant-cell arteritis (GCA) is a large vessel vasculitis. Data regarding mortality are controversial. We describe the mortality data of the French death certificates for the period of 2005 to 2014.Using multiple-cause-of-death (MCOD) analysis, we calculated age-adjusted mortality rates for GCA, examined differences in mortality rates according

2018 Autoimmunity reviews

9. Ultrasound could help diagnose giant cell arteritis

Ultrasound could help diagnose giant cell arteritis Ultrasound could help diagnose giant cell arteritis Discover Portal Discover Portal Ultrasound could help diagnose giant cell arteritis Published on 14 February 2017 doi: Ultrasound may aid giant cell arteritis diagnosis in people referred from the community. It is less invasive than biopsy and might provide quicker results than a biopsy, but its role and place in the diagnostic pathway remain unclear. Giant cell arteritis is a disease (...) of medium to large sized arteries and can lead to a range of eye, brain and other complications. Sudden or gradual blindness is a real risk and anyone with suspected giant cell arteritis is referred to hospital for a biopsy and started on high dose steroids. This NIHR-funded study found that ultrasound correctly picks up more cases than biopsies, but also falsely identifies some people who do not have the condition. Biopsies falsely diagnose giant cell arteritis in fewer people without the condition

2019 NIHR Dissemination Centre

10. Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England

Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England Most patients with polymyalgia rheumatica or giant cell arteritis are treated with glucocorticoid therapy in primary care. We estimated dose-response risks of infection for this population in England.We conducted a retrospective record-linkage study involving a cohort of people with polymyalgia rheumatica or giant cell arteritis (...) , bacterial, viral, parasitic and fungal infection conferred by oral glucocorticoids in people with polymyalgia rheumatica or giant cell arteritis and found strong dose responses for all types, even at daily doses of less than 5 mg prednisolone.© 2019 Joule Inc. or its licensors.

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2019 EvidenceUpdates

11. Ultrasound could help diagnose giant cell arteritis

Ultrasound could help diagnose giant cell arteritis Ultrasound could help diagnose giant cell arteritis Discover Portal Discover Portal Ultrasound could help diagnose giant cell arteritis Published on 14 February 2017 doi: Ultrasound may aid giant cell arteritis diagnosis in people referred from the community. It is less invasive than biopsy and might provide quicker results than a biopsy, but its role and place in the diagnostic pathway remain unclear. Giant cell arteritis is a disease (...) of medium to large sized arteries and can lead to a range of eye, brain and other complications. Sudden or gradual blindness is a real risk and anyone with suspected giant cell arteritis is referred to hospital for a biopsy and started on high dose steroids. This NIHR-funded study found that ultrasound correctly picks up more cases than biopsies, but also falsely identifies some people who do not have the condition. Biopsies falsely diagnose giant cell arteritis in fewer people without the condition

2018 NIHR Dissemination Centre

12. Combined bilateral ophthalmic artery occlusion & central retinal vein occlusion from presumed giant cell arteritis (PubMed)

Combined bilateral ophthalmic artery occlusion & central retinal vein occlusion from presumed giant cell arteritis To report on a severe case of presumed giant cell arteritis (GCA) presenting with partial and complete ophthalmic artery occlusion along with bilateral central retinal vein occlusions (CRVO).A 73-year-old female presented with bilateral complete vision loss of sudden onset. The patient also experienced a mild frontal headache prior to onset of vision loss. Fundus examination

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2018 American journal of ophthalmology case reports

13. The impact of temporal artery biopsy for the diagnosis of giant cell arteritis in clinical practice in a tertiary university hospital. (PubMed)

The impact of temporal artery biopsy for the diagnosis of giant cell arteritis in clinical practice in a tertiary university hospital. Temporal artery biopsy (TAB) is useful in assisting with giant cell arteritis (GCA) diagnosis but lacks sensitivity. The aim of our study was to assess the diagnostic impact of TAB histology in patients with suspected GCA on hospital admission.A prospectively maintained database was queried for all TABs performed between 1-1-2000 until 31-12-2017

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2019 PLoS ONE

14. Aspirin as adjunctive treatment for giant cell arteritis. (PubMed)

Aspirin as adjunctive treatment for giant cell arteritis. Giant cell arteritis (GCA) is a common inflammatory condition that affects medium and large-sized arteries and can cause sudden, permanent blindness. At present there is no alternative to early treatment with high-dose corticosteroids as the recommended standard management. Corticosteroid-induced side effects can develop and further disease-related ischaemic complications can still occur. Alternative and adjunctive therapies are sought (...) . Aspirin has been shown to have effects on the immune-mediated inflammation in GCA, hence it may reduce damage caused in the arterial wall.To assess the safety and effectiveness of low-dose aspirin, as an adjunctive, in the treatment of giant cell arteritis (GCA).We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2013, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to January 2014

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2014 Cochrane

15. Color duplex ultrasonography findings of temporal arteries in a case of giant cell arteritis: role in diagnosis and follow-up (PubMed)

Color duplex ultrasonography findings of temporal arteries in a case of giant cell arteritis: role in diagnosis and follow-up Giant cell arteritis (GCA) is a systemic autoimmune disease that affects medium- and large-sized arteries. The diagnostic gold standard is the temporal artery biopsy, but it has limited sensitivity and some difficulties in reproducibility. Color duplex ultrasonography is a noninvasive, reproducible, and inexpensive method for diagnosis of temporal arteries involvement (...) (temporal arteritis [TA]) in GCA with high sensitivity and specificity. We present the ultrasound findings at baseline and during follow-up in a case of TA in a patient with GCA.

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2017 Open access rheumatology : research and reviews

16. Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients? (PubMed)

Giant cell arteritis, polymyalgia rheumatica, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients? To report two patients with giant cell arteritis (GCA) who developed rheumatoid arthritis (RA) and to review the literature in terms of coexistence of RA, GCA, and polymyalgia rheumatica (PMR).We conducted a comprehensive review of the English literature from 1980 to 2015 to analyze data on the coexistence of GCA and RA. The PubMed, Web (...) of Science, Proquest, and Ovid databases were searched for articles using the term RA combined with temporal arteritis, GCA, and PMR.We identified 17 other cases of coexistent GCA and RA reported in the English literature, together with our 2 cases (19 cases). They included 14 females and 5 males, with a mean age of 74.3 years (range: 57-84) at the time of GCA. The mean age at the time of RA diagnosis was 69.6 years (range 24-83). The average time elapsed between the onset of GCA and the development

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2017 European journal of rheumatology

17. Estimating the Cost of Illness of Giant Cell Arteritis in the United States (PubMed)

Estimating the Cost of Illness of Giant Cell Arteritis in the United States Giant cell arteritis (GCA) is a chronic vasculitis affecting approximately 230,000 Americans. Limited data exist on the healthcare resource utilization and costs attributable to GCA. The objective of this study was to estimate the cost of illness in patients with GCA in the US.A cohort of patients with a new GCA diagnosis was identified from a large US claims database between 1 January 2008 and 31 December 2012. Newly

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2017 Rheumatology and therapy

18. Temporal artery ultrasound versus temporal artery biopsy for giant cell arteritis [Cochrane protocol]

Temporal artery ultrasound versus temporal artery biopsy for giant cell arteritis [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2019 PROSPERO

19. Increased Incidence of Giant Cell Arteritis in Urban Areas? (PubMed)

Increased Incidence of Giant Cell Arteritis in Urban Areas? 30647168 2019 03 02 0315-162X 46 3 2019 Mar The Journal of rheumatology J. Rheumatol. Increased Incidence of Giant Cell Arteritis in Urban Areas? 327-328 10.3899/jrheum.180714 Brekke Lene Kristin LK http://orcid.org/0000-0001-5599-2498 Hospital for Rheumatic Diseases, Haugesund, and Department of Clinical Science, University of Bergen, and Bergen Group of Epidemiology and Biomarkers in Rheumatic Disease (BEaBIRD), Department

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2019 Journal of Rheumatology

20. Efficacy of Methotrexate in Real-world Management of Giant Cell Arteritis: A Case-control Study. (PubMed)

Efficacy of Methotrexate in Real-world Management of Giant Cell Arteritis: A Case-control Study. To determine the effect of methotrexate (MTX) on relapse risk and glucocorticoid (GC) use in a large single-institution cohort of patients with giant cell arteritis (GCA).Patients diagnosed with GCA from 1998 to 2013 with confirmed evidence of temporal artery biopsy and/or radiographic evidence of large vessel vasculitis were identified. Each patient with GCA treated with adjunct MTX (case

2019 Journal of Rheumatology

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