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1. American Geriatrics Society White Paper on Healthy Aging

American Geriatrics Society White Paper on Healthy Aging American Geriatrics Society White Paper on Healthy Aging Logging In... × Welcome to GeriatricsCareOnline! AGS or ADGAP MEMBER Attention AGS Members! As an AGS Member, you already have an account automatically set up on GeriatricsCareOnline.org. Your username and password are the same that you use to log onto MyAGS. (If you do not remember your MyAGS credentials, ). Please do not register for a new user account if you are an AGS member (...) - if you create a new account, you will not be recognized as a member in the system. Username Password remember Remember me Login NON-AGS MEMBER Username Password Remember me Login Search: Toggle navigation Search: American Geriatrics Society White Paper on Healthy Aging PRODUCT DETAILS × PIN Subscriprion Validating... Product Titile : American Geriatrics Society White Paper on Healthy Aging Enter PIN * × PIN Subscriprion Subscription is completed successfully. Click OK button to go to MyLibrary page

2018 American Geriatrics Society

2. Getting Old through the Blood: Circulating Molecules in Aging and Senescence of Cardiovascular Regenerative Cells Full Text available with Trip Pro

Getting Old through the Blood: Circulating Molecules in Aging and Senescence of Cardiovascular Regenerative Cells Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues. As the western population is getting older, we are witnessing an increase in the burden of cardiovascular events, some of which are known to be directly linked to cellular senescence and dysfunction (...) . In this review, we will focus on the description of a few circulating molecules, which have been correlated to life span, aging, and cardiovascular homeostasis. We will review the current literature concerning the circulating levels and related signaling pathways of selected proteins (insulin-like growth factor 1, growth and differentiation factor-11, and PAI-1) and microRNAs of interest (miR-34a, miR-146a, miR-21), whose bloodstream levels have been associated to aging in different organisms. In particular

2017 Frontiers in cardiovascular medicine

3. Burosumab-twza (Crysvita) - To treat adults and children ages 1 year and older with x-linked hypophosphatemia (XLH), a rare, inherited form of rickets

Burosumab-twza (Crysvita) - To treat adults and children ages 1 year and older with x-linked hypophosphatemia (XLH), a rare, inherited form of rickets Drug Approval Package: CRYSVITA (burosumab-twza) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: CRYSVITA (burosumab-twza) Company: Ultragenyx Pharmaceutical, Inc. Application Number: 761068 Approval Date: 04/17/2018 Persons with disabilities having problems accessing the PDF files below may call (301 (...) ) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: May 15, 2018 Vision impaired people having problems accessing certain pages of a PDF file may call (301) 796-3634 for assistance. Note: Documents in PDF format require the . Note: If you need help accessing information in different file formats, see . Language Assistance Available: | | | | | | | | | | | | | | | FDA Popular Content Product Areas

2018 FDA - Drug Approval Package

4. Study of a Simplified Geriatric Evaluation Performed by Oncologists Prior to Cancer Treatment by Radiotherapy or Chemotherapy in Subjects Aged 70 Years or Older With Inoperable Squamous Cell Cancer of the Head and Neck

Date : June 2019 Resource links provided by the National Library of Medicine related topics: (AHRQ) related information: Groups and Cohorts Go to Group/Cohort Intervention/treatment Inoperable squamous cell cancer of the head and neck patients 70 years of age or older with ENT carcinoma Other: Geriatric Screening Test G8 Geriatric screening test (Oncodage-G8). The oncologist realizes it and proposes the oncological treatment which seems to him then the most adapted (treatment which can be different (...) Study of a Simplified Geriatric Evaluation Performed by Oncologists Prior to Cancer Treatment by Radiotherapy or Chemotherapy in Subjects Aged 70 Years or Older With Inoperable Squamous Cell Cancer of the Head and Neck Study of a Simplified Geriatric Evaluation Performed by Oncologists Prior to Cancer Treatment by Radiotherapy or Chemotherapy in Subjects Aged 70 Years or Older With Inoperable Squamous Cell Cancer of the Head and Neck - Full Text View - ClinicalTrials.gov Hide glossary Glossary

2018 Clinical Trials

5. Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes Full Text available with Trip Pro

Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes As average life span and elderly people prevalence in the western world population is gradually increasing, the incidence of age-related diseases such as cancer, heart diseases, diabetes, and dementia is increasing, bearing social and economic consequences worldwide. Understanding the molecular basis of aging-related processes can help extend the organism's health span, i.e., the life period (...) in which the organism is free of chronic diseases or decrease in basic body functions. During the last few decades, immense progress was made in the understanding of major components of aging and healthy aging biology, including genomic instability, telomere attrition, epigenetic changes, proteostasis, nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and intracellular communications. This progress has been made by three spear-headed strategies: in vitro (cell

2018 Frontiers in medicine

6. Preventing respiratory illness in older adults aged 60 years and above living in long-term care

Preventing respiratory illness in older adults aged 60 years and above living in long-term care Preventing respiratory illness in older adults aged 60 years and above living in long-term care - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Preventing respiratory illness in older adults aged 60 years and above living in long-term care March 28, 2020 Patricia Rios, Amruta Radhakrishnan, Sonia M. Thomas (...) ) or mixed evidence of effectiveness (e.g., rimantadine, zanamivir, hand hygiene, personal protective equipment). The mixed evidence on hand hygiene and use of personal protective equipment does not imply these should not be used in outbreaks BACKGROUND The Infection Prevention & Control of the World Health Organization (WHO) Health Emergency Programme commissioned a review on preventing and managing COVID-19 in older adults aged 60 years and above living in long-term care facilities. The overall

2020 Oxford COVID-19 Evidence Service

7. Guidelines for preventing respiratory illness in older adults aged 60 years and above living in long-term care

Guidelines for preventing respiratory illness in older adults aged 60 years and above living in long-term care Guidelines for preventing respiratory illness in older adults aged 60 years and above living in long-term care - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Guidelines for preventing respiratory illness in older adults aged 60 years and above living in long-term care March 28, 2020 Patricia (...) , these recommendations should be viewed with caution as it is unclear how many of these guidelines are based on the best available evidence due to their poor overall quality. BACKGROUND The Infection Prevention & Control of the World Health Organization (WHO) Health Emergency Programme commissioned a review on preventing and managing COVID-19 in older adults aged 60 years and above living in long-term care facilities. The overall objective of this rapid review of clinical practice guidelines was to identify

2020 Oxford COVID-19 Evidence Service

8. Measuring ageing: An introduction to the Ageing Better Measures Framework

Better 2019 Local monitoring and evaluation We are also making use of the ABMF at a local level. We are working with the Greater Manchester Combined Authority, Leeds City Council and Leeds Older People’s Forum, supporting them, as well as other members of the UK Network of Age-Friendly Communities, in their use of data and measures to understand local experiences of ageing and monitor progress. We look forward to continuing to work with these and other partners interested in measuring what matters (...) Measuring ageing: An introduction to the Ageing Better Measures Framework Measuring ageing: An introduction to the Ageing Better Measures Framework Centre for Ageing Better January 20193 © Centre for Ageing Better 2019 About the Centre for Ageing Better The Centre for Ageing Better is a charity, funded by an endowment from The National Lottery Community Fund, working to create a society where everyone enjoys a good later life. We want more people to be in fulfilling work, in good health, living

2020 The Centre for Ageing Better

9. When Women Rise, We All Rise: American Geriatrics Society Position Statement on Achieving Gender Equity in Geriatrics

When Women Rise, We All Rise: American Geriatrics Society Position Statement on Achieving Gender Equity in Geriatrics Geriatrics Care | Geriatric Resources | Online events | Updates - Geriatrics Care Online Search: Toggle navigation Search: Login Loging In... GeriatricsCareOnline.org Log in Follow Us Quick Links Loading... Sign up for Alerts Enter your email address : Close © 2017 All Rights Reserved. An Solution

2019 American Geriatrics Society

10. Framework for Decision-making for Older Adults with Multiple Chronic Conditions: Action Steps for the AGS Guiding Principles on the Care of Older Adults with Multimorbidity

with Multiple Chronic Condit PRODUCT DETAILS × PIN Subscriprion Validating... Product Titile : Framework for Decision-making for Older Adults with Multiple Chronic Conditions: Action Steps for the AGS Guiding Principles on the Care of Older Adults with Multimorbidity Enter PIN * × PIN Subscriprion Subscription is completed successfully. Click OK button to go to MyLibrary page. Product Type : Guidelines, Recommendations & Position Statements Language : ENGLISH Publisher : American Geriatrics Society Year (...) Framework for Decision-making for Older Adults with Multiple Chronic Conditions: Action Steps for the AGS Guiding Principles on the Care of Older Adults with Multimorbidity Framework for Decision-making for Older Adults with Multiple Chronic Conditions: Action Steps for the AGS Guiding Principles on the Care of Older Adults with Multimorbidity Logging In... × Welcome to GeriatricsCareOnline! AGS or ADGAP MEMBER Attention AGS Members! As an AGS Member, you already have an account automatically

2019 American Geriatrics Society

11. American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults

released its latest update to one of geriatrics’ most frequently cited reference tools: The AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. With more than 90% of older people using at least one prescription and more than 66% using three or more in any given month, the AGS Beers Criteria® plays a vital role in helping health professionals, older adults, and caregivers work together to ensure medications are appropriate. DIGITAL : × Best Value To get the most for your (...) American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults Logging In... × Welcome to GeriatricsCareOnline! AGS or ADGAP MEMBER Attention AGS Members! As an AGS Member, you already have an account automatically set up on GeriatricsCareOnline.org. Your username and password are the same that you use to log onto MyAGS. (If you do

2019 American Geriatrics Society

12. Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

Circulation. ;0:CIR.0000000000000741 Abstract Longevity is increasing, and more adults are living to the stage of life when age-related biological factors determine a higher likelihood of cardiovascular disease in a distinctive context of concurrent geriatric conditions. Older adults with cardiovascular disease are frequently admitted to cardiac intensive care units (CICUs), where care is commensurate with high age-related cardiovascular disease risks but where the associated geriatric conditions (...) Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search December 2019 November

2019 American Heart Association

13. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. (Abstract)

and associated neuropathology shown by SAMP8 mice. To this end, the potent SIRT2-selective inhibitor, 33i (5 mg/kg i.p. 8 weeks) was administered to 5-month-old (early treatment) and 8-month-old (late treatment) SAMP8 and aged matched control, senescence-accelerated mouse resistant-1 (SAMR1) mice. 33i administration to 5-month-old SAMP8 mice improved spatial learning and memory impairments shown by this strain in the Morris water maze. SAMP8 showed hyperphosphorylation of tau protein and decrease levels (...) Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. The senescence-accelerated mouse prone-8 (SAMP8) model has been considered as a good model for aged-related cognitive decline and Alzheimer's disease (AD). Since epigenetic alterations represent a crucial mechanism during aging, in the present study we tested whether the inhibition of the histone deacetylase sirtuin 2 (SIRT2) could ameliorate the age-dependent cognitive impairments

2019 Neuropsychopharmacology

14. Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging. Full Text available with Trip Pro

Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging. Histones mediate dynamic packaging of nuclear DNA in chromatin, a process that is precisely controlled to guarantee efficient compaction of the genome and proper chromosomal segregation during cell division and to accomplish DNA replication, transcription, and repair. Due to the important structural and regulatory roles played by histones, it is not surprising that histone functional (...) result in stable proteins that reside in the nucleus, bind to chromatin, disrupt proper compaction of DNA, and are associated with a specific methylation pattern. Cells expressing these mutant proteins have a dramatically reduced proliferation rate and competence, hardly enter into the S phase, and undergo accelerated senescence. Remarkably, clinical assessment of a relatively large cohort of subjects sharing these mutations revealed a premature aging phenotype as a previously unrecognized feature

2019 American Journal of Human Genetics

15. Cellular senescence: at the nexus between ageing and diabetes. Full Text available with Trip Pro

entered clinical trials. In this review, we explore the biological links between ageing and diabetes, specifically focusing on cellular senescence. We summarise the current data on cellular senescence in key target tissues associated with the development and clinical phenotypes of type 2 diabetes and discuss the therapeutic potential of targeting cellular senescence in diabetes. (...) Cellular senescence: at the nexus between ageing and diabetes. Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been described and recently

2019 Diabetologia

16. The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro. (Abstract)

aging models in vitro to explore the age-related changes and to compare the differences in these two astrocyte aging models. The Seahorse Extracellular Flux Analyzer was used to examine the mitochondrial metabolism and glycolysis activities of the young and senescent astrocytes. The results showed that the mitochondrial ATP-linked oxygen consumption rates (OCRs) were decreased markedly both in the d-gal-induced and naturally occurring senescent astrocytes. The basal glycolysis activity was increased (...) The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro. Previously, we successfully established a d-galactose (d-gal)-induced astrocyte aging model in vitro. However, whether the changes in the aged astrocytes induced by d-gal are similar to those occurred in naturally are unknown. Therefore, in current study, we simultaneously established d-gal-induced and naturally aged astrocyte

2019 Experimental Gerontology

17. Yellow fever vaccine: stronger precautions in people with weakened immunity and in those aged 60 years or older

Yellow fever vaccine: stronger precautions in people with weakened immunity and in those aged 60 years or older Yellow fever vaccine: stronger precautions in people with weakened immunity and in those aged 60 years or older - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve (...) accepted all cookies. You can at any time. Hide Search Yellow fever vaccine: stronger precautions in people with weakened immunity and in those aged 60 years or older The Commission on Human Medicines has issued a series of recommendations to strengthen measures to minimise risk with the yellow fever vaccine (Stamaril) following very rare fatal reactions. Key recommendations include new and updated contraindications and strengthened precautions to protect those with a weakened immune systems (including

2019 MHRA Drug Safety Update

18. Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing Full Text available with Trip Pro

, obesity and diabetes can potentially create an environment that accelerates cell senescence within other tissues of the body. This can consequently manifest as age-related biological impairments and secondary diseases. Cell senescence in cell types linked with obesity and diabetes, namely adipocytes and pancreatic beta cells will be explored, followed by a discussion on the role of obesity and diabetes in accelerating ageing through induction of premature cell senescence mediated by high glucose (...) Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes is a major risk factor in the development of additional health conditions, such as cardiovascular disease, kidney disease and cancer. Since senescent cells can drive disease development

2018 Biogerontology

19. FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence Full Text available with Trip Pro

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechanisms remain unknown. Here we show, through direct live-cell imaging of young, middle-aged, and old-aged primary human dermal fibroblasts, that aneuploidy increases with aging due to general dysfunction of the mitotic machinery. Increased chromosome mis-segregation (...) in elderly mitotic cells correlates with an early senescence-associated secretory phenotype (SASP) and repression of Forkhead box M1 (FoxM1), the transcription factor that drives G2/M gene expression. FoxM1 induction in elderly and Hutchison-Gilford progeria syndrome fibroblasts prevents aneuploidy and, importantly, ameliorates cellular aging phenotypes. Moreover, we show that senescent fibroblasts isolated from elderly donors' cultures are often aneuploid, and that aneuploidy is a key trigger into full

2018 Nature communications

20. Senescence and aging: Causes, consequences, and therapeutic avenues Full Text available with Trip Pro

secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease. In this regard, recent experimental evidence has shown that the genetic or pharmacological ablation of senescent cells extends life span and improves health span. Here, we review the cellular and molecular links between cellular senescence and aging and discuss the novel therapeutic avenues (...) Senescence and aging: Causes, consequences, and therapeutic avenues Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies. Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory

2018 The Journal of cell biology

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