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1. Lumacaftor/ivacaftor (cystic fibrosis in children aged 2 to 5 years) - Benefit assessment according to §35a Social Code Book V

Lumacaftor/ivacaftor (cystic fibrosis in children aged 2 to 5 years) - Benefit assessment according to §35a Social Code Book V Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Lumacaftor/Ivacaftor (zystische Fibrose bei Kindern zwischen 2 und 5 Jahren) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 13 May 2019). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely (...) authoritative and legally binding. IQWiG Reports – Commission No. A19-13 Lumacaftor/ivacaftor (cystic fibrosis in children aged 2 to 5 years) – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A19-13 Version 1.0 Lumacaftor/ivacaftor (cystic fibrosis in children aged 2 to 5 years) 13 May 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Lumacaftor/ivacaftor

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

2. Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) ? Benefit assessment according to § 35a Social Code Book V

Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) ? Benefit assessment according to § 35a Social Code Book V Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Vandetanib (Schilddrüsenkarzinom) – Nutzenbewertung gemäß § 35a SGB V (Version 1.1; Status: 1 June 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally (...) was to assess the added benefit of vandetanib compared with best supportive care (BSC) as appropriate comparator therapy (ACT) in adolescents and children aged 5 years and older with aggressive and symptomatic medullary thyroid carcinoma (MTC) with unresectable, locally advanced or metastatic disease. Table 2 shows the therapeutic indication to be assessed and the ACT specified by the G-BA for it. Table 2: Research question of the benefit assessment of vandetanib Research question Therapeutic indication

2017 Institute for Quality and Efficiency in Healthcare (IQWiG)

3. Common clinical conditions in aged care (Silver Book)

Common clinical conditions in aged care (Silver Book) RACGP - Silver Book - Part A Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship Fellowship International (...) clinical guide (Silver Book) Silver Book - Part A Silver Book - Part A Search: Last revised: 05 Sep 2019 Common clinical conditions in aged care Introduction Part A: Common clinical conditions in aged care is intended to be used as a point-of-care reference for general practitioners (GPs) in all stages of their careers. It is designed to assist in clinical decision making by presenting a snapshot view of the diagnosis and management of a range of common clinical conditions in aged care. As with all

2019 The Royal Australian College of General Practitioners

4. [Teduglutide (short bowel syndrome patients from the age of 1 year) - assessment according to õ 35a (para. 1, sentence 10) Social Code Book V]

[Teduglutide (short bowel syndrome patients from the age of 1 year) - assessment according to õ 35a (para. 1, sentence 10) Social Code Book V] Teduglutid (für patienten ab dem alter von 1 jahr): bewertung gemäß § 35a abs. 1 satz 10 SGB V; dossierbewertung; auftrag G16-10 [Teduglutide (short bowel syndrome; patients from the age of 1 year) – assessment according to § 35a (para. 1, sentence 10) Social Code Book V] Teduglutid (für patienten ab dem alter von 1 jahr): bewertung gemäß § 35a abs. 1 (...) satz 10 SGB V; dossierbewertung; auftrag G16-10 [Teduglutide (short bowel syndrome; patients from the age of 1 year) – assessment according to § 35a (para. 1, sentence 10) Social Code Book V] Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und

2017 Health Technology Assessment (HTA) Database.

5. [Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) - Benefit assessment according to õ 35a Social Code Book V]

[Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) - Benefit assessment according to õ 35a Social Code Book V] Vandetanib (Schilddrüsenkarzinom): nutzenbewertung gemäß § 35a SGB V; dossierbewertung; auftrag A17-01 [Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) – benefit assessment according to § 35a Social Code Book V] Vandetanib (Schilddrüsenkarzinom): nutzenbewertung gemäß § 35a SGB V; dossierbewertung; auftrag A17 (...) -01 [Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) – benefit assessment according to § 35a Social Code Book V] Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Vandetanib

2017 Health Technology Assessment (HTA) Database.

6. Ageing and mobility: A grand challenge

as a barrier to use and improvement. This results in difficulties for individuals to navigate the systems and weakens system-wide incentives for integration and innovation. On average at least one-third of older people report unmet travel needs. It worsens with age, and women were reported to be more affected than men. (Luiu et al 2016). Mobility challenges faced in later life6 © Centre for Ageing Better 20197 © Centre for Ageing Better 2019 As we grow older, we are more likely to have health conditions (...) % of older people cannot reach a hospital within 30 minutes by public transport. (Future of Mobility: Evidence Review). Accessible and inclusive new technologies, services and business models Opportunities for innovation8 © Centre for Ageing Better 2019 Specific issues to address in their development include: - New vehicles, including Autonomous Vehicles, need to be designed to be accessible for people with limited mobility. - Addressing the door to vehicle portion of the journey, which can

2020 The Centre for Ageing Better

7. Jeffrey Aronson: When I use a word . . . Grimley Evans, geriatrics, gerontology, and geratology

has access to the Shorter Oxford English dictionary whence he has plucked the archaic implication of decadence and impending extinction that he quotes. I could wish that he also had a copy of Collins dictionary from which he would learn that nowadays geratology is ‘the branch of medicine concerned with ageing’. “Dr Alex Comfort pointed out [in The Biology of Senescence , RKP 1956] that while ‘geriatrics’ is a serviceable term for medical practice among old people, ‘gerontology’ is a false coining (...) to inform the professional and enliven the private lives of geratologists.” Here is what Comfort wrote on page 3 of his book , in a footnote to the word “gerontologist”: “I dislike this word, but it is probably too well grown for eradication. It should mean ‘a student of old men’ (γέρων) and gerontology the study of old men. For the study of age itself, the subject of this book, we require geratology (γῆρας), upon which it would be fruitless to insist.” Comfort, better known as the author of The Joy

2018 The BMJ Blog

8. Optical coherence tomography (OCT) for neovascular age-related macular degeneration as well as diabetic retinopathy with macular oedema

Optical coherence tomography (OCT) for neovascular age-related macular degeneration as well as diabetic retinopathy with macular oedema 1 Translation of the key statement of the final report D15-01 Optische Kohärenztomografie bei neovaskulärer altersbedingter Makuladegeneration sowie beim Makulaödem im Rahmen der diabetischen Retinopathie (Version 1.1; Status: 7 July 2017). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English (...) -language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. D15-01 Optical coherence tomography (OCT) for neovascular age-related macular degeneration as well as diabetic retinopathy with macular oedema 1 Extract of final report D15-01 Version 1.1 Optical coherence tomography for maculo- and retinopathy 7 July 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

9. Association between availability of children’s book and the literacy-numeracy skills of children aged 36 to 59 months: secondary analysis of the UNICEF Multiple-Indicator Cluster Surveys covering 35 countries Full Text available with Trip Pro

Association between availability of children’s book and the literacy-numeracy skills of children aged 36 to 59 months: secondary analysis of the UNICEF Multiple-Indicator Cluster Surveys covering 35 countries Stimulating home environments that have children's books, pictures and play toys facilitate caregiver-child interactions and enhance children's development. Although this has been demonstrated in small-scale intervention studies, it is important to document whether book ownership (...) . The main exposure was availability of children's book to the child within household. Analysis considered the survey design, assessed and ranked risk ratios of being on track, adjusting for potential confounders such as child's age (in months), maternal education, household wealth index quintile and area of residence (rural/urban). Ecological analysis was performed using meta-regression after grouping countries by World Bank income groups (low- to high-income).Only half (51.8%) of children from all

2018 Journal of global health

10. The digital age: new approaches to supporting people in later life get online

for different people, at different ages and to different extents. Perception of cognitive ability “I think it makes us seem stupid. This is what you’re frightened of. With people. And you’re not, but it’s a different world. It’s much quicker than we’re used to.” Maybe it appears harder, like to be able to memorise, or maybe it’s the idea that as you get older you shouldn’t really bother so much, that’s somewhere in the brain somewhere, and as I just keep telling myself, ‘It’s not true, never mind how old I (...) About the Centre for Ageing Better About Good Things Foundation This report was written by Jemma Mouland, Senior Programme Manager, based on research conducted by Good Things Foundation (full report available online). We would like to thank James Richardson for his work on this research and Leela Damadoran for her contributions in reviewing the research findings. http://doi.org/10.31077/ageing.better.2018.05a1 © Centre for Ageing Better 2018 Executive summary There are now more people online

2018 The Centre for Ageing Better

11. Clinical Practice Guideline for the Treatment of Depression Across Three Age Cohorts

First Street, NE, Washington, DC 20002-4242. E-mail: cpg@apa.org. APA GUIDELINE FOR THE TREATMENT OF DEPRESSION ii Abstract The American Psychological Association (APA) developed this clinical practice guideline to provide recommendations for the treatment of depressive disorders (including major depression, subsyndromal depression, and persistent depressive disorder). It addresses three developmental cohorts: children and adolescents; general adults; and older adults (ages 60 and over). Ten (...) Across Three Age Cohorts 1 Scope of the Problem 1 Children and Adolescents 2 General Adult Population 11 Older Adult Population 14 The Need for a Clinical Practice Guideline and Decisions about Scope and Goals of the Clinical Practice Guideline 18 The APA Clinical Practice Guideline for the Treatment of the Problem 19 Guideline Purpose and Scope: What the Guideline Does and Does Not Address 23 APA GUIDELINE FOR THE TREATMENT OF DEPRESSION iv Process and Method 26 Vetting and Appointment of Members

2019 American Psychological Association

12. Healthy Ageing in Scotland: the pilot survey

in Older Age in Scotland Volunteering Participation Volunteering Intensity Volunteering and Expectations of Longevity Volunteers are more connected to those around them Volunteering Participation and Enthusiasm About HAGIS Volunteering Participation and Survey Incentives Volunteering Participation and Data Linkage Consents 6. Time and Risk Preferences in Older Persons in Scotland Number of responses 9. Financial Literacy Regression Analyses of Financial Literacy Score and Population Characteristics (...) of ageing) and metabolic diseases. Feifei Bu Dr Feifei Bu is a research fellow at the Faculty of Social Sciences, University of Stirling. Her current r esear ch agenda is focused on the influences of population aging, health and social car e for older people, and health costs etc. She has particular expertise in quantitative methodologies including multilevel modelling, panel methods, structural equation modelling and missing data analysis. Steve Burt Pr ofessor Steve Burt pursues his academic and r

2018 Health Economics Research Unit

13. Management of an Acute Asthma Attack in Adults (aged 16 years and older)

and experience in monitoring acutely ill, asthma patients and are proficient at administering appropriate medications for this. • Every acute hospital admissions unit should have a senior clinical individual who is responsible for ensuring that asthma care across all departments conforms to the Management of an 9 | A National Clinical Guideline | Management of an Acute Asthma Attack in Adults (aged 16 years and older) Acute Asthma Attack in Adults guideline, and to ensure that records and audit processes (...) including using sedation in some cases are also factors linked to asthma deaths. Deaths from asthma, while uncommon, are generally preventable and occur usually 53 deaths 99 discharges from ICU 5,396 inpatients discharges 19,370 attendees in ED Approximately 50,000 asthma attendances to GPOOH services 248,400 patients with non-controlled asthma 460,000 people in the Republic of Ireland with doctor-diagnosed-asthma10 | Management of an Acute Asthma Attack in Adults (aged 16 years and older) | A National

2015 National Clinical Guidelines (Ireland)

14. How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal care in pregnancy vary by socioeconomic status or age of mother?

% CI 4.09-5.96 for age >=40 (6) ? Adverse obstetric outcomes/pregnancy complications o From 47,951 singleton births, women aged 30-34 had 27% higher odds of an obstetric event compared to 25-29 year olds, while women aged 40 and older had 61% higher odds (9); this paper also states that “while women of extremely advanced maternal age face the highest risk as individuals, prevention of maternal and neonatal morbidity How does smoking, alcohol use, folic acid, maternal obesity and timing of antenatal (...) by socioeconomic status or age of mother? KLS Evidence Briefing November 29 th 2017 Question This briefing summarises the evidence on five risk factors in pregnancy (use of alcohol, smoking, maternal obesity, folic acid supplementation and timing of antenatal care) for women of different ages and socioeconomic status (SES), from Jan 2008 to Nov 2017. Key messages ? advanced maternal age (AMA) of 35yrs or older was often associated with an increased risk of stillbirth, low birthweight, preterm birth, Caesarean

2017 Public Health England - Evidence Briefings

15. Improving Quality of Life: Substance Use and Aging

Improving Quality of Life: Substance Use and Aging SUBSTANCE USE IN CANADA 2018 Improving Quality of Life: Substance Use and Aging Foreword by Rita Notarandrea Foreword by Samuel Weiss Introduction Terminology Notes Improving Quality of Life: Substance Use and Aging PRINCIPAL EDITORS Alastair J. Flint, MB, FRCPC, FRANZCP Professor and Vice-Chair, Research, Department of Psychiatry, University of Toronto Senior Scientist, Toronto General Hospital Research Institute Specialist in Geriatric (...) use, as we do in this report, is key to developing new and more tailored strategies for reducing the harms of alcohol and drugs on older adults. Since 2005, the series now known as Substance Use in Canada has highlighted alcohol- and drug-related issues that are in need of greater attention. For this seventh edition, we began with two questions: How can we help people age in a healthy way? and How can we ensure they have the supports they need to sustain a good quality of life in their later years

2018 Canadian Centre on Substance Abuse

16. Book Review: 'Eye Corps: Coming of Age at the DMZ'

Book Review: 'Eye Corps: Coming of Age at the DMZ' Book Review: 'Eye Corps: Coming of Age at the DMZ' | RAND Objective Analysis. Effective Solutions. Site-wide navigation Trending Topics Featured Research Activities Spotlight Commentary: Commentary: By Research Area Drawing upon decades of experience, RAND provides research services, systematic analysis, and innovative thinking to a global clientele that includes government agencies, foundations, and private-sector firms. Who We Work For Work (...) guys getting killed and hurt and brain-fried—I wasn't sure how it would affect me. So I avoided the subject. Still, it bothered me.” This excerpt is from Jack Walker's powerful, insightful and moving Eye Corps: Coming of Age at the DMZ, his self-published book that details his experiences as a recon patrol leader in Vietnam. Walker served from 1964 to 1968—a time when our country's involvement in the conflict escalated dramatically. When Walker volunteered for the Marines in 1964 when he was 22

2018 The RAND blog

17. Books: The Future of the Professions: How Technology Will Transform the Work of Human Experts: Existential Angst in a Digital Age Full Text available with Trip Pro

Books: The Future of the Professions: How Technology Will Transform the Work of Human Experts: Existential Angst in a Digital Age 29074693 2018 11 02 1478-5242 67 664 2017 11 The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract Books: The Future of the Professions: How Technology Will Transform the Work of Human Experts: Existential Angst in a Digital Age. 521 10.3399/bjgp17X693377 Mackintosh William W Coach and Horses Surgery

2017 The British Journal of General Practice

18. Geriatric Books

Geriatric Books Geriatric Books Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Geriatric Books Geriatric Books Aka: Geriatric Books (...) , Geriatric Resources II. Resources: Primary Care Library Recommendations Kane (2013) Essentials Clinical , McGraw-Hill Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Geriatric Books." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in General About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency

2018 FP Notebook

19. Are genetics link to Polycystic ovarian syndrome in women of reproductive age

Are genetics link to Polycystic ovarian syndrome in women of reproductive age Q&A - Are genetics link to Polycystic ovarian syndrome in women of reproductive age - Trip Database NEW! or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing (...) the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Asked 8 Nov 2019 · , Student, US Are genetics link to Polycystic ovarian syndrome in women of reproductive age 1 Please log in to post a reply Your response: Reply Notes about answers If you see something you feel is wrong, don’t criticise (that misses the point of Triple

2019 Trip Community Q&A

20. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

. Racial and Ethnic Differences in Treatment e61 10.2. Sex-Related Issues e61 10.2.1. Women e62 10.2.2. Pregnancy e62 10.3. Age-Related Issues e63 10.3.1. Older Persons e63 10.3.2. Children and Adolescents e64 11. Other Considerations e64 11.1. Resistant Hypertension e64 11.2. Hypertensive Crises—Emergencies and Urgencies e65 11.3. Cognitive Decline and Dementia e68 11.4. Sexual Dysfunction and Hypertension e69 11.5. Patients Undergoing Surgical Procedures e69 12. Strategies to Improve Hypertension (...) , American Academy of Physician Assistants (AAPA), Association of Black Cardiologists (ABC), American College of Preventive Medicine (ACPM), American Geriatrics Society (AGS), American Pharmacists Association (APhA), American Society of Hypertension (ASH), American Society for Preventive Cardiology (ASPC), National Medical Association (NMA), and Preventive Cardiovascular Nurses Association (PCNA). 1.3. Document Review and Approval This document was reviewed by 2 official reviewers nominated by the ACC

2017 American Heart Association

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