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Genital Herpes

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2. Genital Herpes: Gynaecological Aspects

Genital Herpes: Gynaecological Aspects No. 207-Genital Herpes: Gynaecological Aspects - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 7, Pages e105–e111 No. 207-Genital Herpes: Gynaecological Aspects x Deborah Money , MD (Principal Author) Vancouver, BC x Marc Steben , MD (Principal Author) Montréal, QC No. 207, April 2008 DOI: To view the full text, please login as a subscribed user or . Click to view (...) the full text on ScienceDirect. Abstract Objective The purpose of this guideline is to provide recommendations to gynaecology health care providers on optimal management of genital herpes. Outcomes More effective prevention of complications and transmission of genital herpes. Evidence Medline was searched for articles published in French and English related to genital herpes and gynaecology. Additional articles were identified through the references of these articles. All study types and recommendation

2017 Society of Obstetricians and Gynaecologists of Canada

3. Guidelines for the Management of Genital Herpes in New Zealand

Guidelines for the Management of Genital Herpes in New Zealand www.herpes.org.nz GUIDELINES FOR THE MANAGEMENT OF GENITAL HERPES IN NEW ZEALAND 12TH EDITION - 2017 Produced by the Professional Advisory Board (PAB) of the Sexually Transmitted Infections Education FoundationHPV Tollfree 0508 11 12 13 www.hpv.org.nz Health professionals’ resources 1. Guidelines for the Management of Genital, Anal and Throat HPV Infection in New Zealand – 9th Edition 2017 Only available online at www.hpv.org.nz 2 (...) . Sexually Transmitted Infections – Summary of Guidelines 2017 Patient information pamphlets 1. Some Questions and Answers about HPV and Genital Warts 2. Cervical Smears and Human Papillomavirus Infection (HPV) 3. Preventing HPV Cancers by Vaccination: What Everyone Should Know 4. HPV and Men 5. HPV and Throat Cancer: Common Questions and Answers HERPES Tollfree 0508 11 12 13 www.herpes.org.nz Health professionals’ resources 1. Guidelines for the Management of Genital Herpes in New Zealand – 12th Edition

2017 New Zealand Sexual Health Society

4. Interventions for men and women with their first episode of genital herpes. (PubMed)

Interventions for men and women with their first episode of genital herpes. Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical presentation of herpes that a person experiences. Current treatment is based around viral suppression in order to decrease the length and severity of the episode.To determine the effectiveness and safety of the different existing treatments for first-episode genital herpes on the duration (...) ), and the Alternative Medicines Specialised Register (from inception to April 2016). We handsearched a number of relevant journals, searched reference lists of all included studies, databases of ongoing trials, and other Internet databases.We included randomised controlled trials (RCTs) on participants with first-episode genital herpes. We excluded vaccination trials, and trials in which the primary objective assessed a complication of HSV infection.All studies written in English were independently assessed

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2016 Cochrane

5. WHO guidelines for the treatment of Genital Herpes Simplex Virus

WHO guidelines for the treatment of Genital Herpes Simplex Virus WHO GUIDELINES FOR THE Treatment of Genital Herpes Simplex VirusWHO GUIDELINES FOR THE Treatment of Genital Herpes Simplex Virus WHO Library Cataloguing-in-Publication Data WHO guidelines for the treatment of genital herpes simplex virus I.World Health Organization. ISBN 978 92 4 154987 5 Subject headings are available from WHO institutional repository © World Health Organization 2016 All rights reserved. Publications of the World (...) epidemiology and burden 5 Why new guidelines for the prevention, treatment and management of STIs? 5 Approach to the revision of STI guidelines 6 References 8 WHO guidelines for the treatment of genital herpes simplex virus 9 1. Introduction 9 1.1 Epidemiology, burden and clinical considerations 9 Clinical presentation 9 Laboratory diagnosis 10 1.2 Rationale for new recommendations 10 1.3 Objectives 10 1.4 Target audience 10 1.5 Structure of the guidelines 11 2. Methods 12 2.1 Guideline Development Group

2016 World Health Organisation Guidelines

6. Genital Herpes Infection: Serologic Screening

Genital Herpes Infection: Serologic Screening Final Update Summary: Genital Herpes Infection: Serologic Screening - US Preventive Services Task Force Search USPSTF Website Text size: Assembly version: 1.0.0.308 Last Build: 11/16/2018 6:27:19 PM You are here: Final Summary Genital Herpes Infection: Serologic Screening Release Date: November 2016 Recommendation Summary Population Recommendation Grade Asymptomatic adolescents and adults, including those who are pregnant The USPSTF recommends (...) against routine serologic screening for genital herpes simplex virus (HSV) infection in asymptomatic adolescents and adults, including those who are pregnant. To read the recommendation statement in JAMA , select . To read the evidence summary in JAMA , select . ( ) Related Information for Consumers There is no related information for consumers. Related Information for Health Professionals There is no related information for health professionals. Supporting Documents ( ) ( ) Clinical Summary Clinical

2016 U.S. Preventive Services Task Force

8. Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials. (PubMed)

Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials. Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed.A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig model of genital herpes. Three doses (...) of intramuscular (IM) vaccine were provided followed by intravaginal challenge with HSV-2 at either 3 weeks or six months after the last vaccination.Both VC2 and gD2 vaccines reduced acute genital disease. VC2 was somewhat more effective in reducing acute vaginal replication, the amount of virus in neural tissue, subsequent recurrent disease and recurrent virus shedding following challenge at 3 weeks post vaccination. Both vaccines continued to provide protection at 6 months after vaccination

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2019 PLoS ONE

9. Herpes Simplex Virus Shedding Rate: Surrogate Outcome for Genital Herpes Recurrence Frequency and Lesion Rates, and Phase 2 Clinical Trials End Point for Evaluating Efficacy of Antivirals. (PubMed)

Herpes Simplex Virus Shedding Rate: Surrogate Outcome for Genital Herpes Recurrence Frequency and Lesion Rates, and Phase 2 Clinical Trials End Point for Evaluating Efficacy of Antivirals. We tested whether genital herpes simplex virus (HSV) shedding is an appropriate surrogate outcome for the clinical outcome of genital herpes lesions in studies of HSV-2 antiviral interventions.We analyzed prospective data from natural history studies and clinical trials of antiviral agents for HSV-2 in which (...) is an appropriate surrogate outcome for genital herpes lesions because it is in the causal pathway to recurrences.

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2018 Journal of Infectious Diseases

10. Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients. (PubMed)

Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients. Genital herpes is caused by herpes simplex virus 1 (HSV-1) or 2 (HSV-2). Some infected people experience outbreaks of genital herpes, typically, characterized by vesicular and erosive localized painful genital lesions.To compare the effectiveness and safety of three oral antiviral drugs (acyclovir, famciclovir and valacyclovir) prescribed to suppress genital herpes outbreaks in non (...) trials including patients with recurrent genital herpes caused by HSV, whatever the type (HSV-1, HSV-2, or undetermined), with at least four recurrences per year (trials concerning human immunodeficiency virus (HIV)-positive patients or pregnant women were not eligible) and comparing suppressive oral antiviral treatment with oral acyclovir, famciclovir, and valacyclovir versus placebo or another suppressive oral antiviral treatment.Two review authors independently selected eligible trials

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2014 Cochrane

11. How well do antivirals shorten genital herpes pain duration?

How well do antivirals shorten genital herpes pain duration? How well do antivirals shorten genital herpes pain duration? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics How well do antivirals shorten genital herpes pain duration? View/ Open Date 2015-03 Contributor Format Metadata Abstract Q: How well do antivirals (...) shorten genital herpes pain duration? Evidence-based answer: Oral and intravenous (IV) acyclovir each shorten the duration of pain for a first primary outbreak of herpes by about 50%; topical acyclovir shortens it by about 25% (strength of recommendation [SOR]: B, small randomized controlled trials [RCTs] with some methodological flaws). Oral valacyclovir and famcyclovir are equivalent to oral acyclovir. Adding topical acyclovir to oral acyclovir doesn’t produce additional benefit (SOR: B, RCTs

2015 Clinical Inquiries

12. Management of Genital Herpes in Pregnancy

Management of Genital Herpes in Pregnancy Management of Genital Herpes in Pregnancy October 20142 Management of Genital Herpes in Pregnancy Foley E, Clarke E, Beckett VA, Harrison S, Pillai A, FitzGerald M, Owen P , Low-Beer N, Patel R. Guideline date: October 2014 Date of review: by 2018 Guideline development group: Elizabeth Foley MB BS BSc FRCP FRCOG (lead author), Consultant in Genitourinary and HIV Medicine, Solent NHS Trust Emily Clarke BSc BM MSc MRCP (UK), ST3 Genitourinary Medicine (...) , Solent NHS Trust Virginia Beckett MB BS BSc FRCOG (lead author on behalf of RCOG), Consultant Obstetrician and Gynaecologist, Bradford Teaching Hospitals NHS Foundation Trust, Honorary Senior Lecturer, University of Bradford Sam Harrison MRCOG, ST6 Obstetrics and Gynaecology, Bradford Teaching Hospitals NHS Foundation Trust Anil Pillai MRCP, Consultant Neonatologist, Bradford Teaching Hospitals NHS Foundation Trust Mark FitzGerald FRCP, Lead Editor, BASHH guideline on Management of Genital Herpes

2014 Royal College of Obstetricians and Gynaecologists

13. A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model (PubMed)

A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease. Some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. A vaccine was developed (...) that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (VZV), a closely related member of the Herpesviridae family. The success of the VZV vaccine has stimulated renewed interest in a therapeutic vaccine for genital herpes. We have been evaluating a trivalent subunit antigen vaccine for prevention of genital herpes. Here, we assess the trivalent vaccine as immunotherapy in guinea pigs that were previously infected intravaginally with HSV-2. The trivalent vaccine contains HSV

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2017 Human vaccines & immunotherapeutics

14. Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement. (PubMed)

Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement. Herpes simplex virus (HSV) has various presentations, depending on the patient's immune status, age, and the route of transmission. In adults, HSV type 1 is found predominantly in the oral area, and HSV type 2 (HSV-2) is commonly found in the genital area. HSV-2 infection without genital lesions (...) is uncommon. Herein we report a unique case of pharyngotonsillitis as an initial manifestation of disseminated HSV-2 infection without genital involvement.A 46-year-old male was admitted to our hospital with a 1-week history of fever and sore throat. His past medical history included hypereosinophilic syndrome diagnosed at age 45 years. Physical examination revealed throat congestion, bilaterally enlarged tonsils with exudates, tender cervical lymphadenopathy in the left posterior triangle, and mild

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2019 BMC Infectious Diseases

15. Sacral Myeloradiculitis: An Uncommon Complication of Genital Herpes Infection. (PubMed)

Sacral Myeloradiculitis: An Uncommon Complication of Genital Herpes Infection. Herpes simplex virus 1 and 2 infections affect up to 50 million people in the United States, with a natural history of recurrent viral shedding with or without recurrence of symptoms. Although many patients remain asymptomatic or with mild symptoms, a spectrum of rare but significant nervous system complications have been reported. Although urinary retention and constipation associated with genital herpesvirus (...) infections is often attributed to painful genital ulcerations, herpesvirus-associated lumbosacral myeloradiculitis has been reported in adults. Here, we report an 18-year-old man with constipation, urinary retention, perineal paresthesias, and erectile dysfunction in the setting of a genital herpes infection. His workup was notable for a cerebrospinal fluid pleocytosis and MRI with enhancement of the cauda equina and nerve roots, all of which are consistent with sacral myeloradiculitis. The patient

2019 Pediatrics

16. Impact of Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Dual Infection on Female Genital Tract Mucosal Immunity and the Vaginal Microbiome. (PubMed)

Impact of Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Dual Infection on Female Genital Tract Mucosal Immunity and the Vaginal Microbiome. Mechanisms linking herpes simplex virus type 2 (HSV-2) with human immunodeficiency virus (HIV) are not fully defined. We tested the hypothesis that HSV-2 and HIV dual infection is associated with cervicovaginal inflammation and/or vaginal dysbiosis.Genital tract samples were obtained weekly over a 12-week period from 30 women seropositive (...) differences in vaginal microbial alpha diversity (Simpson index) (P = .0046). Specifically, when comparing HIV-1+/HSV-2+ to HIV-1-/HSV-2- women, a decrease in Lactobacillus crispatus and increase in diverse anaerobes was observed. The number of genital HSV outbreaks was greater in HIV+ versus HIV- women (39 versus 12) (P = .04), but there were no significant differences when comparing outbreak to non-outbreak visits.Increased microbial diversity and cervicovaginal inflammation in HIV and HSV-2 dually

2019 Journal of Infectious Diseases

17. Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study. (PubMed)

Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study. We performed a randomized double-blind controlled trial to compare the efficacy and safety of multistrain probiotic and acyclovir in women patients with recurrent genital herpes simplex virus type 2 (HSV-2) infections. Eighty-one patients enrolled in the study were being treated with multistrain Lactobacillus brevis one vaginal capsule (...) , and no side effect of L. brevis are valuable properties of probiotic therapy compared with acyclovir. Therefore, we concluded that multistrain L. brevis could play an important role in suppression of recurrent genital herpes simplex virus infection.

2019 Probiotics and antimicrobial proteins Controlled trial quality: predicted high

18. Herpes simplex - genital

Herpes simplex - genital Herpes simplex - genital - NICE CKS Share Herpes simplex - genital: Summary Genital herpes simplex is a sexually transmitted infection (STI), caused by infection with herpes simplex virus (HSV) 1 or HSV-2, which can cause oral, genital and ocular ulcers. A first episode of genital herpes presents with multiple painful blisters, which quickly burst to leave erosions and ulcers, on the external genitalia (as well as on the cervix, rectum, thighs, and buttocks). Lesions (...) are usually bilateral and develop 4–7 days after exposure to HSV infection. People may complain of dysuria, vaginal or urethral discharge, and systemic symptoms such as fever and malaise. A primary episode can last up to 20 days, and is often more severe than a recurrent episode. Following primary infection, the virus becomes latent in local sensory ganglia. Recurrent genital herpes refers to a recurrence of clinical symptoms due to reactivation of pre-existent HSV infection after a latent period. People

2017 NICE Clinical Knowledge Summaries

19. Genital Herpes

Genital Herpes Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently, provides support for coping with the pressures of resident life, and equips you

2016 Now@NEJM

20. Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement. (PubMed)

Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement. Genital herpes is a prevalent sexually transmitted infection in the United States, occurring in almost 1 in 6 persons aged 14 to 49 years. Infection is caused by 2 subtypes of the herpes simplex virus (HSV), HSV-1 and HSV-2. Antiviral medications may provide symptomatic relief from outbreaks but do not cure HSV infection. Neonatal herpes infection, while uncommon, can result (...) in substantial morbidity and mortality.To update the 2005 US Preventive Services Task Force (USPSTF) recommendation on screening for genital herpes.The USPSTF reviewed the evidence on the accuracy, benefits, and harms of serologic screening for HSV-2 infection in asymptomatic persons, including those who are pregnant, as well as the effectiveness and harms of preventive medications and behavioral counseling interventions to reduce future symptomatic episodes and transmission to others.Based on the natural

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2016 JAMA

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