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Gelatin Hemostatic

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1. Effectiveness of hemostatic gelatin sponge as a packing material after septoplasty: A prospective, randomized, multicenter study. (PubMed)

Effectiveness of hemostatic gelatin sponge as a packing material after septoplasty: A prospective, randomized, multicenter study. Although hemostatic gelatin sponge is a gelatin-based packing material with a powerful hemostatic effect, there were no studies in regard to its efficacy for packing material after septoplasty. The purpose of this study was to investigate the efficacy of hemostatic gelatin sponge nasal packing on patient's subjective symptoms, hemostasis, and wound healing following (...) septoplasty.Seventy six adult patients with nasal septum deviation requiring septoplasty were included. Following surgery, one nasal cavity was packed with hemostatic gelatin sponge and the other one with polyvinyl acetate. Patients' subjective symptoms while the packing was in situ, hemostatic properties, patients' pain on removal, degree of bleeding on removal of the packing, time for hemostasis after removal, postoperative wound healing, and the cost of the pack were evaluated.Both packs were equally effective

2018 Auris, nasus, larynx

2. Use of a gelatin-thrombin hemostatic matrix in obstetrics and gynecological surgery (PubMed)

Use of a gelatin-thrombin hemostatic matrix in obstetrics and gynecological surgery Gelatin-thrombin matrix (GTM) is a hemostatic sealant consisting of bovine-derived gelatin matrix and human-derived thrombin, combining both mechanical and active mechanisms to achieve hemostasis. It was approved by the Food and Drug Administration in 1999. GTM has been used by several surgical specialties; however, it is a possibly an under-used tool in obstetrics and gynecology. A limited number of studies (...) such as fatal or near-fatal thromboembolism and small bowel obstruction. Although GTM is mostly a safe product, it is still not free of complications and risks. In conclusion, although routine use of GTM cannot be recommended due to concerns about its safety, cost, and availability, it may prove useful when conventional hemostatic methods such as suturing and electrocauterization fail or are not appropriate.

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2018 Turkish Journal of Obstetrics and Gynecology

3. Gelatin-thrombin hemostatic matrix in the management of placental site postpartum hemorrhage: a case report. (PubMed)

Gelatin-thrombin hemostatic matrix in the management of placental site postpartum hemorrhage: a case report. Gelatin-thrombin matrix (FloSeal, Baxter Healthcare Corporation, Fremont, California), a biodegradable hemostatic sealant, has been shown to control bleeding in multiple intraoperative scenarios and surgical disciplines. However, limited data is available regarding its use in obstetrics. A case of placental-site obstetric hemorrhage controlled with gelatin-thrombin matrix at time (...) of cesarean delivery is presented.A 28-year-old woman underwent a tertiary repeat cesarean delivery for complete placenta previa. The placenta was removed without evidence of placenta accreta. Profuse bleeding occurred over the placental implantation site, resulting in hemorrhage, uncontrolled by conservative uterine-sparing methods. Upon preparation for emergency hysterectomy, gelatin-thrombin matrix was applied, resulting in rapid control of hemorrhage.Abnormal placentation is a predisposing factor

2017 Journal of Reproductive Medicine

4. Osteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge (PubMed)

Osteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge Bone tissue engineering provides many advantages for repairing skeletal defects. Although many different kinds of biomaterials have been used for bone tissue engineering, safety issues must be considered when using them in a clinical setting. In this study, we examined the effects of using a common clinical item, a hemostatic gelatin sponge, as a scaffold for bone tissue engineering. The use of such a clinically (...) acceptable item may hasten the translational lag from laboratory to clinical studies. We performed both degradation and biocompatibility studies on the hemostatic gelatin sponge, and cultured preosteoblasts within the sponge scaffold to demonstrate its osteogenic differentiation potential. In degradation assays, the gelatin sponge demonstrated good stability after being immersed in PBS for 8 weeks (losing only about 10% of its net weight and about 54% decrease of mechanical strength), but pepsin

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2016 Scientific reports

5. Real-world surgical outcomes of a gelatin-hemostatic matrix in women requiring a hysterectomy: A matched case-control study. (PubMed)

Real-world surgical outcomes of a gelatin-hemostatic matrix in women requiring a hysterectomy: A matched case-control study. The aim of this study was to compare adverse events and surgical outcomes of hysterectomy with or without use of a gelatin-hemostatic matrix (SURGIFLO(®) ).Prospective case-control study (Canadian Task Force classification II2) of total hysterectomy (Piver Type 1) provided by surgeons in Australia between November 2005 and May 2015. Data were collected via (...) SurgicalPerformance, a web-based data project which aims to provide confidential feedback to surgeons about their surgical outcomes. Of 2440 records of women who received a hysterectomy, 1351 were eligible for these analyses; 107 received SURGIFLO(®) hemostatic matrix to prevent postoperative blood loss and 1244 did not.Patients with or without SURGIFLO(®) differed in age, Charlson comorbidity index, and American Society of Anesthesiologists physical status classification system score (ASA), and also differed

2016 Acta Obstetricia et Gynecologica Scandinavica

6. Gelatin Hemostatic

Gelatin Hemostatic Gelatin Hemostatic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Gelatin Hemostatic Gelatin Hemostatic Aka (...) : Gelatin Hemostatic , Topical Gelatin Hemostatic Agent , Gelfoam , Surgifoam II. Indications Small vessel bleeding typically from bone III. Mechanism Gelatin based network traps platelets and s, facilitating clotting Gelatin is absorbant, swelling and compressing small bleeding sites IV. Technique Various forms may be applied to bleeding sites including plugging bleeding open wounds V. Adverse Effects Risk of local infection at application site VI. References Berry in Schrage (2013) s, Medscape

2018 FP Notebook

7. Use of a Gelatin-Thrombin Hemostatic Matrix for Secondary Bleeding After Pediatric Tonsillectomy. (PubMed)

Use of a Gelatin-Thrombin Hemostatic Matrix for Secondary Bleeding After Pediatric Tonsillectomy. Secondary posttonsillectomy bleeding associated with oozing from multiple sites or overcauterized tonsillar bed deserves special evaluation.To evaluate the use of an absorbable, flowable gelatin-thrombin hemostatic matrix (GTHM) sealant for secondary bleeding after tonsillectomy.This was a retrospective data analysis, with information gathered from medical records of pediatric patients (...) of secondary bleeding. All patients except for 1 (41 of 42) were discharged without further bleeding following treatment. No adverse effects were reported.Results suggest that GTHM is generally simple, safe, and effective for use in the treatment of posttonsillectomy secondary bleeding types not associated with a direct vein or artery source but oozing from multiple sites and/or overcauterized tonsillar bed that cannot be stopped by traditional hemostatic methods.

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2016 JAMA otolaryngology-- head & neck surgery

8. Effect on hemostasis of an absorbable hemostatic gelatin sponge after transrectal prostate needle biopsy. (PubMed)

Effect on hemostasis of an absorbable hemostatic gelatin sponge after transrectal prostate needle biopsy. To examine the usefulness of an absorbable hemostatic gelatin sponge for hemostasis after transrectal prostate needle biopsy.The subjects comprised 278 participants who underwent transrectal prostate needle biopsy. They were randomly allocated to the gelatin sponge insertion group (group A: 148 participants) and to the non-insertion group (group B: 130 participants). In group A, the gelatin (...) from the questionnaire did not differ significantly between the two groups. In multivariate analysis, only "insertion of a gelatin sponge into the rectum" emerged as a significant predictor of hemostasis.Insertion of a gelatin sponge into the rectum after transrectal prostate needle biopsy significantly increases hemostasis without increasing patient symptoms, such as pain and a sense of discomfort.

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2015 International braz j urol : official journal of the Brazilian Society of Urology

9. A Gelatin-Thrombin Matrix Topical Hemostatic Agent (Floseal) in Combination With Harmonic Scalpel Is Effective in Patients Undergoing Total Thyroidectomy: A Prospective, Multicenter, Single-Blind, Randomized Controlled Trial. (PubMed)

A Gelatin-Thrombin Matrix Topical Hemostatic Agent (Floseal) in Combination With Harmonic Scalpel Is Effective in Patients Undergoing Total Thyroidectomy: A Prospective, Multicenter, Single-Blind, Randomized Controlled Trial. Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic (...) + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P < .0001) versus the other 3 treatments.Floseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy.© The Author(s) 2015.

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2015 Surgical innovation

10. FDG PET/CT Features of Hemostatic Absorbable Gelatin (Gelfoam) (PubMed)

FDG PET/CT Features of Hemostatic Absorbable Gelatin (Gelfoam) We present the PET/CT findings of hemostatic absorbable gelatin (Gelfoam) in a 41-year-old woman who had hysterectomy and bilateral oophorectomy. CT showed a very low attenuation lesion (-232 HU) in the surgical bed, but PET showed no significant activity.

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2015 Radiology Case Reports

11. Blue-violet light-emitting diode irradiation in combination with hemostatic gelatin sponge (Spongel) application ameliorates immediate socket bleeding in patients taking warfarin. (PubMed)

Blue-violet light-emitting diode irradiation in combination with hemostatic gelatin sponge (Spongel) application ameliorates immediate socket bleeding in patients taking warfarin. The control of bleeding after tooth extraction is a major concern in patients taking warfarin. Light-emitting diode (LED) irradiation with hemostatic gelatin sponge application was investigated.Patients who took warfarin and required tooth extraction were divided randomly into 3 groups. The first group was irradiated (...) with blue-violet LED after tooth extraction. The second group was treated with a hemostatic gelatin sponge and LED irradiation. The third group was treated with only hemostatic gelatin sponges. Hemostasis was evaluated at 30 seconds after treatment.Less than 30% of the patients achieved hemostasis within 30 seconds in the hemostatic sponge group; approximately 50% of the patients in the simple LED irradiation group achieved hemostasis within 30 seconds; and 86.7% of the patients in the LED

2014 Oral surgery, oral medicine, oral pathology and oral radiology

13. Injectable Gelatin utilized as Hemostatic Agent to Stop Pedicle Bleeding in Long Deformity Surgeries - Does it Embolize? (PubMed)

Injectable Gelatin utilized as Hemostatic Agent to Stop Pedicle Bleeding in Long Deformity Surgeries - Does it Embolize? Prospective porcine animal model.Determine if injecting FloSeal into pedicles for hemostasis causes emboli.Bleeding from spinal deformity cases can be substantial, especially when surgical procedures involve bilateral fixation at multiple segments. It is not unusual to observe hemorrhage from vascular pedicles during each step of pedicle screw tract preparation. When multiple (...) fixation points are required, blood loss can be excessive. To minimize estimated blood loss and associated morbidity, surgeons have injected liquefied gelatin into pedicles after drilling, palpating, and/or tapping. FloSeal is one of the most popular commercially available injectable agents and we sought to investigate the potential for embolization when used as an intrapedicular hemostatic agent.Two adult minipigs were anesthetized and underwent sequential bilateral pedicle cannulation from T-spine

2014 Spine

14. Evaluation of the safety and efficacy of a new hemostatic powder using a quantitative surface bleeding severity scale. (PubMed)

Evaluation of the safety and efficacy of a new hemostatic powder using a quantitative surface bleeding severity scale. The safety and efficacy of a hemostatic powder (HP) versus a control agent, absorbable gelatin sponge and thrombin (G + T), were assessed, using a validated, quantitative bleeding severity scale.Subjects were randomized to receive HP (256 subjects) or G + T (132 subjects) for treatment of minimal, mild, or moderate bleeding at 20 investigational sites. The primary efficacy

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2019 Journal of cardiac surgery

15. Floseal hemostatic matrix (Baxter Healthcare Corporation) for hemostasis during tonsillectomy or adenoidectomy

Floseal hemostatic matrix (Baxter Healthcare Corporation) for hemostasis during tonsillectomy or adenoidectomy Floseal hemostatic matrix (Baxter Healthcare Corporation) for hemostasis during tonsillectomy or adenoidectomy Floseal hemostatic matrix (Baxter Healthcare Corporation) for hemostasis during tonsillectomy or adenoidectomy Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation Floseal hemostatic matrix (Baxter Healthcare Corporation) for hemostasis during tonsillectomy or adenoidectomy. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2014 Authors' conclusions Tonsillectomy is one of the most common surgeries in the United States with more than 530,000 procedures performed each year in children younger than 15 years of age. The most common indications for tonsillectomy are chronic infection (tonsillitis) and sleep-disordered breathing

2014 Health Technology Assessment (HTA) Database.

16. Chitosan Pad, Cellulose Membrane, or Gelatin Sponge for Peridural Bleeding: An Efficacy Study on a Lumbar Laminectomized Rat Model (PubMed)

Chitosan Pad, Cellulose Membrane, or Gelatin Sponge for Peridural Bleeding: An Efficacy Study on a Lumbar Laminectomized Rat Model Experimental study in an animal model.This study aims to evaluate the hemostatic properties of four common hemostatic materials including the chitosan clot pad, absorbable gelatin sponge, cellulose membrane, and gauze on peridural bleeding using a rat model.Intraoperative bleeding during spinal surgery can lead to morbidities. Hemostatic materials have been (...) . The overall bleeding volumes for the cellulose membrane, gelatin sponge, and chitosan pad were significantly lower than the overall bleeding volume for gauze.Chitosan clot pads, gelatin sponges, and cellulose membranes have better hemostatic properties than gauze. The chitosan pad had the lowest average bleeding volume, followed by gelatin sponge and cellulose membrane.

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2018 Asian spine journal

17. Autogenous Bone Mixed With Xenograft Versus Xenograft Alone Versus Absorbent Gelatin Sponge

for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Bone Resorption Alveolar Bone Loss Bone Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Diseases Mouth Diseases Stomatognathic Diseases Gelatin Sponge, Absorbable Hemostatics Coagulants (...) Autogenous Bone Mixed With Xenograft Versus Xenograft Alone Versus Absorbent Gelatin Sponge Autogenous Bone Mixed With Xenograft Versus Xenograft Alone Versus Absorbent Gelatin Sponge - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

18. ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation

ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03674684 Recruitment Status : Completed First Posted : September 17, 2018 Last Update Posted : September 19, 2018 Sponsor

2018 Clinical Trials

19. Comparison the efficacy of hemorrhage control of Surgiflo Haemostatic Matrix and absorbable gelatin sponge in posterior lumbar surgery: A randomized controlled study. (PubMed)

Comparison the efficacy of hemorrhage control of Surgiflo Haemostatic Matrix and absorbable gelatin sponge in posterior lumbar surgery: A randomized controlled study. To compare the hemostatic effect of hematostatic agent Surgiflo and absorbable gelatin sponge (AGS) in posterior lumbar surgery.A total of 60 cases were recruited during August 2016 and June 2017 according to the inclusion and exclusion criteria. Patients were randomly allocated to the Surgiflo Haemostatic Matrix (SHM) group (...) were followed up for at least 1 month. The RBC and HCT of the AGS group before operation were lower than those in the control group (P = .039, P = .029), but there was no difference after operation (P >.05). In the control group, 19 cases were successfully hemostatic in 3 minutes, 4 cases were successful in 5 minutes, and 7 cases were combined with hemostasis. In the SHM group, it was 22, 3, and 5 cases respectively. There was significant difference in blood loss during hemostatic process between

2018 Medicine

20. In vitro analysis of growth patterns of invasive fungal species on commonly used endonasal hemostatic agents. (PubMed)

In vitro analysis of growth patterns of invasive fungal species on commonly used endonasal hemostatic agents. Previous studies have not examined the potential role of endonasal hemostatic agents in facilitating growth of fungal species. We aim to determine the possibility of these to serve as a nutrient source for fungal growth.Cultures of Aspergillus, Fusarium, and Mucor were harvested and placed in solution in sterile saline at standardized high and low concentrations. Thrombin gelatin matrix (...) , carboxyl methylcelluose, and potato starch derivative agents were prepared following manufacturer instructions and applied to two separate Petri dishes per agent. Each substrate was then inoculated with either high or low concentrations of fungal species. Negative and positive control plates with each organism were included. Dishes were sealed, incubated, and examined daily for fourteen days for microscopic and macroscopic growth.Thrombin gelatin matrix was relatively resilient to growth, although

2018 American Journal of Otolaryngology

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