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Galantamine

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81. Two galantamine titration regimens in patients switched from donepezil. (Abstract)

Two galantamine titration regimens in patients switched from donepezil. In addition to inhibiting acetylcholinesterase, galantamine has allosteric-modulating activity at nicotinic receptors. This may make galantamine an attractive option for patients starting treatment for Alzheimer's disease (AD), but also for those who have not benefited from their current therapy. This study explored outcomes in subjects with AD transitioning from donepezil because of insufficient tolerability (...) or efficacy.Subjects previously receiving donepezil for mild-to-moderate AD were enrolled in a 12-week randomized, open-label study. After screening and a 7-day washout, subjects were randomly allocated to galantamine fast (8 mg/week increments) or slow (8 mg/4 week) titration to 16-24 mg. Efficacy outcomes included the Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog/11), Mini-Mental State Examination (MMSE), Clinician's Interview-Based Impression of Change - Plus Caregiver's Input (CIBIC-plus

2012 Acta neurologica Scandinavica Controlled trial quality: uncertain

82. Mixed-effect circadian rhythm model for human erythrocyte acetylcholinesterase activity--application to the proof of concept of cholinesterase inhibition by acorn extract in healthy subjects with galantamine as positive control. (Abstract)

Mixed-effect circadian rhythm model for human erythrocyte acetylcholinesterase activity--application to the proof of concept of cholinesterase inhibition by acorn extract in healthy subjects with galantamine as positive control. The aim of this study was to develop a non-linear mixed effect circadian rhythm model of acetylcholinesterase (AChE) activity variation and to evaluate the inhibitory effect of acorn extract (2 g) and galantamine (16 mg), used as positive control, on human AChE in red (...) blood cells (RBC).This was an open-label, randomized, three-way crossover study involving 12 healthy subjects who received one of the treatments in each study period: no treatment, acorn extract, and galantamine. RBC AChE activity was measured in peripheral blood samples collected at 0 (pre-dose), 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16 and 24 h post-dose administration. Non-linear mixed effect modeling was performed using NONMEM (ver. 7.0).The circadian variation of AChE activity was best

2012 European journal of clinical pharmacology Controlled trial quality: uncertain

83. A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI. (Abstract)

A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI. Mild cognitive impairment (MCI) is etiologically heterogeneous, and a substantial proportion of MCI subjects will develop different dementia disorders. One subtype of this syndrome, amnestic MCI, occurs preferentially but not exclusively in prodromal AD and is characterized by defined deficits of episodic memory.For a 2-year, double-blinded, placebo-controlled study MCI patients, presenting (...) with an amnestic syndrome but not necessarily based on presumed prodromal AD were randomized.Patients received (a) a combination of 16 mg galantamine plus 20 mg memantine, or (b) 16 mg galantamine alone or (c) placebo.The primary objective was to explore the differential impact of these interventions on the progression to dementia and on cognitive changes as measured by the ADAScog.After recruitment of 232 subjects, the trial was halted before reaching the planned sample size, because safety concerns arose

2012 The journal of nutrition, health & aging Controlled trial quality: predicted high

84. Quantification of galantamine in human plasma by validated liquid chromatography-tandem mass spectrometry using glimepride as an internal standard: application to bioavailability studies in 32 healthy Korean subjects. Full Text available with Trip Pro

Quantification of galantamine in human plasma by validated liquid chromatography-tandem mass spectrometry using glimepride as an internal standard: application to bioavailability studies in 32 healthy Korean subjects. A simple, rapid and selective liquid chromatography method coupled with tandem mass spectrometry is developed and validated for the quantification of galantamine in human plasma using a commercially available compound, glimepride, as an internal standard (IS). Following simple one (...) -step liquid-liquid extraction by ethyl acetate, the analytes are separated using an isocratic mobile phase consisting of acetonitrile and 0.01M ammonium acetate (95/5, v/v) on a reverse-phase C18 column and analyzed by tandem mass spectrometry in the multiple reaction monitoring mode using the transitions of respective (M + H)(+) ions, m/z 288.22 → 213.20 and m/z 491.17 → 352.30 for the quantification of galantamine and IS, respectively. The standard calibration curves show good linearity within

2012 Journal of chromatographic science Controlled trial quality: uncertain

85. Galantamine, an Acetylcholinesterase Inhibitor and Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors, Attenuates Nicotine Taking and Seeking in Rats. Full Text available with Trip Pro

Galantamine, an Acetylcholinesterase Inhibitor and Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors, Attenuates Nicotine Taking and Seeking in Rats. Current smoking cessation pharmacotherapies have limited efficacy in preventing relapse and maintaining abstinence during withdrawal. Galantamine is an acetylcholinesterase inhibitor that also acts as a positive allosteric modulator of nicotinic acetylcholine receptors. Galantamine has recently been shown to reverse nicotine (...) withdrawal-induced cognitive impairments in mice, which suggests that galantamine may function to prevent relapse in human smokers. However, there are no studies examining whether galantamine administration modulates nicotine self-administration and/or reinstatement of nicotine seeking in rodents. The present experiments were designed to determine the effects of galantamine administration on nicotine taking and reinstatement of nicotine-seeking behavior, an animal model of relapse. Moreover, the effects

2012 Neuropsychopharmacology

86. The effect of galantamine on the blood pressure of the rat. Full Text available with Trip Pro

The effect of galantamine on the blood pressure of the rat. 4380412 1966 11 28 2018 11 13 0366-0826 26 2 1966 Feb British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The effect of galantamine on the blood pressure of the rat. 295-301 Chrusciel M M Varagić V V eng Comparative Study Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Ganglionic Blockers 0 Parasympatholytics 0 Sympatholytics 0D3Q044KCA Galantamine IM Adrenalectomy Animals Blood Pressure drug (...) effects Female Galantamine pharmacology Ganglionic Blockers pharmacology Male Parasympatholytics pharmacology Rats Sympatholytics pharmacology 1966 2 1 1966 2 1 0 1 1966 2 1 0 0 ppublish 4380412 PMC1510659 J Physiol. 1948 Mar 15;107(2):162-4 16991795 Br J Pharmacol Chemother. 1964 Aug;23:34-42 14206267 J Physiol. 1953 Jan;119(1):43-57 13035716 Br J Pharmacol Chemother. 1964 Aug;23:80-9 14206271 Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;230(5):448-56 13526758 J Pharmacol Exp Ther. 1962 Jan

1966 British journal of pharmacology and chemotherapy

87. Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition

Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Galantamine (...) Study Details Study Description Go to Brief Summary: Galantamine Hydrobromide Tablets, Bioequivalence study of Dr. Reddy's under Fed condition. Condition or disease Intervention/treatment Phase Fed Drug: Reminyl Phase 1 Detailed Description: Comparative, Randomized, Single-Dose, 2-way Crossover Bioavailability Study of Dr.Reddy's Laboratories, ltd. and Janssen Pharmaceutical Products, l.P. (Reminyl®)4 mg Galantamine HBr Tablets in Healthy Adult Male Volunteers under Fed Conditions Study Design Go

2011 Clinical Trials

88. Galantamine Bioequivalence Study of Dr. Reddy's Under Fasting Condition

Galantamine Bioequivalence Study of Dr. Reddy's Under Fasting Condition Galantamine Bioequivalence Study of Dr. Reddy's Under Fasting Condition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Galantamine (...) Limited Study Details Study Description Go to Brief Summary: Galantamine Hydrobromide Tablets, Bioequivalence study of Dr. Reddy's under Fasting condition. Condition or disease Intervention/treatment Phase Fasting Drug: Reminyl Phase 1 Detailed Description: Comparative, Randomized, Single-Dose. 2-way Crossover Bioavailability Study of Dr.Reddy's laboratories, ltd. and Janssen Pharmaceutical Products. L.P. (Reminyte®)4 mg Galantamine HBr Tablets In Healthy Adult Male Volunteers under fasting Conditions

2011 Clinical Trials

89. Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment

Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment (COGICRehab) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01508494 Recruitment Status : Unknown Verified April 2015 by Institut National de la Santé Et de la Recherche Médicale, France. Recruitment status was: Recruiting

2011 Clinical Trials

90. Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil

Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01478633

2011 Clinical Trials

91. Galantamine Effects on Nicotine Responses in Smokers

Galantamine Effects on Nicotine Responses in Smokers Galantamine Effects on Nicotine Responses in Smokers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Galantamine Effects on Nicotine Responses in Smokers (...) University Study Details Study Description Go to Brief Summary: This will be a 2-4 week double-blind, placebo-controlled study. Twenty four male and female smokers will first have two 4-day treatment periods, in which they will be randomized to galantamine (8 mg/day) or placebo. These treatment periods will be separated by a 3 to 14 day washout period. During the first 3-days of each treatment period, smokers will have daily clinic visits, where they will receive study medications and any adverse effects

2011 Clinical Trials

92. Galantamine Alleviates Inflammation and Other Obesity-Associated Complications in High-Fat Diet–Fed Mice Full Text available with Trip Pro

Galantamine Alleviates Inflammation and Other Obesity-Associated Complications in High-Fat Diet–Fed Mice Obesity, a serious and growing health threat, is associated with low-grade inflammation that plays a role in mediating its adverse consequences. Previously, we have discovered a role for neural cholinergic signaling in controlling inflammation, and demonstrated that the cholinergic agent galantamine suppresses excessive proinflammatory cytokine release. The main objective of this study (...) was to examine the efficacy of galantamine, a clinically-approved drug, in alleviating obesity-related inflammation and associated complications. After 8 wks on a high-fat diet, C57BL/6J mice were treated with either galantamine (4 mg/kg, intraperitoneally [i.p.]) or saline for 4 wks in parallel with mice on a low-fat diet and treated with saline. Galantamine treatment of obese mice significantly reduced body weight, food intake, abdominal adiposity, plasma cytokine and adipokine levels, and significantly

2011 Molecular Medicine

93. Galantamine augmentation of long-acting injectable risperidone for cognitive impairments in chronic schizophrenia. (Abstract)

Galantamine augmentation of long-acting injectable risperidone for cognitive impairments in chronic schizophrenia. Galantamine, a reversible cholinesterase inhibitor with effects on nicotinic receptors, has shown mixed effects on cognitive impairments in patients with schizophrenia. Given these mixed results we examined whether galantamine compared to adjunctive placebo may improve cognitive functions in patients treated concomitantly with a long acting atypical antipsychotic.The parent study (...) was a 52-week double-blind, randomized study of treatment with long-acting injectable risperidone 25mg or 50mg every two weeks. Adjunctive galantamine or placebo treatment was administered from Month 6 to 12. Outcome measures were neurocognitive, psychopathology, social and quality of life functions. Patients were randomized to blinded galantamine up to 24mg/day or matching placebo tablets. All patients were maintained on their randomized long-acting injectable risperidone regimen for the duration

2011 Schizophrenia research Controlled trial quality: uncertain

94. Effects of galantamine in Alzheimer's disease: double-blind withdrawal studies evaluating sustained versus interrupted treatment. (Abstract)

Effects of galantamine in Alzheimer's disease: double-blind withdrawal studies evaluating sustained versus interrupted treatment. To evaluate the effects of galantamine withdrawal, and compare this with uninterrupted therapy, two 6-week double-blind withdrawal studies (Studies 1 and 2) were performed. These enrolled individuals who had completed one of two 3- or 5-month randomized clinical trials (parent trials) involving patients with mild to moderate Alzheimer's disease (AD). In Study 1 (GAL (...) -USA-11; n'723), patients continuously treated with galantamine 16 mg/day exhibited a mean (± standard error [SE]) improvement in 11-item cognitive subscale of the Alzheimer's Disease Assessment Scale score of 1.8 (± 0.46) points at Week 6 compared with the parent trial baseline, (p < 0.001 vs placebo; observed cases analysis). Over the same period, patients switched from galantamine to placebo and those who had received continuous placebo, exhibited mean (± SE) deteriorations of 0.7 (± 0.49

2011 Current Alzheimer research Controlled trial quality: uncertain

95. Long-term effects of galantamine on cognitive function in Alzheimer's disease: a large-scale international retrospective study. Full Text available with Trip Pro

Long-term effects of galantamine on cognitive function in Alzheimer's disease: a large-scale international retrospective study. In Alzheimer's disease (AD), it is important to consider long-term effects, not only in patients receiving treatment, but also in subjects in whom therapy has been discontinued. The present analysis evaluates the long-term effects of galantamine on cognitive function in AD in terms of Mini-Mental State Examination (MMSE) scores for up to 7 years, using both clinical (...) data and epidemiological modeling. Consideration is given not only to patients continuing to receive galantamine therapy, but also to those who stop this treatment. In a retrospective review of medical notes, re-contacted study investigators obtained data from 258 patients originally recruited into three previously described randomized clinical trials involving galantamine: two placebo-controlled trials in mild-to-moderate AD (of 3 and 6 months' duration, followed by open-label extensions

2011 Journal of Alzheimer's disease : JAD Controlled trial quality: uncertain

96. Cessation versus continuation of galantamine treatment after 12 months of therapy in patients with Alzheimer's disease: a randomized, double blind, placebo controlled withdrawal trial. Full Text available with Trip Pro

Cessation versus continuation of galantamine treatment after 12 months of therapy in patients with Alzheimer's disease: a randomized, double blind, placebo controlled withdrawal trial. Galantamine improved symptoms in Alzheimer's disease (AD) patients after 5 to 6 months of treatment. To examine long-term outcomes, this study assessed if continuing of galantamine treatment beyond 12 months delayed further cognitive deterioration. It consisted of two phases: an open label (OL) phase (12 months (...) ), followed by a double blind, randomized, placebo controlled withdrawal phase (up to 24 months). Subjects with mild to moderate AD were included in the study and titrated up to 16 mg/day of galantamine. Subjects were eligible to enter the double blind phase if a cognitive decline of <4 points on AD Assessment Scale-cognitive subscale (ADAS-cog)/11 was recorded at the end of the OL phase. The differences between galantamine and placebo in time to dropout were estimated using the Cox proportional hazard

2011 Journal of Alzheimer's disease : JAD Controlled trial quality: predicted high

97. Development and in vivo evaluation of novel monolithic controlled release compositions of galantamine hydrobromide as against reservoir technology. (Abstract)

Development and in vivo evaluation of novel monolithic controlled release compositions of galantamine hydrobromide as against reservoir technology. The objective of this study is to develop and in vivo evaluation of novel monolithic matrix mini tablets approach to control the release of galantamine hydrobromide (GAH) in comparison with desired release profile to the Innovator formulation Razadyne(®) ER capsules. The direct compression method was employed for preparation of matrix mini tablets

2011 Pharmaceutical development and technology Controlled trial quality: uncertain

98. Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients. (Abstract)

Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients. The effects of galantamine (16 to 24 mg/day) treatment on brain functional activities (blood flow and glucose metabolism) were examined in 18 patients with mild Alzheimer's disease (AD) in relation to brain acetylcholinesterase (AChE) activity and nicotinic receptors and cognitive function. The study consisted of an initial double-blind phase of three months (short-term (...) patient in order to follow changes in cognition during the treatment period. Throughout the study, different cortical areas showed significant increases in rCBF after galantamine treatment. rCBF positively correlated with AChE activity, nicotinic receptors and cognition. In addition to these positive changes, an increase in rCMRglc in the frontal brain region and stabilization in other cortical areas was observed after 12 months galantamine treatment. This stabilization in rCMRglc was also correlated

2011 Journal of Alzheimer's disease : JAD Controlled trial quality: uncertain

99. Galantamine improves sustained attention in chronic cocaine users. Full Text available with Trip Pro

Galantamine improves sustained attention in chronic cocaine users. Chronic cocaine users are known to have cognitive deficits that are predictive of poor treatment response. Whether these deficits improve with medications targeting specific cognitive functions has not been examined in previous studies. The goal of this study was to evaluate galantamine's efficacy on selected cognitive outcomes, including measures of sustained attention, response inhibition, and attentional bias in recently (...) abstinent cocaine users. Galantamine, a reversible and competitive inhibitor of acetylcholinesterase, is used clinically in the treatment of Alzheimer's dementia. In a randomized, double-blind, parallel-group study, 34 participants were randomized to galantamine (8 mg/day) or placebo treatment for 10 days. Cognitive and self-report mood measures were obtained at baseline and on Days 5 and 10 after the initiation of treatment. Galantamine treatment, compared to placebo, improved the reaction time, F(2

2011 Experimental and clinical psychopharmacology Controlled trial quality: uncertain

100. Effects of galantamine on cocaine use in chronic cocaine users. Full Text available with Trip Pro

Effects of galantamine on cocaine use in chronic cocaine users. 21477060 2011 08 23 2018 12 01 1521-0391 20 3 2011 May-Jun The American journal on addictions Am J Addict Effects of galantamine on cocaine use in chronic cocaine users. 302-3 10.1111/j.1521-0391.2011.00130.x Sofuoglu Mehmet M Carroll Kathleen M KM eng K02 DA021304-02 DA NIDA NIH HHS United States K05-DA00457 DA NIDA NIH HHS United States P50 DA009241 DA NIDA NIH HHS United States K05 DA000457 DA NIDA NIH HHS United States P50 (...) -DA009241 DA NIDA NIH HHS United States K02 DA021304 DA NIDA NIH HHS United States 02-DA021304 DA NIDA NIH HHS United States Letter Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. 2011 03 17 England Am J Addict 9208821 1055-0496 0 Cholinesterase Inhibitors 0 Delayed-Action Preparations 0D3Q044KCA Galantamine UC6VBE7V1Z Methadone IM Adult Cholinesterase Inhibitors adverse effects therapeutic use Cocaine-Related Disorders drug therapy therapy

2011 The American Journal on Addictions Controlled trial quality: uncertain

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