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181. Serotonergic and cholinergic modulation of functional brain connectivity: A comparison between young and older adults. Full Text available with Trip Pro

) and the acetylcholinesterase inhibitor galantamine (8 mg) was measured in 12 young and 17 older volunteers during a randomized, double blind, placebo-controlled, crossover study. A powerful dataset consisting of 522 RS-fMRI scans was obtained by acquiring multiple scans per subject before and after drug administration. Group × treatment interaction effects on voxelwise connectivity with ten functional networks were investigated (p < .05, FWE-corrected) using a non-parametric multivariate analysis technique (...) with cerebrospinal fluid, white matter, heart rate and baseline measurements as covariates. Both groups showed a decrease in sensorimotor network connectivity after citalopram administration. The comparable findings after citalopram intake are possibly due to relatively similar serotonergic systems in the young and older subjects. Galantamine altered connectivity between the occipital visual network and regions that are implicated in learning and memory in the young subjects. The lack of a cholinergic response

2018 NeuroImage Controlled trial quality: uncertain

182. Touchscreen Technology and Art for People With Dementia in Care Homes

, Icchp 2016, Pt I, 9758, 509-514. doi:10.1007/978-3-319-41264-1_69 Mihailidis, A., Blunsden, S., Boger, J., Richards, B., Zutis, K., Young, L., & Hoey, J. (2010). Towards the development of a technology for art therapy and dementia: Definition of needs and design constraints. The Arts in Psychotherapy, 37(4), 293-300. NICE. (2011). Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease. Retrieved from Smith, S. K. (2015

2018 Clinical Trials

183. ANAVEX2-73 Study in Parkinson's Disease Dementia

, dopamine agonists, MAO-B inhibitors, or the COMT inhibitor entacapone), which has been stable for at least 4 weeks prior to Baseline. Treatment with cholinesterase inhibitor (rivastigmine, donepezil and galantamine (Exelon®, Aricept®, or Reminyl®) will be permitted, provided the dose has been stable for a minimum of 8 weeks prior to randomization. Subjects with history of depression on antidepressant medications will be allowed if depression is controlled and they have been on a stable daily dose

2018 Clinical Trials

184. Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy Full Text available with Trip Pro

, among which galantamine is the only naturally occurring substance. However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs. Therefore, this mini-review aimed to recapitulate last decade studies on the anti-AChE activity of plant species, their respective extracts, as well as isolated compounds. The anti-AChE activity of extracts prepared from 54

2018 Frontiers in pharmacology

185. Identification of the optimal cognitive drugs among Alzheimer’s disease: a Bayesian meta-analytic review Full Text available with Trip Pro

Identification of the optimal cognitive drugs among Alzheimer’s disease: a Bayesian meta-analytic review The increasing prevalence of Alzheimer's disease (AD) demands more effective drugs, which are still unclear. The aim of this study is to compare the effectiveness of six drugs, such as donepezil, rivastigmine, galantamine, memantine, huperzine-A, and tacrine, in senior AD patients and identify the most effective one to improve patients' cognitive function.A system of search strategies (...) the trials included.Among the 35 trials included, no obvious heterogeneity (I2=0.0%, P=0.583) was revealed according to the pooled data for cognition in NMA and the mean difference (MD) of memantine (MD=1.7, 95% CI: 0.73, 2.8) showed that the memantine was significantly efficacious in the treatment group in terms of MMSE. Followed by galantamine, huperzine-A, rivastigmine, tacrine, and donepezil.As the first NMA comparing the major drugs in market for AD, our study suggests that memantine might have

2018 Clinical interventions in aging

186. Strategies for Continued Successful Treatment in Patients with 
Alzheimer’s Disease: An Overview of Switching Between Pharmacological Agents Full Text available with Trip Pro

Strategies for Continued Successful Treatment in Patients with 
Alzheimer’s Disease: An Overview of Switching Between Pharmacological Agents Alzheimer's disease (AD) is the most common cause of dementia, characterized by a progressive decline in cognition and function. Current treatment options for AD include the cholinesterase inhibitors (ChEIs) donepezil, galantamine, and rivastigmine, as well as the N-methyl-Daspartate receptor antagonist memantine. Treatment guidelines recommend the use

2018 Current Alzheimer research

187. In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease Full Text available with Trip Pro

, and Salvadorin showed least binding energy and highest binding affinity among all the scrutinized compounds. Post-docking analyses showed the following free energy change for Albiziasaponin-A, Salvadorin, and Iso-Orientin (-9.8 to -15.0 kcal/mol) as compared to FDA approved drugs (donepezil, galantamine, and rivastigmine) for AD (-6.6 to -8.2 Kcal/mol) and interact with similar amino acid residues (Pro-266, Asp-344, Trp-563, Pro-568, Tyr-103, Tyr-155, Trp-317, and Tyr-372) with the target proteins

2018 Frontiers in pharmacology

188. Anti-Dementia Drugs for Psychopathology and Cognitive Impairment in Schizophrenia: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

effects model.We identified 37 studies (n=1,574): 14 donepezil-based (n=568), 10 galantamine-based (n=371), 4 rivastigmine-based (n=146), and 9 memantine-based (n=489) studies. Pooled ADD+AP treatments were superior to placebo+AP in improving the overall symptoms (24 studies, 1,069 patients: standardized mean difference [SMD]=-0.34, 95% confidence interval [CI]=-0.61 to -0.08, P=0.01), negative symptoms (24 studies, 1,077 patients: SMD=-0.62, 95% CI=-0.92 to -0.32, Pcorrected=0.00018), and MMSE scores

2018 International Journal of Neuropsychopharmacology

189. An update on the safety of current therapies for Alzheimer’s disease: focus on rivastigmine Full Text available with Trip Pro

An update on the safety of current therapies for Alzheimer’s disease: focus on rivastigmine Alzheimer's disease (AD) is the most common cause of major neurocognitive disorders worldwide. Despite all research efforts, therapeutic options for AD are still limited to two drug classes: cholinesterase inhibitors (ChEIs) and the NMDA-receptor antagonist memantine. Donepezil, rivastigmine and galantamine are the three ChEIs FDA-approved as first-line treatment for AD. Although they share the same

2018 Therapeutic advances in drug safety

190. Symptomatic Treatment of Vascular Cognitive Impairment (STREAM-VCI): Protocol for a Cross-Over Trial Full Text available with Trip Pro

with vascular damage to the cholinergic system will in turn respond to a cholinergic challenge.The STREAM-VCI is a single center, double blind, three-way cross-over trial among 30 people with VCI, in which subjects received a single dose of galantamine, methylphenidate, or placebo on separate occasions. The most important inclusion criteria were a diagnosis of VCI with a Mini-Mental State Examination score of ≥16 and a Clinical Dementia Rating of 0.5-1.0. For each person, the challenges consisted (...) of a single 16 mg dose of galantamine, 10 mg of methylphenidate, and placebo, in random order on three separate visits. Change in performance in executive functioning and memory was assessed directly after the challenge using standardized neuropsychological tests. We will correlate a positive response to the cholinergic and monoaminergic treatment with differences in structural and functional connectivity at baseline using structural magnetic resonance imaging (MRI), diffusion tension MRI, and resting

2018 JMIR Research Protocols Controlled trial quality: uncertain

191. What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink Full Text available with Trip Pro

their first prescription for each drug class-namely, acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, galantamine) and N-methyl-D-aspartate (NMDA) receptor antagonists (memantine). Trend analysis using joinpoint models was then applied to identify up to two trend changes per treatment of interest.The overall trend was for increasing prescriptions in each drug class over the period in which they were studied. This was indicated by the average monthly percentage change, which was 6.0% (95

2018 Alzheimer's research & therapy

192. Safety, and Efficacy of a New Buccal Film of Montelukast in Patients With Mild to Moderate Alzheimer's Disease

will undergo screening assessments to determine eligibility. This study will enroll patients who are ≥50 years of age with mild to moderate Alzheimer's Disease and on a stable treatment of donepezil, rivastigmine or galantamine for ≥3 months. Patients will be randomized (using a balanced block randomization schedule) to one of two treatment groups: Group A: 10-mg Montelukast buccal film Group B: Matching placebo buccal film In addition to the global NTB composite, patients will also be evaluated using (...) Healthy Volunteers: No Criteria Inclusion Criteria: Mild to moderate Alzheimer's Disease. MMSE score of 14 - 22 CT or MRI within 18 months prior to screening indicating clinical phenotype of Alzheimer's Disease Treated daily with donepezil, rivastigmine or galantamine for ≥ 3 months All other medications for chronic conditions should have been at a stable dose for at least 2 weeks prior to first dose. No clinically meaningful abnormalities on electrocardiogram (ECG), physical examination and clinical

2018 Clinical Trials

193. Open-label, PK and Safety Study in Mild-to-moderate Alzheimer's Disease Patients

at home, senior residential setting, or an institutional setting without the need for continuous (i.e. 24-h) nursing care General health status acceptable for participation in the study Fluency (oral and written) in English or Spanish If receiving memantine, rivastigmine, galantamine or an AChEI, receiving a stable dose for at least 3 months (90 days) before screening and with continuous dosing for at least 3 months. If receiving donepezil, receiving any dose lower than 23 mg once daily. The patient

2018 Clinical Trials

194. Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition

(Aricept), Galantamine (Reminyl), Rivastigmine (Exelon), Tacrine (Cognex), Bethanechol (Urecholine), Memantine (Namenda) Selegiline (Eldepryl) or any other medication for cognitive impairment. Subject has a known sensitivity to the study product. Individual has a condition the chief investigator believes would interfere with his or her ability to provide informed consent, comply with the study protocol, might confound the interpretation of study results or put the subject at undue risk. Contacts

2018 Clinical Trials

195. Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL)

the patients. The main objective of the SOS trial is to demonstrate that the benefit of CI at the early phase of dementia is the same as at the later phase. Condition or disease Intervention/treatment Phase Alzheimer Disease Cholinesterase Inhibitors Drug: cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine) Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 1205 participants Allocation: Randomized (...) Experimental: Group randomized for continuing treatment Group who continues the cholinesterase inhibitors (CI). The treatment is one of the CI (donepezil, galantamine or rivastigmine) with market authorization and commercialized for more than 15 years in France. The choice of the treatment will be done by the specialist according to his habits; the specialist will monitor the treatment as usual. All randomised patients will then be followed-up for two years with regular assessment of judgment criteria

2018 Clinical Trials

196. Quality of the Management of Diabetes in Elderly People With Dementia in France

by the National Library of Medicine related topics: related topics: resources: Groups and Cohorts Go to Group/Cohort Intervention/treatment Case : ADRS group Incidence analysis in ADRS group defined by the first recording of one of the following criteria: (i) LTD registration for ADRS (ICD-10 codes: "F00-F03", "G30", or "G31"), (ii) hospital stay reporting a diagnosis code of ADRS (similar ICD-10 codes) or (iii) reimbursement for at least one acetylcholinesterase inhibitor (rivastigmine, galantamine

2018 Clinical Trials

197. ADvance II Study: DBS-f in Patients With Mild Alzheimer's Disease

caregiver or other appropriate knowledgeable informant who can reliably report on daily activities and function and signs the informed consent for participation as such. Patient must be a good surgical candidate for placement of a deep brain stimulator as judged by the DBS surgical team. Fluency (oral and written) in the language in which standardized tests will be administered. The patient is taking a stable dose of cholinesterase inhibitor (AChEI) medication (donepezil, galantamine, or rivastigmine

2018 Clinical Trials

198. DHA Brain Delivery Trial

in the last 3 months > 200 mg/day of DHA consumption using a validated questionnaire Use of donepezil, rivastigmine, galantamine and/or memantine Alcohol or drug abuse A concomitant serious disease such as active cancer treatment or HIV. Participation in a clinical trial in the last 30 days Use of anticoagulants such as Plavix or Coumadin or the newer generation blood thinners. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor

2018 Clinical Trials

199. Examining the Effects of One-Month Probiotic Treatment on Mental Fatigue

, dabigatran, ticagrelor non-steroidal anti-inflammatory drugs (NSAIDS; excluded only for daily use) over-the-counter sleep medication (not categorized as sedatives, hypnotics or anti-depressants) anti-cholinergic drugs or acetylcholinesterase inhibitors: bethanechol (Urecholine), donepezil (Aricept), rivastigmine (Exelon), galantamine (Reminyl), neostigmine (Prostigmin) anti-histamines that cause drowsiness (eg. Ranitidine) pseudoephedrine and phenylephrine Currently taking (from day of screening onwards

2018 Clinical Trials

200. New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship Full Text available with Trip Pro

the excellent activity with IC50 values of 0.11-0.76 μM and high selectivity toward AChE relative to butyrylcholinesterase (BChE), superior to galantamine (IC50 = 0.79 μM), a selective AChE inhibitor drug. Kinetic analysis showed that the action mechanisms of both compounds B and A are a competitive inhibition model. Structure-activity relationship analyses showed that the C = N+ moiety is a determinant for the activity. Substituents at 6, 7 or 4' site, the indole-N-alkyl and the aromatization of the C-ring

2018 Scientific reports

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