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Galactorrhea

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1. Hyperprolactinemia with Galactorrhea Due to Subclinical Hypothyroidism: A Case Report and Review of Literature Full Text available with Trip Pro

Hyperprolactinemia with Galactorrhea Due to Subclinical Hypothyroidism: A Case Report and Review of Literature Hyperprolactinemia is a common finding in primary hypothyroidism, but increased prolactin in the setting of subclinical hypothyroidism (SCH) has been scarcely reported in the literature. This is a rare case of hyperprolactinemia due to SCH that resolved with thyroid hormone replacement therapy. The patient was not on any medications known to cause hyperprolactinemia but she was using (...) isoniazid for her latent tuberculosis. Isoniazid therapy may explain breast pain, but there is no reported relationship between isoniazid use causing subclinical hypothyroidism and hyperprolactinemia. A literature review reveals that few cases of galactorrhea associated with subclinical hypothyroidism have been reported. Similar to the reported cases in the literature, our patient's thyroid stimulating hormone (TSH) and prolactin levels returned to normal with levothyroxine therapy.

2018 Cureus

2. Galactorrhea Probably Related with Switching from Osmotic-release Oral System Methylphenidate (MPH) to Modified-release MPH: An Adolescent Case Full Text available with Trip Pro

Galactorrhea Probably Related with Switching from Osmotic-release Oral System Methylphenidate (MPH) to Modified-release MPH: An Adolescent Case Galactorrhea, as an adverse effect of psychotropic medications, usually develops due to high dose of antipsychotics. Selective serotonin reuptake inhibitors (SSRIs) have also been reported to be related to galactorrhea. To the best of our knowledge, no previous study reported galactorrhea with methylphenidate (MPH) use. Hereby, we report a case (...) of an adolescent girl who developed galactorrhea after increasing his modifed-release oral MPH to 50 mg/day while under treatment of sertraline and very low dose haloperidol.

2017 Clinical Psychopharmacology and Neuroscience

3. Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine Full Text available with Trip Pro

Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further (...) by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment.

2017 Clinical Psychopharmacology and Neuroscience

4. An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient? Full Text available with Trip Pro

An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient? A female hemodialysis patient with galactorrhea due to hyperprolactinemia was treated with different dialysis modalities to assess the effect on prolactin levels. A single session of both high-flux hemodialysis and hemodiafiltration resulted in decreased prolactin levels (16,6% and 77,2%, resp.). However, baseline prolactin levels measured immediately before (...) the next dialysis session did not change markedly. After cabergoline treatment was started, prolactin levels normalized and galactorrhea disappeared. Thus, dopaminergic inhibition of prolactin secretion might be reduced in patients with end-stage renal disease. This dopaminergic resistance could be an important mechanism of hyperprolactinemia in hemodialysis patients and its subsequent treatment strategies.

2017 Case reports in nephrology

5. Galactorrhoea of the neck following pectoralis major reconstruction of a pharyngeal defect Full Text available with Trip Pro

Galactorrhoea of the neck following pectoralis major reconstruction of a pharyngeal defect We describe a case of postoperative galactorrhea following the use of a pedicled pectoralis major myocutaneous flap for reconstruction of a pharyngolaryngeal defect in a woman with squamous cell carcinoma. We believe this to be unique in the literature, and an important complication to be reported, due to the similarities in appearance of galactorrhoea and postoperative aerodigestive tract/cutaneous

2017 Annals of the Royal College of Surgeons of England

6. Galactorrhea

not associated with childbirth (C0235660) Concepts Disease or Syndrome ( T047 ) MSH ICD9 611.6 ICD10 SnomedCT 78622004 , 198115002 French GALACTORRHEE , Allaitement non puerpéral , Galactorrhée non liée à la naissance , Galactorrhée chez la femme , Lactation non puerpérale , LACTATION NON PUERPERALE , Galactorrhée English Galactorrhea not associated with childbirth , GALACTORRHEA , GALACTORRHOEA , LACTATION NONPUERPERAL , Inappropriate milk production , nonpuerperal galactorrhea , nonpuerperal galactorrhea (...) (diagnosis) , Galactorrhea - non-obstetric , Galactorrhoea - non-obstetric , Galactorrhea female , Lactation non-puerperal , Lactation nonpuerperal , Galactorrhea-nonobstet , Nonpuerperal galactorrhea , Galactorrhoea female , Galactorrhea , Galactorrhoea , Inappropriate lactation , Inappropriate production of milk , Milk from non-pregnant breast , Galactorrhoea not associated with childbirth , Galactorrhea due to non-obstetric cause , Galactorrhoea due to non-obstetric cause , Galactorrhea due to non

2018 FP Notebook

7. Acute myeloid leukemia presenting as galactorrhea Full Text available with Trip Pro

Acute myeloid leukemia presenting as galactorrhea Acute myeloid leukemia (AML) presents with symptoms related to pancytopenia (weakness, infections, bleeding diathesis) and organ infiltration with leukemic cells. Galactorrhea is an uncommon manifestation of AML. We report a case of AML presenting with galactorrhea.

2016 Proceedings (Baylor University. Medical Center)

8. A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism Full Text available with Trip Pro

A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism Graves' hyperthyroidism has a various number of well-recognized manifestations. Galactorrhea is a rare manifestation in this disease. We describe a 33-year-old man who presented with the symptoms of hyperthyroidism, gynaecomastia, and galactorrhea for 2 months. Physical examination revealed goitre, gynaecomastia, and galactorrhea, bilaterally. Laboratory investigations demonstrated high free (...) thyroxine with suppressed thyroid-stimulating hormone level together with elevated anti-TSH receptor; therefore, the diagnosis of Graves' disease was confirmed. Other investigations to elucidate the etiology of galactorrhea were normal, so the galactorrhea was hypothesized to be caused by Graves' disease. The gynaecomastia and galactorrhea resolved with the successful treatment of hyperthyroidism. Although the galactorrhea is extremely rare in thyrotoxicosis male patients, to the best of our knowledge

2016 Case reports in endocrinology

9. Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea Full Text available with Trip Pro

Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea Secondary amenorrhoea and galactorrhoea represent a common endocrine presentation. We report a case of an oestrogen-producing juvenile granulosa cell tumour (JGCT) of the ovary in a 16-year-old post-pubertal woman with hyperprolactinaemia amenorrhoea and galactorrhoea which resolved following surgical resection of the tumour. This patient presented with a 9-month history of secondary (...) amenorrhoea and a 2-month history of galactorrhoea. Elevated serum prolactin at 7081 mIU/l and suppressed gonadotropins (LH <0.1 U/l; FSH <0.1 U/l) were detected. Serum oestradiol was significantly elevated at 7442 pmol/l with undetectable β-human chorionic gonadotropin. MRI showed a bulky pituitary with no visible adenoma. MRI of the abdomen showed a 4.8 cm mass arising from the right ovary with no evidence of metastatic disease. Serum inhibin B was elevated at 2735 ng/l. A right salpingo-oophorectomy

2016 Endocrinology, diabetes & metabolism case reports

10. Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine Full Text available with Trip Pro

Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine While fluoxetine (FXT) is a frequently prescribed selective serotonin reuptake inhibitor (SSRI), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing, manifestation of galactorrhea by altering prolactin release in those on FXT. We report here a case of FXT-induced hyperprolactinemic galactorrhea

2015 Clinical Psychopharmacology and Neuroscience

11. Diagnosis and management of galactorrhea after breast augmentation. (Abstract)

Diagnosis and management of galactorrhea after breast augmentation. A known but not fully understood complication of breast augmentation is galactorrhea. To date, all publications on this subject have been case reports. The purpose of this retrospective study was to examine a large group of consecutive patients who had undergone breast augmentation and identify the incidence of galactorrhea and galactocele, and the associated preoperative and intraoperative risk factors. The authors also (...) evaluated the treatment algorithm used.A retrospective chart review was performed on patients who underwent primary breast augmentation using silicone implants in a single group practice from 2008 to 2013. Logistic regression for rare events data was applied to evaluate the risk of galactorrhea according to the variables.The study included 832 patients (1664 implants) who had undergone breast augmentation. The follow-up period ranged from 12 to 52 months (mean, 15 months). Eight patients (0.96 percent

2015 Plastic and reconstructive surgery

12. Emotionally induced galactorrhoea in a non-lactating female -"Pseudo- Lactation"? Full Text available with Trip Pro

Emotionally induced galactorrhoea in a non-lactating female -"Pseudo- Lactation"? Galactorrhoea is a common clinical problem in endocrinology. Visual and auditory cues from the newborn are known to stimulate prolactin secretion in lactating women. However, hyperprolactinaemia and galactorrhoea in a non-lactating female due to visual and auditory stimuli from an unrelated newborn has not been reported in the past. We report the first such case of 'pseudo-lactation'.An 18-year-old girl with type (...) 1 diabetes mellitus presented with galactorrhoea. Apparently galactorrhoea was preceded by seeing the baby, hearing her cries or when remembering her memories. Her menstrual cycles were normal and did not complain of any headache or visual disturbances. She was only on metformin and insulin. Symptoms have rapidly resolved after the newborn was shifted to another location. Examination revealed scanty nipple discharge with gentle pressure. Investigations revealed an elevated serum prolactin

2014 BMC Endocrine Disorders

13. Galactorrhea associated with epilepsy: a systematic review of the role of prolactin

Galactorrhea associated with epilepsy: a systematic review of the role of prolactin Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing

2016 PROSPERO

14. Burns, hypertrophic scar and galactorrhea Full Text available with Trip Pro

Burns, hypertrophic scar and galactorrhea An 18-year-old woman was admitted to Motahari Burn Center suffering from 30% burns. Treatment modalities were carried out for the patient and she was discharged after 20 days. Three to four months later she developed hypertrophic scar on her chest and upper limbs. At the same time she developed galactorrhea in both breasts and had a disturbed menstrual cycle four months post-burn. On investigation, we found hyperprolactinemia and no other reasons

2013 Journal of Injury and Violence Research

15. A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series Full Text available with Trip Pro

A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series With the exception of fluoxetine, all selective serotonin reuptake inhibitors (SSRIs) commonly cause hyperprolactinemia through presynaptic mechanisms indirectly via 5-hydroxytryptamine (5-HT)-mediated inhibition of tuberoinfundibular dopaminergic neurons. However, there is little insight regarding the mechanisms by which fluoxetine causes hyperprolactinemia (...) via the postsynaptic pathway. In this text, analysis of five spontaneously reported clinical cases of hyperprolactinemia resulting in overt symptoms of amenorrhea with or without galactorrhea, were scrupulously analyzed after meticulously correlating relevant literature and an attempt was made to explore the putative postsynaptic pathway of fluoxetine inducing hyperprolactinemia. Hypothetically, serotonin regulates prolactin release either by increasing oxytocin (OT) level via direct stimulation

2013 Therapeutic Advances in Psychopharmacology

16. Acute lymphoblastic leukaemia presenting with galactorrhoea Full Text available with Trip Pro

Acute lymphoblastic leukaemia presenting with galactorrhoea A teenage girl presented with galactorrhoea and moderate hyperprolactinaemia. She was subsequently diagnosed to have acute lymphoblastic leukaemia. Further investigations supported the presence of ectopic prolactin production as suggested by the presence of prolactin mRNA in the patient's marrow at diagnosis. Both the ectopic prolactin mRNA and galactorrhoea eventually resolved upon disease remission after treatment.

2013 BMJ case reports

17. Proximal subcutaneous migration of the distal end of a ventriculoperitoneal shunt presenting with recurrent cerebrospinal fluid galactorrhea. Full Text available with Trip Pro

Proximal subcutaneous migration of the distal end of a ventriculoperitoneal shunt presenting with recurrent cerebrospinal fluid galactorrhea. The authors report an unusual case of recurrent proximal migration of the distal end of a ventriculoperitoneal shunt catheter presenting as CSF galactorrhea. The authors review the pertinent literature and discuss the possible causes as well as techniques to prevent a similar occurrence.

2013 Journal of Neurosurgery

18. Galactorrhea

not associated with childbirth (C0235660) Concepts Disease or Syndrome ( T047 ) MSH ICD9 611.6 ICD10 SnomedCT 78622004 , 198115002 French GALACTORRHEE , Allaitement non puerpéral , Galactorrhée non liée à la naissance , Galactorrhée chez la femme , Lactation non puerpérale , LACTATION NON PUERPERALE , Galactorrhée English Galactorrhea not associated with childbirth , GALACTORRHEA , GALACTORRHOEA , LACTATION NONPUERPERAL , Inappropriate milk production , nonpuerperal galactorrhea , nonpuerperal galactorrhea (...) (diagnosis) , Galactorrhea - non-obstetric , Galactorrhoea - non-obstetric , Galactorrhea female , Lactation non-puerperal , Lactation nonpuerperal , Galactorrhea-nonobstet , Nonpuerperal galactorrhea , Galactorrhoea female , Galactorrhea , Galactorrhoea , Inappropriate lactation , Inappropriate production of milk , Milk from non-pregnant breast , Galactorrhoea not associated with childbirth , Galactorrhea due to non-obstetric cause , Galactorrhoea due to non-obstetric cause , Galactorrhea due to non

2015 FP Notebook

19. Non-puerperal galactorrhea; with case reports. Full Text available with Trip Pro

Non-puerperal galactorrhea; with case reports. 13273609 2003 05 01 2018 12 01 29 4 1955 Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School Q Bull Northwest Univ Med Sch Non-puerperal galactorrhea; with case reports. 350-4 GRIMM E G EG eng Journal Article United States Q Bull Northwest Univ Med Sch 19220080R Nonpuerperal galactorrhea OM Amenorrhea Female Galactorrhea Humans Lactation Disorders Pregnancy 5629:25651 LACTATION DISORDERS 1955 1 1 1955 1 1 0 1 1955 1 1 0 0

1955 Quarterly Bulletin of the Northwestern University Medical School

20. A Case of Galactorrhoea Full Text available with Trip Pro

A Case of Galactorrhoea 20315001 2010 06 24 2010 06 24 0008-4409 14 6 1924 Jun Canadian Medical Association journal Can Med Assoc J A Case of Galactorrhoea. 498-500 Cameron A T AT Ferrier H J HJ Thorlakson P H PH eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 2010 3 24 6 0 1924 6 1 0 0 1924 6 1 0 1 ppublish 20315001 PMC1707818

1924 Canadian Medical Association Journal

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