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Galactorrhea

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1. Laboratory Endocrine Testing Guidelines: Galactorrhea

Laboratory Endocrine Testing Guidelines: Galactorrhea LABORATORY ENDOCRINE TESTING: GALACTORRHEA Clinical Practice Guideline | January 2008 These recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making. OBJECTIVE Alberta clinicians optimize laboratory testing for investigation of suspected galactorrhea TARGET (...) POPULATION Patients with non-puerperal secretions of milk EXCLUSIONS None RECOMMENDATIONS ? Evaluate secretions during breast examination ? Repeat testing if equivocal prolactin results ? Measure prolactin level at least one hour after a breast examination as breast trauma or manipulation can affect prolactin levels ? Refer to algorithm (Appendix A) for diagnostic options BACKGROUND Any type of nipple discharge should not be assumed to be galactorrhea. 1 Galactorrhea is defined as the non-puerperal

2014 Toward Optimized Practice

2. Hyperprolactinemia with Galactorrhea Due to Subclinical Hypothyroidism: A Case Report and Review of Literature (Full text)

Hyperprolactinemia with Galactorrhea Due to Subclinical Hypothyroidism: A Case Report and Review of Literature Hyperprolactinemia is a common finding in primary hypothyroidism, but increased prolactin in the setting of subclinical hypothyroidism (SCH) has been scarcely reported in the literature. This is a rare case of hyperprolactinemia due to SCH that resolved with thyroid hormone replacement therapy. The patient was not on any medications known to cause hyperprolactinemia but she was using (...) isoniazid for her latent tuberculosis. Isoniazid therapy may explain breast pain, but there is no reported relationship between isoniazid use causing subclinical hypothyroidism and hyperprolactinemia. A literature review reveals that few cases of galactorrhea associated with subclinical hypothyroidism have been reported. Similar to the reported cases in the literature, our patient's thyroid stimulating hormone (TSH) and prolactin levels returned to normal with levothyroxine therapy.

2018 Cureus PubMed

3. Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine (Full text)

Dose Dependent Course of Hyperprolactinemic and Normoprolactinemic Galactorrhea Induced by Venlafaxine Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further (...) by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment.

2017 Clinical Psychopharmacology and Neuroscience PubMed

4. Galactorrhea Probably Related with Switching from Osmotic-release Oral System Methylphenidate (MPH) to Modified-release MPH: An Adolescent Case (Full text)

Galactorrhea Probably Related with Switching from Osmotic-release Oral System Methylphenidate (MPH) to Modified-release MPH: An Adolescent Case Galactorrhea, as an adverse effect of psychotropic medications, usually develops due to high dose of antipsychotics. Selective serotonin reuptake inhibitors (SSRIs) have also been reported to be related to galactorrhea. To the best of our knowledge, no previous study reported galactorrhea with methylphenidate (MPH) use. Hereby, we report a case (...) of an adolescent girl who developed galactorrhea after increasing his modifed-release oral MPH to 50 mg/day while under treatment of sertraline and very low dose haloperidol.

2017 Clinical Psychopharmacology and Neuroscience PubMed

5. An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient? (Full text)

An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient? A female hemodialysis patient with galactorrhea due to hyperprolactinemia was treated with different dialysis modalities to assess the effect on prolactin levels. A single session of both high-flux hemodialysis and hemodiafiltration resulted in decreased prolactin levels (16,6% and 77,2%, resp.). However, baseline prolactin levels measured immediately before (...) the next dialysis session did not change markedly. After cabergoline treatment was started, prolactin levels normalized and galactorrhea disappeared. Thus, dopaminergic inhibition of prolactin secretion might be reduced in patients with end-stage renal disease. This dopaminergic resistance could be an important mechanism of hyperprolactinemia in hemodialysis patients and its subsequent treatment strategies.

2017 Case reports in nephrology PubMed

6. Acute myeloid leukemia presenting as galactorrhea (Full text)

Acute myeloid leukemia presenting as galactorrhea Acute myeloid leukemia (AML) presents with symptoms related to pancytopenia (weakness, infections, bleeding diathesis) and organ infiltration with leukemic cells. Galactorrhea is an uncommon manifestation of AML. We report a case of AML presenting with galactorrhea.

2016 Proceedings (Baylor University. Medical Center) PubMed

7. Galactorrhea

Galactorrhea Galactorrhea Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Galactorrhea Galactorrhea Aka: Galactorrhea From Related (...) Chapters II. Definition Non- al milk production and discharge from the Men and children Women (non-lactating, >12 months postpartum) III. Causes See Causes of See IV. Differential Diagnosis See V. History See Pathologic discharge Unilateral discharge or discharge from a single duct Bloody, serosanguineous or purulent discharge Normal discharge Galactorrhea is typically milky, bilateral and multi-ductal Coloration can vary (yellow to brown, or even green) Precipitated by stimulation Medications s

2018 FP Notebook

8. A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism (Full text)

A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism Graves' hyperthyroidism has a various number of well-recognized manifestations. Galactorrhea is a rare manifestation in this disease. We describe a 33-year-old man who presented with the symptoms of hyperthyroidism, gynaecomastia, and galactorrhea for 2 months. Physical examination revealed goitre, gynaecomastia, and galactorrhea, bilaterally. Laboratory investigations demonstrated high free (...) thyroxine with suppressed thyroid-stimulating hormone level together with elevated anti-TSH receptor; therefore, the diagnosis of Graves' disease was confirmed. Other investigations to elucidate the etiology of galactorrhea were normal, so the galactorrhea was hypothesized to be caused by Graves' disease. The gynaecomastia and galactorrhea resolved with the successful treatment of hyperthyroidism. Although the galactorrhea is extremely rare in thyrotoxicosis male patients, to the best of our knowledge

2016 Case reports in endocrinology PubMed

9. Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine (Full text)

Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine While fluoxetine (FXT) is a frequently prescribed selective serotonin reuptake inhibitor (SSRI), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing, manifestation of galactorrhea by altering prolactin release in those on FXT. We report here a case of FXT-induced hyperprolactinemic galactorrhea

2015 Clinical Psychopharmacology and Neuroscience PubMed

10. Diagnosis and management of galactorrhea after breast augmentation. (PubMed)

Diagnosis and management of galactorrhea after breast augmentation. A known but not fully understood complication of breast augmentation is galactorrhea. To date, all publications on this subject have been case reports. The purpose of this retrospective study was to examine a large group of consecutive patients who had undergone breast augmentation and identify the incidence of galactorrhea and galactocele, and the associated preoperative and intraoperative risk factors. The authors also (...) evaluated the treatment algorithm used.A retrospective chart review was performed on patients who underwent primary breast augmentation using silicone implants in a single group practice from 2008 to 2013. Logistic regression for rare events data was applied to evaluate the risk of galactorrhea according to the variables.The study included 832 patients (1664 implants) who had undergone breast augmentation. The follow-up period ranged from 12 to 52 months (mean, 15 months). Eight patients (0.96 percent

2015 Plastic and reconstructive surgery

11. Proximal subcutaneous migration of the distal end of a ventriculoperitoneal shunt presenting with recurrent cerebrospinal fluid galactorrhea. (Full text)

Proximal subcutaneous migration of the distal end of a ventriculoperitoneal shunt presenting with recurrent cerebrospinal fluid galactorrhea. The authors report an unusual case of recurrent proximal migration of the distal end of a ventriculoperitoneal shunt catheter presenting as CSF galactorrhea. The authors review the pertinent literature and discuss the possible causes as well as techniques to prevent a similar occurrence.

2013 Journal of Neurosurgery PubMed

12. Burns, hypertrophic scar and galactorrhea (Full text)

Burns, hypertrophic scar and galactorrhea An 18-year-old woman was admitted to Motahari Burn Center suffering from 30% burns. Treatment modalities were carried out for the patient and she was discharged after 20 days. Three to four months later she developed hypertrophic scar on her chest and upper limbs. At the same time she developed galactorrhea in both breasts and had a disturbed menstrual cycle four months post-burn. On investigation, we found hyperprolactinemia and no other reasons

2013 Journal of Injury and Violence Research PubMed

13. A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series (Full text)

A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series With the exception of fluoxetine, all selective serotonin reuptake inhibitors (SSRIs) commonly cause hyperprolactinemia through presynaptic mechanisms indirectly via 5-hydroxytryptamine (5-HT)-mediated inhibition of tuberoinfundibular dopaminergic neurons. However, there is little insight regarding the mechanisms by which fluoxetine causes hyperprolactinemia (...) via the postsynaptic pathway. In this text, analysis of five spontaneously reported clinical cases of hyperprolactinemia resulting in overt symptoms of amenorrhea with or without galactorrhea, were scrupulously analyzed after meticulously correlating relevant literature and an attempt was made to explore the putative postsynaptic pathway of fluoxetine inducing hyperprolactinemia. Hypothetically, serotonin regulates prolactin release either by increasing oxytocin (OT) level via direct stimulation

2013 Therapeutic Advances in Psychopharmacology PubMed

14. Galactorrhea associated with epilepsy: a systematic review of the role of prolactin

Galactorrhea associated with epilepsy: a systematic review of the role of prolactin Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing

2016 PROSPERO

15. Galactorrhea

Galactorrhea Galactorrhea Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Galactorrhea Galactorrhea Aka: Galactorrhea From Related (...) Chapters II. Definition Non- al milk production and discharge from the Men and children Women (non-lactating, >12 months postpartum) III. Causes See Causes of See IV. Differential Diagnosis See V. History See Pathologic discharge Unilateral discharge or discharge from a single duct Bloody, serosanguineous or purulent discharge Normal discharge Galactorrhea is typically milky, bilateral and multi-ductal Coloration can vary (yellow to brown, or even green) Precipitated by stimulation Medications s

2015 FP Notebook

16. Metoclopramide hydrochloride and galactorrhea. (Full text)

Metoclopramide hydrochloride and galactorrhea. 1033026 1977 01 25 2018 11 13 0008-4409 115 9 1976 Nov 06 Canadian Medical Association journal Can Med Assoc J Metoclopramide hydrochloride and galactorrhea. 845 Finnis W A WA Bird C E CE Wilson D L DL eng Case Reports Letter Canada Can Med Assoc J 0414110 0008-4409 L4YEB44I46 Metoclopramide AIM IM Adult Female Galactorrhea chemically induced Humans Lactation Disorders chemically induced Metoclopramide adverse effects Pregnancy 1976 11 6 1976 11 6

1976 Canadian Medical Association Journal PubMed

17. Neurosurgery—Epitomes of Progress: Galactorrhea, Amenorrhea: An Algorithm (Full text)

Neurosurgery—Epitomes of Progress: Galactorrhea, Amenorrhea: An Algorithm 18748512 2010 06 30 2018 11 13 0093-0415 131 5 1979 Nov The Western journal of medicine West. J. Med. Neurosurgery-epitomes of progress: galactorrhea, amenorrhea: an algorithm. 431-2 Weiss M H MH eng Journal Article United States West J Med 0410504 0093-0415 1979 11 1 0 0 1979 11 1 0 1 1979 11 1 0 0 ppublish 18748512 PMC1271878 N Engl J Med. 1977 Mar 17;296(11):589-600 840242

1979 Western Journal of Medicine PubMed

18. Non-puerperal galactorrhea; with case reports. (Full text)

Non-puerperal galactorrhea; with case reports. 13273609 2003 05 01 2018 12 01 29 4 1955 Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School Q Bull Northwest Univ Med Sch Non-puerperal galactorrhea; with case reports. 350-4 GRIMM E G EG eng Journal Article United States Q Bull Northwest Univ Med Sch 19220080R Nonpuerperal galactorrhea OM Amenorrhea Female Galactorrhea Humans Lactation Disorders Pregnancy 5629:25651 LACTATION DISORDERS 1955 1 1 1955 1 1 0 1 1955 1 1 0 0

1955 Quarterly Bulletin of the Northwestern University Medical School PubMed

19. The effect of levodopa on galactorrhea in the Forbes-Albright syndrome. (Full text)

The effect of levodopa on galactorrhea in the Forbes-Albright syndrome. 5066538 1972 10 27 2018 11 13 0008-4409 107 6 1972 Sep 23 Canadian Medical Association journal Can Med Assoc J The effect of levodopa on galactorrhea in the Forbes-Albright syndrome. 534 passim Edmonds M M Friesen H H eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 63-84-3 Dihydroxyphenylalanine 9002-62-4 Prolactin 9002-72-6 Growth Hormone AIM IM Adenoma, Chromophobe complications surgery Adult

1972 Canadian Medical Association Journal PubMed

20. Tranquillizer-induced galactorrhea. (Full text)

Tranquillizer-induced galactorrhea. 5064121 1972 08 09 2018 11 13 0008-4409 106 10 1972 May 20 Canadian Medical Association journal Can Med Assoc J Tranquillizer-induced galactorrhea. 1107-8 Hussain M Z MZ Harinath M M Murphy J J eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Tranquilizing Agents 1806D8D52K Amitriptyline 214IZI85K3 Trifluoperazine 9S7OD60EWP Chlorprothixene FTA7XXY4EZ Perphenazine J6292F8L3D Haloperidol N3D6TG58NI Thioridazine Q3JTX2Q7TU Diazepam

1972 Canadian Medical Association Journal PubMed

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