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GBS Culture

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1. Evaluation of StrepBSelect Chromogenic Medium and the Fast-Track Diagnostics Group B Streptococcus (GBS) Real-Time PCR Assay Compared to Routine Culture for Detection of GBS during Antepartum Screening (PubMed)

Evaluation of StrepBSelect Chromogenic Medium and the Fast-Track Diagnostics Group B Streptococcus (GBS) Real-Time PCR Assay Compared to Routine Culture for Detection of GBS during Antepartum Screening Life-threatening infection in neonates due to group B Streptococcus (GBS) is preventable by screening of near-term pregnant women and treatment at delivery. A total of 295 vaginal-rectal swabs were collected from women attending antepartum clinics in Calgary, Alberta, Canada. GBS colonization (...) was detected by the standard culture method (Strep B Carrot Broth subcultured to blood agar with a neomycin disk) and compared to recovery with Strep Group B Broth (Dalynn Biologicals) subcultured to StrepBSelect chromogenic medium (CM; Bio-Rad Laboratories) and the Fast-Track Diagnostics GBS real-time PCR (quantitative PCR [qPCR]) assay (Phoenix Airmid Biomedical Corp.) performed with broth-enriched samples and the Abbott m2000sp/m2000rt system. A total of 62/295 (21%) women were colonized with GBS; 58

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2017 Journal of clinical microbiology

2. Comparison of BD MAX GBS and GenomEra GBS assays for rapid intrapartum PCR detection of vaginal carriage of group B streptococci. (PubMed)

Comparison of BD MAX GBS and GenomEra GBS assays for rapid intrapartum PCR detection of vaginal carriage of group B streptococci. To compare the diagnostic performance of BD MAX and GenomEra PCR assays for a rapid PCR detection of vaginal carriage of group B streptococci at delivery.This is a retrospective laboratory analysis of vaginal swab samples taken intrapartum from a randomly selected cohort of pregnant women giving birth at a single childbirth and maternity unit.Ninety-one culture (...) -positive and 279 culture-negative vaginal samples were included from a cohort of 902 women. One-hundred-and-two specimens were found positive with the BD MAX and 84 with the GenomEra PCR assay. No statistically significant difference was observed compared to culture, sensitivity of BD MAX 84.6% (77/91) [95%CI 75.5-91.3] and of GenomEra 71.4% (65/91) [95%CI 61.0-80.4]. When compared to a combined reference standard, no statistically significant differences were seen between culture, BD MAX and GenomEra

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2019 PLoS ONE

3. A Phase II Randomized, Control Trial of Group B Streptococcus (GBS) Type III Capsular Polysaccharide -Tetanus Toxoid (GBS III-TT) Vaccine to Prevent Vaginal Colonization with GBS III. (PubMed)

) vaccine was evaluated for safety and efficacy in preventing acquisition of GBS colonization.Healthy, age 18-40 years, non-pregnant women, screened to be GBS III vaginal and rectal culture negative, were randomized to receive III-TT conjugate or tetanus diphtheria toxoid (Td) vaccine in a multicenter, observer blinded trial. GBS vaginal and rectal cultures and blood were obtained bimonthly over 18 months. Serum concentrations of GBS III CPS-specific antibodies were determined by ELISA.Among 1525 women (...) A Phase II Randomized, Control Trial of Group B Streptococcus (GBS) Type III Capsular Polysaccharide -Tetanus Toxoid (GBS III-TT) Vaccine to Prevent Vaginal Colonization with GBS III. Group B Streptococcus (GBS) frequently colonizes pregnant women and can cause sepsis and meningitis in young infants. If colonization was prevented through maternal immunization, a reduction in perinatal GBS disease might be possible. A GBS type III capsular polysaccharide (CPS)-tetanus toxoid conjugate (III-TT

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2018 Clinical Infectious Diseases

4. GBS Culture

GBS Culture GBS Culture Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 GBS Culture GBS Culture Aka: GBS Culture , Group B (...) Streptococcus Culture II. Indications Prenatal GBS Screening III. Technique: Obtaining culture Use l culture swab (often red topped swab as used for ) Swab the vaginal introitus Swab the inside of the anal sphincter with same swab or a different swab Notify lab that culture is for Group B Streptoccus Clearly label culture swab as vaginal and rectal source for GBS Culture Order swab for GBS Culture Note in order if high risk for with or allergy ( , , history) Lab will perform and susceptibility testing

2018 FP Notebook

5. Modelling the effect of the introduction of antenatal screening for group B <i>Streptococcus</i> (GBS) carriage in the UK. (PubMed)

Modelling the effect of the introduction of antenatal screening for group B Streptococcus (GBS) carriage in the UK. To estimate the potential impact of the addition of culture-based screening for group B streptococcus (GBS) carriage in pregnancy to a risk-based prevention policy in the UK. We aimed to establish agreement within a multidisciplinary group of key stakeholders on the model input parameters.Deterministic model using a consensus approach for the selection of input parameters.A (...) theoretical annual cohort of 711 999 live births in the UK (excluding births by elective caesarean section).Culture-based screening for GBS at 35-37 weeks of pregnancy added to the recommended risk-based prevention policy in place on the date of modelling.Outcomes assessed included use of intrapartum antibiotic prophylaxis (IAP), early onset GBS (EOGBS), EOGBS mortality, severe EOGBS-related morbidity and maternal penicillin anaphylaxis.With no prophylaxis strategy, the model estimated that there would

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2019 BMJ open

6. Group B streptococcus late-onset disease,contaminated breast milk and mothers persistently GBS negative: report of 3cases. (PubMed)

newborns. Fresh breast milk cultures yielded GBS, but mothers of neonates had no signs of mastitis and remained persistently GBS negative at rectovaginal site.Breast milk containing group B Streptococcus can be a risk factor for late onset disease. The persistent negative maternal GBS status supports the assumption that newborns, colonised in the throat, could be the initial source of GBS, while the mammary gland could act as a GBS replication site. It is unclear whether a low bacterial load may (...) Group B streptococcus late-onset disease,contaminated breast milk and mothers persistently GBS negative: report of 3cases. Human milk is fundamental for its nutritional properties and to protect newborns, but it is not sterile and can sometime transmit bacteria. Few anecdotal cases suggest that breast milk could be a possible source of group B Streptococcus (GBS) late onset disease, although the pathogenesis is not entirely understood.We report 3 cases of GBS late onset disease in full-term

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2018 BMC Pediatrics

7. Antenatal Probiotics Against GBS Colonization

with GBS occurs in up to 30% of adult women, with highest rates in African Americans. Pregnant women can pass GBS to their fetuses during vaginal birth, putting them at risk for Early Onset Group B Streptococcus Disease (EOGBSD), which is associated with a neonatal mortality rate of 5-10% and morbidity of approximately 50%. The Centers for Disease Control and Prevention (CDC) 2010 guidelines require universal antepartum GBS screening by vaginal to rectal cultures of all women at 35-37 weeks gestation (...) capsule 1 capsule daily from 28 weeks until the time of birth. Biological: Florajen3 Probiotic combination product One capsule daily by mouth. No Intervention: Placebo Microcrystalline Cellulose Outcome Measures Go to Primary Outcome Measures : Proportion of participants with positive qualitative GBS culture [ Time Frame: 36 weeks gestation ] Qualitative Secondary Outcome Measures : GBS quantitive colony counts in colony forming units (CFU) [ Time Frame: 36 weeks gestation ] quantitative GBS

2018 Clinical Trials

8. Probiotic on Prevention of GBS Vaginal Infection During Pregnancy

women are randomly assigned to one of the two groups. The study group is treated with two oral capsules of probiotics once daily (before sleeping) for 18 weeks, and the control group will take 2 capsules of placebos. Vaginal and rectal GBS culture is repeated in 35-37 week of gestation and intrapartum period. All participators will treat according to GBS guideline by CDC in 2010. Cervical diagnosis will be completed at the 6th week after delivery. Through the results of this study, investigators try (...) through GBS test for both vagina and rectum in 35-37 weeks pregnant women and during laboring. [ Time Frame: 18 weeks ] 100 participants with GBS positive result recruit on 28th week gestation for each group will recheck GBS colonization through GBS culture test of vagina and rectum in 35-37 weeks gestation as well as during laboring. The percentage of GBS positive turned to negative in the two time points will be measured for study group and placebo group. Secondary Outcome Measures : The number

2018 Clinical Trials

9. Loop Mediated Isothermal Amplification (LAMP) assay for Rapid detection of Streptococcus agalactiae (Group B Streptococcus - GBS) in vaginal swabs - A Proof of Concept Study. (PubMed)

Loop Mediated Isothermal Amplification (LAMP) assay for Rapid detection of Streptococcus agalactiae (Group B Streptococcus - GBS) in vaginal swabs - A Proof of Concept Study. Neonatal sepsis caused by Streptococcus agalactiae [group B streptococcus (GBS)] is a life-threatening condition, which is preventable if colonized mothers are identified and given antibiotic prophylaxis during labour. Conventional culture is time consuming and unreliable, and many available non-culture diagnostics are too (...) complex to implement routinely at point of care. Loop-mediated isothermal amplification (LAMP) is a method that, enables the rapid and specific detection of target nucleic acid sequences in clinical materials without the requirement for extensive sample preparation.A prototype LAMP assay targeting GBS sip gene is described.The assay was 100 % specific for GBS, with a limit of detection of 14 genome copies per reaction. The clinical utility of the LAMP assay for rapid direct molecular detection of GBS

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2017 Journal of Medical Microbiology

10. Rapid detection of Group B Streptococcus directly from vaginal-rectal specimens using liquid swabs and the BD Max GBS assay. (PubMed)

Rapid detection of Group B Streptococcus directly from vaginal-rectal specimens using liquid swabs and the BD Max GBS assay. We adapted the BD Max GBS assay, an automated platform for the detection of Group B streptococcus (GBS) DNA in vaginal-rectal swab specimens after LIM broth enrichment, to directly detect GBS in specimens collected using cellular foam swabs in Amies liquid medium. We compared the BD Max GBS assay performance to that of enriched culture and the BD GeneOhm StrepB (...) assay.Seventy-two reference vaginal-rectal specimens were employed to determine the limit of GBS detection and the preferred test volume for direct detection of GBS. A total of 304 clinical specimens were then tested by the optimized BD Max GBS assay, both by direct testing and following broth enrichment.The limit of GBS detection was 75 CFU/mL and the preferred test volume was 100 μL. Of 304 clinical specimens tested, GBS was detected in 62 specimens by enriched culture (20.4%); 61 of these yielded GBS

2017 Clinical Microbiology and Infection

11. Green Banana (GB) Mixed Diet in the Management of Persistent Diarrhea (PD)

Green Banana (GB) Mixed Diet in the Management of Persistent Diarrhea (PD) Green Banana (GB) Mixed Diet in the Management of Persistent Diarrhea (PD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Green (...) Banana (GB) Mixed Diet in the Management of Persistent Diarrhea (PD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03366740 Recruitment Status : Recruiting First Posted : December 8, 2017 Last Update Posted : January 15

2017 Clinical Trials

12. Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia (PubMed)

pregnant women and (3) To identify associated risk factors with GBS colonization among pregnant women.The median age of the participants was 24.5 years (range 16-38) and 86% participants were urban residents. The total prevalence of maternal GBS colonization from vaginal swab culture was 12.2% (22/180). The prevalence of GBS colonization rate was significantly higher in those pregnant women above 37 weeks of gestation [AOR, 95% CI 2.1 (1.2, 11.6), P = 0.03] and married ones [AOR, 95% CI 3.2 (1.8, 11.6 (...) Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia The main objective of this study was to determine the prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women. The specific objectives include; (1) To determine the prevalence of GBS colonization among pregnant women (2) To determine the drug susceptibility pattern of GBS among

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2017 BMC research notes

13. Xpert GBS test for the intrapartum detection of group B streptococcus

. A secondary aim was to evaluate the efficacy of intrapartum antibiotic prophylaxis to prevent GBS colonisation in the baby. During this phase, 229 women across 6 delivery units in Sweden were randomised into 2 groups: 112 to group A and 117 to group B. Group A were swabbed for both Xpert GBS PCR (using the older version of the device) and conventional bacterial culture, and intrapartum antibiotic prophylaxis was administered if the PCR assay result was positive or invalid for GBS. Group B were swabbed (...) for conventional bacterial culture only and were treated with intrapartum antibiotic prophylaxis according to the Swedish recommended guidelines, which advocate a risk-based approach. In both groups, the babies were swabbed for conventional culture to determine their GBS colonisation status. The second phase was non-randomised and aimed to evaluate the performance of an upgraded version of the Xpert GBS test in 94 women across 3 of the 6 centres from the first phase. All of the women were tested for GBS using

2015 National Institute for Health and Clinical Excellence - Advice

14. Universal antenatal culture-based screening for maternal Group B Streptococcus (GBS) carriage to prevent early-onset GBS disease: a rapid review

Universal antenatal culture-based screening for maternal Group B Streptococcus (GBS) carriage to prevent early-onset GBS disease: a rapid review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2016 PROSPERO

15. Intrapartum Effect of Vancomycin on Rectovaginal GBS Colonization

of neonates whose mothers received vancomycin intrapartum. This study aims to identify the time after administration of IV vancomycin at which GBS colonies are 100% eradicated. Condition or disease Intervention/treatment Group B Streptococcal Infection Biological: Vaginal and rectovaginal swab cultures Detailed Description: Prophylaxis of group B streptococcus has been a major component of prenatal care in preventing early onset of neonatal sepsis. While penicillin remains the gold standard medication (...) by the National Library of Medicine related topics: available for: Groups and Cohorts Go to Group/Cohort Intervention/treatment IV Vancomycin GBS positive laboring women who are allergic to penicillin and clindamycin and are treated using IV vancomycin. Biological: Vaginal and rectovaginal swab cultures The only intervention that will occur in this study is obtaining vaginal and recto-vaginal swab cultures upon admission to the labor and delivery room and every two hours to follow until 8 hours after

2016 Clinical Trials

16. Validation of the GenePOC GBS Assay for the Detection of the Cfb Gene From Streptococcus Agalactiae Strains

Posted : December 13, 2018 Last Update Posted : December 13, 2018 Sponsor: GenePOC Information provided by (Responsible Party): GenePOC Study Details Study Description Go to Brief Summary: The primary purpose of this clinical investigation is to verify the performance of the GenePOC GBS Assay on the GenePOC Instrument. This will be achieved by comparing the Assay to the a Culture, a conventional method for detection of Streptococcus agalactiae in vaginal/rectal swab specimens from antepartum women (...) polymerase chain reaction (PCR) to detect a cfb gene sequence specific to the Streptococcus agalactiae genome. The GenePOC GBS Test is indicated for the identification of antepartum GBS colonization and does not provide susceptibility results. Culture isolates are needed for performing susceptibility testing as recommended for penicillin-allergic women. The GenePOC GBS is an IVD system is comprised of the GenePOC Diagnostics System and the GenePOC Group B Step [GBS] Test, the components of which

2016 Clinical Trials

17. Mutations in Pseudorabies Virus Glycoproteins gB, gD, and gH Functionally Compensate for the Absence of gL (PubMed)

Mutations in Pseudorabies Virus Glycoproteins gB, gD, and gH Functionally Compensate for the Absence of gL Entry of herpesviruses depends on the combined action of viral glycoprotein B (gB) and the heterodimeric gH/gL complex, which are activated by binding of the virion to specific cellular receptors. While gB carries signatures of a bona fide fusion protein, efficient membrane fusion requires gH/gL. However, although gB and gH/gL are essential for entry, the alphaherpesvirus pseudorabies (...) virus (PrV) is capable of limited cell-to-cell spread in the absence of gL. To understand gH/gL function in more detail, the limited spread of PrV-ΔgL was used for reversion analyses by serial cell culture passages. In a first experiment, an infectious gL-negative mutant in which gL function was replaced by generation of a gD-gH hybrid protein was isolated (B. G. Klupp and T. C. Mettenleiter, J Virol 73:3014-3022, 1999). In a second, independent experiment PrV-ΔgLPassB4.1, which also replicated

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2016 Journal of virology

18. Detection of Group B Streptococcus Directly from Collected ESwab Samples by Use of the BD Max GBS Assay (PubMed)

Detection of Group B Streptococcus Directly from Collected ESwab Samples by Use of the BD Max GBS Assay Group B Streptococcus detection directly from Copan ESwab collected samples, using the BD Max GBS assay, was evaluated on receipt in the laboratory and after 24 h at room temperature. Results were compared to those using Lim broth enrichment PCR and culture. No significant difference was observed between 24 h ESwab and Lim broth PCRs.Copyright © 2016 Silbert et al.

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2016 Journal of clinical microbiology

19. Behavior That Undermines a Culture of Safety

Behavior That Undermines a Culture of Safety Behavior That Undermines a Culture of Safety - ACOG Menu ▼ Behavior That Undermines a Culture of Safety Page Navigation ▼ Number 683, January 2017 (Replaces Committee Opinion Number 508, October 2011) Committee on Patient Safety and Quality Improvement This Committee Opinion was developed by the American College of Obstetricians and Gynecologists’ Committee on Patient Safety and Quality Improvement. This document reflects emerging concepts on patient (...) safety and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Behavior That Undermines a Culture of Safety ABSTRACT: A key element of an organizational safety culture is maintaining an environment of professionalism that encourages communication and promotes high-quality care. Behavior that undermines a culture of safety, including disruptive or intimidating behavior, has a negative effect on the quality and safety

2017 American College of Obstetricians and Gynecologists

20. GBS Culture

GBS Culture GBS Culture Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 GBS Culture GBS Culture Aka: GBS Culture , Group B (...) Streptococcus Culture II. Indications Prenatal GBS Screening III. Technique: Obtaining culture Use l culture swab (often red topped swab as used for ) Swab the vaginal introitus Swab the inside of the anal sphincter with same swab or a different swab Notify lab that culture is for Group B Streptoccus Clearly label culture swab as vaginal and rectal source for GBS Culture Order swab for GBS Culture Note in order if high risk for with or allergy ( , , history) Lab will perform and susceptibility testing

2015 FP Notebook

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