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Frontal Lobe

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101. Three-dimensional intracranial EEG monitoring in presurgical assessment of MRI-negative frontal lobe epilepsy. Full Text available with Trip Pro

Three-dimensional intracranial EEG monitoring in presurgical assessment of MRI-negative frontal lobe epilepsy. Magnetic resonance imaging (MRI)-negative epilepsy is associated with poor clinical outcomes prognosis. The present study was aimed to assess whether intracranial 3D interictal and ictal electroencephalography (EEG) findings, a combination of EEG at a different depth, in addition to clinical, scalp EEG, and positron emission tomography-computed tomography (PETCT) data help to predict (...) outcome in a series of patients with MRI-negative frontal lobe epilepsy (FLE) after surgery.Patients with MRI-negative FLE who were presurgically evaluated by 3D-intracranial EEG (3D-iEEG) recording were included. Outcome predictors were compared in patients with seizure freedom (group 1) and those with recurrent seizures (group 2) at least 24 months after surgery.Forty-seven patients (15 female) were included in this study. MRI was found normal in 38 patients, whereas a focal or regional

2016 Medicine

102. Frontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease: An Analysis of Linked Data. Full Text available with Trip Pro

Frontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease: An Analysis of Linked Data. To determine the association between frontal lobe function and risk of hip fracture in patients with Alzheimer disease (AD).Retrospective cohort study using multicenter hospital-based dementia registry and national health insurance claim data was done. Participants who had available data of neuropsychological test, national health insurance claim, and other covariates were included (...) . A total of 1660 patients with AD were included based on Stroop Test results. A total of 1563 patients with AD were included based on the Controlled Oral Word Association Test (COWAT) results. Hip fracture was measured by validated identification criteria using national health insurance claim data. Frontal lobe function was measured by Stroop Test and COWAT at baseline.After adjusting for potential covariates, including cognitive function in other domains (language, verbal and nonverbal memory

2015 Medicine

103. Quantitative electroencephalographic and neuropsychological investigation of an alternative measure of frontal lobe executive functions: the Figure Trail Making Test Full Text available with Trip Pro

Quantitative electroencephalographic and neuropsychological investigation of an alternative measure of frontal lobe executive functions: the Figure Trail Making Test The most frequently used measures of executive functioning are either sensitive to left frontal lobe functioning or bilateral frontal functioning. Relatively little is known about right frontal lobe contributions to executive functioning given the paucity of measures sensitive to right frontal functioning. The present investigation (...) reports the development and initial validation of a new measure designed to be sensitive to right frontal lobe functioning, the Figure Trail Making Test (FTMT). The FTMT, the classic Trial Making Test, and the Ruff Figural Fluency Test (RFFT) were administered to 42 right-handed men. The results indicated a significant relationship between the FTMT and both the TMT and the RFFT. Performance on the FTMT was also related to high beta EEG over the right frontal lobe. Thus, the FTMT appears

2015 Brain Informatics

104. Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort. (Abstract)

Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort. The criteria for behavioral variant frontotemporal dementia (bvFTD) incorporate MRI and [18F]-FDG-PET. Cerebrospinal fluid (CSF) analysis is merely advised for excluding Alzheimer's disease.We aimed to assess the impact of biomarkers on diagnostic certainty and contingent changes of bvFTD diagnosis within the clinically relevant (...) neuropsychiatric differential diagnosis of subjects with a late-onset frontal lobe syndrome (LOF).We included 137 patients with LOF, aged 45-75 years, 72% males. Biomarker disclosure was considered contributing after any substantial difference in diagnostic certainty or a diagnostic change. Percentages of contributing biomarkers were compared between three major diagnostic groups (bvFTD, psychiatry, other neurological disorders). Certainty levels in stable diagnostic groups were compared to those

2015 Dementia and Geriatric Cognitive Disorders

105. Co-operative Behavior and Decision-making in Frontal Lobe Epilepsy

Co-operative Behavior and Decision-making in Frontal Lobe Epilepsy Co-operative Behavior and Decision-making in Frontal Lobe Epilepsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Co-operative Behavior (...) and Decision-making in Frontal Lobe Epilepsy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02441478 Recruitment Status : Completed First Posted : May 12, 2015 Last Update Posted : September 22, 2015 Sponsor: Hospices Civils de Lyon Information provided by (Responsible Party): Hospices Civils de Lyon Study

2015 Clinical Trials

106. Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition. Full Text available with Trip Pro

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition. In executive function, specifically in response inhibition, numerous studies support the essential role for the inferior frontal cortex (IFC). Hypoactivation of the IFC during response-inhibition tasks has been found consistently in subjects with bipolar disorder during manic and euthymic states. The aim of this study was to examine whether reduced IFC activation also exists (...) in right frontal regions, including the IFC (Brodmann's area (BA) 47), middle frontal gyrus (BA 10), as well as other frontal and temporal regions. IFC hypoactivation may be a persistent deficit in subjects with bipolar disorder in both acute mood states as well as euthymia, thus representing a trait feature of bipolar disorder. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

2015 Psychiatry research Controlled trial quality: uncertain

107. Distinctive effects of nicotinic receptor intracellular-loop mutations associated with nocturnal frontal lobe epilepsy Full Text available with Trip Pro

Distinctive effects of nicotinic receptor intracellular-loop mutations associated with nocturnal frontal lobe epilepsy Previously characterized nicotinic acetylcholine receptor (nAChR) autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)-associated mutations are found in α2, α4 and β2 subunit transmembrane (TM) domains. They predominantly increase ACh potency and, for β2-subunit mutants, increase macroscopic currents. Two recently-identified mutations, α4(R336H) and β2(V337G), located

2015 Neuropharmacology

108. Commentary: Is the Frontal Lobe Involved in Conscious Perception? Full Text available with Trip Pro

Commentary: Is the Frontal Lobe Involved in Conscious Perception? 26617558 2015 11 30 2018 11 13 1664-1078 6 2015 Frontiers in psychology Front Psychol Commentary: Is the Frontal Lobe Involved in Conscious Perception? 1736 10.3389/fpsyg.2015.01736 Naber Marnix M Department of Experimental Psychology, Helmholtz Institute, Utrecht University Utrecht, Netherlands. Brascamp Jan J Department of Psychology, Michigan State University, East Lansing MI, USA. eng Journal Article 2015 11 12 Switzerland (...) Front Psychol 101550902 1664-1078 binocular rivalry conscious awareness conscious perception content of consciousness frontal lobe perceptual switching prefrontal cortex visual perception 2015 08 27 2015 10 28 2015 12 1 6 0 2015 12 1 6 0 2015 12 1 6 1 epublish 26617558 10.3389/fpsyg.2015.01736 PMC4641901 Neuron. 1998 Oct;21(4):753-9 9808462 Front Neurosci. 2011 Sep 30;5:115 21994487 Science. 1989 Aug 18;245(4919):761-3 2772635 Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):323-8 17190824 J Neurosci

2015 Frontiers in psychology

109. Behavioral profiles in frontal lobe epilepsy: Autobiographic memory versus mood impairment. (Abstract)

Behavioral profiles in frontal lobe epilepsy: Autobiographic memory versus mood impairment. Autobiographic memory encompasses the encoding and retrieval of episodes, people, and places encountered in everyday life. It can be impaired in both epilepsy and frontal lobe damage. Here, we performed an initial investigation of how autobiographic memory is impacted by chronic frontal lobe epilepsy (FLE) together with its underlying pathology.We prospectively studied a series of nine consecutive (...) patients with medically refractory FLE, relative to 24 matched healthy controls. Seven of the nine patients had frontal lobe structural abnormalities. Episodic and semantic autobiographic memory functioning was profiled, and factors associated with impaired autobiographic memory were identified among epileptologic, neuroimaging, neuropsychiatric, and cognitive variables including auditory-verbal and visual memory, and the executive function of cognitive control.Results showed that the FLE group

2015 Epilepsia

110. BOLD responses related to focal spikes and widespread bilateral synchronous discharges generated in the frontal lobe. (Abstract)

BOLD responses related to focal spikes and widespread bilateral synchronous discharges generated in the frontal lobe. To investigate whether specific frontal regions have a tendency to generate widespread bilateral synchronous discharges (WBSDs) and others focal spikes and to determine the regions most involved when WBSDs occur; to assess the relationships between the extent of electroencephalography (EEG) discharges and the extent of metabolic changes measured by EEG/functional magnetic (...) more common in the WBSD group (14/17) than in the Focal group (7/20), p = 0.004. Deactivation in the default mode network was significantly more common in the WBSD group (14/17) than in the Focal group (10/20), p = 0.04.The spatial distribution and extent of blood oxygen level-dependent (BOLD) responses correlate well with electrophysiologic changes. Focal frontal spikes and WBSDs are not region specific in the frontal lobe, and the same frontal region can generate focal and generalized discharges

2015 Epilepsia

111. Nocturnal frontal lobe epilepsy with paroxysmal arousals due to CHRNA2 loss of function. Full Text available with Trip Pro

Nocturnal frontal lobe epilepsy with paroxysmal arousals due to CHRNA2 loss of function. We assessed the mutation frequency in nicotinic acetylcholine receptor (nAChR) subunits CHRNA4, CHRNB2, and CHRNA2 in a cohort including autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and sporadic nocturnal frontal lobe epilepsy (NFLE). Upon finding a novel mutation in CHRNA2 in a large family, we tested in vitro its functional effects.We sequenced all the coding exons and their flanking

2015 Neurology

112. Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the Sleep/Wake System? Full Text available with Trip Pro

Are Absence Epilepsy and Nocturnal Frontal Lobe Epilepsy System Epilepsies of the Sleep/Wake System? System epilepsy is an emerging concept interpreting major nonlesional epilepsies as epileptic dysfunctions of physiological systems. I extend here the concept of reflex epilepsy to epilepsies linked to input dependent physiological systems. Experimental and clinical reseach data were collected to create a coherent explanation of underlying pathomechanism in AE and NFLE. We propose that AE should

2015 Behavioural neurology

113. Identifying bvFTD Within the Wide Spectrum of Late Onset Frontal Lobe Syndrome: A Clinical Approach. (Abstract)

Identifying bvFTD Within the Wide Spectrum of Late Onset Frontal Lobe Syndrome: A Clinical Approach. The behavioral variant of frontotemporal dementia (bvFTD) can be difficult to diagnose because of the extensive differential diagnosis, including many other diseases presenting with a frontal lobe syndrome. We aimed to identify the diagnostic spectrum causing a late onset frontal lobe syndrome and examine the quality of commonly used instruments to distinguish between bvFTD and non-bvFTD (...) patients, within this syndrome.A total of 137 patients fulfilling the criteria of late onset frontal lobe syndrome, aged 45 to 75 years, were included in a prospective observational study. Diagnoses were made after clinical and neuropsychological examination, and neuroimaging and cerebral spinal fluid results were taken into account. Baseline characteristics and the scores on the Mini-Mental State Exam (MMSE), frontal assessment battery (FAB), Frontal Behavioral Inventory (FBI), and Stereotypy Rating

2015 The American Journal of Geriatric Psychiatry

114. Recurrent secondary generalization in frontal lobe epilepsy: Predictors and a potential link to surgical outcome? (Abstract)

Recurrent secondary generalization in frontal lobe epilepsy: Predictors and a potential link to surgical outcome? Frontal lobe epilepsy (FLE) frequently leads to secondary generalized tonic-clonic seizures (SGTCS). However, little is known about the clinical, electrophysiologic, and radiologic correlates of SGTCS and whether these could influence diagnosis and treatment.A cohort of 48 patients with confirmed FLE was retrospectively identified and dichotomized into a group with and a group

2015 Epilepsia

115. Reorganization of Language Areas in Patient with a Frontal Lobe Low Grade Glioma – fMRI Case Study Full Text available with Trip Pro

Reorganization of Language Areas in Patient with a Frontal Lobe Low Grade Glioma – fMRI Case Study Functional magnetic resonance (fMRI) studies results in case of an adult patient with low grade glioma (LGG) in dominant hemisphere suggest brain plasticity process with acquisition of language functions by the non-dominant hemisphere speech regions.A 36-years old right-handed woman was admitted to the Department of Neurosurgery for surgical treatment of brain tumor. An MRI examination revealed (...) a pathological mass in the left frontal lobe, in close topographical relationship to the Broca's area. A left fronto-parietal craniotomy was performed, with an intraoperative awake language mapping procedure. A total resection of the pathological mass was achieved. The tumor was examined histologically as LGG. In the follow-up MRI exam 32 months after the operation a tumor recurrence was suggested. The fMRI exams performed preoperative and 3, 32 and 41 months after the operation showed changes in language

2015 Polish Journal of Radiology

116. Putting the brakes on inhibitory models of frontal lobe function Full Text available with Trip Pro

Putting the brakes on inhibitory models of frontal lobe function There has been much recent debate regarding the neural basis of motor response inhibition. An influential hypothesis from the last decade proposes that a module within the right inferior frontal cortex (RIFC) of the human brain is dedicated to supporting response inhibition. However, there is growing evidence to support the alternative view that response inhibition is just one prominent example of the many cognitive control

2015 NeuroImage

117. Errors on the Trail Making Test Are Associated with Right Hemispheric Frontal Lobe Damage in Stroke Patients Full Text available with Trip Pro

Errors on the Trail Making Test Are Associated with Right Hemispheric Frontal Lobe Damage in Stroke Patients Measures of performance on the Trail Making Test (TMT) are among the most popular neuropsychological assessment techniques. Completion time on TMT-A is considered to provide a measure of processing speed, whereas completion time on TMT-B is considered to constitute a behavioral measure of the ability to shift between cognitive sets (cognitive flexibility), commonly attributed (...) to the frontal lobes. However, empirical evidence linking performance on the TMT-B to localized frontal lesions is mostly lacking. Here, we examined the association of frontal lesions following stroke with TMT-B performance measures (i.e., completion time and completion accuracy measures) using voxel-based lesion-behavior mapping, with a focus on right hemispheric frontal lobe lesions. Our results suggest that the number of errors, but not completion time on the TMT-B, is associated with right hemispheric

2015 Behavioural neurology

118. Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study. (Abstract)

Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study. A clinical frontal lobe syndrome (FLS) is generally attributed to functional or structural disturbances within frontal-subcortical circuits. We studied the distribution of pathological brain changes in FLS. Additionally, the prevalence of FLS among various disorders was studied.We systematically screened clinical files of donors to the Netherlands Brain Bank (n = 2,814) for FLS. A total of 262 (...) FLS cases were identified, and the distribution of postmortem pathological changes within the frontal-subcortical circuits was extracted from their neuropathological reports.In 244 out of 262 patients (93%), pathological changes within the frontal-subcortical circuits were found: 90 subjects (34%) with frontal cortical pathology and 18 (7%) with pathology restricted to subcortical grey matter nuclei, whereas 136 subjects (52%) showed both cortical and subcortical pathology. In 18 subjects (7

2015 Dementia and Geriatric Cognitive Disorders

119. Older people experiencing homelessness show marked impairment on tests of frontal lobe function. (Abstract)

Older people experiencing homelessness show marked impairment on tests of frontal lobe function. Reported rates of mild and moderate cognitive impairment in older people experiencing homelessness range from 5-80%. The objective of this study was to determine the prevalence and characteristics of cognitive impairment in older people experiencing homelessness in the inner city of Sydney, Australia.Men and women experiencing homelessness aged 45 years and over in the inner city were screened (...) and physical illness were identified, and 75% of subjects who were cognitively impaired performed poorly on frontal lobe tests. The trail-making test, part B was the most sensitive measure of frontal function.This study demonstrated that a large majority of older people experiencing homelessness, in the inner city of a high-income country, showed impairment on tests of frontal lobe function, a finding that could have significant implications for any medical or psychosocial intervention.Copyright © 2015

2015 International Journal of Geriatric Psychiatry

120. Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis Full Text available with Trip Pro

is an adequate tool for detecting cognitive impairments related to frontal lobe pathology in the relatively mild stage of ALS, independent of physical dysfunctions. (...) Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis To determine the potential utility of the frontal assessment battery (FAB) in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated the association between the FAB score and regional gray matter volume, and ascertained whether the regional brain alterations related to cognitive impairments occur in relatively mild stage of ALS.Twenty-four ALS patients with a Mini-Mental State

2017 Brain and behavior

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