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Frontal Lobe

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81. Dissociation between Conceptual and Perceptual Implicit Memory: Evidence from Patients with Frontal and Occipital Lobe Lesions Full Text available with Trip Pro

Dissociation between Conceptual and Perceptual Implicit Memory: Evidence from Patients with Frontal and Occipital Lobe Lesions The latest neuroimaging studies about implicit memory (IM) have revealed that different IM types may be processed by different parts of the brain. However, studies have rarely examined what subtypes of IM processes are affected in patients with various brain injuries. Twenty patients with frontal lobe injury, 25 patients with occipital lobe injury, and 29 healthy (...) controls (HC) were recruited for the study. Two subtypes of IM were investigated by using structurally parallel perceptual (picture identification task) and conceptual (category exemplar generation task) IM tests in the three groups, as well as explicit memory (EM) tests. The results indicated that the priming of conceptual IM and EM tasks in patients with frontal lobe injury was poorer than that observed in HC, while perceptual IM was identical between the two groups. By contrast, the priming

2016 Frontiers in human neuroscience

82. Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes Full Text available with Trip Pro

Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age.Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic resonance imaging of 90 older men, aged ∼ 73 years. A measure of general fluid (...) intelligence (gf) associated with dorsolateral frontal regions was also derived from a contemporaneous psychological test battery.Despite highly discordant raw volumes for the same nominal regions, Manual and FreeSurfer (but not Stereology) left dorsolateral measures were significantly correlated with gf (r > 0.22), whereas orbital and inferior lateral volumes were not, consistent with the hypothesized frontal localization of gf.Individual differences in specific frontal lobe brain volumes--variously

2016 Journal of computer assisted tomography

83. The Doors and People Test: The Effect of Frontal Lobe Lesions on Recall and Recognition Memory Performance Full Text available with Trip Pro

The Doors and People Test: The Effect of Frontal Lobe Lesions on Recall and Recognition Memory Performance Memory deficits in patients with frontal lobe lesions are most apparent on free recall tasks that require the selection, initiation, and implementation of retrieval strategies. The effect of frontal lesions on recognition memory performance is less clear with some studies reporting recognition memory impairments but others not. The majority of these studies do not directly compare recall (...) and recognition within the same group of frontal patients, assessing only recall or recognition memory performance. Other studies that do compare recall and recognition in the same frontal group do not consider recall or recognition tests that are comparable for difficulty. Recognition memory impairments may not be reported because recognition memory tasks are less demanding.This study aimed to investigate recall and recognition impairments in the same group of 47 frontal patients and 78 healthy controls

2016 Neuropsychology

84. Frontal lobe regulation of blood glucose levels: support for the limited capacity model in hostile violence-prone men Full Text available with Trip Pro

Frontal lobe regulation of blood glucose levels: support for the limited capacity model in hostile violence-prone men Hostile men have reliably displayed an exaggerated sympathetic stress response across multiple experimental settings, with cardiovascular reactivity for blood pressure and heart rate concurrent with lateralized right frontal lobe stress (Trajanoski et al., in Diabetes Care 19(12):1412-1415, 1996; see Heilman et al., in J Neurol Neurosurg Psychiatry 38(1):69-72, 1975 (...) ). The current experiment examined frontal lobe regulatory control of glucose in high and low hostile men with concurrent left frontal lobe (Control Oral Word Association Test [verbal]) or right frontal lobe (Ruff Figural Fluency Test [nonverbal]) stress. A significant interaction was found for Group × Condition, F (1,22) = 4.16, p ≤ .05 with glucose levels (mg/dl) of high hostile men significantly elevated as a function of the right frontal stressor (M = 101.37, SD = 13.75) when compared to the verbal

2016 Brain Informatics

85. Frontal lobe tuberculoma Full Text available with Trip Pro

Frontal lobe tuberculoma Tuberculomas are usually infratentorial in children, and supratentorial lesions predominate in adults. We present a 4-year-old girl with multiple seizures, papilloedema and brisk reflexes. On investigation, she was found to have a large left parafalcine tuberculoma. She was treated with antitubercular treatment (ATT) and steroids. The child improved, seizures stopped and the papilloedema gradually disappeared. Follow-up magnetic resonance imaging brain after 8 months

2016 Oxford Medical Case Reports

86. Frontal lobe signs after posterior fossa surgery: Is hypoperfusion ignored? Full Text available with Trip Pro

Frontal lobe signs after posterior fossa surgery: Is hypoperfusion ignored? 26981321 2016 03 16 2018 11 13 2229-5097 7 2016 Surgical neurology international Surg Neurol Int Frontal lobe signs after posterior fossa surgery: Is hypoperfusion ignored? 20 10.4103/2152-7806.176673 Goudihalli Sachin Ranganatha SR Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Srinivasan Anirudh A Department of Neurosurgery, Postgraduate Institute of Medical

2016 Surgical neurology international

87. Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe Full Text available with Trip Pro

Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe Expression quantitative trait loci (eQTL) analysis is a powerful method to detect correlations between gene expression and genomic variants and is widely used to interpret the biological mechanism underlying identified genome wide association studies (GWAS) risk loci. Numerous eQTL studies have been performed on different cell types and tissues of which the majority has been based on microarray (...) technology.We present here an eQTL analysis based on cap analysis gene expression sequencing (CAGEseq) data created from human postmortem frontal lobe tissue combined with genotypes obtained through genotyping arrays, exome sequencing, and CAGEseq. Using CAGEseq as an expression profiling technique combined with these different genotyping techniques allows measurement of the molecular effect of variants on individual transcription start sites and increases the resolution of eQTL analysis by also including

2016 Genome medicine

88. Fantastic confabulation in right frontal lobe epilepsy Full Text available with Trip Pro

Fantastic confabulation in right frontal lobe epilepsy Interictal behavioral symptoms in frontal lobe epilepsy (FLE) are variable and often difficult to discriminate from other localization-related epilepsies.We report two female patients with right FLE who exhibited fantastic confabulations. One of the patients had a 14-year history of hypermotor seizures, and the other had a 10-year history of dyscognitive seizures with automatism. Their fantastic confabulations arose in the context

2016 Epilepsy & behavior case reports

89. Controllable yawning expressed as focal seizures of frontal lobe epilepsy Full Text available with Trip Pro

Controllable yawning expressed as focal seizures of frontal lobe epilepsy Excessive yawning was described in some neurological conditions as part of periictal or ictal manifestations of epilepsy, most commonly temporal lobe. We present the first case of controllable yawning as a primary seizure semiology with dominant frontal lobe involvement in a 20-year-old man. Video electroencephalography recorded 8 yawning episodes accompanied with right arm movement correlating with rhythmic diffuse theta (...) range activity with left hemispheric predominance. Magnetoencephalography coherence source imaging was consistent with persistent neuronal networks with areas of high coherence reliably present over the left lateral orbitofrontal region. Epileptogenic areas may have widespread networks involving the dominant frontal lobe in unique symptomatogenic areas.

2016 Epilepsy & behavior case reports

90. Rostro-caudal Architecture of the Frontal Lobes in Humans Full Text available with Trip Pro

Rostro-caudal Architecture of the Frontal Lobes in Humans The nature of the inputs and outputs of a brain region defines its functional specialization. The frontal portion of the brain is essential for goal-directed behaviors, however, the biological basis for its functional organization is unknown. Here, exploring structural connectomic properties, we delineated 12 frontal areas, defined by the pattern of their white matter connections. This result was highly reproducible across neuroimaging (...) associated with the varying degree of information processing complexity. These new anatomical signatures shed light onto the structural organization of the frontal lobes and could help strengthen the prediction or diagnosis of neurodevelopmental and neurodegenerative disorders.© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

2016 Cerebral Cortex (New York, NY)

91. A Consensus Network of Gene Regulatory Factors in the Human Frontal Lobe Full Text available with Trip Pro

A Consensus Network of Gene Regulatory Factors in the Human Frontal Lobe Cognitive abilities, such as memory, learning, language, problem solving, and planning, involve the frontal lobe and other brain areas. Not much is known yet about the molecular basis of cognitive abilities, but it seems clear that cognitive abilities are determined by the interplay of many genes. One approach for analyzing the genetic networks involved in cognitive functions is to study the coexpression networks of genes (...) with known importance for proper cognitive functions, such as genes that have been associated with cognitive disorders like intellectual disability (ID) or autism spectrum disorders (ASD). Because many of these genes are gene regulatory factors (GRFs) we aimed to provide insights into the gene regulatory networks active in the human frontal lobe. Using genome wide human frontal lobe expression data from 10 independent data sets, we first derived 10 individual coexpression networks for all GRFs including

2016 Frontiers in genetics

92. Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior Full Text available with Trip Pro

Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior Traumatic brain injury (TBI) is a major cause of chronic disability in the world. Moderate to severe TBI often results in damage to the frontal lobe region and leads to cognitive, emotional, and social behavioral sequelae that negatively affect quality of life. More specifically, TBI patients often develop persistent deficits in social behavior, anxiety, and executive functions such as attention, mental flexibility (...) , and task switching. These deficits are intrinsically associated with prefrontal cortex (PFC) functionality. Currently, there is a lack of analogous, behaviorally characterized TBI models for investigating frontal lobe injuries despite the prevalence of focal contusions to the frontal lobe in TBI patients. We used the controlled cortical impact (CCI) model in mice to generate a frontal lobe contusion and studied behavioral changes associated with PFC function. We found that unilateral frontal lobe

2016 PloS one

93. Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus Full Text available with Trip Pro

Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus 27748348 2017 02 27 2018 12 02 2542-5641 129 20 2016 10 20 Chinese medical journal Chin. Med. J. Late-onset Juvenile Myoclonic Epilepsy or Frontal Lobe Epilepsy with Myoclonus. 2508-2509 10.4103/0366-6999.191829 Zhang Xin-Yue XY Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin 130021, China. Yu Jin-Bei JB Department of Neurology, Neuroscience Center, First Hospital (...) Anticonvulsants 33CM23913M Carbamazepine VZI5B1W380 Oxcarbazepine IM Adult Anticonvulsants therapeutic use Brain drug effects pathology physiopathology Carbamazepine analogs & derivatives therapeutic use Electroencephalography Epilepsy, Frontal Lobe diagnosis drug therapy Female Humans Myoclonic Epilepsy, Juvenile diagnosis drug therapy Myoclonus diagnosis drug therapy Oxcarbazepine 2016 10 18 6 0 2016 10 18 6 0 2017 2 28 6 0 ppublish 27748348 ChinMedJ_2016_129_20_2508_191829 10.4103/0366-6999.191829

2016 Chinese medical journal

94. Three-year intractable hiccup: compression of the right frontal lobe by meningioma. Full Text available with Trip Pro

Three-year intractable hiccup: compression of the right frontal lobe by meningioma. 27593610 2017 12 11 2017 12 11 1555-7162 130 1 2017 Jan The American journal of medicine Am. J. Med. Three-Year Intractable Hiccups: Compression of the Right Frontal Lobe by Meningioma. e17-e18 S0002-9343(16)30852-X 10.1016/j.amjmed.2016.08.012 Hu Zhuoqing Z Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. Cui Liao L Department of Pharmacology, Guangdong Key (...) of Natural Drugs, Guangdong Medical University, Zhanjiang, China. eng Case Reports Journal Article 2016 09 02 United States Am J Med 0267200 0002-9343 AIM IM Aged Chronic Disease Follow-Up Studies Frontal Lobe pathology Hiccup etiology physiopathology Humans Intracranial Pressure Male Meningeal Neoplasms complications diagnostic imaging surgery Meningioma complications diagnostic imaging surgery Neurosurgical Procedures methods Quality of Life Risk Assessment Tomography, X-Ray Computed methods Treatment

2016 American Journal of Medicine

95. Identifying Specific Clinical Symptoms of Behavioral Variant Frontotemporal Dementia Versus Differential Psychiatric Disorders in Patients Presenting With a Late-Onset Frontal Lobe Syndrome. (Abstract)

Identifying Specific Clinical Symptoms of Behavioral Variant Frontotemporal Dementia Versus Differential Psychiatric Disorders in Patients Presenting With a Late-Onset Frontal Lobe Syndrome. Early differentiation between psychiatric disorders and behavioral variant frontotemporal dementia (bvFTD) is of paramount importance in patients with the late-onset frontal lobe syndrome. As bvFTD in patients will deteriorate, psychiatric disorders are treatable. To date, misdiagnosis often occurs due (...) to an overlap of symptoms and lack of specific biomarkers. The aim of our study was to investigate whether specific symptoms could separate bvFTD from psychiatric disorders.In a naturalistic, prospective, multicenter study, 137 patients (aged 45-75 years, 72% male) with a late-onset frontal lobe syndrome were included based on their scores on the Frontal Behavioral Inventory (FBI) and the Stereotypy Rating Inventory (SRI) from April 2011 to June 2013. In a multidisciplinary consensus meeting, diagnoses were

2016 Journal of Clinical Psychiatry

96. Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage. Full Text available with Trip Pro

Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage. Neurocognitive deficits are common among survivors of aneurysmal subarachnoid hemorrhage, even among those with good outcomes and no structural lesions. This study aims to probe the neurophysiological underpinnings of cognitive dysfunction among patients with ruptured intracranial aneurysms using magnetoencephalography (MEG).Thirteen patients who had undergone uncomplicated coiling for aneurysmal subarachnoid hemorrhage (...) and 13 matched controls were enrolled. Neuropsychological tests were done before magnetoencephalography scans. Magnetoencephalography data were acquired in a 151-channel, whole-head magnetoencephalography system for resting state and 2 cognitive tasks (go-no-go and set-shifting). Mean time from treatment to test was 18.8 months.Cognitive tasks of inhibition (go-no-go) indicated greater activation in the right anterior cingulate and inferior frontal gyrus, and cognitive set-shifting tasks (mental

2016 Stroke

97. Three-dimensional intracranial EEG monitoring in presurgical assessment of MRI-negative frontal lobe epilepsy. Full Text available with Trip Pro

Three-dimensional intracranial EEG monitoring in presurgical assessment of MRI-negative frontal lobe epilepsy. Magnetic resonance imaging (MRI)-negative epilepsy is associated with poor clinical outcomes prognosis. The present study was aimed to assess whether intracranial 3D interictal and ictal electroencephalography (EEG) findings, a combination of EEG at a different depth, in addition to clinical, scalp EEG, and positron emission tomography-computed tomography (PETCT) data help to predict (...) outcome in a series of patients with MRI-negative frontal lobe epilepsy (FLE) after surgery.Patients with MRI-negative FLE who were presurgically evaluated by 3D-intracranial EEG (3D-iEEG) recording were included. Outcome predictors were compared in patients with seizure freedom (group 1) and those with recurrent seizures (group 2) at least 24 months after surgery.Forty-seven patients (15 female) were included in this study. MRI was found normal in 38 patients, whereas a focal or regional

2016 Medicine

98. Frontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease: An Analysis of Linked Data. Full Text available with Trip Pro

Frontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease: An Analysis of Linked Data. To determine the association between frontal lobe function and risk of hip fracture in patients with Alzheimer disease (AD).Retrospective cohort study using multicenter hospital-based dementia registry and national health insurance claim data was done. Participants who had available data of neuropsychological test, national health insurance claim, and other covariates were included (...) . A total of 1660 patients with AD were included based on Stroop Test results. A total of 1563 patients with AD were included based on the Controlled Oral Word Association Test (COWAT) results. Hip fracture was measured by validated identification criteria using national health insurance claim data. Frontal lobe function was measured by Stroop Test and COWAT at baseline.After adjusting for potential covariates, including cognitive function in other domains (language, verbal and nonverbal memory

2015 Medicine

99. Quantitative electroencephalographic and neuropsychological investigation of an alternative measure of frontal lobe executive functions: the Figure Trail Making Test Full Text available with Trip Pro

Quantitative electroencephalographic and neuropsychological investigation of an alternative measure of frontal lobe executive functions: the Figure Trail Making Test The most frequently used measures of executive functioning are either sensitive to left frontal lobe functioning or bilateral frontal functioning. Relatively little is known about right frontal lobe contributions to executive functioning given the paucity of measures sensitive to right frontal functioning. The present investigation (...) reports the development and initial validation of a new measure designed to be sensitive to right frontal lobe functioning, the Figure Trail Making Test (FTMT). The FTMT, the classic Trial Making Test, and the Ruff Figural Fluency Test (RFFT) were administered to 42 right-handed men. The results indicated a significant relationship between the FTMT and both the TMT and the RFFT. Performance on the FTMT was also related to high beta EEG over the right frontal lobe. Thus, the FTMT appears

2015 Brain Informatics

100. Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort. (Abstract)

Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort. The criteria for behavioral variant frontotemporal dementia (bvFTD) incorporate MRI and [18F]-FDG-PET. Cerebrospinal fluid (CSF) analysis is merely advised for excluding Alzheimer's disease.We aimed to assess the impact of biomarkers on diagnostic certainty and contingent changes of bvFTD diagnosis within the clinically relevant (...) neuropsychiatric differential diagnosis of subjects with a late-onset frontal lobe syndrome (LOF).We included 137 patients with LOF, aged 45-75 years, 72% males. Biomarker disclosure was considered contributing after any substantial difference in diagnostic certainty or a diagnostic change. Percentages of contributing biomarkers were compared between three major diagnostic groups (bvFTD, psychiatry, other neurological disorders). Certainty levels in stable diagnostic groups were compared to those

2015 Dementia and Geriatric Cognitive Disorders

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