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Frontal Lobe

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5121. Cliniconeuropathologic findings of familial frontal lobe epilepsy in Shetland sheepdogs Full Text available with Trip Pro

Cliniconeuropathologic findings of familial frontal lobe epilepsy in Shetland sheepdogs We examined an epileptic focus by electroencephalography (EEG) by using an international 10-20 electrode system in 11 Shetland sheep dogs affected with familial idiopathic epilepsy. We also performed an evaluation of the amino acids in the cerebrospinal fluid (CSF) and a pathologic examination of the brains of 8 dogs that died from status epilepticus. Continuous electroencephalography demonstrated (...) that an epileptic focus was initially detected in the frontal lobe, particularly the internal area, and that paroxysmal foci developed diffusely in other lobes of affected dogs with recurrent convulsions. The EEG analyses indicated spike and sharp wave complexes, which were considered to be paroxysmal discharges. An increased value for glutamate or aspartate was found in the CSF of some epileptic dogs. Histologically, acute neuronal necrosis and astrocytosis were distributed predominantly in the cingulate

2002 Canadian Journal of Veterinary Research

5122. Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy Full Text available with Trip Pro

Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy 1. The normal and a mutant (S248F) human neuronal alpha4beta2 nicotinic receptors, and their interaction with the channel blocker carbamazepine (CBZ) have been modelled. The mutant, responsible for the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), has an enhanced sensitivity to and a slower recovery from desensitization, a lower

2002 British journal of pharmacology

5123. Are ictal vocalisations related to the lateralisation of frontal lobe epilepsy? Full Text available with Trip Pro

Are ictal vocalisations related to the lateralisation of frontal lobe epilepsy? The purpose was to analyse whether non-speech vocalisations in seizures originating in the frontal lobe do have lateralising value. Patients were included who had undergone presurgical evaluation with ictal video-EEG monitoring at the Epilepsy Centre, had had resective epilepsy surgery involving the frontal lobe, and who had remained seizure free>1 year postoperatively. Twenty seven patients aged 1-42 years (mean 18 (...) ) met the inclusion criteria. Age at epilepsy onset ranged from 1 month to 41 years (mean 7.1 years). All selected patients had a unilateral MRI detected lesion within the frontal lobe. Fifteen patients had right sided, 12 patients had left sided epileptogenic zones. Seizures recorded during EEG-video monitoring were re-evaluated to identify the occurrence of ictal vocalisations. Pure ictal vocalisations were distinguished from ictal sound productions due to motor or vegetative seizure activity

2000 Journal of neurology, neurosurgery, and psychiatry

5124. Sertraline for the Treatment of Patients With Frontal Lobe Dementia (FLD)

Sertraline for the Treatment of Patients With Frontal Lobe Dementia (FLD) Sertraline for the Treatment of Patients With Frontal Lobe Dementia (FLD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sertraline (...) for the Treatment of Patients With Frontal Lobe Dementia (FLD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00001777 Recruitment Status : Completed First Posted : December 10, 2002 Last Update Posted : March 4, 2008 Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Information provided

1999 Clinical Trials

5125. Studies of Frontal Lobe Brain Functioning in Schizophrenia

Studies of Frontal Lobe Brain Functioning in Schizophrenia Studies of Frontal Lobe Brain Functioning in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Studies of Frontal Lobe Brain (...) (CC) Study Details Study Description Go to Brief Summary: The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers. Participants in this study will undergo a positron emission tomography (PET) scan of the brain while performing neuropsychological tests. Some of the tests involve cognitive operations that depend upon the frontal

1999 Clinical Trials

5126. Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00001178 Recruitment Status : Terminated First Posted : November 4, 1999 Last Update Posted : March 25, 2019 Sponsor: National Institute of Neurological Disorders and Stroke

1999 Clinical Trials

5127. Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function. (Abstract)

Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function. A minority of patients with obsessive-compulsive disorder (OCD) have a chronic course and extreme disability, with symptoms refractory to pharmacological and psychological treatment. Considerable uncontrolled evidence suggests such cases may respond to neurosurgical intervention. The authors update current stereotactic procedures and their efficacy, safety, and side effect (...) profiles. The design of an ongoing placebo-controlled trial of Gamma Knife capsulotomy for refractory OCD is outlined. Drug treatment of OCD may be assumed to affect a proposed functional imbalance between the frontal lobes and other parts of the brain. As for neurosurgical treatments, both the effects and side effects may be viewed as expressions of their influence on this functional imbalance.

1994 The Journal of neuropsychiatry and clinical neurosciences Controlled trial quality: uncertain

5128. Neuropsychological performance on tests of frontal-lobe functioning and aggressive behavior in men. (Abstract)

Neuropsychological performance on tests of frontal-lobe functioning and aggressive behavior in men. The authors tested the relationship between frontal-lobe functioning and physical aggression in young men in a laboratory setting. Seventy-two men completed two putative neuropsychological measures of frontal-lobe functioning--the Self-Ordered Pointing (SOP) Task and the Conditional Association Task (CAT)--and an abbreviated version of the Wechsler Adult Intelligence Scale--Revised. Aggression (...) between frontal-lobe functioning and aggressive behavior.

1994 Journal of abnormal psychology Controlled trial quality: uncertain

5129. Hypothalamic amnesia and frontal lobe function disorders after Langerhans cell histiocytosis Full Text available with Trip Pro

Hypothalamic amnesia and frontal lobe function disorders after Langerhans cell histiocytosis 12933957 2003 10 07 2017 11 14 0022-3050 74 9 2003 Sep Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Hypothalamic amnesia and frontal lobe function disorders after Langerhans cell histiocytosis. 1348 Manning L L Sellal F F eng Case Reports Comment Letter England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Neurology. 2001 Jun 12;56(11):1597-600 11402128 Aged (...) Amnesia etiology pathology Female Frontal Lobe pathology Histiocytosis, Langerhans-Cell complications Humans Hypothalamus pathology Magnetic Resonance Imaging Neuropsychological Tests 2003 8 23 5 0 2003 10 8 5 0 2003 8 23 5 0 ppublish 12933957 PMC1738640

2003 Journal of neurology, neurosurgery, and psychiatry

5130. Calcium and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE) Full Text available with Trip Pro

Calcium and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE) 15346160 2018 11 13 1535-7597 3 6 2003 Nov Epilepsy currents Epilepsy Curr Calcium and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE). 221-222 Mody Istvan I eng Journal Article United States Epilepsy Curr 101135954 1535-7511 2004 9 4 5 0 2004 9 4 5 0 2004 9 4 5 0 ppublish 15346160 10.1046/j.1535-7597.2003.03603.x PMC321217 Pflugers Arch. 2001 Aug;442(5):642-51 11512019 Neuron. 2003 Jan 23;37(2):287-97 12546823

2003 Epilepsy Currents

5131. Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage. Full Text available with Trip Pro

Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage. We report on our analysis of a patient who developed personality changes which strongly resembled an antisocial personality disorder after surgical resection of a pituitary tumor. Despite behavioral changes that were obvious to friends, family and health care professionals, formal neuropsychological and personality testing revealed no specific cognitive deficits or psychopathology (...) . We hypothesize that damage to a circumscribed region of the left orbitofrontal cortex, illustrated by magnetic resonance imaging, underlies these personality alterations. In contrast to previous reports, which ascribe such personality changes to bilateral frontal lobe injury, we suggest that unilateral frontal lobe damage alone may have resulted in the development of this syndrome.

1992 Journal of Psychiatry and Neuroscience

5132. Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13. Full Text available with Trip Pro

Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13. PLO-SL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy) is a recessively inherited disorder characterized by systemic bone cysts and progressive presenile frontal-lobe dementia, resulting in death at <50 years of age. Since the 1960s, approximately 160 cases have been reported, mainly in Japan and Finland. The pathogenesis of the disease is unknown. In this article, we report

1998 American Journal of Human Genetics

5133. Refractory symptomatic schizophrenia resulting from frontal lobe lesion: response to clozapine. Full Text available with Trip Pro

Refractory symptomatic schizophrenia resulting from frontal lobe lesion: response to clozapine. A 34-year-old man with a 10-year history of persistent auditory hallucinations and passivity delusions had failed to respond to a variety of conventional antipsychotic medications. He had a history of head trauma 8 years before the onset of psychiatric symptoms. Recent investigations revealed a post-traumatic infarct, situated in the left frontal lobe, on a magnetic resonance imaging scan. Treatment

1999 Journal of Psychiatry and Neuroscience

5134. Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Full Text available with Trip Pro

Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Autosomal dominant nocturnal frontal-lobe epilepsy (ADNFLE) is a recently identified partial epilepsy in which two different mutations have been described in the alpha4 subunit of the neuronal nicotinic acetylcholine receptor (CHRNA4). An additional seven families are presented in which ADNFLE is unlinked to the CHRNA4 region on chromosome 20q13.2. Seven additional sporadic cases

1998 American Journal of Human Genetics

5135. New MR/MCA syndrome with distinct facial appearance and general habitus, broad and webbed neck, hypoplastic inverted nipples, epilepsy, and pachygyria of the frontal lobes Full Text available with Trip Pro

New MR/MCA syndrome with distinct facial appearance and general habitus, broad and webbed neck, hypoplastic inverted nipples, epilepsy, and pachygyria of the frontal lobes 10928857 2000 08 02 2011 11 17 1468-6244 37 6 2000 Jun Journal of medical genetics J. Med. Genet. New MR/MCA syndrome with distinct facial appearance and general habitus, broad and webbed neck, hypoplastic inverted nipples, epilepsy, and pachygyria of the frontal lobes. 460-2 Fryns J P JP Aftimos S S eng Case Reports Letter (...) England J Med Genet 2985087R 0022-2593 IM Abnormalities, Multiple genetics physiopathology Adolescent Child Child, Preschool Epilepsy genetics Face abnormalities Female Frontal Lobe abnormalities physiopathology Humans Infant, Newborn Intellectual Disability genetics physiopathology Male Neck abnormalities Nipples abnormalities Syndrome 2000 8 6 2000 8 6 0 1 2000 8 6 0 0 ppublish 10928857 PMC1734613

2000 Journal of Medical Genetics

5136. CHRNB2 Is the Second Acetylcholine Receptor Subunit Associated with Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Full Text available with Trip Pro

CHRNB2 Is the Second Acetylcholine Receptor Subunit Associated with Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is an uncommon, idiopathic partial epilepsy characterized by clusters of motor seizures occurring in sleep. We describe a mutation of the beta2 subunit of the nicotinic acetylcholine receptor, effecting a V287M substitution within the M2 domain. The mutation, in an evolutionary conserved region of CHRNB2, is associated

2000 American Journal of Human Genetics

5137. Retrograde amnesia in patients with diencephalic, temporal lobe or frontal lesions. (Abstract)

Retrograde amnesia in patients with diencephalic, temporal lobe or frontal lesions. Patients with focal diencephalic, temporal lobe, or frontal lobe lesions were examined on various measures of remote memory. Korsakoff patients showed a severe impairment with a characteristic 'temporal gradient', whereas two patients with focal diencephalic damage (and anterograde amnesia) were virtually unimpaired on remote memory measures. Patients with frontal lobe pathology were severely impaired (...) in the recall of autobiographical incidents and famous news events. Patients with temporal lobe pathology showed severe impairment but a relatively 'flat' temporal gradient, largely attributable to herpes encephalitis patients. From recognition and cued recall tasks, it is argued that there is an important retrieval component to the remote memory deficit across all the lesion groups. In general, the pattern of performance by the frontal lobe and temporal lobe groups was closely similar

1999 Neuropsychologia Controlled trial quality: uncertain

5138. Effects of frontal lobe damage on interference effects in working memory. (Abstract)

Effects of frontal lobe damage on interference effects in working memory. Working memory is hypothesized to comprise a collection of distinct components or processes, each of which may have a unique neural substrate. Recent neuroimaging studies have isolated a region of the left inferior frontal gyrus that appears to be related specifically to one such component: resolving interference from previous items in working memory. In the present study, we examined working memory in patients (...) with unilateral frontal lobe lesions by using a modified version of an item recognition task in which interference from previous trials was manipulated. In particular, we focused on patient R.C., whose lesion uniquely impinged on the region identified in the neuroimaging studies of interference effects. We measured baseline working memory performance and interference effects in R.C. and other frontal patients and in age-matched control subjects and young control subjects. Comparisons of each of these groups

2002 Cognitive, affective & behavioral neuroscience Controlled trial quality: uncertain

5139. Effects of experimentally-induced emotional states on frontal lobe cognitive task performance. (Abstract)

Effects of experimentally-induced emotional states on frontal lobe cognitive task performance. A growing body of evidence suggests that dysphoric and euphoric emotional states are associated with reliable patterns of frontal lobe activity. Specifically, dysphoric affect coincides with greater right than left frontal lobe activity, and euphoric affect tends to correspond with a converse pattern of activity. The present study examined whether cognitive outcomes associated with the left and right (...) frontal lobes are differentially influenced by dysphoric and euphoric affect. In a completely between-groups design, 60 dextral women were administered either the positive or negative conditions of the Velten Mood Induction Procedure, and they subsequently completed either a verbal or figural fluency test. Euphoria resulted in better verbal than figural fluency performance, and dysphoria yielded better figural than verbal fluency outcomes. These findings are consistent with electrophysiological data

1999 Neuropsychologia Controlled trial quality: uncertain

5140. 31P-spectroscopy of frontal lobe in schizophrenia: alterations in phospholipid and high-energy phosphate metabolism. (Abstract)

31P-spectroscopy of frontal lobe in schizophrenia: alterations in phospholipid and high-energy phosphate metabolism. Studies using 31P-magnetic resonance spectroscopy (MRS) reported on abnormalities in frontal lobe metabolism in schizophrenia. The most consistent findings were a reduction in the resonances of phosphomonoesters (PME) and/or increased phosphodiesters (PDE), which are, respectively, the precursors and the metabolites of membrane phospholipids, thus suggesting an accelerated (...) phospholipid metabolism in the disease. Other studies reported increased high-energy phosphates (ATP-adenosine triphosphate and PCr-phosphocreatine) in schizophrenia, reflecting decreased use of energy in the frontal lobe. We investigated 53 schizophrenic patients (DSM-IV) and 35 healthy controls. Eighteen from these patients were drug nai;ve and the remaining 35 were drug-free for an average of 6 months. Phospholipid metabolism and high-energy phosphates were assessed in the left frontal lobe using 31P

2002 Schizophrenia Research

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