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Free Thyroxine Index

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161. Thyroid function and ischemic heart disease: a Mendelian randomization study (PubMed)

Thyroid function and ischemic heart disease: a Mendelian randomization study To clarify the role of thyroid function in ischemic heart disease (IHD) we assessed IHD risk and risk factors according to genetically predicted thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) positivity. Separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization) was used in an extensively genotyped case (n = 64,374)-control (n (...)  = 130,681) study, CARDIoGRAMplusC4D. Associations with lipids, diabetes and adiposity were assessed using the Global Lipids Genetics Consortium Results (n = 196,475), the DIAbetes Genetics Replication And Meta-analysis case (n = 34,380)-control (n = 114,981) study, and the Genetic Investigation of ANthropometric Traits (body mass index in 152,893 men and 171,977 women, waist-hip ratio in 93,480 men and 116,741 women). Genetically predicted thyroid function was not associated with IHD (odds ratio

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2017 Scientific reports

162. Association between thyroid autoimmunity and Helicobacter pylori infection (PubMed)

a health promotion center. A total of 5,502 subjects were analysed. Thyroid status was assessed by free thyroxine, thyroid stimulating hormone, and anti-thyroid peroxidase antibody (TPO-Ab). Immunoglobulin G (IgG) antibodies to H. pylori were measured as an indication of H. pylori infection. We compared the prevalence of TPO-Ab in subjects with and without H. pylori infection.H. pylori IgG antibodies were found in 2,875 subjects (52.3%), and TPO-Ab were found in 430 (7.8%). Individuals positive for H (...) . pylori Ab were older than those negative for H. pylori Ab (p < 0.01). The proportion of females was significantly higher in the TPO-Ab positive group (41.0% vs. 64.2%, p < 0.01). Prevalence of TPO-Ab positivity was higher in subjects with H. pylori infection (8.6% vs. 7.00%, p = 0.03), and this association was significant after adjusting for age, sex, and body mass index (odds ratio, 1.02; 95% confidence interval, 1.00 to 1.03; p = 0.04).In our study, prevalence of TPO-Ab positivity is more frequent

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2017 The Korean journal of internal medicine

163. Iodine-131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease (PubMed)

131I therapy remained significantly higher than in control subjects (P<0.01). Conversely, serum ICAM-1 levels in patients with GD were gradually increased in the 12 months following 131I therapy and reached a relatively stable level thereafter. Furthermore, the Pearson's correlation analysis indicated that the serum levels of IL-6, CXCL-10 and ICAM-1 were not associated with free triiodothyronine, the free thyroxine index, and thyroid-stimulating hormone in these patients. 131I therapy was able

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2017 Experimental and therapeutic medicine

164. The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans (PubMed)

The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans Subclinical hyperthyroidism and subclinical hypothyroidism are characterized by abnormal thyroid stimulating hormone (TSH) with normal free thyroxine. Subclinical thyroid diseases, to date, have received less attention compared with other thyroid diseases since they are asymptomatic. This study aimed to verify the association between subclinical thyroid diseases and cardiovascular diseases (...) stratification by gender. The TSH reference range was between 0.61 and 6.91 mIU/L in this study. TSH showed a positive association with the 10-year CVD risk score only in the female population (P = 0.001). There were significant differences in the least squares means of 10-year CVD risk score by the effect of subclinical hypothyroidism compared with euthyroidism (normal group) in females, after adjusting for body mass index, white blood cell, and urine iodine (P = 0.006 and Bonferroni corrected P = 0.012

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2017 Journal of Korean medical science

165. Comparative analysis of thyroid function parameters in pregnant women (PubMed)

Comparative analysis of thyroid function parameters in pregnant women The aim of the present study was to investigate the serum levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) during pregnancy and comparative analysis of serum markers levels in non-pregnant women and pregnant women. Pregnant women were divided into four groups according to their gestational age: 8-14, 15-20, 21-36 and ≥37 weeks. Non-pregnant women were divided into three groups (...) according to their age: 20-40, 41-55 and 56-85 years, and women of reproductive age (20-40 years) as control, which match their age and body mass index with pregnant women. The levels of serum markers were measured by magnetic microparticle chemiluminescence immunoassay and compared among different gestational weeks or with the control. In pregnant women, from 8-14 to ≥37 weeks, FT3 and FT4 levels declined, and significant differences were identified between each group, except for FT4 at 21-36 weeks

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2017 Biomedical reports

166. High levels of Nesfatin-1 in relation to the dysfunction of the hypothalamic–pituitary–adrenal and hypothalamus–pituitary–thyroid axes in depressed patients with subclinical hypothyroidism (PubMed)

to the patients in terms of weight and body mass index. The Hamilton Depression Rating Scale was administered to both the groups. The enzyme-linked immunosorbent assay method was used to measure plasma Nesfatin-1, corticosterone, and TSH levels. A radioimmunoassay kit was used for the measurement of the plasma-free triiodothyronine and plasma-free thyroxine. The results showed that the Hamilton Depression Rating Scale scores and average Nesfatin-1, corticosterone, and TSH levels were significantly higher

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2017 Neuropsychiatric disease and treatment

167. Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese Children (PubMed)

in this study. Diagnosis of AN was done by clinical examination. Body mass index (BMI), fasting blood sugar, total cholesterol, triglycerides (TG), alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, high- and low-density lipoprotein cholesterol, insulin, thyroid-stimulating hormone, free thyroxin (fT4), calcium, phosphorus and 25-hydroxyvitamin D were measured with routine techniques. Collected data were compared between cases with AN and without AN. Independent t-test

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2017 Journal of clinical and diagnostic research : JCDR

168. Uptravi (selexipag) - pulmonary arterial hypertension

Plasma concentration at the end of one dose interval C trough,ss Plasma concentration at the end of one dose interval at steady-state Cu/C concentration of free (unbound) to total plasma concentration CV Coefficient of variation CVb Inter-subject coefficient of variation CVw Intra-subject coefficient of variation DMC Data Monitoring Committee (also referred to as DSMB, Data Safety Monitoring Board) DSMB Data Safety Monitoring Board eGFR estimated glomerular filtration rate EOS End of study ERA (...) al. 2014). A decreased expression of the IP receptor has been found in the remodeled pulmonary arterial smooth muscle. The applicant provided non clinical data from a full non clinical programme as detailed below. The non clinical studies performed with selexipag are summarized. In most original reports of the in-vitro functional assays, the Applicant has given IC 50 /EC 50 values for the total concentrations. In the following the values for free IC 50 /EC 50 values are also given, taking

2016 European Medicines Agency - EPARs

169. Cabometyx (cabozantinib) - advanced renal cell carcinoma

electrocardiogram ECOG Eastern Cooperative Oncology Group EMA European Medicines Agency EPO erythropoietin ER emergency room ESA erythropoiesis-stimulating agent ESC Exelixis Safety Committee FACT Functional Assessment of Cancer Therapy FBE free base equivalent FDA Food and Drug Administration FFPE formalin-fixed paraffin embedded FKSI-19 FACT Kidney Symptom Index questionnaire FT4 free thyroxine G-CSF granulocyte colony-stimulating factor GGT gamma-glutamyl transpeptidase GI gastrointestinal GM-CSF granulocyte (...) Network ND not determined NE not estimable NPACT nonprotocol anticancer therapy ONJ osteonecrosis of the jaw ORR objective response rate OS overall survival PD progressive disease PK pharmacokinetics PE pulmonary embolism PFS progression-free survival PITT primary endpoint intent-to-treat population PPD Pharmaceutical Product Development, Incorporated PPES palmar-plantar erythrodysesthesia syndrome PR partial response PS performance status qd once daily QT time interval in ECG reading QTcF corrected

2016 European Medicines Agency - EPARs

170. Effect of Dietary Selenium Deficiency on the Cell Apoptosis and the Level of Thyroid Hormones in Chicken. (PubMed)

(containing 0.033 mg of Se/kg). Fifteen chickens were killed in each group on days 30, 60, and 90, respectively. Then, serum and testes were collected and used in the detection of experimental index. Results indicated that GSH-Px activity and Bcl-2 mRNA level in the testes and thyroidal triiodothyronine (T3) and free triiodothyronine (FT3) levels in serum by dietary Se deficiency were significantly decreased compared to the corresponding control groups. Se deficiency-treated group showed a significant (...) increase in MDA concent, TUNEL-positive cells, and mRNA level of Bax, Caspase3, and p53 in the testes and thyroidal thyroxine (T4), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) levels in serum. Histopathologically, Se deficiency caused impairments in the testes. These results suggested that dietary Se deficiency exerts significant harmful effects on male reproductive organ and that the intrinsic and extrinsic pathways and the upstream regulators such as p53, Bax, and Bcl-2 were all

2017 Biological trace element research Controlled trial quality: uncertain

171. Thyroid hormones and changes in body weight and metabolic parameters in response to weight-loss diets: The POUNDS LOST trial. (PubMed)

participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months.Participants lost an average of 6.6 kg of body weight during the first 6 months (...) and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (P<0.05) after multivariate adjustments including dietary

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2017 International Journal of Obesity Controlled trial quality: uncertain

172. Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST). (PubMed)

Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST). Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the effect of thyroid hormone treatment. We describe the protocol of a large randomised controlled trial (RCT) of Levothyroxine treatment (...) ), fatal and non-fatal cardiovascular events, handgrip strength, executive cognitive function (Letter Digit Coding Test), basic and instrumental activities of daily living, haemoglobin, blood pressure, weight, body mass index and waist circumference. Patients are monitored for specific adverse events of interest including incident atrial fibrillation, heart failure and bone fracture.This large multicentre RCT of levothyroxine treatment of subclinical hypothyroidism is powered to detect clinically

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2017 BMC Endocrine Disorders Controlled trial quality: predicted high

173. Briviact - brivaracetam

transaminase AUC area under the curve AUCt area under the curve over a dosing interval BCRP Breast Cancer Resistance Protein BCS Biopharmaceutics Classification System BID Twice daily BMI body mass index BOCF baseline observation carried forward BRV brivaracetam BSEP Bile Salt Export Pump c av average concentration CBZ carbamazepine CFU Colony Forming Units CHMP Committee for Medicinal Products for Human Use CI confidence interval CL Total plasma clearance c max Maximum observed plasma concentration CNS (...) for epilepsy is antiepileptic drugs (AEDs) aiming at preventing or reducing seizures as quickly as possible. Improved seizure control is likely to reduce morbidity and premature mortality associated with continuing seizures, especially convulsive attacks. In addition, seizure remission is a major determinant of good quality of life (Duncan et al. 2006). It is estimated that roughly 70-80 % of adults with new onset epilepsy will become seizure free with available AEDs, although around half will experience

2016 European Medicines Agency - EPARs

174. Management of Thyroid Cancer

Differentiated thyroid cancer* EBRT External beam radiotherapy EORTC European Organisation for Research and Treatment of Cancer ETA European Thyroid Association FACS Fluorescent activated cell sorter FNMTC Familial non-medullary thyroid cancer FDG Fluoro-deoxy-glucose FKGL Flesch-Kincaid Grade Level FMTC Familial medullary thyroid cancer FNAB Fine-needle aspiration biopsy FNAC Fine-needle aspiration cytology FRAX Fracture Risk Assessment Tool FTC Follicular thyroid cancer* FT4 free thyroxine FVPTC follicular

2014 British Association of Endocrine and Thyroid Surgeons

175. Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Patient

of this article, please visit: Copyright © 2013 AACE. AbbreviA tions AACe = American Association of Clinical Endocrinologists; ACs = American College of Surgery; AsMbs = American Association of Metabolic and Bariatric Surgery; bAC = blood alcohol content; beD = binge eating disorder; beL = best evidence level; bMi = body mass index; bPD-Ds = biliopancreatic diversion with duodenal switch; CCs = clinical case series; CK = creatine kinase; CPAP = continuous posi- tive airway pressure; CPG (...) ? (R72-74) evidence base (Q1-7) references introDUCtion Obesity continues to be a major public health problem in the United States, with more than one-third of adults considered obese in 2009-2010, as defined by a body mass index (BMI) =30 kg/m 2 (1 [EL 3, SS]). Obesity has been associated with an increased hazard ratio for all-cause mortality (2 [EL 3, SS]), as well as significant medical and psychological co-morbidity. Indeed, obesity is not only a chronic medical condition but should be regarded

2013 American Association of Clinical Endocrinologists

176. Management of Thyroid Dysfunction during Pregnancy and Postpartum

range (5–12 μg/dl or 50–150 nmol/liter) can be adapted in the second and third trimesters by multiplying this range by 1.5-fold. Alternatively, the free T 4 index (“adjusted T 4 ”) appears to be a reliable assay during pregnancy. U.S. Preventive Service Task Force (USPSTF) recommendation level: B; evidence, fair (GRADE 2|⊕⊕○○). 1.2.1. Overt maternal hypothyroidism is known to have serious adverse effects on the fetus. Therefore, maternal hypothyroidism should be avoided. For overt hypothyroidism (...) above the upper limit of the nonpregnant reference range, USPSTF recommendation level: B; evidence, fair (1|⊕⊕○○), or to maintain total T 4 at 1.5 times the upper limit of the normal reference range or the free T 4 index in the upper limit of the normal reference range. USPSTF recommendation level: I; evidence, poor (2|⊕○○○). 2.1.3. Propylthiouracil (PTU), if available, is recommended as the first-line drug for treatment of hyperthyroidism during the first trimester of pregnancy because

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2012 The Endocrine Society

178. SNMMI Procedure Standard for Therapy of Thyroid Disease with 131I (Sodium Iodide) 3.0

University Medical Center, Nashville, Tennessee; 11 Beth Israel Deaconess Medical Center, Boston, Massachusetts; 12 Mallinckrodt Institute of Radiology, St. Louis, Missouri; 13 Jacobi Medical Center, Bronx, New York; 14 Vanderbilt University, Nashville, Tennessee; and 15 Cedars-Sinai Medical Center, Los Angeles, California INDEX Preamble 1 I. Introduction: patient management, licensure 2 II. Goals 2 III. De?nitions: risk levels 2 IV. Common clinical indications 3 V. Quali?cations and responsibilities (...) therapy. The consent form should include TABLE 1 Pharmaceuticals Blocking Radioiodine Uptake Type of medication Recommended time of withdrawal Thionamide medications (e.g., propylthiouracil, methimazole carbimazole) 3d Multivitamins containing iodide 7–10 d Natural or synthetic thyroid hormones 10–14 d for triiodothyronine 3–4 wk for thyroxine Kelp, agar, carrageenan, Lugol solution 2–3 wk, depending on iodide content Saturated solution of potassium iodide 2–3wk Topical iodine (e.g., surgical skin

2012 Society of Nuclear Medicine and Molecular Imaging

179. Clinical Practice Guidelines for Hypothyroidism in Adults

is the metabolically available moiety (70), have been developed, and assess- ment of serum free T 4 has now largely replaced measure- ment of serum total T 4 as a measure of thyroid status. These methods include the serum free T 4 index, which is derived as the product of total T 4 and a thyroid hormone binding ratio, and the direct immunoassay of free T 4 after ultrafil - tration or equilibrium dialysis of serum or after addition of anti-T 4 antibody to serum (71). Table 6 Assessment of Free Thyroxine Test Method (...) 4 vs. total T 4 1011992 R8 Using free T 4 to monitor L-thyroxine treatment 1012 R9 Estimating serum free T 4 in pregnancy 1012 R10 Prohibition against using T 3 to diagnose hypothyroidism 1012 R11 Measuring TSH in hospitalized patients 1012 R12 Serum T 4 vs. TSH for management of central hypothyroidism 1012 Q5 When should TSH levels be measured in patients being treated for hypothyroidism? 1012 R13 When to measure TSH in patients taking L-thyroxine for hypothyroidism 1012 Q6 What should

2012 American Association of Clinical Endocrinologists

180. Oral anticoagulation with warfarin - 4th edition

Oral anticoagulation with warfarin - 4th edition Guidelines on oral anticoagulation with warfarin – fourth edition - Keeling - 2011 - British Journal of Haematology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted at is unavailable due to technical difficulties. guideline Free Access Guidelines on oral anticoagulation with warfarin – fourth edition

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2011 British Committee for Standards in Haematology

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