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61. The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial

, trial nested within the TRUST trial, Swiss participants ages ≥65 years with subclinical hypothyroidism (thyroid-stimulating hormone [TSH] 4.60-19.99 mIU/L; free thyroxine level within reference range) were randomized to levothyroxine (starting dose of 50 µg daily) to achieve TSH normalization or placebo. The primary outcomes were the left ventricular ejection fraction for systolic function and the ratio between mitral peak velocity of early filling to early diastolic mitral annular velocity (E/e (...) ' ratio) for diastolic function. Secondary outcomes included e' lateral/septal, left atrial volume index, and systolic pulmonary artery pressure. Results: A total of 185 participants (mean age 74.1 years, 47% women) underwent echocardiography at the end of the trial. After a median treatment duration of 18.4 months, the mean TSH decreased from 6.35 mIU/L to 3.55 mIU/L with levothyroxine (n = 96), and it remained elevated at 5.29 mIU/L with placebo (n = 89). The adjusted between-group difference

2020 EvidenceUpdates

62. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

the effectiveness and safety of interventions targeting sensory challenges in children with autism spectrum disorder (ASD). Data sources. We searched MEDLINE ® , Embase ® , the Cumulative Index of Nursing and Allied Health Literature ® , and PsycINFO ® from January 2010 to September 2016. Review methods. We included studies comparing interventions incorporating sensory-focused modalities with alternative treatments or no treatment. Studies had to include at least 10 children with ASD ages 2–12 years. Two (...) disorders. Current Opinion in Neurology. 2011;24(2):132-9 8p. doi: 10.1097/WCO.0b013e3283446450. PMID: 104865655. Language: English. Entry Date: 20110527. Revision Date: 20150711. Publication Type: Journal Article.X-1 686. Johnson CR, Handen BL, Zimmer M, et al. Effects of gluten free / casein free diet in young children with autism: A pilot study. Journal of Developmental and Physical Disabilities. 2011 2015-12- 09;23(3):213-25. doi: D-59 http://dx.doi.org/10.1007/s10882-010-9217- x. PMID: 888750170

2017 Effective Health Care Program (AHRQ)

63. CRACKCast E128 – Thyroid and Adrenal Disorders

! Shownotes – Key Concepts Hyperthyroidism Thyroid hormone exerts effects on nearly every organ system. A high degree of suspicion is needed to diagnose hyperthyroidism. The laboratory evaluation of choice is determination of the TSH concentration with free T4 and T3 levels. Total T4 and T3 levels are of limited value. Thyroid storm is a life-threatening thyrotoxic crisis that requires prompt recognition and therapy, as well as identification and treatment of any precipitating cause, such as infection (...) event in patients with untreated or undertreated hypothyroidism. Treatment with thyroid hormone replacement must be initiated, often solely on clinical findings. Adrenal Insufficiency Clinical manifestations of primary and secondary adrenal insufficiency may be vague and nonspecific and require a high index of suspicion for diagnosis. Predominant complaints include fatigue, weakness, dizziness, nausea, vomiting, and other nonspecific GI symptoms. Patients with primary adrenal insufficiency

2017 CandiEM

64. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

Keep me logged in Search April 2019 March 2019 February 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (...) guideline updates prior JNC reports. 1.1. Methodology and Evidence Review An extensive evidence review, which included literature derived from research involving human subjects, published in English, and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline, was conducted between February and August 2015. Key search words included but were not limited to the following: adherence; aerobic

2017 American Heart Association

65. Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association (Full text)

with cyanotic CHD. 212,213 Hy- peruricemia is a marker of disease severity in cyanotic patients and is negatively correlated with cardiac index. Those with the highest uric acid levels had worse survival in a cohort of 94 patients with Eisenmenger syndrome. 214 Management Hyperuricemia is diagnosed by testing serum uric acid, which should be done annually in cyanotic CHD. 2 Di- agnosis of gout is difficult because patients with Eisen- menger syndrome often have pain resulting from hy- pertrophic

2017 American Heart Association PubMed abstract

66. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary (Full text)

! Login to your account Email Password Keep me logged in Search April 2019 March 2019 February 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart (...) (JNC) BP guidelines were published to assist the practice community and improve prevention, awareness, treatment, and control of high BP. The present guideline updates prior JNC reports. 1.1. Methodology and Evidence Review An extensive evidence review, which included literature derived from research involving human subjects, published in English, and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases

2017 American Heart Association PubMed abstract

67. The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association

. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share on Jump to Free Access article The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association , MD, PhD, MPH, FAHA, Chair , MD, PhD, FAHA, Co-Chair , PhD, FAHA , MD, FAHA , MD, FAHA , MD, MHS, FAHA , MD, MPH, FAHA , MD , and MD, FAHA MD, MS, FAHAon behalf of the American Heart Association Committee on Molecular (...) . Biomarker studies can broadly be divided into targeted (or candidate-driven) and untargeted (or discovery) approaches. The targeted approaches are based on a hypothesis about a specific mechanism or pathway; therefore, they typically focus on 1 or a few biomarkers representing that biological system. In contrast, the untargeted approaches are hypothesis free, or rather hypothesis generating, and aim at surveying a whole class of biomarkers in an unbiased way. The use of untargeted approaches

2017 American Heart Association

68. Functional Hypothalamic Amenorrhea

, we recommend obtaining the following laboratory tests: serum thyroid-stimulating hormone (TSH), free thyroxine (T4), prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and anti-Müllerian hormone (AMH). Clinicians should obtain total testosterone and dehydroepiandrosterone sulfate (DHEA-S) levels in patients with clinical hyperandrogenism and 8 AM 17-hydroxyprogesterone levels if clinicians suspect late-onset congenital adrenal hyperplasia (CAH). (1|⊕⊕⊕⊕) 2.5 (...) efficacy, but minimal potential for harm, clinicians can consider a trial of CBT in women with FHA who wish to conceive, as this treatment has the potential to restore ovulatory cycles and fertility without the need for medical intervention. (2|⊕⊕⚪⚪) 3.10 We suggest that clinicians should only induce ovulation in women with FHA that have a body mass index (BMI) of at least 18.5 kg/m2 and only after attempts to normalize energy balance, due to the increased risk for fetal loss, small-for-gestational-age

2017 The Endocrine Society

69. NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nu

: Complete blood count (CBC) with differential, AST, bilirubin (total, conjugated), alkaline phosphatase, GGT, international normalized ratio (INR), albumin, total protein, hemoglobin A1c Exclude infections (eg, hepatitis A IgM, hepatitis B surface antigen, hepatitis C antibody, other chronic viral infections) Exclude endocrine disorders (thyroid-stimulating hormone [TSH], free thyroxine [T4]) Exclude autoimmune causes of ALT elevation (total IgA, total IgG and tissue transglutaminase antibody (...) pediatric studies, independent of body mass index (BMI) and standard metabolic risk factors (11,12). It is not known whether OSA treatment ameliorates NASH. Among children newly diagnosed with type 2 diabetes mellitus (T2DM), elevated ALT is more frequent in Hispanic children compared to African American children (13). In addition, pediatric patients with panhypopituitarism appear to have increased risk of NAFLD, NASH, and even cirrhosis (14,15), similar to the increased preva- lence (77%) and severity

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

70. Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer's-Type Dementia

. There was not a separate, independent Key Informant panel. The role of the Technical Expert Panel was then filled by the National Academies Committee. A complete description of the methods can be found in the full report. ES-4 Literature Search Strategy We searched Ovid Medline ® , Ovid PsycINFO ® , Ovid Embase ® , and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify randomized controlled trials (RCTs), nonrandomized controlled trials, and prospective cohort studies published and indexed

2017 Effective Health Care Program (AHRQ)

71. Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer's-Type Dementia

. There was not a separate, independent Key Informant panel. The role of the Technical Expert Panel was then filled by the National Academies Committee. A complete description of the methods can be found in the full report. ES-4 Literature Search Strategy We searched Ovid Medline ® , Ovid PsycINFO ® , Ovid Embase ® , and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify randomized controlled trials (RCTs), nonrandomized controlled trials, and prospective cohort studies published and indexed

2017 Effective Health Care Program (AHRQ)

72. Cabometyx (cabozantinib) - advanced renal cell carcinoma

electrocardiogram ECOG Eastern Cooperative Oncology Group EMA European Medicines Agency EPO erythropoietin ER emergency room ESA erythropoiesis-stimulating agent ESC Exelixis Safety Committee FACT Functional Assessment of Cancer Therapy FBE free base equivalent FDA Food and Drug Administration FFPE formalin-fixed paraffin embedded FKSI-19 FACT Kidney Symptom Index questionnaire FT4 free thyroxine G-CSF granulocyte colony-stimulating factor GGT gamma-glutamyl transpeptidase GI gastrointestinal GM-CSF granulocyte (...) Network ND not determined NE not estimable NPACT nonprotocol anticancer therapy ONJ osteonecrosis of the jaw ORR objective response rate OS overall survival PD progressive disease PK pharmacokinetics PE pulmonary embolism PFS progression-free survival PITT primary endpoint intent-to-treat population PPD Pharmaceutical Product Development, Incorporated PPES palmar-plantar erythrodysesthesia syndrome PR partial response PS performance status qd once daily QT time interval in ECG reading QTcF corrected

2016 European Medicines Agency - EPARs

73. Uptravi (selexipag) - pulmonary arterial hypertension

Plasma concentration at the end of one dose interval C trough,ss Plasma concentration at the end of one dose interval at steady-state Cu/C concentration of free (unbound) to total plasma concentration CV Coefficient of variation CVb Inter-subject coefficient of variation CVw Intra-subject coefficient of variation DMC Data Monitoring Committee (also referred to as DSMB, Data Safety Monitoring Board) DSMB Data Safety Monitoring Board eGFR estimated glomerular filtration rate EOS End of study ERA (...) al. 2014). A decreased expression of the IP receptor has been found in the remodeled pulmonary arterial smooth muscle. The applicant provided non clinical data from a full non clinical programme as detailed below. The non clinical studies performed with selexipag are summarized. In most original reports of the in-vitro functional assays, the Applicant has given IC 50 /EC 50 values for the total concentrations. In the following the values for free IC 50 /EC 50 values are also given, taking

2016 European Medicines Agency - EPARs

74. Briviact - brivaracetam

transaminase AUC area under the curve AUCt area under the curve over a dosing interval BCRP Breast Cancer Resistance Protein BCS Biopharmaceutics Classification System BID Twice daily BMI body mass index BOCF baseline observation carried forward BRV brivaracetam BSEP Bile Salt Export Pump c av average concentration CBZ carbamazepine CFU Colony Forming Units CHMP Committee for Medicinal Products for Human Use CI confidence interval CL Total plasma clearance c max Maximum observed plasma concentration CNS (...) for epilepsy is antiepileptic drugs (AEDs) aiming at preventing or reducing seizures as quickly as possible. Improved seizure control is likely to reduce morbidity and premature mortality associated with continuing seizures, especially convulsive attacks. In addition, seizure remission is a major determinant of good quality of life (Duncan et al. 2006). It is estimated that roughly 70-80 % of adults with new onset epilepsy will become seizure free with available AEDs, although around half will experience

2016 European Medicines Agency - EPARs

75. Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial. (Full text)

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial. The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training.In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8

2018 Archives of endocrinology and metabolism Controlled trial quality: uncertain PubMed abstract

76. Management of Toxicities from Immunotherapy: ESMO Clinical Practice Guidelines

prednisolone 0.5 mg/kg and taper If unwell, withhold ICPi and consider restarting when symptoms controlled Figure 5. ICPi monitoring and management: thyroid function. Ab, antibody; CT, computed tomography; CTLA4, cytotoxic T-lymphocyte associated antigen 4; DDx, differential diagnosis; FT4, free thyroxine; ICPi, immune checkpoint inhibitor; PD-1, pro- grammed death 1; PD-L1, programmed death ligand 1; T3, triiodothyronine; T4, thyroxine; TFT, thyroid function test; TPO, thyroid peroxidase; TSH, thyroid (...) cycle; If symptoms, consider thyroxine if TSH > 10 If no symptoms, repeat next cycle; If symptoms, initiate thyroxine Low Elevated FT4 Low FT4 If no symptoms, repeat next cycle; If symptoms hyperthyroidism: beta blocker, thyroid Abs and uptake scan Check 9 am cortisol (may indicate hypopituitarism) Baseline Endocrine Panel: TSH, FT4, T3* TFTs Baseline abnormal values do not preclude treatment; discuss with endocrinologist if uncertain *when indicated Monitoring during treatment: Anti-CTLA4

2017 European Society for Medical Oncology

77. National minimum retesting intervals in pathology: A final report detailing consensus recommendations for minimum retesting intervals for use in pathology

Summaries CMV Cytomegalovirus CPS Clinical Practice Section EASL European Association of the Study of the Liver ED Exposure day e-GFR Estimated glomerular filtration rate EGTM European Group on Tumour Markers EP Electrophoresis ESR Erythrocyte sedimentation rate ESC European of Society of Cardiology FSH Follicule stimulating hormone FBC Full blood count FMH Fetomaternal haemorrhage fT3 Free triiodothyronine fT4 Free thyroxine GAD65 Glutamic acid decarboxylase antibody GAIN Guidelines and Audit (...) ACB Association for Clinical Biochemistry and Laboratory Medicine AFB Acid-fast bacilli ALP Alkaline phosphatase AMPA 2 Amino-3 (5-Methyl 3 Oxo-1,2 Oxazole 4 Yl) Propanoic Acid ANA Antinuclear antibody ANCA Antineutrophil cytoplasmic antibodies APTT Activated Partial Thromboplastin Time (APTT) ASCO American Society of Clinical Oncology ASO Antistreptolysin O ATPOab Anti-thyroid peroxidase antibodies BCSH British Committee for Standards in Haematology BMI Body mass index BNF British National

2016 Royal College of Pathologists

78. Special Endocrine Testing

: Diagnoses and Monitoring of Thyroid Function Disorders in Adults. Free Thyroxine (fT4) MSP cost: $12.12 Indications Non-Indications Used to screen for all causes of primary hypothyroidism and hyperthyrodism. Monitoring of patients treated with thyroid hormone. Not for use in an initial screen for thyroid dysfunction except in the unusual circumstance that there is specific reason to suspect pituitary disease. Free Triiodothyronine (fT3) MSP cost: $9.35 Indications Non-Indications Rarely indicated (...) . Reserved for situations where hyperthyroidism is suspected clinically and TSH is suppressed, but fT4 is not elevated. Not for use in an initial screen for thyroid dysfunction. Total thyroxine/ triiodothyronine (Total T4/T3) Indications Non-Indications Not currently offered by any lab in BC. Replaced by free hormone determination. Anti-thyroid peroxidase MSP cost: $20.22 Indications Non-Indications Used for the diagnosis of Hashimoto’s thyroiditis in the investigation of primary hypothyroidism. Serial

2016 Clinical Practice Guidelines and Protocols in British Columbia

79. The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum

and raised free thyroxine levels with or without a suppressed thyroid stimulating hormone level. These patients rarely have thyroid antibodies and are euthyroid clinically. The biochemical thyrotoxicosis resolves as the HG improves 22 and treatment with antithyroid drugs is inappropriate. Liver function tests are abnormal in up to 40% of women with HG, 23 with the most likely abnormality being a rise in transaminases. Bilirubin levels can be slightly raised but without jaundice, and amylase levels can (...) is in the first trimester of pregnancy and other causes of nausea and vomiting have been excluded. How is HG diagnosed? HG can be diagnosed when there is protracted NVP with the triad of more than 5% prepregnancy weight loss, dehydration and electrolyte imbalance. How can the severity of NVP be classified? An objective and validated index of nausea and vomiting such as the Pregnancy-Unique Quantification of Emesis (PUQE) score can be used to classify the severity of NVP . What initial clinical assessment

2016 Royal College of Obstetricians and Gynaecologists

80. Fexeric - ferric citrate coordination complex

binding drug. About the product KRX-0502 (ferric citrate coordination complex, also referred to as Fexeric, ferric citrate or JTT-751) is an oral iron-based phosphate binder. In the context of treatments for hyperphosphataemia, it can be considered a calcium-free phosphate binder. KRX-0502 reduces intestinal absorption of dietary phosphate by binding to and then precipitating phosphate in the gastrointestinal (GI) tract. Ferric [Fe3+] iron reacts with ingested phosphate to form an insoluble ferric (...) in a bacterial reverse mutation test and a chromosomal aberration test in Chinese hamster fibroblasts. A number of in vitro and in vivo genotoxicity studies have been reported for various iron containing compounds and for citric acid as well. Results from in vivo genotoxicity studies are more relevant than those from in vitro studies since iron is not presented to cells in a free state (unbound to transferrin) in the body, as it is in the in vitro studies. Out of twelve compounds with published genotoxicity

2015 European Medicines Agency - EPARs

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