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41. Canadian Cardiovascular Society/Canadian Heart Failure Society Joint Position Statement on the Evaluation and Management of Patients With Cardiac Amyloidosis Full Text available with Trip Pro

cardiac involvement are immunoglobulin light chain (AL), a plasma cell dyscrasia, and transthyretin (ATTR), itself subdivided into a hereditary subtype caused by a gene mutation of the ATTR protein, and an age-related wild type, which occurs in the absence of a gene mutation. Clinical recognition requires a high index of suspicion, inclusive of the extracardiac manifestations of both subtypes. Diagnostic workup includes screening for serum and/or urine monoclonal protein suggestive of immunoglobulin (...) in the transport of thyroxine and retinol binding protein. The formation of amyloid from TTR can be directly attributed to mutations of the TTR gene (hereditary ATTR amyloidosis; hATTR), with certain variants altering protein stability, but is also observed in predominantly older patients without mutations (wild type ATTR; wtATTR). ATTR and AL amyloidosis are responsible for most of cardiac amyloidosis. Demographic profiles of these subtypes are provided in . Other amyloid precursor proteins have been

2020 Canadian Cardiovascular Society

42. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Full Text available with Trip Pro

and will be automatically unlocked in 30 mins. For immediate assistance, contact Customer Service: 800-638-3030 (within USA), 301-223-2300 (international) Invalid username or password. Try again or register an account. default message Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. or Register for a free account Registered users can save articles, searches, and manage email alerts. All registration fields are required. I have read & acknowledge (...) Pediatric Society, and the French Society of Intensive Care. The remaining authors have disclosed that they do not have any potential conflicts of interest. For information regarding this article, E-mail: Pediatric Critical Care Medicine: doi: 10.1097/PCC.0000000000002198 Free Metrics Abstract Objectives: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis -associated organ dysfunction

2020 Society of Critical Care Medicine

43. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

, adrenocorticotropic hormone; CBG, corticosteroid-binding globulin; CRH, corticotropin-releasing hormone; FFA, free fatty acids; FSH, follicle-stimulating hormone; FT4, free thyroxine; GH-BP, growth hormone-binding protein; GHRH, growth hormone- releasing hormone; GLP, glucagon-like peptide; GnRH, gonadotropin-releasing hormone; HPA, hypothalamic–pituitary–adrenal axis; IGF, insulin-like growth factor; LH, luteinizing hormone; PCOS, polycystic ovary syndrome; PTH, parathyroid hormone; SHBG, sex hormone-binding (...) , developmental delay PTH ? calcium ? phosphate ? ACTH, adrenocorticotropic hormone; FSH, follicle-stimulating hormone; FT4, free thyroxine; GH, growth hormone; IGF, insulin-like growth factor; LH, luteinizing hormone; MC4R, melanocortin receptor 4; ODST, overnight dexamethasone suppression test; PCSK, proprotein convertase subtilisin/kexin; PTH, parathyroid hormone; TSH, thyroid-stimulating hormone. Downloaded from at 02/19/2020 06:38:23AM via free accessEuropean Journal of Endocrinology

2020 European Society of Endocrinology

44. Subacute granulomatous thyroiditis

recent viral infection myalgia malaise tremor heat intolerance viral infection HLA-Bw35 and B35 Diagnostic investigations thyroid-stimulating hormone (TSH) total T4, total T3, T3 resin uptake, free thyroxine index T3:T4 ratio radioactive iodine uptake ESR CRP antithyroid antibodies (thyroid peroxidase antibodies) fine needle aspiration biopsy ultrasonography of thyroid salivary CRP Treatment algorithm ACUTE Contributors Authors Associate Chief Director of the Thyroid Health Center Section

2018 BMJ Best Practice

45. Levothyroxine

Levothyroxine sodium is widely prescribed to treat primary hypothyroidism. There is consensus that levothyroxine should be taken in the morning (...) on an empty stomach. A pilot study showed that levothyroxine intake at bedtime significantly decreased thyrotropin levels and increased free thyroxine and total triiodothyronine levels. To date, no large randomized trial investigating the best time of levothyroxine intake, including quality-of-life evaluation, has been performed. To ascertain if levothyroxine (...) with subclinical hypothyroidism and TSH values <10mIU/L. METHODS: A case-control study in which patients 65years or older with TSH (...) levels of 4.2-10mIU/L who died in the years 2012-2016 ('cases') were compared with matched individuals who did not die during this period ('controls'). Matching was based on gender, age, Charlson comorbidity index, date of TSH testing, duration of follow-up and TSH quartile. All cases of known thyroid disease or cases in which anti-thyroid medications or glucocorticoids were

2018 Trip Latest and Greatest

46. Propranolol

of remission with the 20-minute (132)I uptake falling to normal, although the free-thyroxine index remains slightly raised. It is likely that these remissions reflect the natural tendency of the disease to remit since propranolol is not considered to have any direct in-vivo effect on thyroid function.However, because of failure to gain 1973 11. Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding Endoscopic Band Ligation (EBL) Versus Propranolol for Primary (...) Br Med J 0372673 0007-1447 9Y8NXQ24VQ Propranolol AIM IM Arch Dis Child. 1974 Oct;49(10):813-5 4429365 Humans Hyperthyroidism drug therapy Infant, Newborn Infant, Premature, Diseases drug therapy (...) Male Propranolol therapeutic use PMC1632113 1977 9 17 1977 9 17 0 1 1977 9 17 0 0 ppublish 912277 PMC1632113 1977 9. Preliminary report on the use of propranolol in thyrotoxicosis: I. Effect on serum thyroxine, triiodothyronine and reverse triiodothyronine concentrations. 688126 1978 11 22 1978 11

2018 Trip Latest and Greatest

47. Inotersen sodium (Tegsedi) - Amyloidosis

EMA/411876/2018 Page 4/142 List of abbreviations A/C Urine albumin/creatinine ratio ADA Antidrug antibodies AE Adverse event AESI Adverse event of special interest ALT Alanine aminotransferase ANCOVA Analysis of covariance aPTT Activated partial thromboplastin time ASO Antisense oligonucleotide AST Aspartate aminotransferase ATTR Transthyretin amyloidosis AUC/ AUC 0-168h Area under the curve / Area under the curve baseline to 168 hours BMI Body mass index BCRP Human breast cancer resistance (...) Interventricular septum Assessment report EMA/411876/2018 Page 5/142 IXRS Interactive voice/web-response system LBM Lean body mass LCRIS Local cutaneous reaction at the injection site LLN Lower limit of normal LSM Least squares mean LV Left ventricular 2’-MOE 2’-O-(2-methoxyethyl) mBMI Modified body mass index MMRM Mixed Effects Model with Repeated Measures mNIS+7 Modified Neuropathy Impairment Score+7 mRNA Messenger ribonucleic acid NIS Neuropathy Impairment Score NIS-C NIS-cranial nerve muscle strength NIS

2018 European Medicines Agency - EPARs

48. Management of Infertility

the analytic framework that guided our work. • KQ 1. What are the comparative safety and effectiveness of available treatment strategies for women with polycystic ovary syndrome who are infertile and who wish to become pregnant? o KQ 1a. Does the optimal treatment strategy vary by patient characteristics such as age, ovarian reserve, race, body mass index (BMI), presence of other potential causes of female infertility, or presence of male factor infertility? • KQ 2. What are the comparative safety (...) , or other adverse outcomes associated with donation? ES-5 Figure A. Analytic framework Abbreviations: ART=assisted reproductive technology; BMI=body mass index; GnRH=gonadotropin-releasing hormone; KQ=Key Question; OHSS=ovarian hyperstimulation syndrome; PCOS=polycystic ovary syndrome Potential Modifiers • Age • Ovarian reserve • Race/ethnicity • Obesity/BMI • Prior treatments • Primary vs. secondary infertility • Maternal parity • Concomitant diagnoses o Male factor + female factor o Multiple female

2019 Effective Health Care Program (AHRQ)

50. The Collaborative Assessment, OTCA12, on “C-reactive protein point-of-care testing (CRP POCT) to guide antibiotic prescribing in primary care settings for acute respiratory tract infections (RTIs)


2019 EUnetHTA

51. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures

circumstances. DOI:10.4158/GL-2019-0406 © 2019 AACE. 7 ABBREVIATIONS A1C = hemoglobin A1C; AACE = American Association of Clinical Endocrinologists; ABCD = adiposity-based chronic disease; ABOM = American Board of Obesity Medicine; ACE = American College of Endocrinology; ADA = American Diabetes Association; AGA = American Gastroenterological Association; AHI = Apnea-Hypopnea Index; ASA = American Society of Anesthesiologists; ASMBS = American Society of Metabolic and Bariatric Surgery; BMI = body mass (...) index; BPD = biliopancreatic diversion; BPD/DS = biliopancreatic diversion with duodenal switch; CI = confidence interval; CPAP = continuous positive airway pressure; CPG = clinical practice guideline; CRP = C-reactive protein; CVD = cardiovascular disease; DBCD = dysglycemia-based chronic disease; DS = duodenal switch; DVT = deep venous thrombosis; DXA = dual- energy X-ray absorptiometry; EL = evidence level; EN = enteral nutrition; ERABS = enhanced recovery after bariatric surgery; ESG

2019 American Association of Clinical Endocrinologists

52. AACE/ACE Guidelines for Management of Growth Hormone Deficiency in Adults and Patients Transitioning from Pediatric to Adult Care

and reduced reported side effects, dependent on age, gender, body mass index, and various other individual characteristics. With care- ful dosing of rhGH replacement, many features of adult GHD are reversible and side effects of therapy can be minimized. Scientific studies have consistently shown rhGH therapy to be beneficial for adults with GHD, includ - ing improvements in body composition and quality of life, and have demonstrated the safety of short- and long-term rhGH replacement. Abbreviations: AACE (...) = American Association of Clinical Endocrinologists; ACE = American College of Endocrinology; AHSG = alpha-2-HS-glycoprotein; AO-GHD = adult-onset growth hormone deficiency; ARG = arginine; BEL = best evidence level; BMD = bone mineral density; BMI = body mass index; CI = confidence interval; CO-GHD = childhood-onset growth hormone deficiency; CPG = clinical practice guideline; CRP = C-reactive protein; DM = diabetes mellitus; DXA = dual-energy X-ray absorptiometry; EL = evidence level; FDA = Food

2019 American Association of Clinical Endocrinologists

53. ASCIA Guidelines: Chronic Spontaneous Urticaria (CSU)

in this document ASST autologous serum skin test CIndU chronic inducible urticaria CSU chronic spontaneous urticaria CU-Q2oL chronic urticaria quality of life questionnaire DLQI dermatology life quality index EAACI European Academy of Allergology and Clinical Immunology EDF European Dermatology Forum GA 2 LEN Global Allergy and Asthma European Network IgE Immunoglobulin E IVIg Intravenous immunoglobulin LTRA leukotriene receptor antagonists QoL quality of life TNF tumour necrosis factor UAS urticaria activity (...) - Leukotriene receptor antagonists (LTRAs) 10 - Omalizumab 10 - Ciclosporin 13 - Dapsone 14 - Hydroxychloroquine 14 - Corticosteroids 14 - Anticoagulants 14 - Thyroxine 14 - Other treatments 14 • Drug treatment in paediatric populations 15 • Drug availability in New Zealand • PBS requirements in Australia • Non-drug management • Management of CSU in pregnancy and lactation 16 16 17 18 3. Treatment algorithms 19 • Australia • New Zealand 4. References 21 ASCIA INFORMATION FOR HEALTH PROFESSIONALS 3 1

2019 Australasian Society of Clinical Immunology and Allergy

54. Clinical Practice Guidelines – Thyroid cancer

of thyroid cancer (TC) are relatively scarce, and the quality of available evidence is suboptimal. Retrospective analyses of treatment ef?cacy frequently show favourable out- comes, but it is dif?cult to discern the extent to which these results are due to the natural history of the disease. The number of cases retrospectively analysed is not an index of the quality of the data or the absence of biases. Consequently, large, well- planned RCTs managed within a network of coordinated centres are urgently (...) populations showed that, if RAI is given in these cases, low activ- ities (30 mCi, 1.1 GBq) following rhTSH and high activities (100 mCi, 3.7 GBq) following levothyroxine withdrawal are equally likely to produce successful ablation [I, A] [47, 48]. This equivalence is also evident at the level of recurrence-free survival, Table 4. Response to treatment categories in DTC patients a Responsesto treatment Treatments TT1RRA TTalone Lobectomy Excellent Negative imaging and Undetectable TgAb and Tg 5ng/ml

2020 European Society for Medical Oncology

55. Avelumab (Bavencio) - Neuroendocrine Tumors

CPP critical process parameter CR complete response CT computed tomography Ctrough concentration at the end of the dosing interval DDI drug-drug interaction DMRIE 1,2-dimyristyloxy-propyl-3-dimethyl-hydroxy ethyl ammonium bromide (transfection reagent) DOR duration of response DP drug product DRR durable response rate DS drug substance ECG electrocardiogram ECOG Eastern Cooperative Oncology Group FT4 free thyroxine HCP host cell proteins HIV human immunodeficiency virus HMW high molecular weight (...) metastatic Merkel cell carcinoma NAb neutralizing antibody NCA non-compartmental analysis NK natural killer NSCLC non-small cell lung cancer ORR objective response rate OS overall survival PBMC peripheral blood mononuclear cell PD-1 programmed death 1 PD-L1 programmed death ligand 1 PFS progression-free survival PK pharmacokinetic(s) Pop PK population pharmacokinetic(s) PR partial response QTc QT interval corrected for heart rate QTcF QT interval corrected for heart rate by Fridericia’s formula QTcP QT

2017 European Medicines Agency - EPARs

56. British Association of Dermatologists? guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis

. Rushbook, 8 R.R. Coelho, 9 S.J. Catten, 1 K.Y.C. Lee, 1 A.M. Skellett, 1 A.G. Af?eck, 10 L.S. Exton, 11 M.F. Mohd Mustapa 11 and N.J. Levell 1 1 Dermatology Department, 2 Haematology Department, 7 Nephrology Department and 8 Hepatology Unit, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, U.K. 3 Dermatology Department, Royal United Hospital, Combe Park, Bath BA1 3NG, U.K. 4 Dermatology Department, Royal Free Hospital, Pond Street, London NW3 2QG, U.K. 5 General Practitioner, Chet (...) and verbal rating scale. 18 The use of a patient-completed 10-cm VAS and perhaps the Dermatology Life Quality Index 19 is rec- ommended to provide a baseline measure of itch activity to help quantify management outcomes. However, as yet, there is no international consensus on how to measure the severity of itch. 20 Moreover, there may be differences in how patients and physicians assess the severity of pruritus. 21–23 The management of pruritus depends on the treatment of any underlying disease

2018 British Association of Dermatologists

57. ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay

possible, evidence based. An initial extensive evidence review, which included literature derived from research involving human subjects, published in English, and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline, was conducted from January 2017 to September 2017. Key search words included but were not limited to the following: AV block, bradycardia, bundle branch block, conduction

2018 American College of Cardiology

58. Management of acute (fulminant) liver failure

, cardiac or oesophageal Dop- pler; the latter is only applicable in patients who are ventilated. Use of invasive monitoring (such as pulmonary artery catheter or pulse contour analysis), provides measures of cardiac index. Pulse contour analysis also measures volume status and allows prediction of the likely response to ?uid challenge. In ventilated patients use of inspiratory hold can also be used to assess the likely response to volume challenge. Passive leg raise, to investi- gate for an increase (...) to have limited or min- imal effect on cardiac index. Drainage of some ascites may improve venous return and improve cardiac index [148]. Following adequate volume loading, persistent hypotension requires treatment with vasopressors. Given the usual clinical pictureinALFofanelevatedcardiacoutputanddecreasedvascu- lar tone, the initial pressor recommended would be nore- pinephrine, at a starting dose of 0.05lg/kg/min. Additional low dose vasopressin (1–2 units/hour), should be considered if nore

2017 European Association for the Study of the Liver

59. The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial

, trial nested within the TRUST trial, Swiss participants ages ≥65 years with subclinical hypothyroidism (thyroid-stimulating hormone [TSH] 4.60-19.99 mIU/L; free thyroxine level within reference range) were randomized to levothyroxine (starting dose of 50 µg daily) to achieve TSH normalization or placebo. The primary outcomes were the left ventricular ejection fraction for systolic function and the ratio between mitral peak velocity of early filling to early diastolic mitral annular velocity (E/e (...) ' ratio) for diastolic function. Secondary outcomes included e' lateral/septal, left atrial volume index, and systolic pulmonary artery pressure. Results: A total of 185 participants (mean age 74.1 years, 47% women) underwent echocardiography at the end of the trial. After a median treatment duration of 18.4 months, the mean TSH decreased from 6.35 mIU/L to 3.55 mIU/L with levothyroxine (n = 96), and it remained elevated at 5.29 mIU/L with placebo (n = 89). The adjusted between-group difference

2020 EvidenceUpdates

60. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

the effectiveness and safety of interventions targeting sensory challenges in children with autism spectrum disorder (ASD). Data sources. We searched MEDLINE ® , Embase ® , the Cumulative Index of Nursing and Allied Health Literature ® , and PsycINFO ® from January 2010 to September 2016. Review methods. We included studies comparing interventions incorporating sensory-focused modalities with alternative treatments or no treatment. Studies had to include at least 10 children with ASD ages 2–12 years. Two (...) disorders. Current Opinion in Neurology. 2011;24(2):132-9 8p. doi: 10.1097/WCO.0b013e3283446450. PMID: 104865655. Language: English. Entry Date: 20110527. Revision Date: 20150711. Publication Type: Journal Article.X-1 686. Johnson CR, Handen BL, Zimmer M, et al. Effects of gluten free / casein free diet in young children with autism: A pilot study. Journal of Developmental and Physical Disabilities. 2011 2015-12- 09;23(3):213-25. doi: D-59 x. PMID: 888750170

2017 Effective Health Care Program (AHRQ)

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