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Free Thyroxine Index

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1. Free Thyroxine Index

Free Thyroxine Index Free Thyroxine Index Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Free Thyroxine Index Free Thyroxine Index (...) Aka: Free Thyroxine Index , Free T4 Index , FTI , FT4I II. Interpretation: Normal Free Thyroxine Index: 4-11 III. Indications Largely replaced by ( ) Corrects for abnormal (TBG) also corrects for is preferred over FTI IV. Measurement Calculated: T4 x ( ) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Free Thyroxine Index." Click on the image (or right click) to open the source website in a new browser window. Related Studies

2018 FP Notebook

2. Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism (PubMed)

Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism The diagnosis of central hypothyroidism is often suspected in patients with hypothalamic/pituitary pathology, in the setting of low, normal, or even slightly elevated serum TSH and low free thyroxine (FT4). We present four cases of central hypothyroidism (three had known pituitary pathology) in whom central hypothyroidism was diagnosed after (...) the serum free thyroxine index (FTI) was found to be low. All had normal range serum TSH and free thyroxine levels. This report illustrates that the assessment of the serum FTI may be helpful in making the diagnosis of central hypothyroidism in the appropriate clinical setting and when free T4 is in the low-normal range, particularly in patients with multiple anterior pituitary hormone deficiencies and/or with symptoms suggestive of hypothyroidism.

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2015 Case reports in endocrinology

3. Follicular fluid thyroid autoantibodies, thyrotropin, free thyroxine levels and assisted reproductive technology outcome (PubMed)

pregnancies.This study enrolled 52 women undergoing ART (26 TAI positive subjects and 26 age and body mass index matched TAI negative controls). Blood samples were drawn before the initiation of protocol for controlled ovarian stimulation, and thyrotropin (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroid peroxidase antibodies (TPOAbs) and thyroglobulin antibodies (TgAbs) levels were measured. TSH, fT4, TPOAbs, TgAbs and progesterone levels were also measured in FF.There were no significant (...) Follicular fluid thyroid autoantibodies, thyrotropin, free thyroxine levels and assisted reproductive technology outcome Although there are substantial data linking thyroid autoimmunity (TAI) and infertility, data regarding assisted reproductive technology (ART) outcomes and TAI markers in follicular fluid (FF) of women undergoing ART are scarce. Objective of the study was to assess the association of the levels of thyroid autoantibodies in FF and ART outcome expressed as the achieved

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2018 PloS one

4. High circulating free thyroxine levels may increase the risk of frailty: The Rotterdam Study. (PubMed)

High circulating free thyroxine levels may increase the risk of frailty: The Rotterdam Study. Thyroid hormones affect metabolism in various tissues, organs, and systems. However, the overall impact of thyroid function on an individual's vulnerability to adverse outcomes remains unclear.To investigate the cross-sectional and prospective association of thyroid function with the frailty index, a well-established measure of overall health.The Rotterdam Study, a population-based, prospective cohort (...) age, 64.9 years). There was a U-shaped association of thyrotropin (TSH; P < 0.0003) and free thyroxine (FT4; P < 0.0001) with frailty at baseline. There was no association of TSH, but a positive association of FT4 with frailty at follow-up and frailty changes over time (β, 1.22; confidence interval, 0.73 to 1.72 per 1 unit FT4).In this population-based study, participants with low and high thyroid function were more likely to be frail than participants with normal thyroid function. However, only

2017 Journal of Clinical Endocrinology and Metabolism

5. Variations in serum free thyroxin concentration within normal ranges predict the incidence of metabolic syndrome in non-obese adults: a Cohort Study. (PubMed)

Variations in serum free thyroxin concentration within normal ranges predict the incidence of metabolic syndrome in non-obese adults: a Cohort Study. The association of changes in thyroid hormone values over time with the incidence of metabolic syndrome (MetS) has not yet been evaluated. For the first time, this study assessed the effect of thyroid hormone variations in the subclinical and euthyroid range on the incidence of MetS and its components over a 10-year follow-up in an adult (...) circumference, and blood pressure were measured, and serum concentrations of lipids and lipoproteins, fasting blood glucose, insulin, free thyroxine (fT4), and TSH were assayed at baseline and during three follow-up studies at three-year intervals. MetS was determined using definition of the Joint Interim Statement, adjusted for the Iranian population.An increase in fT4 values overtime was associated with lower odds of abdominal obesity (odds ratio [OR] = 0.49 [confidence interval (CI) 0.35-0.69

2017 Thyroid

6. The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys.

The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys. Among women with urinary iodine concentration <100 μg/l in the 2001-2002 National Health and Nutrition Examination Survey (NHANES), urinary perchlorate was associated with significant changes in thyroid stimulating hormone and total thyroxine (T4). Although perchlorate, nitrate, and thiocyanate all (...) perchlorate, nitrate, and thiocyanate and serum free T4 in individuals with low urinary iodine levels and pregnant women. Multivariate regression models of free T4 were conducted and included urinary perchlorate, nitrate, thiocyanate, and covariates known to have an impact on the thyroid (anti-thyroid peroxidase (TPO) antibodies, age, race/ethnicity, body mass index, and hours of fasting). Meta-analyses were also conducted on non-pregnant and on pregnant women from the two survey cycles. Urinary nitrate

2017 Journal of exposure science & environmental epidemiology

7. Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease (PubMed)

March 2013 to November 2013. 811 subjects (185 women and 626 men) were included in this study. PASP was measured by transthoracic Doppler echocardiography. 86 patients were diagnosed as PH and had significantly higher free thyroxine (FT4) levels than those without PH. Multiple logistic regression analysis demonstrated an independent association of FT4 levels with PH after adjustment of gender, age, body mass index, systolic blood pressure, left ventricular ejection fraction, hypertension (...) Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease The aim of this study was to evaluate the association between thyroid hormone levels, pulmonary hypertension (PH), and pulmonary artery systolic pressure (PASP) in euthyroid patients with coronary artery disease (CAD). A cross-sectional study was conducted in individuals who underwent coronary angiography and were diagnosed as CAD from

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2017 International journal of endocrinology

8. Thyroid status in the newborn infant: Effective thyroxine ratio and free thyroxine index (PubMed)

Thyroid status in the newborn infant: Effective thyroxine ratio and free thyroxine index 4207709 1974 06 28 2018 11 13 1468-2044 49 3 1974 Mar Archives of disease in childhood Arch. Dis. Child. Thyroid status in the newborn infant. Effective thyroxine ratio and free thyroxine index. 225-7 Brien T G TG Fay J A JA Griffin E A EA eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Thyroxine-Binding Proteins Q51BO43MG4 Thyroxine IM Adult Blood Humans Hyperthyroidism diagnosis Infant (...) Infant, Newborn Infant, Premature Thyroid Function Tests Thyroid Gland metabolism Thyroxine blood Thyroxine-Binding Proteins analysis Umbilical Cord 1974 3 1 1974 3 1 0 1 1974 3 1 0 0 ppublish 4207709 PMC1648712 Arch Dis Child. 1970 Jun;45(241):374-5 4193553 J Nucl Med. 1972 Feb;13(2):165-8 4109299 J Clin Endocrinol Metab. 1972 Jan;34(1):225-8 5008228 J Clin Pathol. 1972 Mar;25(3):259-62 4623000 J Clin Pathol. 1972 Aug;25(8):726-9 4627748 J Pediatr. 1972 Nov;81(5):916-9 4628754 Clin Endocrinol (Oxf

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1974 Archives of Disease in Childhood

9. Comparison between Determination of Free Thyroxine Index and Effective Thyroxine Ratio in Human Serum (PubMed)

Comparison between Determination of Free Thyroxine Index and Effective Thyroxine Ratio in Human Serum Four thyroid function indices were determined in the sera of 181 patients: total thyroxine (T-4), the triiodothyronine resin uptake (T-3 B.C.-index), the free thyroxine (T-4) index, and the effective thyroxine ratio (E.T.R.).A statistically significant correlation between the free T-4 index and E.T.R. could be established though this correlation seemed to be worse than could be expected from (...) instead.The advantages and disadvantages of the E.T.R. and free T-4 index determination are described.

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1974 British medical journal

10. Letter: Comparison between free thyroxine index and effective thyroxine ratio. (PubMed)

Letter: Comparison between free thyroxine index and effective thyroxine ratio. 4138283 1975 01 15 2018 11 13 0007-1447 4 5938 1974 Oct 26 British medical journal Br Med J Letter: Comparison between free thyroxine index and effective thyroxine ratio. 225-6 eng Comparative Study Journal Article England Br Med J 0372673 0007-1447 0 Iodine Radioisotopes Q51BO43MG4 Thyroxine AIM IM Humans Iodine Radioisotopes Thyroid Function Tests Thyroxine blood 1974 10 26 1974 10 26 0 1 1974 10 26 0 0 ppublish

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1974 British medical journal

11. Letter: Comparison between free thyroxine index and effective thyroxine ratio. (PubMed)

Letter: Comparison between free thyroxine index and effective thyroxine ratio. 4373115 1975 03 10 2018 11 13 0007-1447 4 5940 1974 Nov 09 British medical journal Br Med J Letter: Comparison between free thyroxine index and effective thyroxine ratio. 343 Boss A M AM Kingstone D D eng Journal Article England Br Med J 0372673 0007-1447 0 Receptors, Cell Surface 0 Thyroxine-Binding Proteins Q51BO43MG4 Thyroxine AIM IM Blood Chemical Analysis methods Humans Receptors, Cell Surface Thyroxine blood (...) Thyroxine-Binding Proteins 1974 11 9 1974 11 9 0 1 1974 11 9 0 0 ppublish 4373115 PMC1612885 J Clin Invest. 1966 Jan;45(1):153-63 4158931 Clin Chim Acta. 1973 May 18;45(3):255-9 4196581

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1974 British medical journal

12. Letter: Comparison between free thyroxine index and effective thyroxine ratio. (PubMed)

Letter: Comparison between free thyroxine index and effective thyroxine ratio. 4434131 1975 02 27 2018 11 13 0007-1447 4 5943 1974 Nov 30 British medical journal Br Med J Letter: Comparison between free thyroxine index and effective thyroxine ratio. 533 Jorgensen J V JV eng Comparative Study Journal Article England Br Med J 0372673 0007-1447 Q51BO43MG4 Thyroxine AIM IM Humans Hyperthyroidism blood Myxedema blood Thyroid Function Tests Thyroxine blood 1974 11 30 1974 11 30 0 1 1974 11 30 0 0

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1974 British medical journal

13. An evaluation of absorbent granule kits for determining serum thyroxine concentration and free thyroxine index in the diagnosis of thyroid function. (PubMed)

An evaluation of absorbent granule kits for determining serum thyroxine concentration and free thyroxine index in the diagnosis of thyroid function. 4850538 1974 10 17 2018 11 13 0021-9746 27 5 1974 May Journal of clinical pathology J. Clin. Pathol. An evaluation of absorbent granule kits for determining serum thyroxine concentration and free thyroxine index in the diagnosis of thyroid function. 372-6 Bell T K TK Boyle D A DA Montgomery D A DA Todd S J SJ eng Journal Article England J Clin (...) Pathol 0376601 0021-9746 0 Blood Proteins 06LU7C9H1V Triiodothyronine Q51BO43MG4 Thyroxine AIM IM Absorption Adolescent Adult Blood Proteins Female Humans Hyperthyroidism blood diagnosis Hypothyroidism blood diagnosis Methods Middle Aged Pregnancy Protein Binding Thyroid Diseases blood Thyroid Function Tests Thyroxine blood Triiodothyronine metabolism 1974 5 1 1974 5 1 0 1 1974 5 1 0 0 ppublish 4850538 PMC478129 J Clin Invest. 1966 Jan;45(1):153-63 4158931 Am J Clin Pathol. 1968 Aug;50(2):194-7

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1974 Journal of Clinical Pathology

14. Letter: Comparison between free thyroxine index and effective thyroxine ratio. (PubMed)

Letter: Comparison between free thyroxine index and effective thyroxine ratio. 806319 1975 09 26 2018 11 13 0007-1447 1 5957 1975 Mar 08 British medical journal Br Med J Letter: Comparison between free thyroxine index and effective thyroxine ratio. 574 Wellby M L ML O'Halloran M W MW Marshall J J eng Comparative Study Journal Article England Br Med J 0372673 0007-1447 0 Thyroxine-Binding Proteins Q51BO43MG4 Thyroxine AIM IM Humans Statistics as Topic Thyroid Function Tests methods Thyroxine (...) blood Thyroxine-Binding Proteins 1975 3 8 1975 3 8 0 1 1975 3 8 0 0 ppublish 806319 PMC1672683 Clin Endocrinol (Oxf). 1974 Jan;3(1):63-8 4209840 Clin Chim Acta. 1973 May 18;45(3):255-9 4196581

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1975 British medical journal

15. Degree of peripheral thyroxin deiodination, frailty and long-term survival in hospitalized older patients. (PubMed)

Degree of peripheral thyroxin deiodination, frailty and long-term survival in hospitalized older patients. Although the association between low free triiodothyronine (FT3) and poor outcome has been extensively reported in literature, the degree of peripheral thyroxin deiodination and its relationship with frailty and survival in hospitalized older patients has not yet been fully established. The aim of the current study was to evaluate the possible correlation between FT3/free thyroxine (FT4 (...) ) ratio reduction, an indirect marker of thyroxin deiodination impairment, and frailty status and survival in hospitalized older patients.We consecutively enrolled older patients, hospitalized in the geriatrics ward of the University of Pisa. At admission, Multidimensional Geriatric Assessment (MGA) and Multi Prognostic Index (MPI), an indirect measure of frailty, were obtained from all the patients. Causes of hospitalization and prevalence of delirium were recorded. Blood samples for FT3, FT4

2018 Journal of Clinical Endocrinology and Metabolism

16. Free Thyroxine Index

Free Thyroxine Index Free Thyroxine Index Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Free Thyroxine Index Free Thyroxine Index (...) Aka: Free Thyroxine Index , Free T4 Index , FTI , FT4I II. Interpretation: Normal Free Thyroxine Index: 4-11 III. Indications Largely replaced by ( ) Corrects for abnormal (TBG) also corrects for is preferred over FTI IV. Measurement Calculated: T4 x ( ) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Free Thyroxine Index." Click on the image (or right click) to open the source website in a new browser window. Related Studies

2015 FP Notebook

17. Establishment of the trimester-specific reference range for free thyroxine index. (PubMed)

Establishment of the trimester-specific reference range for free thyroxine index. Accurate assessment of thyroid status during pregnancy is vital for maternal and fetal health. Because free thyroxine (FT4) values in pregnancy vary widely between methods, assessment of total T4 (TT4) and FT4 index (FT4I) may be superior to FT4 in pregnant women. However, trimester-specific reference intervals for FT4I have not yet been established. In this longitudinal self-sequential survey, we aimed

2012 Thyroid

18. High-normal free thyroxine levels are associated with low trabecular bone scores in euthyroid postmenopausal women. (PubMed)

postmenopausal women and 728 men) were recruited from a community-based cohort in Korea. Free thyroxine (fT4) levels, thyroid stimulating hormone (TSH) levels, BMD, and TBS were measured and compared.There was no significant relationship between either fT4 or TSH levels and BMD in men and women. Multiple linear regression analysis showed that high-normal fT4 levels were negatively correlated with TBS (β = -0.111; P = 0.002, after adjusting for both age and body mass index [BMI]) in postmenopausal women (...) High-normal free thyroxine levels are associated with low trabecular bone scores in euthyroid postmenopausal women. Trabecular bone scores (TBS) have recently been developed as a diagnostic tool to assess bone texture. We studied thyroid status and TBS in a population-based cohort and demonstrated that high-normal thyroxine levels are associated with low TBS in healthy euthyroid postmenopausal women.Increased thyroid hormone levels affect bone mineral density (BMD) and, if untreated, increase

2015 Osteoporosis International

19. Serum Free Thyroxine Concentration is Associated with Metabolic Syndrome in Euthyroid Subjects. (PubMed)

Serum Free Thyroxine Concentration is Associated with Metabolic Syndrome in Euthyroid Subjects. The association between thyroid hormones within the euthyroid range and metabolic syndrome is not clear.This study evaluated the relationship between thyroid hormones and metabolic syndrome and its components in euthyroid subjects.This is a cross-sectional population based study conducted within the framework of the cohort of the Tehran Thyroid Study.Out of 5786 subjects aged ≥ 20 years, 3755 (...) euthyroid subjects without a history of thyroid disorders, diabetes, or use of steroids or lipid-lowering agents were investigated.Body weight, waist circumference (WC), and blood pressure (BP) were measured. Serum concentrations of lipids and lipoproteins, fasting blood glucose (FBG), insulin, free T4 (FT4), and thyrotropin (TSH) were assayed. Metabolic syndrome was determined by definition of the Joint Interim Statement adjusted for the Iranian population.After adjustment for age, sex, and smoking

2014 Thyroid

20. A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families (PubMed)

: The proband was 12.6 years old when she presented for delayed puberty and was placed on L-T4. Although her serum TSH normalized, her serum T4 remained low. Affected family members had low total T4 and T3, but a normal free T4 index, even when serum TSH concentrations were normal. Family 2: A 71-year-old male presented with a history of a nonfunctioning pituitary adenoma and normal pituitary axes except for low total T4 and T3. His brother had a similar thyroid phenotype.Following direct DNA sequencing (...) A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families Thyroxine-binding globulin (TBG) is the major thyroid hormone transport protein in serum. Located on the long arm of the X chromosome, TBG (SERPINA7) gene mutations most commonly produce inherited partial TBG deficiency (TBG-PD).We report a novel TBG variant associated with TBG-PD identified in 2 different families of Ashkenazi origin residing in greater Chicago.Family 1

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2017 European thyroid journal

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