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Freckles

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1. Comparison of the efficacy and safety of a picosecond alexandrite laser and a Q-switched alexandrite laser for the treatment of freckles in Chinese patients. (PubMed)

Comparison of the efficacy and safety of a picosecond alexandrite laser and a Q-switched alexandrite laser for the treatment of freckles in Chinese patients. 30092321 2019 01 24 2019 01 24 1097-6787 79 6 2018 Dec Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Comparison of the efficacy and safety of a picosecond alexandrite laser and a Q-switched alexandrite laser for the treatment of freckles in Chinese patients. 1155-1156 S0190-9622(18)32349-1 10.1016/j.jaad.2018.07.047

2019 Journal of the American Academy of Dermatology

2. The iris signal: blue periphery, tan collaret and freckles pattern - strong indicators for epidermal skin cancer in South-Eastern Europe. (PubMed)

The iris signal: blue periphery, tan collaret and freckles pattern - strong indicators for epidermal skin cancer in South-Eastern Europe. Eye and skin share the embryological origin. Both are established risk factors in epidermal skin cancer. There are few reports using iris colour classification scales, most of them analyse colour in general or are too complex to use in daily practice.To investigate which iris colour pattern is associated with epidermal skin cancer in a S-E European Caucasian (...) skin cancer was blue periphery with light brown collaret and freckles present. In terms of individual parameters, the strongest indicators for skin cancer patients were blue periphery and blue collaret.The results of this study sustain the hypothesis that blue periphery with light brown collaret and freckles iris pattern is a reliable phenotypic marker for epidermal skin cancer. The results of this study differ from previous reports in which skin cancer risk was associated with a homogeneous blue

2018 Journal of the European Academy of Dermatology and Venereology

3. Piebaldism with multiple café-au-lait–like hyperpigmented macules and inguinal freckling caused by a novel KIT mutation (PubMed)

Piebaldism with multiple café-au-lait–like hyperpigmented macules and inguinal freckling caused by a novel KIT mutation 29693058 2019 02 26 2352-5126 4 4 2018 May JAAD case reports JAAD Case Rep Piebaldism with multiple café-au-lait-like hyperpigmented macules and inguinal freckling caused by a novel KIT mutation. 318-321 10.1016/j.jdcr.2017.10.005 Nagaputra Jerry C JC Dermatology Service, KK Women's & Children's Hospital, Singapore. Koh Mark J A MJA Dermatology Service, KK Women's

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2018 JAAD Case Reports

4. Iris Freckles a Potential Biomarker for Chronic Sun Damage. (PubMed)

Iris Freckles a Potential Biomarker for Chronic Sun Damage. To investigate the role of sunlight exposure in iris freckles formation.We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure.Six hundred thirty-two participants (n = 360; 57% female) were examined. Mean (...) age of all participants was 38.4 ± 18.4 years (range, 4-84 years). Of all individuals, 76.1% (n = 481) exhibited at least one iris freckle. Most freckles were observed in the inferior temporal quadrant. The presence of iris freckles was associated with higher age (participants with iris freckles: 41.8 ± 16.8 years versus participants without iris freckles: 27.6 ± 19.2 years), a high number of sunburns during lifetime (>10: 31% vs. 19%), sunlight-damaged skin (26% vs. 11%), presence of actinic

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2017 Investigative Ophthalmology & Visual Science

5. Treatment of Freckles Using a Fractional Nonablative 2940nm Erb:YAG Laser in a Series of Asian Patients (PubMed)

Treatment of Freckles Using a Fractional Nonablative 2940nm Erb:YAG Laser in a Series of Asian Patients OBJECTIVE: The purpose of this study was to demonstrate a novel, effective, and safe way to utilize the Erb:YAG laser to clear freckles in Type III/IV Asian skin. DESIGN: This was a prospective study. SETTING: The setting was a Singapore-based clinic. PARTICIPANTS: Participants included five women, aged 25 to 38 years, three with Skin Type III and two with Skin Type IV. All of them had (...) freckles. MEASUREMENTS: Photographs were taken pretreatment and one month after laser treatment. Three independent physicians evaluated the photographs using a grading system. Patients were followed clinically for a total of six months post-laser treatment to monitor for post-inflammatory hyperpigmentation and recurrence. RESULTS: At one month post-laser treatment, all five patients were evaluated. The three independent physicians agreed that all five patients had greater than 90-percent clearance

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2017 The Journal of clinical and aesthetic dermatology

6. Anti-Freckles Herbal Treatment in Iranian Traditional Medicine (PubMed)

Anti-Freckles Herbal Treatment in Iranian Traditional Medicine Freckles are numerous pigmented spots of the skin, mainly confined to the face, even arms and back. Although freckles are light-brown macules, most frequently observed in individuals with red or blond hair, they are common to Asian people too. Freckles increase in number, size, and depth of pigmentation during the summer months. Histologically, freckles show increased production of melanin pigment by a normal number of melanocytes (...) . Freckles commonly stop spreading before adolescence and last for life, but could sometimes be subtle in adulthood. Treatments are often requested for cosmetic purposes. Before the advent of lasers, treatment modalities for pigmentary disorders included surgical excision, dermabrasion, chemical bleaching, and peeling. These treatments may lead to unwanted side effects of potential scarring or undesired pigmentation changes. In Iranian traditional medicine (ITM), freckles have been known as well. "Namash

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2016 Iranian journal of medical sciences

7. Evaluating the Causes of Freckle and Nevus from the Viewpoint of Iranian Traditional Medicine (PubMed)

Evaluating the Causes of Freckle and Nevus from the Viewpoint of Iranian Traditional Medicine Freckles are due to an increase in the amount of dark pigments called melanin. These spots are more likely developed on the sun-exposed skin areas like the cheeks, nose, and forehead. Nevus is usually a benign melanocytic tumor and can be congenital or acquired. Due to the high influence of skin lesions on the person's appearance and quality of life, the aim of this study was to evaluate the causes (...) and Barash" being equivalent to freckle. Nevus formation is caused by congestion of gradually hardened and dense black bile humor in the skin after leaking through the vessels. The main cause of these problems is dysfunction of the gastrointestinal tract, liver, spleen, and uterus. Human's intellectual body function called "nature" and is by default designed to eradicate this residue from the essential internal organs and the skin.Based on ITM theory, since "nature" prefers excreting residue from

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2016 Iranian journal of medical sciences

8. Freckles

Freckles Freckles Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Freckles Freckles Aka: Freckles , Freckle , Ephelides From Related (...) Chapters II. Epidemiology Common occurrence in light-skinned, red-haired patients Onset in childhood, after III. Signs Characteristics Light, tan or brown s, each 1-2 mm with sharp demarcation Darkens with Vary in number from a few to hundreds of Freckles Distribution Face and nose more commonly affected Neck, chest, arms, legs are also affected IV. Differential Diagnosis (juvenile onset in childhood, or in older adults) does not darken on sunlight exposure V. Management Skin Sun avoidance Frequent

2018 FP Notebook

9. Freckle Defect Formation near the Casting Interfaces of Directionally Solidified Superalloys (PubMed)

Freckle Defect Formation near the Casting Interfaces of Directionally Solidified Superalloys Freckle defects usually appear on the surface of castings and industrial ingots during the directional solidification process and most of them are located near the interface between the shell mold and superalloys. Ceramic cores create more interfaces in the directionally solidified (DS) and single crystal (SX) hollow turbine blades. In order to investigate the location of freckle occurrence (...) in superalloys, superalloy CM247 LC was directionally solidified in an industrial-sized Bridgman furnace. Instead of ceramic cores, Alumina tubes were used inside of the casting specimens. It was found that freckles occur not only on the casting external surfaces, but also appear near the internal interfaces between the ceramic core and superalloys. Meanwhile, the size, initial position, and area of freckle were investigated in various diameters of the specimens. The initial position of the freckle chain

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2016 Materials

10. A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling (PubMed)

A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling Piebaldism is a rare autosomal dominant genodermatosis, manifesting as congenital and stable depigmentation of the skin and white forelock. It has been found to be associated with mutations in the KIT or SLUG genes. We report a Chinese piebaldism family including a 28-year-old woman and her 3-year-old son with characteristics of white patches and forelock (...) . No potentially pathogenic variant was identified in SLUG or NF1 genes. The nucleotide substitution was not found in 100 unrelated control individuals. This study reveals a novel KIT mutation in piebaldism, and it further supports that café-au-lait macules and intertriginous freckling of piebaldism are parts of pigmented anomaly in piebaldism, which does not necessarily represent coexistence of neurofibromatosis type 1 (NF1).

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2015 Therapeutics and clinical risk management

11. Acral freckling with palmar pits (PubMed)

Acral freckling with palmar pits 26009732 2015 05 26 2018 11 13 2229-5178 6 3 2015 May-Jun Indian dermatology online journal Indian Dermatol Online J Acral freckling with palmar pits. 234-5 10.4103/2229-5178.156445 Adya Keshavmurthy A KA Department of Dermatology, Venereology and Leprosy, SBMP Medical College, Hospital and Research Center, BLDE University, Bijapur, Karnataka, India. Inamadar Arun C AC Department of Dermatology, Venereology and Leprosy, SBMP Medical College, Hospital

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2015 Indian dermatology online journal

12. Interactions between Ultraviolet Light and MC1R and OCA2 Variants Are Determinants of Childhood Nevus and Freckle Phenotypes. (PubMed)

Interactions between Ultraviolet Light and MC1R and OCA2 Variants Are Determinants of Childhood Nevus and Freckle Phenotypes. Melanocytic nevi (moles) and freckles are well known biomarkers of melanoma risk, and they are influenced by similar UV light exposures and genetic susceptibilities to those that increase melanoma risk. Nevertheless, the selective interactions between UV exposures and nevus and freckling genes remain largely undescribed.We conducted a longitudinal study from ages 6 (...) nevus counts in children with rs12913832 blue eye color alleles and facial freckling scores in those with MC1R red hair color variants. Sunburns increased the numbers of larger nevi (≥2 mm) in subjects with certain MC1R and rs12913832 genotypes.Complex interactions between different UV exposure profiles and genotype combinations determine nevus numbers and size, and the degree of facial freckling.Our findings emphasize the importance of implementing sun-protective behavior in childhood regardless

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2014 Cancer Epidemiology & Biomarkers and Prevention

13. Ephelides (Freckles) (Overview)

Ephelides (Freckles) (Overview) Dermatology Articles (Diagnosis, Dermatologic Surgery, Histology, Prognosis, Follow-up) - Medscape Reference  Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Articles on Dermatology Change Show articles : By Category Alphabetically Expand All Allergy and Immunology Bacterial Infections Benign Neoplasms Bullous Diseases

2014 eMedicine.com

14. Ephelides (Freckles) (Diagnosis)

Ephelides (Freckles) (Diagnosis) Dermatology Articles (Diagnosis, Dermatologic Surgery, Histology, Prognosis, Follow-up) - Medscape Reference  Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Articles on Dermatology Change Show articles : By Category Alphabetically Expand All Allergy and Immunology Bacterial Infections Benign Neoplasms Bullous Diseases

2014 eMedicine.com

15. Ephelides (Freckles) (Treatment)

Ephelides (Freckles) (Treatment) Dermatology Articles (Diagnosis, Dermatologic Surgery, Histology, Prognosis, Follow-up) - Medscape Reference  Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Articles on Dermatology Change Show articles : By Category Alphabetically Expand All Allergy and Immunology Bacterial Infections Benign Neoplasms Bullous Diseases

2014 eMedicine.com

16. Ephelides (Freckles) (Follow-up)

Ephelides (Freckles) (Follow-up) Dermatology Articles (Diagnosis, Dermatologic Surgery, Histology, Prognosis, Follow-up) - Medscape Reference  Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Articles on Dermatology Change Show articles : By Category Alphabetically Expand All Allergy and Immunology Bacterial Infections Benign Neoplasms Bullous Diseases

2014 eMedicine.com

17. Freckles and solar lentigines have different risk factors in Caucasian women. (PubMed)

Freckles and solar lentigines have different risk factors in Caucasian women. To date, few epidemiological data on the relationships between solar lentigines, freckles and behavioural and constitutional risk factors in Caucasian populations exist.To investigate the potential impact of behavioural and phenotypic variables, as well as the MC1R genetic background, on the history of facial freckles and the severity of solar lentigines in Caucasian women.The severity of solar lentigines was graded (...) from facial digital images of 523 French middle-aged women by a dermatologist and summarized by a score afterwards. The history of facial freckles was assessed and the sun-exposure behaviour was characterized using a six-category typology. Risk factors including MC1R polymorphism were evaluated using logistic regression models.Two constitutive host factors were found to be independently associated with a history of facial freckles: frequent sunburns and the presence of diminished function variants

2013 Journal of the European Academy of Dermatology and Venereology

18. A meta-analysis of pigmentary characteristics, sun sensitivity, freckling and melanocytic nevi and risk of basal cell carcinoma of the skin. (PubMed)

A meta-analysis of pigmentary characteristics, sun sensitivity, freckling and melanocytic nevi and risk of basal cell carcinoma of the skin. To calculate pooled risk estimates of the association between pigmentary characteristics and basal cell carcinoma (BCC) of the skin.We searched three electronic databases and reviewed the reference lists of the retrieved articles until July 2012 to identify eligible epidemiologic studies. Eligible studies were those published in between 1965 and July 2012 (...) that permitted quantitative assessment of the association between histologically-confirmed BCC and any of the following characteristics: hair colour, eye colour, skin colour, skin phototype, tanning and burning ability, and presence of freckling or melanocytic nevi. We included 29 studies from 2236 initially identified. We calculated summary odds ratios (ORs) using weighted averages of the log OR, using random effects models.We found strongest associations with red hair (OR 2.02; 95% CI: 1.68, 2.44), fair

2013 Cancer epidemiology

19. Freckles

Freckles Freckles Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Freckles Freckles Aka: Freckles , Freckle , Ephelides From Related (...) Chapters II. Epidemiology Common occurrence in light-skinned, red-haired patients Onset in childhood, after III. Signs Characteristics Light, tan or brown s, each 1-2 mm with sharp demarcation Darkens with Vary in number from a few to hundreds of Freckles Distribution Face and nose more commonly affected Neck, chest, arms, legs are also affected IV. Differential Diagnosis (juvenile onset in childhood, or in older adults) does not darken on sunlight exposure V. Management Skin Sun avoidance Frequent

2015 FP Notebook

20. Efficacy and Safety of Fractional Carbon Dioxide Laser for Treatment of Facial Freckles.

Efficacy and Safety of Fractional Carbon Dioxide Laser for Treatment of Facial Freckles. Efficacy and Safety of Fractional Carbon Dioxide Laser for Treatment of Facial Freckles. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Efficacy and Safety of Fractional Carbon Dioxide Laser for Treatment of Facial Freckles. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01545869 Recruitment Status : Completed First Posted : March 7, 2012 Last Update Posted : April 7, 2014 Sponsor: Cairo University Information

2012 Clinical Trials

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