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1. Surgery: Frailty and frailty-related factors are associated with postoperative complications in older patients undergoing elective surgery

Surgery: Frailty and frailty-related factors are associated with postoperative complications in older patients undergoing elective surgery Frailty and frailty-related factors are associated with postoperative complications in older patients undergoing elective surgery | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Frailty and frailty-related factors are associated with postoperative complications in older patients undergoing elective

2018 Evidence-Based Medicine

2. Diagnostic test accuracy of self-reported frailty screening instruments in identifying community-dwelling older people at risk of frailty and pre-frailty: a systematic review protocol. (Abstract)

Diagnostic test accuracy of self-reported frailty screening instruments in identifying community-dwelling older people at risk of frailty and pre-frailty: a systematic review protocol. The question of this systematic review is: What is the diagnostic test accuracy of self-reported frailty screening instruments among community-dwelling older people against any of the following reference standard tests: the frailty phenotype, frailty index and comprehensive geriatric assessment?

2017 JBI database of systematic reviews and implementation reports

3. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants Full Text available with Trip Pro

Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants Frailty is associated with older age and multimorbidity (two or more long-term conditions); however, little is known about its prevalence or effects on mortality in younger populations. This paper aims to examine the association between frailty, multimorbidity, specific long-term conditions, and mortality in a middle-aged (...) and older aged population.Data were sourced from the UK Biobank. Frailty phenotype was based on five criteria (weight loss, exhaustion, grip strength, low physical activity, slow walking pace). Participants were deemed frail if they met at least three criteria, pre-frail if they fulfilled one or two criteria, and not frail if no criteria were met. Sociodemographic characteristics and long-term conditions were examined. The outcome was all-cause mortality, which was measured at a median of 7 years follow

2018 The Lancet. Public health

4. Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review. Full Text available with Trip Pro

Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review. To summarize the best available evidence regarding the effectiveness of interventions for preventing frailty progression in older adults.Frailty is an age-related state of decreased physiological reserves characterized by an increased risk of poor clinical outcomes. Evidence supporting the malleability of frailty, its prevention and treatment, has been presented.The review (...) considered studies on older adults aged 65 and over, explicitly identified as pre-frail or frail, who had been undergoing interventions focusing on the prevention of frailty progression. Participants selected on the basis of specific illness or with a terminal diagnosis were excluded. The comparator was usual care, alternative therapeutic interventions or no intervention. The primary outcome was frailty. Secondary outcomes included: (i) cognition, quality of life, activities of daily living, caregiver

2018 JBI database of systematic reviews and implementation reports

5. Exercise Interventions for the Delayed Progression or Reversal of Frailty

Exercise Interventions for the Delayed Progression or Reversal of Frailty Exercise Interventions for the Delayed Progression or Reversal of Frailty | CADTH.ca Find the information you need Exercise Interventions for the Delayed Progression or Reversal of Frailty Exercise Interventions for the Delayed Progression or Reversal of Frailty Last updated: May 25, 2018 Project Number: RB1221-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report (...) Question What is the effectiveness of exercise interventions to reverse or delay the progression of frailty in those with frailty? Key Message Ten systematic reviews (two with meta-analyses), ten randomized controlled trials, and four non-randomized studies were identified regarding the effectiveness of exercise interventions to reverse or delay the progression of frailty in those with frailty. Files Rapid Response Summary of Abstracts Published : May 25, 2018 Related Content Follow us: © 2019 Canadian

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

6. Nutritional Interventions for the Delayed Progression or Reversal of Frailty: Clinical Effectiveness

Nutritional Interventions for the Delayed Progression or Reversal of Frailty: Clinical Effectiveness Nutritional Interventions for the Delayed Progression or Reversal of Frailty: Clinical Effectiveness | CADTH.ca Find the information you need Nutritional Interventions for the Delayed Progression or Reversal of Frailty: Clinical Effectiveness Nutritional Interventions for the Delayed Progression or Reversal of Frailty: Clinical Effectiveness Last updated: May 28, 2018 Project Number: RB1222-000 (...) Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the effectiveness of nutritional interventions for delaying or reversing the progression of frailty in those with frailty? Key Message One systematic review and five randomized controlled trials were identified regarding the effectiveness of nutrition interventions to reverse or delay the progression of frailty in those with frailty. Files Rapid Response Summary of Abstracts

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Nutritional and Exercise Interventions for the Delayed Progression or Reversal of Frailty: Cost-Effectiveness

Nutritional and Exercise Interventions for the Delayed Progression or Reversal of Frailty: Cost-Effectiveness Nutritional and Exercise Interventions for the Delayed Progression or Reversal of Frailty: Cost-Effectiveness | CADTH.ca Find the information you need Nutritional and Exercise Interventions for the Delayed Progression or Reversal of Frailty: Cost-Effectiveness Nutritional and Exercise Interventions for the Delayed Progression or Reversal of Frailty: Cost-Effectiveness Last updated: June (...) 8, 2018 Project Number: RB1230-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the cost-effectiveness of nutritional interventions for the delayed progression or reversal of frailty? What is the cost-effectiveness of exercise interventions for the delayed prevention or reversal of frailty? Key Message One systematic review and four economic evaluations were identified regarding the cost-effectiveness of nutritional

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Comprehensive Care - Older people with frailty in hospital

Comprehensive Care - Older people with frailty in hospital COMPREHENSIVE CARE Older people living with frailty in hospitals NIHR Dissemination Centre December 2017 NIHR research on older people living with frailty in hospitals THEMED REVIEW2 NIHR Themed Review: Comprehensive Care FOREWORD O ver my twenty years in clinical practice, we have made great inroads into reducing premature deaths from disease and more people are living longer. By 2040, nearly one in seven people are projected (...) to be over 75. We have also begun to understand more about the condition of frailty. Frailty is associated with age, but not all older people are living with frailty and not all people with frailty are old. Frailty is much more effective than age as a means of identifying people who may be at greater risk of future hospitalisation, care home admission or death. NHS England has characterised frailty as a long-term condition that can be routinely identified and managed to improve a person’s quality of life

2018 NIHR Dissemination Centre - Themed Reviews

9. Correction: Stakeholders' views and experiences of care and interventions for addressing frailty and pre-frailty: A meta-synthesis of qualitative evidence. Full Text available with Trip Pro

Correction: Stakeholders' views and experiences of care and interventions for addressing frailty and pre-frailty: A meta-synthesis of qualitative evidence. [This corrects the article DOI: 10.1371/journal.pone.0180127.].

2018 PLoS ONE

10. Frailty in Older Adults - Early Identification and Management

Frailty in Older Adults - Early Identification and Management Frailty in Older Adults - Early Identification and Management - Province of British Columbia theme_3_collection theme_3_frontend theme_3_collection theme_3_frontend Birth, Adoption, Death, Marriage & Divorce theme_1_collection theme_1_frontend theme_1_collection theme_1_frontend British Columbians & Our Governments theme_data_collection data_frontend theme_data_collection data_frontend Data theme_5_collection theme_5_frontend (...) theme_10_collection theme_10_frontend Sports, Recreation, Arts & Culture theme_8_collection theme_8_frontend theme_8_collection theme_8_frontend Taxes & Tax Credits theme_14_collection theme_14_frontend theme_14_collection theme_14_frontend Tourism & Immigration Search default_collection default_frontend Section Navigation Frailty in Older Adults - Early Identification and Management Effective Date: October 25th, 2017 Recommendations and Topics ​ Scope This guideline addresses the early identification

2017 Clinical Practice Guidelines and Protocols in British Columbia

11. Patient versus Physician Perceptions of Frailty: A Comparison of Clinical Frailty Scale Scores of Older Adults in the Emergency Department. (Abstract)

Patient versus Physician Perceptions of Frailty: A Comparison of Clinical Frailty Scale Scores of Older Adults in the Emergency Department. Frailty is a state of vulnerability to impairments in mobility, balance, muscle strength, motor processing, physical function, disability, cognition, nutrition, endurance, and physical activity. Prevalence estimates vary widely from 4.0 to 59.1% (weighted estimate 10.9%), with prevalence increasing with age. The risk of adverse outcomes for frail older (...) adults including falls, delirium, disability and death is increased compared to similarly aged individuals without frailty, and may be a more important predictor of death than age for older adults. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Academic Emergency Medicine

12. Variation in center-level frailty burden and the impact of frailty on long-term survival in patients undergoing elective repair for abdominal aortic aneurysms. Full Text available with Trip Pro

Variation in center-level frailty burden and the impact of frailty on long-term survival in patients undergoing elective repair for abdominal aortic aneurysms. Frailty is increasingly recognized as a key determinant in predicting postoperative outcomes. Centers that see more frail patients may not be captured in risk adjustment, potentially accounting for poorer outcomes in hospital comparisons. We aimed to (1) determine the effect of frailty on long-term mortality in patients undergoing (...) elective abdominal aortic aneurysm (AAA) repair and (2) evaluate the variability in frailty burden among centers in the Vascular Quality Initiative (VQI) database.Patients undergoing elective open and endovascular AAA repair (2003-2017) were identified, and those with complete data on component variables of the VQI-derived Risk Analysis Index (VQI-RAI) and centers with ≥10 AAA repairs were included. VQI-RAI characteristics are sex, age, body mass index, renal failure, congestive heart failure, dyspnea

2019 Journal of Vascular Surgery

13. Frailty in Older Patients Undergoing Emergency Laparotomy: Results From the UK Observational Emergency Laparotomy and Frailty (ELF) Study. Full Text available with Trip Pro

Frailty in Older Patients Undergoing Emergency Laparotomy: Results From the UK Observational Emergency Laparotomy and Frailty (ELF) Study. This study aimed to document the prevalence of frailty in older adults undergoing emergency laparotomy and to explore relationships between frailty and postoperative morbidity and mortality.The majority of adults undergoing emergency laparotomy are older adults (≥65 y) that carry the highest mortality. Improved understanding is urgently needed to allow (...) development of targeted interventions.An observational multicenter (n=49) UK study was performed (March-June 2017). All older adults undergoing emergency laparotomy were included. Preoperative frailty score was calculated using the progressive Clinical Frailty Score (CFS): 1 (very fit) to 7 (severely frail). Primary outcome measures were the prevalence of frailty (CFS 5-7) and its association to mortality at 90 days postoperative. Secondary outcomes included 30-day mortality and morbidity, length

2019 Annals of Surgery

14. Prevalence and Postdischarge Outcomes Associated with Frailty in Medical Inpatients: Impact of Different Frailty Definitions. Full Text available with Trip Pro

Prevalence and Postdischarge Outcomes Associated with Frailty in Medical Inpatients: Impact of Different Frailty Definitions. We compared prevalence estimates and prognostication if frailty were defined using the face-to-face Clinical Frailty Scale (CFS) or the administrative-data-derived Hospital Frailty Risk Score (HFRS). We evaluated 489 adults from a prospective cohort study of medical patients being discharged back to the community; 276 (56%) were deemed frail (214 [44%] on the HFRS (...) and 161 [33%] on the CFS), but only 99 (20%) met both frailty definitions (kappa 0.24, 95% CI 0.16-0.33). Patients classified as frail on the CFS exhibited significantly higher 30-day readmission/death rates, 19% versus 10% for those not frail (aOR [adjusted odds ratio] 2.53, 95% CI 1.40-4.57) and 21% versus 6% for those aged >65 years (aOR 4.31, 95% CI 1.80-10.31). Patients with HFRS-defined frailty exhibited higher 30-day readmission/death rates that were not statistically significant (16% vs 11

2019 Journal of Hospital Medicine

15. FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults. Full Text available with Trip Pro

FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults. Dozens of scales and questionnaires have been used in the detection of frailty; however, a generalized method for its screening and diagnosis is still lacking in clinical settings. FRAILTOOLS´ main objective is to evaluate the usefulness of frailty scales in the detection (...) of frailty in different clinical and social settings, and its integration in management algorithms for the frail older patient.FRAILTOOLS is an observational, longitudinal and prospective study with a follow-up of 6, 12 and 18 months. People older than 75 years old will be recruited from three separate clinical settings (acute geriatric wards, geriatric outpatient clinics and primary care) and one social setting (nursing homes). Exclusion criteria include Mini-mental State Examination < 20 points

2019 BMC Geriatrics

16. Frailty state among Indonesian elderly: prevalence, associated factors, and frailty state transition. Full Text available with Trip Pro

Frailty state among Indonesian elderly: prevalence, associated factors, and frailty state transition. Information about frailty status and its transition is important to inform clinical decisions. Predicting frailty transition is beneficial for its prevention. While Indonesia is the 4th largest geriatric population in Asia, data about frailty transition is limited. This study aimed to obtain data on prevalence of frailty, its risk factors, frailty state transition and its prognostic factors (...) , as well as to develop prognostic score for frailty state transition.Multicenter study on subjects aged ≥60 years old was done to obtain the prevalence of frailty status and to identify risk factors of frailty. Prospective cohort over 12 months was done to obtain data on frailty state transition. Multiple logistic regression analysis was performed to identify its prognostic factors from several clinical data, which then were utilized to develop prognostic score for frailty state worsening.Cross

2019 BMC Geriatrics

17. Southampton Arm Fracture Frailty and Sarcopenia Study (SAFFSS): a study protocol for the feasibility of assessing frailty and sarcopenia among older patients with an upper limb fracture. Full Text available with Trip Pro

Southampton Arm Fracture Frailty and Sarcopenia Study (SAFFSS): a study protocol for the feasibility of assessing frailty and sarcopenia among older patients with an upper limb fracture. Falls are a major health problem for older people; 35% of people aged 65+ years fall every year, leading to fractures in 10%-15%. Upper limb fractures are often the first sign of osteoporosis and routine screening for osteoporosis is recommended by the National Institute for Health and Care Excellence (...) to prevent subsequent hip fractures. However, both frailty and sarcopenia (muscle weakness) are associated with increased risk of falling and fracture but are not routinely identified in this group. The aim of this study is to evaluate the feasibility of assessing and managing frailty and sarcopenia among people aged 65+ years with an upper limb fracture.This study will be conducted in three fracture clinics in one acute trust in England. 100 people aged 65+ years with an upper arm fracture

2019 BMJ open

18. Frailty Levels In Geriatric Hospital paTients (FLIGHT)-the prevalence of frailty among geriatric populations within hospital ward settings: a systematic review protocol. Full Text available with Trip Pro

Frailty Levels In Geriatric Hospital paTients (FLIGHT)-the prevalence of frailty among geriatric populations within hospital ward settings: a systematic review protocol. Frailty is a common and clinically significant condition in geriatric populations, associated with adverse health outcomes such as hospitalisation, disability and mortality. Although there are systematic reviews/meta-analyses assessing the prevalence of frailty in community-dwelling older adults, nursing home residents (...) , and cancer and general surgery patients, there are none assessing the overall prevalence of frailty in geriatric hospital inpatients.This review will systematically search and analyse the prevalence of frailty within geriatric hospital inpatients within the literature. A search will be employed on the platforms of Ovid, Web of Science and databases of Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus, SCOPUS and the Cochrane Library. Any observational or experimental study design

2019 BMJ open

19. Measuring Frailty in Administrative Claims Data: Comparative Performance of Four Claims-Based Frailty Measures in the United States Medicare Data. Full Text available with Trip Pro

Measuring Frailty in Administrative Claims Data: Comparative Performance of Four Claims-Based Frailty Measures in the United States Medicare Data. There has been increasing effort to measure frailty in the United States Medicare data. The performance of claims-based frailty measures has not been compared.This cross-sectional study included 3,097 community-dwelling fee-for-service Medicare beneficiaries (mean age 75.6 years) who participated in the 2008 Health and Retirement Study examination (...) . Four claims-based frailty measures developed by Davidoff, Faurot, Segal, and Kim were compared against frailty phenotype, a deficit-accumulation frailty index (FI), and activities-of-daily living (ADL) dependence using Spearman correlation coefficients and C-statistics.Claims-based frailty measures were positively associated with frailty phenotype (prevalence in ≤10th vs >90th percentile: 8.0% vs 41.3% for Davidoff; 5.9% vs 53.1% for Faurot; 3.3% vs 48.0% for Segal; 2.9% vs 51.0% for Kim) and FI

2019 Biological Sciences and Medical Sciences

20. The Association Between Vitamin D, Frailty and Progression of Frailty in Community-Dwelling Older Women. Full Text available with Trip Pro

The Association Between Vitamin D, Frailty and Progression of Frailty in Community-Dwelling Older Women. Vitamin D (25OHD) plays a role in many physiological functions which decline with age, contributing to frailty and increased risk for negative health outcomes. However, whether 25OHD can be a long-term risk marker for frailty over a longer time-period and whether it is consistent with advancing age is unclear.To investigate the association between 25OHD and frailty in women aged 75, followed (...) for 10 years.Prospective, population-based, cohort study from Malmö, Sweden.Community-dwelling women aged 75(±0.1) (n=1044) with reassessments at ages 80(±0.2) (n=715) and 85(±0.1) (n=382).Frailty was quantified using a 10-variable frailty-index, ranging from 0 (lowest) to 1 (highest). Women were categorized as vitamin D insufficient (<50nmol/L) or sufficient (≤50nmol/L).At both ages 75 and 80, 25OHD insufficient women were more frail compared to women with sufficient 25OHD (0.23 vs 0.18; p<0.001

2019 Journal of Clinical Endocrinology and Metabolism

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