How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,793 results for

Fractional Excretion of Sodium

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1681. Is kidney function altered by the duration of cardiopulmonary bypass? (Abstract)

excretion of sodium, urine concentrations of N-acetyl-beta-D-glucosaminidase, alpha1-microglobulin, glutathione transferase-pi, and glutathione transferase-alpha were measured after induction of anesthesia at the end of the operation, and on the first and second postoperative days in the intensive care unit.CPB times were 58 +/- 12 minutes and 116 +/- 18 minutes, respectively. Hemodynamics, volume replacement, and use of catecholamines during cardiopulmonary bypass (CPB) were without significant (...) Is kidney function altered by the duration of cardiopulmonary bypass? Cardiopulmonary bypass (CPB) is considered responsible for kidney damage. By using sensitive markers of kidney damage we assessed whether the length of CPB influences kidney function.In a prospective study, 50 consecutive cardiac operation patients with CPB times of less than 70 minutes were compared with 50 consecutive patients showing CPB times of more than 90 minutes. Aside from creatinine clearance and fractional

2003 Annals of Thoracic Surgery

1682. Arixtra (fondaparinux sodium)

Arixtra (fondaparinux sodium) 1/45 ?EMEA 2004 SCIENTIFIC DISCUSSION This module reflects the initial scientific discussion and scientific discussion on procedures which have been finalised before 1 November 2004. For scientific information on procedures after this date please refer to module 8B. Introduction Arixtra is indicated for the prevention of Venous Thromboembolic Events (VTE) in patients undergoing major orthopaedic surgery of the lower limbs (MOSLL) such as hip fracture surgery (HFS (...) metabolism was detected in blood, urine, bile and hepatocytes by means of the detection of [ 35 S]-SO 4 2- ions. Urine secretion data in rat indicated some activity-reducing metabolism. The elimination of fondaparinux from the circulation was significantly faster in rat, rabbit and monkey compared with man. The terminal half-life did not change with dose in the animals. Drug-related radioactivity was mainly excreted via urine, whereas the faecal excretion was low (rat) or negligible (monkey). Toxicology

2005 European Medicines Agency - EPARs

1683. Concentrated Saline Infusions and Increased Dietary Sodium With Diuretics for Heart Failure With Kidney Dysfunction

in renal function, a fractional excretion of urea <35%, or a fractional excretion of sodium <1%. For GFR 30-60: must have serum sodium /= 120 mg/d in furosemide equivalents OR concomitant thiazide use). For GFR <30: no additional criteria needed. Exclusion Criteria: Admit estimated GFR < 15mL/min or predicted need for chronic hemodialysis within the next 60 days. Cause of acute kidney injury other than prerenal physiology (...) Concentrated Saline Infusions and Increased Dietary Sodium With Diuretics for Heart Failure With Kidney Dysfunction Concentrated Saline Infusions and Increased Dietary Sodium With Diuretics for Heart Failure With Kidney Dysfunction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2007 Clinical Trials

1684. The Effect of Atorvastatin on Renal Function in Healthy Subjects During Normal and High Sodium Intake

by the National Library of Medicine available for: Arms and Interventions Go to Intervention Details: Drug: Atorvastatin 80 mg atorvastatin on two following days each Outcome Measures Go to Primary Outcome Measures : Glomerular filtration rate, clearance of sodium and lithium, fractional excretion of sodium and lithium, U-AQP-2, total sodium excretion, free water clearance [ Time Frame: 6 months ] Secondary Outcome Measures : AVP, Ang-II, Aldosterone, ANP, BNP, PRC, BP and HR. [ Time Frame: 6 months (...) Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: The Effect of Acute HMG-CoA-Reductase Inhibition (Atorvastatin) on Renal Sodium Excretion, Renal Hemodynamics, Tubular Function and Vasoactive Hormones in Healthy Subjects During Normal and High Sodium Intake Study Start Date : January 2007 Actual Primary Completion Date : October 2007 Actual Study Completion Date : October 2007 Resource links provided

2008 Clinical Trials

1685. Safety and Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) Plus Valsartan in Patients With Kidney Transplants (MYTHOS

clearance of unlabeled iohexol, after 6 and 12 months; Albumin excretion rate and fractional clearance of albumin after 6 and 12 months; Fasting blood glucose levels, total cholesterol, triglyceride and HDL levels and systolic and diastolic blood pressure after 6 and 12 months; Incidence of acute rejection after 6 and 12 months; Patient and graft survival at 12 months; Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal (...) Safety and Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) Plus Valsartan in Patients With Kidney Transplants (MYTHOS Safety and Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) Plus Valsartan in Patients With Kidney Transplants (MYTHOS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2006 Clinical Trials

1686. The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease

saline infusion after 4 days on high and low sodium diet, respectively. ] Urinary ENaC (beta) corrected for creatinine FENa [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] fractional sodium excretion CH2O [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] Free water excretion u-cAMP [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low (...) Identifier: Other Study ID Numbers: med.res.hos.2006.cc.03 First Posted: December 12, 2006 Last Update Posted: March 20, 2018 Last Verified: March 2018 Keywords provided by Carolina Cannillo, Regional Hospital Holstebro: ADPKD Urinary Aquaporin-2 ENaC Fractional sodium excretion High/low sodium diet Additional relevant MeSH terms: Layout table for MeSH terms Kidney Diseases Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Urologic Diseases Kidney Diseases, Cystic Abnormalities, Multiple

2006 Clinical Trials

1687. The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans.

: Behavioral: High Sodium Diet 250-350 mmol Behavioral: Low Sodium Diet 25-35 mmol Outcome Measures Go to Primary Outcome Measures : u-AQP-2 [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] fractional sodium excretion [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] p-aldosterone [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium (...) ClinicalTrials.gov Identifier: Other Study ID Numbers: med.res.hos.2006.cc.01 First Posted: June 27, 2006 Last Update Posted: June 28, 2011 Last Verified: June 2011 Keywords provided by Regional Hospital Holstebro: Urinary Aquaporin 2 High/low Sodium Diet Fractional Sodium Excretion

2006 Clinical Trials

1688. The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension

days on high and low sodium diet, respectively. ] fractional sodium excretion [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] p-vasopressin [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] p-aldosterone [ Time Frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively. ] Secondary Outcome Measures : u-p-AQP-2 [ Time (...) Identifier (NCT Number): Layout table for additonal information Responsible Party: Carolina Cannillo Graffe, Department of Medical Research, Holstebro Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: med.res.hos.2006.cc.02 First Posted: June 27, 2006 Last Update Posted: June 28, 2011 Last Verified: June 2011 Keywords provided by Regional Hospital Holstebro: urinary aquaporin-2 ENaC fractional sodium excretion High/low sodium diet Additional relevant MeSH terms: Layout table for MeSH terms

2006 Clinical Trials

1689. Hemodynamic effect of angiotensin II receptor blockade in postmenopausal women on a high-sodium diet: A double-blind, randomized, placebo-controlled study. Full Text available with Trip Pro

excretion compared with placebo (135 [13] vs 106 [13] μmol/min; P < 0.05) and a significant decrease at night (109 [13] vs 136 [19] μmol/min; P < 0.05). Fractional excretion of lithium (FELi), an inverse marker of proximal sodium reabsorption, increased significantly during the daytime with irbesartan compared with placebo (47% [6.5%] vs 35% [4.7%]; P < 0.05). At nighttime, FELi was significantly higher in the hypertensive subjects receiving irbesartan compared with placebo (43% [7.2%] vs 29% [6.5%]; P (...) < 0.05). The fractional distal reabsorption of sodium did not change significantly with irbesartan compared with placebo.The results from this study suggest that angiotensin II receptor blockade had a favorable impact on BP, renal hemodynamics, and renal sodium handling in these salt-replete postmenopausal women. Blockade of the renin-angiotensin system restored the normal pattern of renal response to high sodium intake in these women.

2008 Current therapeutic research, clinical and experimental Controlled trial quality: uncertain

1690. Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate

Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00165503 Recruitment Status : Terminated (lack of acurral

2005 Clinical Trials

1691. Promising ternary dry powder inhaler formulations of cromolyn sodium: formulation and in vitro-in vivo evaluation. (Abstract)

that were inhaled via a Handihaler showed significantly higher drug fine particle fractions (P<0.001) than that of the same formulae aerosolized via other devices. Upon storage of the prepared formulae under uncontrolled humidity, that may be encountered during storage and use, marked reductions in these fractions were observed. Incorporation of an optimum Aerosil 200 concentration, as a ternary component, minimized this effect. A urinary excretion pharmacokinetic method was used to evaluate (...) Promising ternary dry powder inhaler formulations of cromolyn sodium: formulation and in vitro-in vivo evaluation. Glucose monohydrate and sorbitol were evaluated as alternative carriers to á-lactose monohydrate in dry powder inhalations. Cromolyn sodium (CS) - carrier binary formulae were prepared and tested in vitro by aerosolization via a twin stage impinger using three types of inhaler devices; Spinhaler, Aerolizer and Handihaler. Glucose monohydrate and sorbitol-containing formulae

2007 Archives of pharmacal research

1692. Eprosartan modulates the reflex activation of the sympathetic nervous system in sodium restricted healthy humans. Full Text available with Trip Pro

of the CPT on renal tubular function. During a SNP induced reduction in MAP of 10 mmHg eprosartan decreased fractional excretions of sodium (0.46 (0.14, 0.76)%) and lithium (5.1 (2.5, 7.6)%) and tended to increase HR (4.1 (-0.26, 8.4) min(-1)) and plasma concentrations of norepinephrine (33.8 (-5.8, 72.1) pg ml(-1)). CONCLUSIONS; These findings suggest that during mild sodium restriction eprosartan has a small inhibitory effect on nonbaroreflex mediated activation of the sympathetic nervous system (...) baroreflex. AIMS To test the hypothesis that eprosartan inhibits both nonbaroreflex and arterial baroreflex mediated activation of the sympathetic nervous system, assessed by renal tubular function, systemic haemodynamics and vasoactive hormones, in sodium restricted healthy humans.The effect of eprosartan on urinary sodium, lithium and water excretion, heart rate (HR), blood pressure and vasoactive hormones was measured before, during and after a cold pressor test (CPT) and sodium nitroprusside (SNP

2008 British journal of clinical pharmacology Controlled trial quality: uncertain

1693. The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure. (Abstract)

. Serum sodium and creatinine, plasma l-DOPA, dopamine, its metabolites, BNP and aldosterone, and 24-h urinary sodium, creatinine, l-DOPA, dopamine and metabolites were measured.The two groups were matched respecting to demographic and clinical parameters. Low-sodium diet caused significant reductions in weight, 24-h urinary volume and sodium and sodium fractional excretion. Renal delivery of l-DOPA and urinary excretion of l-DOPA significantly decreased while dopamine and metabolites were (...) The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure. This work evaluates the effect of a low-sodium diet on clinical and neurohumoral parameters and on renal dopaminergic system activity in heart failure (HF) patients.We included 24 patients with mild-to-moderate stable HF with left ventricle ejection fraction <40%. Twelve patients were studied before and after a 15-day low-sodium diet; 12 maintained their usual diet

2004 European journal of heart failure Controlled trial quality: uncertain

1694. Effects of statins on renal sodium and water handling: acute and short-term effects of atorvastatin on renal haemodynamics, tubular function, vasoactive hormones, blood pressure and pulse rate in healthy, normocholesterolemic humans. Full Text available with Trip Pro

natriuretic peptide (ANP), brain natriuretic peptide (BNP), aldosterone (Aldo), vasopressin (AVP) and blood pressure (BP) were determined.In Study 1 AS decreased fractional excretion of sodium (FE(Na)) significantly (P = 0.035), but very modestly, and reduced diastolic BP (P = 0.024). Apart from this, we found no significant differences in GFR, RPF, tubular function and vasoactive hormones in either Study 1 or 2.An acute dose of AS decreased FE(Na) and DBP in healthy humans. The reduction in fractional (...) urinary sodium excretion was very modest and transitory, and most likely secondary to the fall in diastolic blood pressure (DBP). However, renal haemodynamics, tubular function, vasoactive hormones and blood pressure were unchanged during short-term statin treatment in healthy man.

2008 Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Controlled trial quality: uncertain

1695. Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD1 Promoter and GRK4. Full Text available with Trip Pro

Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD1 Promoter and GRK4. Activation of type-1 dopamine receptors (DRD1) reduces renal sodium reabsorption. In a family-based random sample of 611 untreated whites (women, 45.0%; mean age, 38.6 years), we measured blood pressure (BP). We used the endogenous lithium clearance to assess fractional sodium excretion (FE(Na)) and proximal (RNa(prox)) and distal (RNa(dist)) tubular sodium reabsorption. We investigated (...) multivariate-adjusted associations with the DRD1 promoter (A-48G, G-94A, and C-800T) and GRK4 (Ala142Val). The frequent DRD1 haplotypes were AGC (48.2%), GGT (34.4%), and AAC (14.3%). While standardizing to mean sodium excretion (8.7 mmol/h) and adjusting for covariates and relatedness, RNa(dist) was lower in DRD1 -94GG homozygotes than -94A allele carriers (effect size, -0.94%; P=0.005) with opposite findings for FE(Na) (+0.084%; P=0.014). AGC carriers (-0.88%; P=0.012) and AAC carriers (+1.00%; P=0.004

2008 Hypertension

1696. Mouse Model of Type II Bartters Syndrome. II. Altered Expression of Renal Sodium- and Water-Transporting Proteins. Full Text available with Trip Pro

Mouse Model of Type II Bartters Syndrome. II. Altered Expression of Renal Sodium- and Water-Transporting Proteins. Bartter's syndrome represents a group of hereditary salt- and water-losing renal tubulopathies caused by loss-of-function mutations in proteins mediating or regulating salt transport in the thick ascending limb (TAL) of Henle's loop. Mutations in the ROMK channel cause type II antenatal Bartter's syndrome that presents with maternal polyhydramnios and postnatal life-threatening (...) volume depletion. We have developed a colony of Romk null mice showing a Bartter-like phenotype and with increased survival to adulthood, suggesting the activation of compensatory mechanisms. To test the hypothesis that upregulation of Na(+)-transporting proteins in segments distal to the TAL contributes to compensation, we studied expression of salt-transporting proteins in ROMK-deficient (Romk(-/-)) mice. Plasma aldosterone was 40% higher and urinary PGE(2) excretion was 1.5-fold higher in Romk

2008 American Journal of Physiology. Renal physiology

1697. Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells. Full Text available with Trip Pro

activity (5.1 +/- 1.1 vs. 9.9 +/- 1.6 micromol/mg pr/hr, P < 0.01) relative to the normal diet. Proximal tubular Na/K-ATPase alpha1 protein density was decreased in the plasmalemma fraction but increased in both early and late endosomes following the high salt diet. In rats fed a high salt diet, anti-MBG antibody caused a 60% reduction in urinary sodium excretion, substantial increases in proximal tubule (86)Rb uptake, and Na/K-ATPase enzymatic activity, as well as significant decreases in the early (...) sodium excretion, as well as MBG excretion, was monitored, and proximal tubules were isolated using a Percoll gradient method. Tubular (86)Rb uptake, Na/K-ATPase enzymatic activity, and Na/K-ATPase alpha1 subunit density were determined.The high salt diet increased urinary sodium (17.8 +/- 1.8 vs. 2.5 +/- 0.3 mEq/day, P < 0.01) and MBG excretion (104 +/- 12 vs. 26 +/- 4 pmol/day), and decreased proximal tubular (86)Rb uptake (0.44 +/- 0.07 vs. 1.00 +/- 0.10, P < 0.01) and Na/K-ATPase enzymatic

2005 Kidney International

1698. EPO and alpha-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney. Full Text available with Trip Pro

urine output, and high fractional excretion of urinary sodium. Consistent with this, immunoblotting and immunocytochemistry revealed that the kidney expression of AQPs (AQP-1, -2 and -3) and sodium transporters [Na,K-ATPase, rat type 1 bumetanide-sensitive Na-K-2Cl cotransporter (BSC-1), Na/H exchanger type 3 (NHE3), and thiazide-sensitive sodium chloride cotransporter (TSC)] in ARF rats was significantly decreased compared to sham-operated control rats. In contrast, EPO treatment at the time (...) EPO and alpha-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney. Ischemia-induced acute renal failure (ARF) is known to be associated with significant impairment of urinary concentrating ability and down-regulation of renal aquaporins (AQPs) and sodium transporters in rats. We tested whether treatment with erythropoietin (EPO) or alpha-melanocyte-stimulating hormone (alpha-MSH) in combination with EPO reduces the renal ischemia/reperfusion (I

2004 Kidney International

1699. A hypothesis linking sodium and lithium reabsorption in the distal nephron. Full Text available with Trip Pro

have shown that under normal circumstances hardly any Li(+) is reabsorbed in the distal nephron, so that the urinary excretion of Li(+), expressed as a fraction of the delivery to the early distal tubule (FE(Li dist)), amounts to approximately 0.97. In contrast, during severe dietary Na(+) restriction, FE(Li dist) decreases to 0.50-0.60. Our hypothesis is that the absence of distal Li(+) reabsorption during intake of a normal diet can be explained by a negative driving force for Li(+) entrance (...) A hypothesis linking sodium and lithium reabsorption in the distal nephron. A hypothesis is proposed linking Na(+) and Li(+) reabsorption in the distal nephron. The handling of these two ions in the distal nephron is related because they share the same apical membrane entry mechanism: the amiloride-sensitive Na(+) channel (ENaC). However, the two ions exit the cell through different transport mechanisms: Na(+) via the Na(+)-K(+)-ATPase and Li(+) via the Na(+)/H(+) exchanger. Studies in rats

2006 Transplantation

1700. Increased systolic blood pressure with rofecoxib in congenital furosemide-like salt loss. Full Text available with Trip Pro

(SDS) values), creatinine clearance (CRC), fractional excretion of sodium (FeNa), and renal excretion of systemic prostaglandins were studied in 28 patients with a genetically proven congenital hypokalaemic salt-losing tubulopathy (SLT) (11 female and 17 male, age: 2-25 years), 19 with a furosemide-like SLT, and nine with a thiazide-like SLT.In furosemide-like SLT patients, systolic SDS bp values were significantly higher with rofecoxib (1.03 +/- 0.16 SDS, n = 107) compared with indomethacin (0.56 (...) +/- 0.09 SDS, n = 282; P = 0.007, 95% CI: 0.12-0.8). Without the drugs, systolic SDS bp values were elevated by 0.63 +/- 0.11 SDS, n = 164. Both drugs reduced renin and aldosterone-plasma levels to a similar extent. SDS values were significantly correlated with the excretion of the vasoconstrictor thromboxane (T x B2) (R2: 0.038, P = 0.021, n: 159), but not with CRC or FeNa. Blood pressure was not increased in thiazide-like SLT patients treated with rofecoxib.Congenital furosemide-like renal salt loss

2006 Transplantation

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>