How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,142 results for

Four Year Prognostic Index

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Ovarian Stimulation for IVF/ICSI

INTRODUCTION 11 LIST OF ALL RECOMMENDATIONS 15 PART A: OVARIAN RESPONSE TESTING 26 1. Pre-stimulation management 26 KEY QUESTION: IS THE ASSESSMENT OF THE PREDICTED RESPONSE TO OVARIAN STIMULATION SUFFICIENTLY RELIABLE? 26 1.1 ANTRAL FOLLICLE COUNT (AFC) 26 1.2 ANTI-MÜLLERIAN HORMONE (AMH) 27 1.3 BASAL FOLLICLE STIMULATING HORMONE (FSH) 28 1.4 INHIBIN B 29 1.5 BASAL OESTRADIOL 30 1.6 AGE 31 1.7 BODY MASS INDEX (BMI) 31 1.8 OVERALL RECOMMENDATION 32 REFERENCES 33 2. Additional hormonal assessment (...) at baseline 35 KEY QUESTION: What is the prognostic value of hormonal assessment at baseline? 35 2.1 Baseline oestradiol 35 2.2 Progesterone 35 References 36 3. Pre-treatment therapies 37 KEY QUESTION: DOES HORMONE PRE-TREATMENT IMPROVE EFFICACY AND SAFETY OF OVARIAN STIMULATION? 37 3.1 OESTROGEN PRE-TREATMENT 37 3.2 PROGESTOGEN PRE-TREATMENT 38 3.3 COMBINED ORAL CONTRACEPTIVE PILL PRE-TREATMENT 38 3.4 GNRH ANTAGONIST PRE-TREATMENT 39 REFERENCES 40 PART B: LH SUPPRESSION AND OVARIAN STIMULATION 42 [4] 4

2019 European Society of Human Reproduction and Embryology

142. Diagnosis and Management of Acute Pulmonary Embolism

Plasminogen Activator for Occluded Coronary Arteries HAS-BLED Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly HERDOO2 Hyperpigmentation, Edema, or Redness in either leg; D-dimer level ≥250 μg/L; Obesity with body mass index ≥30 kg/m 2 ; or Older age, ≥65 years H-FABP Heart-type fatty acid-binding protein HIV Human immunodeficiency virus HR Hazard ratio INR International (...) Integration of aggravating conditions and comorbidity into risk assessment of acute pulmonary embolism 20 5.6 Prognostic assessment strategy 20 6 Treatment in the acute phase 22 6.1 Haemodynamic and respiratory support 22 6.1.1 Oxygen therapy and ventilation 22 6.1.2 Pharmacological treatment of acute right ventricular failure 22 6.1.3 Mechanical circulatory support and oxygenation 23 6.1.4 Advanced life support in cardiac arrest 23 6.2 Initial anticoagulation 23 6.2.1 Parenteral anticoagulation 23 6.2.2

Full Text available with Trip Pro

2019 European Society of Cardiology

143. Management of Dyslipidaemias

for low-density lipoprotein cholesterol 22 Recommendations for pharmacological low-density lipoprotein cholesterol lowering 35 Recommendations for drug treatment of patients with hypertriglyceridaemia 38 Recommendations for the detection and treatment of patients with heterozygous familial hypercholesterolaemia 40 Recommendations for the treatment of dyslipidaemias in older people (aged >65 years) 43 Recommendations for the treatment of dyslipidaemias in diabetes mellitus 45 Recommendations for lipid (...) 2 Risk estimation charts for different countries 14 Box 3 Qualifiers 14 Box 4 Factors modifying Systematic Coronary Risk Estimation risks 14 Box 5 Risk estimation: key messages 15 Box 6 Management of dyslipidaemia in women 42 Box 7 Summary of dyslipidaemia in metabolic syndrome and type 2 diabetes mellitus 44 Box 8 Key messages 55 Box 9 Gaps in the evidence 55 Box 10 Methods for enhancing adherence to lifestyle changes 56 Abbreviations and acronyms ABI Ankle–brachial index ACCELERATE Assessment

Full Text available with Trip Pro

2019 European Society of Cardiology

144. Systemic Adjuvant Therapy for Adult Patients at High Risk for Recurrent Melanoma

238) or a portion of stage IIIA patients (Keynote 054, COMBI-AD). For Stage IIIA diseases, Keynote 054 excluded N1a melanomas with nodal metastasis 1 mm); for this group four- year DFS was 69% versus 62% (HR=0.58; 95% CI=0.32 to 1.06). Overall survival at three years was also better (86% vs. 77%), although not statistically significant due to interim boundaries set in the protocol. ? Vemurafenib is being evaluated in the BRIM8 trial [28], which to date found two-year DFS benefit in stage IIC-IIIB (...) % versus 26.2%. Grade 3 to 4 immune-related AEs were especially prevalent (41.6% vs. 2.7%), with deaths in five patients (1.1% vs. 0%). Discontinuation Guideline 8-1 version 5 Section 2: Guideline Page 9 of treatment due to drug-related AEs occurred in 53% of patients. ? The Checkmate 238 trial [1,11] reported two-year RFS of 62.6% for nivolumab (3 mg/kg) versus 50.2% for ipilimumab (10 mg/kg) (HR=0.66, p 1 mm. Adjuvant HD-IFN-a improved DFS (HR=0.83, 95% CI 0.78 to 0.87, p 50 years of age. Staging

2019 Cancer Care Ontario

145. Adjuvant Systemic Chemotherapy for Stage II and III Colon Cancer Following Complete Resection

of the disease. High-risk stage II disease is associated with an outcome similar to that of patients with stage III disease, with a five-year OS of 40% to 50%. The definition of “high risk” is a subject of considerable debate and research, and remains inadequately captured in current TNM staging (see Appendix 3 for a comparison of staging systems). Possible prognostic factors that may indicate a higher risk of recurrence include T4 stage, perforation at the site of the tumour, inadequately sampled lymph (...) , the anticipated morbidity, the presence of high-risk prognostic features on individual prognosis, and patient preferences. ? The enrolment of resected stage II patients in clinical trials is encouraged. Additional trials comparing adjuvant therapy with observation are needed and are ethically acceptable in stage II colon cancer. Recommendation 2 When treated with adjuvant therapy, high-risk stage II patients should receive a fluoropyrimidine. There are insufficient data in support of oxaliplatin providing

2019 Cancer Care Ontario

146. Complex surgery and perioperative systemic therapy for genitourinary cancer of the retroperitoneum

that were not included in the above systematic review. These are reported in Table 4-3. The PROTECT study by Motzer et al. investigated pazopanib versus placebo. This study did not meet its primary endpoint of DFS in the ITT analysis (HR, 0.86; 95% CI, 0.70 to 1.06; p=0.16). After an additional year of follow-up the updated DFS showed an HR of 0.94 (95% CI, 0.77 to 1.14; p=0.51) [12]. The Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI)-19 showed that both groups had similarly high (...) a prolonged median survival in those with metachronous lung metastases and an interval of at least two years. Metastasectomy may provide a possible survival benefit for a selected group of patients with lung metastases only, a long metachronous disease-free interval, and a response to immunotherapy targeted therapy before resection. No systemic treatment is Guideline 3-20 Section 2: Guideline - August 8, 2019 Page 8 recommended after metastasectomy [6]. Key Evidence for Recommendation 3 We endorse

2019 Cancer Care Ontario

147. Baseline Staging Imaging for Distant Metastasis in Women with Stage I, II, and III Breast Cancer

. Interpretation of Evidence for Recommendation 2 Women with newly diagnosed stage III breast cancer have been clearly shown to be at an increased risk of distant metastasis. Baseline staging with either conventional anatomic or metabolic imaging is a reasonable practice as these modalities could provide additional diagnostic and prognostic information, and would likely change treatment. IMPLEMENTATION CONSIDERATIONS Patient-specific material needs to be developed to educate patients on the choices made (...) Intercollegiate Guidelines Network (SIGN), American Society of Clinical Oncology (ASCO), and National Health and Medical Research Council - Australia. To be considered for endorsement or adaptation, guidelines must have reported a clear systematic review and evidence synthesis methodology, including a search for clinical practice guidelines, systematic reviews, meta-analyses, and/or clinical studies; and be issued within the past three years (2015-2018). Three recently published guidelines were located

2019 Cancer Care Ontario

148. Position Statement – Testing for ovarian cancer in asymptomatic women: Technical Report

) Technical Report – Testing for ovarian cancer in asymptomatic women 14 Screening strategies ? PLCO – single screening group with simultaneous CA125 and transvaginal ultrasonography (TVUS) testing for first four years, then CA125 only for the final two years ? UKCTOCS – two screening groups: o TVUS only o CA125 only unless levels elevated, then TVUS Number of screening rounds ? PLCO – 6 ? UKCTOCS – 7-11 15 Technical Report – Testing for ovarian cancer in asymptomatic women Table 0.1 Characteristics (...) at high risk of ovarian cancer: four prospective cohort studies (UKFOCSS Phase I, UKFOCSS Phase II, CGN/GOG, UK-Netherlands-Norway study), one prospective cohort survey (Fox Chase Cancer Centre study), and a post hoc analysis of a high-risk subgroup from the PLCO population screening RCT (PLCO-HR). As random assignment to a no-surveillance arm is considered unethical in high-risk women, no studies included a no-surveillance comparator group, instead relying on historical controls or before/after

2019 Cancer Australia

149. Management of stable angina

evaluation or investigation. The Revised Cardiac Risk Index (RCRI) is a simple risk-stratification tool that combines patient risk and procedural risk and can aid clinical decision making (see Table 4). 198 In this report of the risk of major cardiac complications with major non-emergency non-cardiac surgery, six factors with approximately equal prognostic importance were identified. 198 Table 4: Revised Cardiac Risk Index Clinical factors • High-risk surgery • History of ischaemic heart disease (IHD (...) equivalents of task (METs). One MET is the oxygen consumption of a 40 year old 70 kg man at rest and is equal to 3.5 ml/min/kg. Patients who are unable to meet a four MET demand during most normal daily activities are at increased risk of perioperative and long-term cardiac events. 207 Different scoring systems are available to measure functional capacity objectively such as the New Y ork Heart Association Score, 208 Karnofsky Performance Scale 209 or the Duke Activity Score which is a self-completed

2018 SIGN

150. Assessment of elevated creatinine

injury: a 10-year study. Nephrol Dial Transplant. 2008 Dec;23(12):3859-66. http://www.ncbi.nlm.nih.gov/pubmed/18632586?tool=bestpractice.com Coca SG, Peixoto AJ, Garg AX, et al. The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis. Am J Kidney Dis. 2007 Nov;50(5):712-20. http://www.ncbi.nlm.nih.gov/pubmed/17954284?tool=bestpractice.com They may also have prognostic significance for estimating the risk of death in many (...) stays and are more often dialysis-dependent at hospital discharge than those without. Ponte B, Felipe C, Muriel A, et al. Long-term functional evolution after an acute kidney injury: a 10-year study. Nephrol Dial Transplant. 2008 Dec;23(12):3859-66. http://www.ncbi.nlm.nih.gov/pubmed/18632586?tool=bestpractice.com Coca SG, Peixoto AJ, Garg AX, et al. The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis. Am J Kidney

2018 BMJ Best Practice

151. Canadian Rheumatology Association recommendations for the assessment and monitoring of systemic lupus erythematosus

the GRADE method for the monitoring of SLE. Existing evidence is largely of low to moderate quality, resulting in more conditional than strong recommendations. Additional rigorous studies and special attention to pediatric SLE popula- tions and patient preferences are needed. (J Rheumatol First Release September 1 2018; doi:10.3899/ jrheum.171459) Key Indexing Terms: SYSTEMIC LUPUS ERYTHEMATOSUS GRADE RECOMMENDATIONS MONITORING ASSESSMENT COMORBIDITIES From the Division of Rheumatology, Department (...) were involved in the development of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the SLEDAI-2K, but do not receive payments from the use of these indices. S.O. Keeling, MD, MSc, FRCP(C), Division of Rheumatology, Department of Medicine, University of Alberta; Z. Alabdurubalnabi, MBBS, ABIM, FRCPC, Division of Rheumatology, Department of Medicine, University of British Columbia; A. Avina-Zubieta, MD, MSc, PhD, FRCPC, Division of Rheumatology, Department of Medicine

2018 CPG Infobase

152. Assessment of elevated creatinine

injury: a 10-year study. Nephrol Dial Transplant. 2008 Dec;23(12):3859-66. http://www.ncbi.nlm.nih.gov/pubmed/18632586?tool=bestpractice.com Coca SG, Peixoto AJ, Garg AX, et al. The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis. Am J Kidney Dis. 2007 Nov;50(5):712-20. http://www.ncbi.nlm.nih.gov/pubmed/17954284?tool=bestpractice.com They may also have prognostic significance for estimating the risk of death in many (...) stays and are more often dialysis-dependent at hospital discharge than those without. Ponte B, Felipe C, Muriel A, et al. Long-term functional evolution after an acute kidney injury: a 10-year study. Nephrol Dial Transplant. 2008 Dec;23(12):3859-66. http://www.ncbi.nlm.nih.gov/pubmed/18632586?tool=bestpractice.com Coca SG, Peixoto AJ, Garg AX, et al. The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis. Am J Kidney

2018 BMJ Best Practice

153. Cardiac arrhythmias in coronary heart disease

in Scotland and is responsible for 12% of all deaths, 2 or around 6,700 deaths each year. 1 Age-standardised death rates for CHD in Scotland are consistently among the highest seen across the UK. Coronary heart disease is associated with many cardiac arrhythmias, with wide-ranging clinical consequences. Arrhythmias are common during acute coronary syndrome (ACS), with ventricular tachyarrhythmias being an important cause of cardiac arrest and sudden cardiac deaths (SCD) in this context. Patients (...) eplerenone unless contraindicated by the presence of renal impairment (chronic kidney disease stage =4–5) and/or elevated serum potassium concentration (K + >5.0 mmol/l). 1 ++ 4 1 + 1 + 1 + Cardiac arrhythmias in coronary heart disease| 15 4.3.3 ASSESSMENT OF RISK OF SUDDEN DEATH Following ACS, sudden death is a continuing cause of mortality (7–10% at two years; up to 50% of total mortality), with the greatest risk being in the first 30 days (1.4% per month), declining during follow up (0.14% per month

2018 SIGN

155. Quality indicators for the management of head and neck squamous cell carcinoma

, by Adapted Charlson Comorbidity Index and number of inpatient bed days during the previous year (2009-2014) 272 Figure 36 – Observed survival by main treatment volume over six years in patients with HNSCC (2009- 2014) 290 Figure 37 – Distribution of HNSCC patients by main treatment centre, by anatomic site (2009-2014) 291 8 Quality indicators for the management of HNSCC KCE Report 305 LIST OF TABLES Table 1 – Summary of dispersion of head and neck cancer care in Flanders (2004-2007) 23 Table 2 – Final (...) status SIGN Scottish Intercollegiate Guidelines Network TNM Tumour – Node – Metastasis UK United Kingdom US(A) United States (of America) UZ – CHU University hospital (‘Universitair ziekenhuis’/‘Centre hospitalier universitair’) WHO World Health Organization WUHNCI Washington University Head and Neck Comorbidity Index X Missing stage 22 Quality indicators for the management of HNSCC KCE Report 305 ? SCIENTIFIC REPORT 1 INTRODUCTION Since several years, the Belgian Health Care Knowledge Centre (KCE

2019 Belgian Health Care Knowledge Centre

156. Diagnosis and management of epilepsy in adults

, EEG recording is not necessary for an informed decision to be made. The higher risks of seizure recurrence with a history of myoclonus reflect the high risk of seizure recurrence following AED withdrawal in juvenile myoclonic epilepsy. The prognostic index has not been validated on an external population, and should be used with caution. No information is available on the risks of seizure recurrence following drug withdrawal in adults who have been seizure free for less than two years, although (...) prolonged AED treatment. The Driver and Vehicle Licensing Agency recommendations should be followed. 154 A Prognostic index indicators can be used to give an estimate of the risks of seizure recurrence following antiepileptic drug withdrawal. ? The question of continued treatment or antiepileptic drug withdrawal should be discussed with people with epilepsy who are at least two years seizure free, so that they can make an informed choice. Factors to be discussed should include driving, employment, fear

2018 SIGN

157. Optimisation of RIZIV – INAMI lump sums for incontinence

in the general population suffer with UI. Daily UI estimated prevalence is 5% to 15%, rising over 15% for women above 70 years who are in residential care. The UI prevalence in men (11-34%) is less than half as common compared to women but prevalence increases more steadily with age. Among young and middle-aged women, only age, body mass index, parity and mode of delivery are unambiguously associated with incontinence, and for all of these, the association with stress UI is greater than with urgency UI (UUI (...) and age at admission for faecal and urinary incontinence (2014) 107 Figure 26 – Distribution of sex and age at admission for faecal and urinary incontinence (2014): patients aged 0 – 20 years 107 Figure 27 – Evolution of number of patients benefiting from a small or large incontinence lump sum, or from reimbursements for self-catheterisation material or incontinence material covered by article 27 (extrapolated from EPS 2008 – 2015) 113 Figure 28 – Age distribution of patients receiving an incontinence

2019 Belgian Health Care Knowledge Centre

158. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

2010, says that in children and adolescents, bariatric surgery can only be done in the setting of a clinical trial. KCE Report 316 Bariatric Surgery 33 Table 2 – Indications for bariatric surgery in young ( 2 or 5 or 35 kg/m²) individuals, however the publication does not specify the time-peirod after surgery where these data refer to. 87 Longer-term follow-up data beyond the formal protocol of the original RCTs have been published: four of them reported 5-year data 13, 74, 75, 77 and 1 published (...) years was reported. The study group of the SOS trial applied matching of patients on the basis of 18 prognostic factors, used rigorous methods in maintaining patients’ follow-up, and reported adjusted estimates after controlling for important factors. Nevertheless, the risk of bias cannot be 48 Bariatric Surgery KCE Report 316 completely excluded since the ‘allocation’ of patients was based on patient desire to opt either for surgery or for conventional medical management. The surgically treated

2019 Belgian Health Care Knowledge Centre

159. Home mechanical ventilation for patients with Amyotrophic Lateral Sclerosis: A CTS Clinical Practice Guideline

usually occurs as a result of progressive respiratory muscle involvement, with 50% of patients dying within three years of symptom onset. Mechanical ventilation is becoming increasingly accepted in ALS. In Canada, noninvasive ventilation is the most common form of ven- tilation applied, with tracheostomy ventilation being very uncommon. The current guideline addresses respiratory muscle testing, the benefits of mechanical ventilation in ALS, timing of initi- ation of ventilation and modes, settings (...) , approximately 3% of ALS cases in referral centres, the first presentation is with respiratory symptoms secondary to early respiratory muscle involvement. 2,3 Regardless of site of first onset, death usually occurs as a result of progressive respira- tory muscle involvement, with 50% of patients dying within three years of symptom onset. 4 Patients with bulbar onset ALS generally have a shorter survival than those with limb onset. 5 The rapid progression to death separates ALS from most other neuromuscular

2019 Canadian Thoracic Society

160. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU

of the urinary tract (e.g., stone disease, diverticulum, neurogenic bladder) Immunocompromised host Multi–drug resistant bacteria Recurrent urinary tract infection Two separate culture-proven episodes of acute bacterial cystitis and associated symptoms within six months or three episodes within one year Asymptomatic bacteriuria Presence of bacteria in the urine that causes no illness or symptoms The index patient for this guideline is an otherwise healthy adult female with an uncomplicated recurrent urinary (...) urine cultures associated with prior symptomatic episodes. (Clinical Principle) 3. Clinicians should obtain repeat urine studies when an initial urine specimen is suspect for contamination, with consideration for obtaining a catheterized specimen. (Clinical Principle) 4. Cystoscopy and upper tract imaging should not be routinely obtained in the index patient presenting with a rUTI. (Expert Opinion) 5. Clinicians should obtain urinalysis, urine culture and sensitivity with each symptomatic acute

2019 Canadian Urological Association

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>