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Four Year Prognostic Index

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121. Prognostic Values of Multichannel Intraluminal Impedance and pH Monitoring in Newborns with Symptoms of Gastroesophageal Reflux Disease. (PubMed)

Prognostic Values of Multichannel Intraluminal Impedance and pH Monitoring in Newborns with Symptoms of Gastroesophageal Reflux Disease. To evaluate the relationship between multichannel intraluminal impedance and pH monitoring (MII/pH) values in newborns with symptoms of gastroesophageal reflux disease (GERD) and clinical history in their first 3 years of life.Sixty-four newborns with GERD symptoms who underwent MII/pH in the first weeks of life were enrolled into a clinical follow-up program (...) . Follow-up visits were programmed at 1, 3, 6, 9, 12, 18, 24, and 36 months. Patients were divided into 3 groups according to duration of symptoms: short (1-3 months), medium (4-9 months), and long (>9 months), and MII/pH values in these groups were compared.Fifty-three patients completed the 3-year follow-up. The number of patients with GERD symptoms decreased each month. A comparison of MII/pH values of the 3 lifetime symptom groups revealed differences in the impedance bolus exposure index (F = 83

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2012 Journal of Pediatrics

122. Prognostic model for total mortality in patients with haemodialysis from the Assessments of Survival and Cardiovascular Events (AURORA) study. (PubMed)

factors (age, albumin, C-reactive protein, history of cardiovascular disease and diabetes) were selected from experience and forced into the regression equation. In a 67% random try-out sample of patients, no further factors amongst 24 candidates added significance (P < 0.01) to mortality outcome as assessed by Cox regression modelling, and individual probabilities of death were estimated in the try-out and test samples. Calibration was explored by calculating the prognostic index with regression (...) coefficients from the try-out sample to patients in the 33% test sample. Discrimination was assessed by receiver operating characteristic (ROC) areas.The strongest prognostic factor in the try-out sample was age, with small differences between the other four factors. Calibration in the test sample was good when the calculated number of deaths was multiplied by a constant of 1.33. The five-factor model discriminated reasonably well between deceased and surviving patients in both the try-out and test samples

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2012 Journal of internal medicine

123. The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low

The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring (...) in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low Risk Myelodysplastic Syndrome (MDS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01566695 Recruitment Status : Active, not recruiting First Posted : March 29

2012 Clinical Trials

124. Prognostic implication of Doppler echocardiographic derived coronary flow reserve in patients with left bundle branch block. (PubMed)

= 0.01), ischaemia at stress echo (HR: 2.30, 95% CI: 1.11-4.77, P = 0.02), and resting wall motion score index (HR: 2.17, 95% CI: 1.11-4.25, P = 0.02) were independently correlated with death or MI. Four-year mortality and 4-year hard event rate were markedly higher in patients with CFR ≤ 2 than in those with CFR >2 (49 vs. 6% and 56 vs. 8%, respectively; P < 0.0001 for both). A CFR of ≤ 2 was associated with a significantly higher annual hard event rate independently of age, sex, ejection fraction (...) , history of coronary artery disease, diabetes, and hypertension. Moreover, it was correlated with an increased (P < 0.0001) yearly mortality and event rate in patients with non-ischaemic stress echo conducted on therapy. At incremental analysis, a CFR of ≤ 2 added prognostic value to clinical findings, resting wall motion score index, ongoing anti-ischaemic therapy, and ischaemia at stress echo when both death and death or MI were the clinical endpoints.Abnormal CFR on LAD is a strong and independent

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2012 European Heart Journal

125. Comparison of four prognostic scores in peripheral T-cell lymphoma. (PubMed)

Comparison of four prognostic scores in peripheral T-cell lymphoma. To compare the usefulness of four prognostic scores in patients with peripheral T-cell lymphoma (PTCL) from a single institution.One hundred twenty-one patients (77 male/36 female, median age 53 years) with PTCL [anaplastic large-cell lymphoma (ALCL) 21, PTCL not otherwise specified 56 and other 44)]. Complete response (CR) rate and 5-year overall survival (OS) were 41% and 31%, respectively. International Prognostic Index (IPI (...) ), Prognostic Index for T-cell lymphoma (PIT), International peripheral T-cell lymphoma Project score (IPTCLP) and modified Prognostic Index for T-cell lymphoma (mPIT) were calculated as in the original references. mPIT was only assembled to 41 patients in whom Ki-67 immunostaining was available. ALCL patients were analyzed separately.Concordance among IPI, PIT and IPTCLP was 52% for low-risk group, 27% for low/intermediate-risk group, 20% for high/intermediate-risk group and 14% for high-risk group. IPI

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2010 Annals of Oncology

126. Usefulness of Ki67 Index in Hormone Receptor-positive Breast Cancer

cancers but is variable within ER-positive cancer, the greatest practical prognostic value of proliferative index seems to be within ER-positive disease. Decisions regarding the use of adjuvant therapy in early operable breast cancer depend on an array of factors that predict prognosis and therapeutic efficacy. Multigene signatures related to cell proliferation show consistent accuracy in the clinical characterization of hormone receptor (HR)-positive BC, hence interest in biologic factors (...) Usefulness of Ki67 Index in Hormone Receptor-positive Breast Cancer Usefulness of Ki67 Index in Hormone Receptor-positive Breast Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Usefulness of Ki67

2011 Clinical Trials

127. Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women. (PubMed)

Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women. We aimed to evaluate the role of body mass index (BMI) as a risk and prognostic factor of endometrioid uterine cancer in Korean women.The records of 937 patients with endometrioid uterine cancer treated between 2000 and 2006 in Korea were reviewed. To determine the disease risk by BMI, four age-matched controls were recruited from healthy women (1-year age group).The obese (BMI > or =25 kg/m

2010 Gynecologic Oncology

128. Prognostic Stratification of Elderly Patients in the Emergency Department: A Comparison Between the "Identification of Seniors at Risk" and the "Silver Code" (PubMed)

period were enrolled. Outcomes were need for hospital admission and mortality at the index ED access, ED return visit, hospitalization, and death at 6 months.Of 1,632 participants (mean age 84 ± 5.5 years), 75% were ISAR positive, and the sample was homogeneously distributed across the four SC risk categories (cutoffs of 0-3, 4-6, 7-10, and 11+). The two scores were mildly correlated (r = .350, p < .001) and had a similar area under the receiver-operating characteristic curve in predicting hospital (...) Prognostic Stratification of Elderly Patients in the Emergency Department: A Comparison Between the "Identification of Seniors at Risk" and the "Silver Code" The increasing number of elderly patients accessing emergency departments (EDs) requires use of validated assessment tools. We compared the Identification of Seniors at Risk (ISAR), using direct patient evaluation, with the Silver Code (SC), based on administrative data.Subjects aged 75+ years accessing a geriatric ED over an 8-month

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2011 Biological Sciences and Medical Sciences

129. Clinical value of prognostic instruments to identify patients with an increased risk for osteoporotic fractures: systematic review. (PubMed)

35 studies enrolling a total of 609,969 patients (median 2546) reporting on 31 derivations and 12 validations after assessing full texts. Median follow-up time was 4.1 years (IQR 3 to 7.7). Only four studies validated an instrument that was developed by another group. None of the existing instruments was validated more than once. The five most frequent included variables in the final model were age, body mass index, bone mass index, past history of falls, and maternal history of fractures (...) Clinical value of prognostic instruments to identify patients with an increased risk for osteoporotic fractures: systematic review. With the broad availability of effective medications, identifying individuals bearing a higher risk for osteoporotic fractures has become an issue of major concern in modern medicine. In recent years various prognostic instruments have become available showing conflicting results regarding estimated risks for individual patients.To provide an overview of current

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2011 PloS one

130. Prognostic Significance of Lymph Node Metastases in Patients with High-Grade Appendiceal Cancer. (PubMed)

database was conducted. Using Kaplan-Meier survival curves and Cox proportional hazards ratio analysis, the effect of LN status, completeness of cytoreduction (CC), and peritoneal cancer index (PCI) was studied.Of 134 patients with appendiceal cancer who underwent CRS/HIPEC, 77 (57%) had PMCA. Mean follow-up was 22 (range, 3-90) months. Overall survival (OS) was 88, 56, and 40% for 1, 3, and 5-year, respectively. Thirty-four patients (44%) had LN metastases, 23 of whom (68%) had CC, whereas in LN (...) Prognostic Significance of Lymph Node Metastases in Patients with High-Grade Appendiceal Cancer. In treating high-grade appendiceal cancer, appropriate patient selection for cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) is essential. The effect of lymph node (LN) status on survival is not clear. We hypothesize that LN metastases negatively affect long-term survival.Retrospective analysis of peritoneal mucinous carcinomatosis (PMCA) patients from a prospective

2011 Annals of Surgical Oncology

131. Specific IgE toward Allergenic Molecules Is a New Prognostic Marker in Patients with Sézary Syndrome. (PubMed)

times, 2.9 versus 8.9 years (p < 0.001). Conversely, no survival difference could be observed when total IgE levels were considered. IgE+ patients had higher levels of CD60+CD49-CD4+ T cells, which also represent another worse prognostic index recently identified.SS patients had specific IgE to both environmental and food allergens. IgE+ SS patients had a significant lower survival rate. High levels of CD60-CD49+CD4+ T cells associated with an IgE- phenotype allow the identification of a restricted (...) Specific IgE toward Allergenic Molecules Is a New Prognostic Marker in Patients with Sézary Syndrome. Sézary syndrome (SS) is the aggressive leukemic form of cutaneous T cell lymphoma characterized by erythroderma, the presence of a malignant circulating T memory cells with skin homing potential, and the ability to produce a variety of Th2 soluble factors, such as IL-4 and IL-5. We measured total and specific IgE in SS patients as a further parameter of a Th2-skewed immune system, and studied

2011 International Archives of Allergy and Immunology

132. Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial. (PubMed)

important.Breast International Group 1-98 trial randomized 6182 women among four groups comparing letrozole and tamoxifen with sequences of each agent; 5177 (84%) had centrally confirmed estrogen receptor (ER) positivity. We assessed whether centrally determined ER, progesterone receptor (PgR), human epidermal growth factor receptor 2, and Ki-67 labeling index, alone or in combination with other prognostic features, predicted the magnitude of letrozole effectiveness compared with either sequence or tamoxifen (...) monotherapy.Individually, none of the markers significantly predicted differential treatment effects. Subpopulation treatment effect pattern plot analysis of a composite measure of prognostic risk revealed three patterns. Estimated 5-year disease-free survival for letrozole monotherapy, letrozole→tamoxifen, tamoxifen→letrozole, and tamoxifen monotherapy were 96%, 94%, 93%, and 94%, respectively, for patients at lowest risk; 90%, 91%, 93%, and 86%, respectively, for patients at intermediate risk; and 80%, 76%, 74

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2011 Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Controlled trial quality: uncertain

133. Arthroscopic Treatment of Osteochondral Defects of the Talus: Outcomes at Eight to Twenty Years of Follow-up. (PubMed)

Arthroscopic Treatment of Osteochondral Defects of the Talus: Outcomes at Eight to Twenty Years of Follow-up. The primary aim of this study was to assess the long-term clinical and radiographic outcomes of arthroscopic debridement and bone marrow stimulation for talar osteochondral defects. The secondary aim was to identify prognostic factors that affect the long-term results.Fifty (88%) of fifty-seven eligible patients with a primary osteochondral defect treated with arthroscopic debridement (...) with population norms and two were superior in the study group. Ninety-four percent of patients had resumed work and 88% had resumed sports. The radiographs indicated an osteoarthritis grade of 0 in 33% of the patients, I in 63%, II in 4%, and III in 0%. Compared with the preoperative osteoarthritis classification, 67% of radiographs showed no progression and 33% showed progression by one grade. None of the prognostic factors was significantly associated with the Ogilvie-Harris score or progression

2013 The Journal of Bone and Joint Surgery. American Volume

134. Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement (PubMed)

aortic valve replacement (SAVR) in patients with pre-procedural chronic kidney disease (CKD).A total of 213 patients (mean age 82 +/- 8 years) undergoing TAVI for the treatment of severe aortic stenosis were included in the study. Acute kidney injury was defined as a reduction of >25% in estimated glomerular filtration rate (eGFR) within 48 h following the procedure or the need for haemodialysis during index hospitalization. Those patients with pre-procedural CKD (eGFR <60 mL/min/1.73 m(2), n = 119 (...) Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement Very few data exist on the occurrence of acute kidney injury (AKI) associated with transcatheter aortic valve implantation (TAVI). The objectives of the present study were (i) to determine the incidence, predictive factors, and prognostic value of AKI following TAVI, and (ii) to compare the occurrence of AKI in TAVI vs. surgical

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2010 EvidenceUpdates

135. Benefit assessment of biotechnologically produced drugs for the treatment of rheumatoid arthritis

less than half a year. Based on available information on disease-specific characteristics (e.g. DAS 28, existing erosions and immunological as well as prognostic factors), severe rheumatoid arthritis could be assumed for the population of all studies at baseline. The populations of 4 studies showed on average a slightly less severe disease compared with the other studies in Study Pool 1.1. For a further study, there was little information to estimate the severity of the disease. Explicit (...) of the disease was usually between 6 and 12 years. Only in 2 studies was it markedly shorter with Extract of final report A16-70 Version 1.0 Biologics for rheumatoid arthritis 23 July 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - 29 - about 2 years. On the basis of the available information on disease-specific characteristics (e.g. DAS 28, existing erosions and immunological as well as prognostic factors), severe rheumatoid arthritis with an unfavourable prognosis could be assumed

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

136. Traumatic Brain Injury and Dementia

and Development (ORD) for an evidence brief on dementia prevalence in Veterans with and without traumatic brain injury (TBI). Findings from this evidence brief will be used to inform research into early diagnosis and potential treatment of dementia in Veterans with TBI. BACKGROUND Traumatic brain injury (TBI) is a common condition among both civilian and military populations. In the United States and Canada, over four million people (1.3% of the population) experience a TBI every year. 1 In general, military (...) guidelines and performance measures; and · Set the direction for future research to address gaps in clinical knowledge. The program is comprised of four ESP Centers across the US and a Coordinating Center located in Portland, Oregon. Center Directors are VA clinicians and recognized leaders in the field of evidence synthesis with close ties to the AHRQ Evidence-based Practice Center Program and Cochrane Collaboration. The Coordinating Center was created to manage program operations, ensure methodological

2019 Veterans Affairs Evidence-based Synthesis Program Reports

137. Preoperative or Postoperative Therapy for the Management of Patients with Stage II or III Rectal Cancer

. Subgroup analyses showed a significant local control benefit for preoperative RT in these patients. This is consistent with the local control benefit for all resectable rectal cancer patients reported in a Cochrane review (8) (hazard ratio [HR], 0.71; 95% confidence interval [CI], 0.64-0.78; number needed to treat [NNT], 22; 95% CI, 17-29, assuming a control group local recurrence rate of 17% at five years). ? Two trials (9,10) comparing preoperative CRT with standard fractionation longer course RT (...) , Controlled Trial (GRECCAR-6). J Clin Oncol. 2016 Nov 1;34(31):3773-3780. 4. Lefevre JH, Mineur L, Cachanado M, Rullier E, Rouanet P, De Chaisemartin C, The French Research Group of Rectal Cancer Surgery (GRECCAR). Does a longer waiting period after neoadjuvant radiochemotherapy improve the oncological prognosis of rectal cancer? Three-year follow-up results of the GRECCAR-6 randomized multicenter trial. ASCO 2019 Jan. Meeting Abstract. 5. Hong YS, Kim SY, Lee JS, Nam BH, Kim JE, Kim KP, et al. Long-term

2019 Cancer Care Ontario

138. Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

in the United States, repre- senting 1.8% of all new cancer cases. The estimated number of deaths as a result of multiple myeloma in 2018 was 12,770, representing 2.1% of all cancer deaths. Despite signi?cant advances and improve- ments in overall survival (OS), multiple myeloma re- mains incurable, and additional treatments are needed. The median survival is just over 5 years, and most pa- tients receive four or more different lines of therapy throughout their diseasecourse.In 2015, therewerean (...) are transplantation eligible and those who are ineligible and for patients with relapsed or refractory disease. Additional information is available at www.asco.org/hematologic-malignancies-guidelines. J Clin Oncol 37. © 2019 by American Society of Clinical Oncology INTRODUCTION The purpose of this guideline is to provide evidence- based recommendations for the treatment of newly diagnosed and relapsed multiple myeloma. The treatment of multiple myeloma has changed signi?- cantly in the last 5 years. Since 2015

2019 Cancer Care Ontario

139. Guidelines on Chronic Coronary Syndromes

and antithrombotic therapy 31 3.3.2.6 Non-cardiac surgery and antithrombotic therapy 32 3.3.3 Statins and other lipid-lowering drugs 34 3.3.4 Renin−angiotensin−aldosterone system blockers 34 3.3.5 Hormone replacement therapy 35 3.4 Revascularization 35 4. Patients with new onset of heart failure or reduced left ventricular function 36 5. Patients with a long-standing diagnosis of chronic coronary syndromes 38 5.1 Patients with stabilized symptoms <1 year after an acute coronary syndrome or patients with recent (...) revascularization 38 5.2 Patients >1 year after initial diagnosis or revascularization 38 6. Angina without obstructive disease in the epicardial coronary arteries 40 6.1 Microvascular angina 41 6.1.1 Risk stratification 41 6.1.2 Diagnosis 41 6.1.3 Treatment 41 6.2 Vasospastic angina 42 6.2.1 Diagnosis 42 6.2.2 Treatment 42 7. Screening for coronary artery disease in asymptomatic subjects 43 8. Chronic coronary syndromes in specific circumstances 44 8.1 Cardiovascular comorbidities 44 8.1.1 Hypertension 44

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2019 European Society of Cardiology

140. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD

therapies 32 7.1.3.1 Beta-blockers 32 7.1.3.2 Blockers of the renin–angiotensin–aldosterone system 32 7.1.3.3 Lipid-lowering drugs 32 7.1.3.4 Nitrates and calcium channel blockers 32 7.1.3.5 Other anti- ischaemic drugs 32 7.1.3.6 Antiplatelet and antithrombotic drugs (see section 6.5) 33 7.2 Revascularization 34 7.2.1 Percutaneous coronary intervention vs. coronary artery bypass graft surgery 34 7.2.2 Adjunctive pharmacotherapy 35 8 Heart failure and diabetes 36 8.1 Prognostic implications of diabetes (...) plasma glucose ABI Ankle–brachial index ABPM Ambulatory blood pressure monitoring ACCORD Action to Control Cardiovascular Risk in Diabetes ACE Acarbose Cardiovascular Evaluation ACEI Angiotensin-converting enzyme inhibitor ACS Acute coronary syndrome ADA American Diabetes Association ADVANCE Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation ADDITION Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care ADOPT

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2019 European Society of Cardiology

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