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Four Year Prognostic Index

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121. Nail involvement as a negative prognostic factor in biological therapy for psoriasis: a retrospective study. (Abstract)

Psoriasis Area Severity Index (PASI) 75 in patients with and without NP treated with biological therapy. The second end point was to evaluate the efficacy of biological therapy to improve NP.A total of 127 patients (88 men and 39 women) with moderate to severe Pso referring to our Service between 2007 and 2014 were included. Inclusion criteria were age ≥18 years and a 24 week treatment. The outcome variable was achievement of PASI 75 at 24 weeks with and without NP. All patients were treated (...) with topical therapy and one of four different biological treatments: adalimumab (44.09%), etanercept (18.11%), infliximab (13.39%) and ustekinumab (24.41%). Physical examinations were performed every 4 weeks, and at each visit, the clinician assessed the PASI and Nail Psoriasis Severity Index (NAPSI).At multivariate Cox regression analysis, a smaller proportion of patients with NP achieved PASI 75 at 24 weeks than patients without NP when adjusted for the epidemiological, clinical features and biological

2016 Journal of the European Academy of Dermatology and Venereology

122. Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome. (Abstract)

. These factors were incorporated together to develop a prognostic nomogram. Concordance index calculation (0.727, 95% CI 0.601-0.853, P=0.018) and calibration curve plotting demonstrated its significant predictive and discriminatory capacity in the validation cohort. This nomogram could be a useful and convenient tool in clinical practice to evaluate individualized prognosis in patients with newly diagnosed POEMS syndrome. (...) Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome. POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) is a multisystem disorder with a good long-term prognosis. In its dozens of clinical features, those with independent prognostic value are still not well characterized. We retrospectively included 362 patients with newly diagnosed POEMS syndrome at our institute from 2000 to 2015. On the basis of a randomized

2016 Leukemia

123. Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure. (Full text)

in HF.Observational, prospective study enrolling patients with HF and reduced systolic function. Patients underwent nocturnal cardiorespiratory monitoring to assess SDB presence by apnoea/hypopnoea index (AHI), and 123I-MIBG imaging to calculate heart-to-mediastinum (H/M) ratios and washout rate. Patients were prospectively followed for 29±18 months for the combined endpoint of cardiovascular death and HF hospitalisation.Ninety-four patients (66.1±9.8 years; left ventricular ejection fraction 32±7%) were enrolled (...) Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure. Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by 123I-metaiodobenzylguanidine (123I-MIBG) imaging and prognosis

2016 Heart PubMed abstract

124. Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery (Full text)

data: The clinical data came from a selection of known, relevant studies, including two main sources. The risk of events while on the waiting list was from a large prospective database; the Swedish Coronary Angiography and Angioplasty Registry, which included 9,935 patients with stable angina, who were followed-up for 3.8 years after their CABG. The prognostic effect of biomarkers, which was the key clinical input, was estimated by undertaking a systematic review of the literature in the MEDLINE (...) ; Prognosis; Quality-Adjusted Life Years; Risk Assessment /economics; Stroke /etiology; Triage /economics; Waiting Lists AccessionNumber 22010000145 Date bibliographic record published 24/02/2010 Date abstract record published 24/03/2010 NHS Economic Evaluation Database (NHS EED) Produced by the Centre for Reviews and Dissemination Copyright © 2019 University of York Homepage Options Print PubMed record Original research Share Message for NHS EED database users

2010 NHS Economic Evaluation Database. PubMed abstract

125. A Systematic Review of the Prognostic Role of Hematologic Scoring Systems in Patients With Renal Cell Carcinoma Undergoing Nephrectomy With Curative Intent. (Abstract)

prognosis associated with a lower GPS on multivariate analysis: 1-year recurrence-free survival hazard ratio (HR), 7.0 (P = .001); CSS HR, 6.7 to 8.6 (P < .001); and OS HR 4.2 (P < .001). Four articles were included for NLR. All articles demonstrated elevated NLR to be associated with a poorer prognosis. Two articles demonstrated elevated NLR to be associated with a lower progression-free survival. One article demonstrated elevated NLR to be associated with a lower CSS (HR, 1.02, P = .009), and 2 (...) A Systematic Review of the Prognostic Role of Hematologic Scoring Systems in Patients With Renal Cell Carcinoma Undergoing Nephrectomy With Curative Intent. The objective is to evaluate the prognostic benefit of the Glasgow Prognostic Score (GPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and Prognostic Nutrition Index (PNI) in patients with localized renal cell carcinoma undergoing nephrectomy with curative intent. Embase and MEDLINE databases were searched for all

2016 Clinical genitourinary cancer

126. Real-PD Trial: Development of Clinical Prognostic Models for Parkinson's Disease

Real-PD Trial: Development of Clinical Prognostic Models for Parkinson's Disease Real-PD Trial: Development of Clinical Prognostic Models for Parkinson's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Real-PD Trial: Development of Clinical Prognostic Models for Parkinson's Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02474329 Recruitment Status : Completed First Posted : June 17, 2015 Last Update Posted : October 12, 2017 Sponsor: Radboud University Collaborators: Michael J. Fox

2015 Clinical Trials

127. Prognostic impact of global left ventricular hemodynamic afterload in severe aortic stenosis with preserved ejection fraction. (Abstract)

survival of high Zva, purposely measured by cardiac catheterization.676 patients with preserved LVEF and severe AS without other valvular heart diseases underwent cardiac catheterization. Zva was derived from catheterization and calculated as follows: mean aortic gradient+systolic blood pressure/indexed LV stroke volume. Zva was considered high when >5mmHg/mL/m(2) based on previous studies. Overall, high Zva was found in 42% of all AS patients. Four-year survival and 8-year survival were significantly (...) Prognostic impact of global left ventricular hemodynamic afterload in severe aortic stenosis with preserved ejection fraction. Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement. We aimed to determine the prevalence and impact on long-term

2015 International journal of cardiology

128. Proposed prognostic scoring system evaluating risk factors for biochemical recurrence of prostate cancer after salvage radiation therapy. (Abstract)

] 2.09, P < 0.001; overall P < 0.001), Gleason score (RR [7 vs <7] 1.63, P < 0.001; RR [8-10 vs <7] 2.28, P < 0.001; overall P < 0.001), and surgical margin status (RR [positive vs negative] 0.71, P = 0.003). We combined these four variables to create a prognostic scoring system that predicted BCR risk with a c-index of 0.66. Scores ranged from 0 to 7, and 5-year freedom from BCR for different levels of the score was as follows: Score = 0-1: 66%, Score = 2: 46%, Score = 3: 28%, Score = 4: 19 (...) Proposed prognostic scoring system evaluating risk factors for biochemical recurrence of prostate cancer after salvage radiation therapy. To update a previously proposed prognostic scoring system that predicts risk of biochemical recurrence (BCR) after salvage radiation therapy (SRT) for recurrent prostate cancer when using additional patients and a PSA value of 0.2 ng/mL and rising as the definition of BCR.We included 577 patients who received SRT for a rising PSA after radical prostatectomy

2015 BJU international

129. Evaluation of inflammation-based prognostic scores in patients undergoing hepatobiliary resection for perihilar cholangiocarcinoma. (Abstract)

(mGPS), neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and prognostic nutritional index) were retrospectively evaluated in 534 patients who underwent resection for perihilar cholangiocarcinoma. Blood samples obtained 1-3 days before surgery after jaundice had fully resolved with biliary drainage and after cholangitis had subsided were used to obtain the scores.Of the four scores evaluated, the mGPS showed prognostic value, whereas the remaining three scores did not. Patients with an mGPS (...) Evaluation of inflammation-based prognostic scores in patients undergoing hepatobiliary resection for perihilar cholangiocarcinoma. Inflammation-based prognostic scores have prognostic value in several kinds of cancer. However, little is known about their value in perihilar cholangiocarcinoma. We evaluated whether inflammation-based prognostic scores are associated with survival of patients with perihilar cholangiocarcinoma.Inflammation-based scores (i.e., the modified Glasgow Prognostic Score

2015 Journal of gastroenterology

130. Four layer bandage compared with short stretch bandage for venous leg ulcers: systematic review and meta-analysis of randomised controlled trials with data from individual patients

controlled trials with data from individual patients O'Meara S, Tierney J, Cullum N, Bland J M, Franks P J, Mole T, Scriven M CRD summary The authors of this review of individual patient data concluded that the four layer bandage increases the chance of healing by approximately 30%, when independent prognostic characteristics are taken into account, and benefits are consistent across different prognostic profiles. This was a well-conducted and reported review and the conclusions are likely to be reliable (...) of eligible trials were scanned, and collaborating trialists were consulted to provide details of any further studies. Study selection Randomised controlled trials (RCTs) comparing the four layer bandage with the short stretch bandage for treating participants with venous leg ulcers (defined as ankle brachial pressure index (ABPI) ≥0.8 plus clinical history) were eligible for inclusion in the review. The primary outcome of interest was time to healing (days). Secondary outcomes included: time to ulcer

2009 DARE.

131. Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index

or other life threatening disease with prognosis <5 years; chronic use of systemic corticosteroids, anti-coagulants, anti-inflammatory, or lipid lowering and anti-diabetics drugs; treatment within the previous 6 weeks with any medication that is known to affect lipoprotein levels or fecal microbiota (specifically, antibiotics); food intolerances; alcohol intake >5 drinks per day or use of narcotic substances; use of antioxidant vitamin or mineral supplements; special diet; pregnancy; smoking. Contacts (...) Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration

2014 Clinical Trials

132. Assessment of the Decision-making Impact of the Breast Cancer Index in Recommending Extended Adjuvant Endocrine Therapy for Patients With Early Stage ER-positive Breast Cancer

of the Breast Cancer Index in Recommending Extended Adjuvant Endocrine Therapy for Patients With Early Stage ER-positive Breast Cancer Study Start Date : January 2014 Actual Primary Completion Date : June 2015 Actual Study Completion Date : June 2015 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment BCI Assay Results The Breast Cancer Index (BCI) is a novel gene expression-based prognostic predictor for ER (...) of the following criteria in order to be considered for enrollment: Histologically confirmed ER positive, stage I-III breast cancer who have been treated with curative intent and completed at least four years of adjuvant endocrine therapy. Life expectancy ≥ 5 years. Must be able to provide informed consent. Willing to consider continuation of endocrine therapy beyond 5 years. Exclusion Criteria: A patient must not be enrolled if any contraindication exists for extended adjuvant endocrine therapy as identified

2014 Clinical Trials

133. The Four Supports Study: Family Support Intervention in Intensive Care Units

item Impact of Events Scale. Other Outcome Measures: Concordance between clinicians and surrogates about patient's prognosis (CSCS) [ Time Frame: Participants are followed at time of enrollment, on day 5 of enrollment, and weekly thereafter for the duration of the hospital stay, an expected average of 4 weeks ] Prognostic estimates of survival and long-term functional impairment are measured responses by assessing the surrogate decision maker and the physician Decisional Conflict Scale (DCS) [ Time (...) involved in surrogate decision-making for the patient, up to a total of four family/surrogates. able to give full informed consent, and able to complete written questionnaires. Surrogate Exclusion Criteria: age <18 years old, unable to read and understand English, and unable to complete questionnaires due to physical or cognitive limitations. Physician Inclusion criteria: 1) Eligible physicians will be the patient's primary attending or his/her designee. If an enrolled patient is cared for by more than

2013 Clinical Trials

134. Obstetrical prognosis and pregnancy outcome following pelvic arterial embolisation for post-partum hemorrhage

. Research : The authors did not state any recommendations for practice. Funding Not stated. Bibliographic details Delotte J, Novellas S, Koh C, Bongain A, Chevallier P. Obstetrical prognosis and pregnancy outcome following pelvic arterial embolisation for post-partum hemorrhage. European Journal of Obstetrics and Gynecology and Reproductive Biology 2009; 145(2): 129-132 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adolescent; Adult; Embolization, Therapeutic (...) Obstetrical prognosis and pregnancy outcome following pelvic arterial embolisation for post-partum hemorrhage Obstetrical prognosis and pregnancy outcome following pelvic arterial embolisation for post-partum hemorrhage Obstetrical prognosis and pregnancy outcome following pelvic arterial embolisation for post-partum hemorrhage Delotte J, Novellas S, Koh C, Bongain A, Chevallier P CRD summary This review concluded that pelvic arterial embolisation offered a safe and conservative alternative

2009 DARE.

135. Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma N (Abstract)

by myeloablative radiochemotherapy and ASCT (control group), or six courses of alternating R-CHOP or R-DHAP (rituximab plus dexamethasone, high-dose cytarabine, and cisplatin) followed by a high-dose cytarabine-containing conditioning regimen and ASCT (cytarabine group). Patients were stratified by study group and international prognostic index. The primary outcome was time to treatment failure from randomisation to stable disease after at least four induction cycles, progression, or death from any cause (...) Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma N Mantle cell lymphoma is characterised by a poor long-term prognosis. The European Mantle Cell Lymphoma Network aimed to investigate whether the introduction of high-dose cytarabine to immunochemotherapy before autologous stem-cell

2016 Lancet (London, England) Controlled trial quality: predicted high

136. Three year functional changes and long-term mortality hazard in community-dwelling older men. (Abstract)

≥71years at wave 2 (baseline of the present analysis), living in the semi-rural community of Merelbeke (Belgium). Physical function assessments included the Short Form-36 (SF-36) Physical Function Index, Grip strength, Chair rising, and Timed Up and Go. Changes over a 3-year time were calculated using data obtained at four annual visits.After a 15-year follow-up, 149 men (87%) died. Median survival time was 8.2 (4.2-12.4) years. Physical function assessed at a single time point (at wave 2 or wave 5 (...) Three year functional changes and long-term mortality hazard in community-dwelling older men. Low levels of physical function have been associated with higher mortality hazard in older persons. However, few studies have investigated the association between functional changes and subsequent mortality. This study aimed to examine whether 3-year functional changes independently predict subsequent all-cause mortality.This population-based cohort study included 171 community-dwelling men aged

2016 European journal of internal medicine

137. Pre-fracture quality of life predicts 1-year survival in elderly patients with hip fracture-development of a new scoring system. (Abstract)

Pre-fracture quality of life predicts 1-year survival in elderly patients with hip fracture-development of a new scoring system. Hip fractures are common in elderly people. Despite great progress in surgical care, the outcome of patients with hip fracture remains disappointing. This study determined four prognostic factors (lower ASA score, higher pre-fracture EQ-5D index, higher MMSE score, and female gender) to predict 1-year survival in patients with hip fracture.This study determined (...) -year follow-up. In multivariate regression analysis, independent predictors of 1-year survival were lower ASA score, higher pre-fracture EQ-5D index, higher MMSE score, and female gender. The different variables were weighted according to their β-coefficient to build the prognostic score, which ranged from 0 to 10 points. The ROC curve for 1-year mortality after hip fracture showed an area under the curve of 0.74 (R (2) = 0.272; 95 % CI 0.68-0.79; p < 0.001).With only four instruments, the new

2016 Osteoporosis International

138. Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients (Full text)

Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients Low tri-iodothyronine syndrome is associated with worse prognosis of severely ill patients. We investigated the association of thyroid hormone levels with discharge outcomes and 5-year mortality in primary brain tumor patients.From January, 2010 until September, 2011, 230 patients (70% women) before brain tumor surgery were evaluated (...) for cognitive (Mini mental State Examination; MMSE) and functional (Barthel index; BI) status, and thyroid function profile. The Low triiodothyronine syndrome was defined as triiodothyronine concentration below the reference range. Unfavorable discharge outcomes were Glasgow outcome scale score of ≤3. Follow-up continued until November, 2015.Seventy-four percent of patients had Low triiodothyronine syndrome. Lower total tri-iodothyronine concentrations were associated with lower MMSE (p=.013) and BI (p=.023

2016 Oncotarget PubMed abstract

139. Congenital Onychodystrophy of the Index Fingers (Overview)

onychodystrophy of the index finger, [ ] Millman and Strier reported a five-generation family in which nine individuals had congenital onychodystrophy of the index finger. [ ] The investigators observed an autosomal dominant pattern of inheritance with variable penetrance. If data from small series, case reports, and retrospective reviews over 30 years are summarized, the four cardinal features of congenital onychodystrophy of the index finger are the following: Unilateral or bilateral hypoplasia of the index (...) affected by congenital onychodystrophy of the index fingers. Age Congenital onychodystrophy of the index fingers is congenital. Previous Next: Prognosis The prognosis is excellent, and patients and their families should be reassured that limitations usually are minimal. The absence of an index fingernail rarely affects the patient's ability to perform functions. Often, the middle fingernail can be used with the thumb if a pincer grip is required. Congenital onychodystrophy of the index finger (COIF

2014 eMedicine.com

140. Congenital Onychodystrophy of the Index Fingers (Diagnosis)

onychodystrophy of the index finger, [ ] Millman and Strier reported a five-generation family in which nine individuals had congenital onychodystrophy of the index finger. [ ] The investigators observed an autosomal dominant pattern of inheritance with variable penetrance. If data from small series, case reports, and retrospective reviews over 30 years are summarized, the four cardinal features of congenital onychodystrophy of the index finger are the following: Unilateral or bilateral hypoplasia of the index (...) affected by congenital onychodystrophy of the index fingers. Age Congenital onychodystrophy of the index fingers is congenital. Previous Next: Prognosis The prognosis is excellent, and patients and their families should be reassured that limitations usually are minimal. The absence of an index fingernail rarely affects the patient's ability to perform functions. Often, the middle fingernail can be used with the thumb if a pincer grip is required. Congenital onychodystrophy of the index finger (COIF

2014 eMedicine.com

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